Me2 (malic enzyme 2) - Rat Genome Database

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Gene: Me2 (malic enzyme 2) Rattus norvegicus
Analyze
Symbol: Me2
Name: malic enzyme 2
RGD ID: 1310321
Description: Predicted to enable malate dehydrogenase (decarboxylating) (NAD+) activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and regulation of NADP metabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human ME2 (malic enzyme 2); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307270; malic enzyme 2, NAD(+)-dependent, mitochondrial; NAD-dependent malic enzyme, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81869,626,073 - 69,676,218 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1869,626,087 - 69,676,218 (-)EnsemblGRCr8
mRatBN7.21867,350,833 - 67,400,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,355,795 - 67,400,987 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1869,463,875 - 69,509,062 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,138,497 - 70,183,469 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,003,831 - 68,049,018 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,737,515 - 69,784,099 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,738,686 - 69,784,099 (-)Ensemblrn6Rnor6.0
Rnor_5.01868,882,367 - 68,927,780 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41870,545,530 - 70,590,828 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1865,538,881 - 65,583,847 (-)NCBICelera
RGSC_v3.11870,619,765 - 70,655,815 (-)NCBI
Cytogenetic Map18q12.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
Bufotalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
gallic acid  (ISO)
glucose  (ISO)
hydralazine  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
triticonazole  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. Piao L, etal., J Mol Med (Berl). 2013 Oct;91(10):1185-97. doi: 10.1007/s00109-013-1064-7. Epub 2013 Jun 21.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:14651853   PMID:18614015   PMID:19691144   PMID:23334421   PMID:37087800  


Genomics

Comparative Map Data
Me2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81869,626,073 - 69,676,218 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1869,626,087 - 69,676,218 (-)EnsemblGRCr8
mRatBN7.21867,350,833 - 67,400,987 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,355,795 - 67,400,987 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1869,463,875 - 69,509,062 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,138,497 - 70,183,469 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,003,831 - 68,049,018 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,737,515 - 69,784,099 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,738,686 - 69,784,099 (-)Ensemblrn6Rnor6.0
Rnor_5.01868,882,367 - 68,927,780 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41870,545,530 - 70,590,828 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1865,538,881 - 65,583,847 (-)NCBICelera
RGSC_v3.11870,619,765 - 70,655,815 (-)NCBI
Cytogenetic Map18q12.2NCBI
ME2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381850,879,118 - 50,954,257 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1850,878,819 - 50,954,257 (+)Ensemblhg38GRCh38
GRCh371848,405,488 - 48,480,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,659,433 - 46,728,258 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341846,659,599 - 46,727,631NCBI
Celera1845,262,199 - 45,332,954 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1845,260,837 - 45,331,606 (+)ENTREZGENEHuRef
CHM1_11848,400,883 - 48,471,611 (+)NCBICHM1_1
T2T-CHM13v2.01851,080,843 - 51,155,984 (+)NCBIT2T-CHM13v2.0
Me2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391873,898,025 - 73,949,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1873,902,974 - 73,948,520 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381873,764,954 - 73,815,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,769,903 - 73,815,449 (-)Ensemblmm10GRCm38
MGSCv371873,929,694 - 73,975,046 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361873,895,409 - 73,940,761 (-)NCBIMGSCv36mm8
Celera1875,007,068 - 75,052,694 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.95NCBI
Me2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,835,578 - 35,894,051 (+)Ensembl
ChiLan1.0NW_00495540235,816,474 - 35,894,051 (+)NCBIChiLan1.0ChiLan1.0
ME2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21768,396,745 - 68,466,631 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11854,090,030 - 54,159,235 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01844,250,067 - 44,319,206 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11847,613,446 - 47,665,330 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,613,446 - 47,665,330 (+)EnsemblpanPan2panpan1.1
ME2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,985,482 - 24,032,642 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,985,994 - 24,025,747 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha124,972,260 - 25,020,810 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0123,876,884 - 23,925,519 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,876,879 - 23,925,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,937,287 - 23,985,836 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,823,416 - 23,872,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,096,731 - 24,145,314 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Me2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,109,234 - 37,174,800 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,353,053 - 12,401,125 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,352,406 - 12,414,014 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ME2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1100,419,760 - 100,476,733 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11100,419,404 - 100,475,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,333,103 - 110,399,885 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ME2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11830,025,734 - 30,095,692 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1830,026,431 - 30,095,691 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660504,156,451 - 4,226,675 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Me2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477814,443,650 - 14,500,017 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477814,423,219 - 14,501,472 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Me2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11558,180,098 - 58,224,483 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Me2
274 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:459
Count of miRNA genes:233
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000049759
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)186438376279484311Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
7794793Mcs34Mammary carcinoma susceptibility QTL 341.54mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)186563556785897775Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)186584644786134022Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat

Markers in Region
RH130986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,355,851 - 67,356,031 (+)MAPPERmRatBN7.2
Rnor_6.01869,738,743 - 69,738,922NCBIRnor6.0
Rnor_5.01868,882,424 - 68,882,603UniSTSRnor5.0
RGSC_v3.41870,545,587 - 70,545,766UniSTSRGSC3.4
Celera1865,538,938 - 65,539,117UniSTS
RH 3.4 Map18685.4UniSTS
Cytogenetic Map18q12.2UniSTS
RH142588  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21867,356,807 - 67,356,934 (+)MAPPERmRatBN7.2
Rnor_6.01869,739,699 - 69,739,825NCBIRnor6.0
Rnor_5.01868,883,380 - 68,883,506UniSTSRnor5.0
RGSC_v3.41870,546,543 - 70,546,669UniSTSRGSC3.4
Celera1865,539,894 - 65,540,020UniSTS
RH 3.4 Map18681.4UniSTS
Cytogenetic Map18q12.2UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049759   ⟹   ENSRNOP00000041737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1869,631,034 - 69,676,218 (-)Ensembl
mRatBN7.2 Ensembl1867,355,795 - 67,400,987 (-)Ensembl
Rnor_6.0 Ensembl1869,738,686 - 69,784,099 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079093   ⟹   ENSRNOP00000073241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1869,631,034 - 69,675,917 (-)Ensembl
mRatBN7.2 Ensembl1867,355,795 - 67,400,898 (-)Ensembl
Rnor_6.0 Ensembl1869,739,675 - 69,780,922 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163051   ⟹   ENSRNOP00000100974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1869,626,087 - 69,676,218 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173790   ⟹   ENSRNOP00000103470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1869,631,034 - 69,675,796 (-)Ensembl
RefSeq Acc Id: NM_001107376   ⟹   NP_001100846
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,631,034 - 69,676,218 (-)NCBI
mRatBN7.21867,355,795 - 67,400,987 (-)NCBI
Rnor_6.01869,738,686 - 69,784,099 (-)NCBI
Rnor_5.01868,882,367 - 68,927,780 (-)NCBI
RGSC_v3.41870,545,530 - 70,590,828 (-)RGD
Celera1865,538,881 - 65,583,847 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254923   ⟹   XP_006254985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,627,842 - 69,673,554 (-)NCBI
mRatBN7.21867,352,604 - 67,397,659 (-)NCBI
Rnor_6.01869,737,515 - 69,782,567 (-)NCBI
Rnor_5.01868,882,367 - 68,927,780 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096780   ⟹   XP_038952708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,626,073 - 69,673,639 (-)NCBI
mRatBN7.21867,350,833 - 67,397,675 (-)NCBI
RefSeq Acc Id: XM_063277298   ⟹   XP_063133368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81869,627,842 - 69,675,998 (-)NCBI
RefSeq Acc Id: NP_001100846   ⟸   NM_001107376
- UniProtKB: D3ZJH9 (UniProtKB/TrEMBL),   A6KRC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254985   ⟸   XM_006254923
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K502 (UniProtKB/TrEMBL),   A6KRC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073241   ⟸   ENSRNOT00000079093
Ensembl Acc Id: ENSRNOP00000041737   ⟸   ENSRNOT00000049759
RefSeq Acc Id: XP_038952708   ⟸   XM_039096780
- Peptide Label: isoform X2
- UniProtKB: A6KRC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133368   ⟸   XM_063277298
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K502 (UniProtKB/TrEMBL),   A6KRC6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103470   ⟸   ENSRNOT00000173790
Ensembl Acc Id: ENSRNOP00000100974   ⟸   ENSRNOT00000163051
Protein Domains
Malic enzyme N-terminal   Malic enzyme NAD-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K502-F1-model_v2 AlphaFold A0A0G2K502 1-591 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700860
Promoter ID:EPDNEW_R11384
Type:initiation region
Name:Me2_1
Description:malic enzyme 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01869,784,145 - 69,784,205EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310321 AgrOrtholog
BioCyc Gene G2FUF-7051 BioCyc
Ensembl Genes ENSRNOG00000015582 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049759 ENTREZGENE
  ENSRNOT00000049759.6 UniProtKB/TrEMBL
  ENSRNOT00000079093.3 UniProtKB/TrEMBL
  ENSRNOT00000163051 ENTREZGENE
  ENSRNOT00000163051.1 UniProtKB/TrEMBL
  ENSRNOT00000173790 ENTREZGENE
  ENSRNOT00000173790.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10380 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  Malic_enzyme_CS UniProtKB/TrEMBL
  Malic_N UniProtKB/TrEMBL
  Malic_N_dom_sf UniProtKB/TrEMBL
  Malic_NAD-bd UniProtKB/TrEMBL
  Malic_OxRdtase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
KEGG Report rno:307270 UniProtKB/TrEMBL
NCBI Gene 307270 ENTREZGENE
PANTHER MALIC ENZYME-RELATED UniProtKB/TrEMBL
  NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
PhenoGen Me2 PhenoGen
PIRSF PIRSF000106 UniProtKB/TrEMBL
PRINTS MALOXRDTASE UniProtKB/TrEMBL
PROSITE MALIC_ENZYMES UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015582 RatGTEx
SMART malic UniProtKB/TrEMBL
  Malic_M UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0A0G2K502 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L9G7_RAT UniProtKB/TrEMBL
  A0ABK0LGJ4_RAT UniProtKB/TrEMBL
  A6KRC6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJH9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Me2  malic enzyme 2  Me2  malic enzyme 2, NAD(+)-dependent, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Me2  malic enzyme 2, NAD(+)-dependent, mitochondrial   Me2_predicted  malic enzyme 2, NAD(+)-dependent, mitochondrial (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Me2_predicted  malic enzyme 2, NAD(+)-dependent, mitochondrial (predicted)      Symbol and Name status set to approved 70820 APPROVED