Adgrf1 (adhesion G protein-coupled receptor F1) - Rat Genome Database

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Gene: Adgrf1 (adhesion G protein-coupled receptor F1) Rattus norvegicus
Analyze
Symbol: Adgrf1
Name: adhesion G protein-coupled receptor F1
RGD ID: 1310285
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; fat cell differentiation; and nervous system development. Predicted to act upstream of or within memory. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1); INTERACTS WITH amphetamine; cocaine; Monobutylphthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adhesion G-protein coupled receptor F1; G protein-coupled receptor 110; Gpr110; LOC301266
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,158,198 - 25,210,744 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl925,147,588 - 25,208,916 (-)EnsemblGRCr8
mRatBN7.2917,661,258 - 17,696,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,660,930 - 17,711,704 (-)EnsemblmRatBN7.2
Rnor_6.0920,343,730 - 20,378,686 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0919,202,510 - 19,318,504 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4913,359,998 - 13,419,131 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera915,370,906 - 15,421,796 (-)NCBICelera
RGSC_v3.1913,358,106 - 13,416,371 (-)NCBI
Cytogenetic Map9q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27759003  


Genomics

Comparative Map Data
Adgrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8925,158,198 - 25,210,744 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl925,147,588 - 25,208,916 (-)EnsemblGRCr8
mRatBN7.2917,661,258 - 17,696,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,660,930 - 17,711,704 (-)EnsemblmRatBN7.2
Rnor_6.0920,343,730 - 20,378,686 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0919,202,510 - 19,318,504 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4913,359,998 - 13,419,131 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera915,370,906 - 15,421,796 (-)NCBICelera
RGSC_v3.1913,358,106 - 13,416,371 (-)NCBI
Cytogenetic Map9q13NCBI
ADGRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,997,708 - 47,042,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,997,708 - 47,042,350 (-)Ensemblhg38GRCh38
GRCh37646,965,445 - 47,010,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,075,772 - 47,118,041 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34647,075,917 - 47,094,194NCBI
Celera648,520,157 - 48,562,426 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,690,703 - 46,732,981 (-)NCBIHuRef
CHM1_1646,971,042 - 47,013,305 (-)NCBICHM1_1
T2T-CHM13v2.0646,835,188 - 46,879,812 (-)NCBIT2T-CHM13v2.0
Adgrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,581,174 - 43,636,767 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,581,220 - 43,635,628 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381743,270,283 - 43,325,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,270,329 - 43,324,737 (+)Ensemblmm10GRCm38
MGSCv371743,407,296 - 43,461,355 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361742,735,601 - 42,789,388 (+)NCBIMGSCv36mm8
Celera1746,686,960 - 46,746,176 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1719.71NCBI
Adgrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,744,342 - 11,772,305 (-)Ensembl
ChiLan1.0NW_00495543711,744,387 - 11,772,260 (-)NCBIChiLan1.0ChiLan1.0
ADGRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2561,495,623 - 61,540,289 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1657,361,859 - 57,406,528 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0646,583,013 - 46,627,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,848,040 - 47,892,695 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,848,040 - 47,892,912 (-)EnsemblpanPan2panpan1.1
ADGRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,149,254 - 15,283,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,150,543 - 15,204,300 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1215,181,601 - 15,315,412 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01215,646,559 - 15,741,910 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,648,211 - 15,702,592 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,161,203 - 15,256,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,254,178 - 15,349,786 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,400,749 - 15,534,732 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adgrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,586,577 - 50,612,890 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647613,358,096 - 13,374,819 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647613,339,985 - 13,373,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl741,806,393 - 41,853,657 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1741,806,385 - 41,853,829 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,466,209 - 48,497,395 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,236,855 - 25,279,589 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1725,237,852 - 25,273,087 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604447,017,749 - 47,049,257 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,722,457 - 13,751,378 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475413,722,528 - 13,749,892 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Adgrf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1486,512,461 - 86,544,871 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adgrf1
288 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
D9Got21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2917,664,358 - 17,664,536 (+)MAPPERmRatBN7.2
Rnor_6.0920,333,114 - 20,333,291NCBIRnor6.0
Rnor_5.0919,205,763 - 19,205,940UniSTSRnor5.0
RGSC_v3.4913,363,882 - 13,364,060RGDRGSC3.4
RGSC_v3.4913,363,883 - 13,364,060UniSTSRGSC3.4
Celera915,374,007 - 15,374,184UniSTS
RGSC_v3.1913,361,205 - 13,361,382RGD
RH 3.4 Map9135.3UniSTS
RH 3.4 Map9135.3RGD
RH 2.0 Map9115.9RGD
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
4 5 12 27 73 39 7 5 30 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000115168   ⟹   ENSRNOP00000093180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,157,992 - 25,208,916 (-)Ensembl
mRatBN7.2 Ensembl917,660,930 - 17,711,704 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125012   ⟹   ENSRNOP00000101357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,147,588 - 25,191,461 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140207   ⟹   ENSRNOP00000107020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl925,157,835 - 25,191,461 (-)Ensembl
RefSeq Acc Id: XM_039084502   ⟹   XP_038940430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,191,230 (-)NCBI
mRatBN7.2917,661,258 - 17,693,969 (-)NCBI
RefSeq Acc Id: XM_039084503   ⟹   XP_038940431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,208,948 (-)NCBI
mRatBN7.2917,661,258 - 17,696,359 (-)NCBI
RefSeq Acc Id: XM_039084504   ⟹   XP_038940432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,191,221 (-)NCBI
mRatBN7.2917,661,258 - 17,693,933 (-)NCBI
RefSeq Acc Id: XM_063267885   ⟹   XP_063123955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8925,158,198 - 25,210,744 (-)NCBI
RefSeq Acc Id: XP_038940431   ⟸   XM_039084503
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940430   ⟸   XM_039084502
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940432   ⟸   XM_039084504
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000093180   ⟸   ENSRNOT00000115168
RefSeq Acc Id: XP_063123955   ⟸   XM_063267885
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000101357   ⟸   ENSRNOT00000125012
Ensembl Acc Id: ENSRNOP00000107020   ⟸   ENSRNOT00000140207
Protein Domains
G-protein coupled receptors family 2 profile   GAIN-B   SEA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310285 AgrOrtholog
BioCyc Gene G2FUF-28103 BioCyc
Ensembl Genes ENSRNOG00000062544 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000115168 ENTREZGENE
  ENSRNOT00000115168.2 UniProtKB/TrEMBL
  ENSRNOT00000125012.1 UniProtKB/TrEMBL
  ENSRNOT00000140207 ENTREZGENE
  ENSRNOT00000140207.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.610 UniProtKB/TrEMBL
  2.60.220.50 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Adhesion_GPCR UniProtKB/TrEMBL
  GAIN_B UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/TrEMBL
  GPCR_2_Ig-hepta-like_rcpt UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  SEA_dom UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
NCBI Gene 301266 ENTREZGENE
PANTHER ADHESION G-PROTEIN COUPLED RECEPTOR F1 UniProtKB/TrEMBL
  PTHR45813 UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
PhenoGen Adgrf1 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/TrEMBL
  IGHEPTARCPTR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/TrEMBL
  GPS UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000062544 RatGTEx
SMART GPS UniProtKB/TrEMBL
Superfamily-SCOP SSF82671 UniProtKB/TrEMBL
UniProt A0A8I6AIR1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKA0_RAT UniProtKB/TrEMBL
  A0ABK0LT83_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Adgrf1  adhesion G protein-coupled receptor F1  Adgrf1  adhesion G protein-coupled receptor F1  Data merged from RGD:149736219 737654 PROVISIONAL
2021-08-09 Adgrf1  adhesion G protein-coupled receptor F1      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-03-16 Adgrf1  adhesion G protein-coupled receptor F1  Gpr110  G protein-coupled receptor 110  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Gpr110  G protein-coupled receptor 110   Gpr110_predicted  G protein-coupled receptor 110 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gpr110_predicted  G protein-coupled receptor 110 (predicted)      Symbol and Name status set to approved 70820 APPROVED