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Gene: Sall3 (spalt-like transcription factor 3) Rattus norvegicus
Analyze
Symbol:
Sall3
Name:
spalt-like transcription factor 3
RGD ID:
1310232
Description:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within limb morphogenesis; negative regulation of smoothened signaling pathway; and olfactory bulb interneuron development. Predicted to be active in nucleus. Orthologous to human SALL3 (spalt like transcription factor 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC364910; sal-like 3; sal-like 3 (Drosophila); sal-like protein 3
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 18 76,680,997 - 76,700,905 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 18 76,681,005 - 76,700,905 (-) Ensembl GRCr8 mRatBN7.2 18 74,406,066 - 74,425,974 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 18 74,407,560 - 74,426,789 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 18 76,511,277 - 76,517,554 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 18 77,180,597 - 77,186,874 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 18 75,024,901 - 75,031,169 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 18 77,572,200 - 77,591,710 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 77,573,702 - 77,579,969 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 18 76,676,425 - 76,694,411 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 18 77,852,386 - 77,858,653 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 18 73,064,077 - 73,070,344 (-) NCBI Celera RGSC_v3.1 18 77,907,213 - 77,943,580 (-) NCBI Cytogenetic Map 18 q12.3 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Sall3 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SALL3 mRNA CTD PMID:32109520 Sall3 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SALL3 mRNA CTD PMID:32109520 Sall3 Rat 4,4'-sulfonyldiphenol increases methylation ISO Sall3 (Mus musculus) 6480464 bisphenol S results in increased methylation of SALL3 exon CTD PMID:33297965 Sall3 Rat 4,4'-sulfonyldiphenol affects methylation ISO Sall3 (Mus musculus) 6480464 bisphenol S affects the methylation of SALL3 gene CTD PMID:31683443 Sall3 Rat 4-hydroxyphenyl retinamide decreases expression ISO Sall3 (Mus musculus) 6480464 Fenretinide results in decreased expression of SALL3 mRNA CTD PMID:28973697 Sall3 Rat aflatoxin B1 decreases expression ISO SALL3 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of SALL3 mRNA CTD PMID:22100608 Sall3 Rat all-trans-retinoic acid decreases expression ISO SALL3 (Homo sapiens) 6480464 Tretinoin results in decreased expression of SALL3 mRNA CTD PMID:21934132 Sall3 Rat benzo[a]pyrene increases methylation ISO SALL3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SALL3 promoter CTD PMID:27901495 Sall3 Rat bis(2-ethylhexyl) phthalate increases expression ISO SALL3 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of SALL3 protein CTD PMID:31163220 Sall3 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SALL3 mRNA CTD PMID:25181051|PMID:41034487 Sall3 Rat bisphenol A decreases methylation ISO SALL3 (Homo sapiens) 6480464 bisphenol A results in decreased methylation of SALL3 gene CTD PMID:31601247 Sall3 Rat bisphenol A multiple interactions ISO SALL3 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SALL3 gene CTD PMID:31601247 Sall3 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SALL3 mRNA CTD PMID:30816183 Sall3 Rat bisphenol F multiple interactions ISO SALL3 (Homo sapiens) 6480464 [bisphenol F co-treated with Fulvestrant] results in increased methylation of SALL3 gene CTD PMID:31601247 Sall3 Rat carbamazepine affects expression ISO SALL3 (Homo sapiens) 6480464 Carbamazepine affects the expression of SALL3 mRNA CTD PMID:25979313 Sall3 Rat Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of SALL3 mRNA CTD PMID:26577399|PMID:27523638 Sall3 Rat dorsomorphin multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Sall3 Rat entinostat decreases expression ISO SALL3 (Homo sapiens) 6480464 entinostat results in decreased expression of SALL3 mRNA CTD PMID:26272509 Sall3 Rat entinostat multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Sall3 Rat ethanol increases expression ISO Sall3 (Mus musculus) 6480464 Ethanol results in increased expression of SALL3 mRNA CTD PMID:30319688 Sall3 Rat folic acid decreases expression ISO Sall3 (Mus musculus) 6480464 Folic Acid results in decreased expression of SALL3 mRNA CTD PMID:25629700 Sall3 Rat fulvestrant affects methylation ISO SALL3 (Homo sapiens) 6480464 Fulvestrant affects the methylation of SALL3 gene CTD PMID:31601247 Sall3 Rat fulvestrant multiple interactions ISO SALL3 (Homo sapiens) 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SALL3 gene; [bisphenol F co-treated more ... CTD PMID:31601247 Sall3 Rat furan increases methylation EXP 6480464 furan results in increased methylation of SALL3 gene CTD PMID:22079235 Sall3 Rat glycidol decreases expression EXP 6480464 glycidol results in decreased expression of SALL3 mRNA CTD PMID:24915197 Sall3 Rat mercury dibromide decreases expression ISO SALL3 (Homo sapiens) 6480464 mercuric bromide results in decreased expression of SALL3 mRNA CTD PMID:26272509 Sall3 Rat mercury dibromide multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Sall3 Rat methylmercury chloride increases expression ISO SALL3 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of SALL3 mRNA CTD PMID:26272509 Sall3 Rat methylmercury chloride decreases expression ISO SALL3 (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of SALL3 mRNA CTD PMID:28001369 Sall3 Rat N-methyl-4-phenylpyridinium decreases expression ISO SALL3 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SALL3 mRNA CTD PMID:24810058 Sall3 Rat p-chloromercuribenzoic acid decreases expression ISO SALL3 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in decreased expression of SALL3 mRNA CTD PMID:26272509 Sall3 Rat p-chloromercuribenzoic acid multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Sall3 Rat panobinostat multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Sall3 Rat panobinostat decreases expression ISO SALL3 (Homo sapiens) 6480464 panobinostat results in decreased expression of SALL3 mRNA CTD PMID:26272509 Sall3 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SALL3 mRNA CTD PMID:33387578 Sall3 Rat phenylmercury acetate decreases expression ISO SALL3 (Homo sapiens) 6480464 Phenylmercuric Acetate results in decreased expression of SALL3 mRNA CTD PMID:26272509 Sall3 Rat phenylmercury acetate multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Sall3 Rat SB 431542 multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386 Sall3 Rat sodium arsenate decreases expression ISO Sall3 (Mus musculus) 6480464 sodium arsenate results in decreased expression of SALL3 mRNA CTD PMID:30953684 Sall3 Rat sodium arsenite affects methylation ISO SALL3 (Homo sapiens) 6480464 sodium arsenite affects the methylation of SALL3 gene CTD PMID:28589171 Sall3 Rat sunitinib increases expression ISO SALL3 (Homo sapiens) 6480464 Sunitinib results in increased expression of SALL3 mRNA CTD PMID:31533062 Sall3 Rat Tetrachlorobisphenol A decreases expression ISO SALL3 (Homo sapiens) 6480464 tetrachlorodian results in decreased expression of SALL3 mRNA CTD PMID:31326446 Sall3 Rat titanium dioxide decreases methylation ISO Sall3 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of SALL3 gene; titanium dioxide results in decreased methylation more ... CTD PMID:35295148 Sall3 Rat titanium dioxide increases methylation ISO Sall3 (Mus musculus) 6480464 titanium dioxide results in increased methylation of SALL3 gene CTD PMID:35295148 Sall3 Rat tributylstannane decreases expression EXP 6480464 tributyltin results in decreased expression of SALL3 mRNA CTD PMID:31129395 Sall3 Rat trichostatin A decreases expression ISO SALL3 (Homo sapiens) 6480464 trichostatin A results in decreased expression of SALL3 mRNA CTD PMID:24935251|PMID:26272509 Sall3 Rat trichostatin A multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Sall3 Rat valproic acid increases methylation ISO SALL3 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of SALL3 gene CTD PMID:29154799 Sall3 Rat valproic acid affects expression ISO SALL3 (Homo sapiens) 6480464 Valproic Acid affects the expression of SALL3 mRNA CTD PMID:25979313 Sall3 Rat valproic acid multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Sall3 Rat valproic acid decreases expression ISO SALL3 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of SALL3 mRNA CTD PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:27188386|PMID:28001369 Sall3 Rat vorinostat decreases expression ISO SALL3 (Homo sapiens) 6480464 vorinostat results in decreased expression of SALL3 mRNA CTD PMID:26272509 Sall3 Rat vorinostat multiple interactions ISO SALL3 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ... CTD PMID:27188386
QTLs in Region (GRCr8)
1331733 Bp233 Blood pressure QTL 233 3.97196 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 25071126 83910656 Rat 12904069 Cm123 Cardiac mass QTL 123 0.001 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 18 33379158 78379158 Rat 1331798 Bp224 Blood pressure QTL 224 3.53873 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31610505 77371277 Rat 12904070 Cm124 Cardiac mass QTL 124 0.01 heart right ventricle mass (VT:0007033) heart right ventricle weight to body weight ratio (CMO:0000914) 18 33379158 78379158 Rat 12904071 Am18 Aortic mass QTL 18 0.001 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 18 33379158 78379158 Rat 2303584 Gluco55 Glucose level QTL 55 2 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 18 50795212 86134022 Rat 1331730 Scl27 Serum cholesterol level QTL 27 3.826 blood HDL cholesterol amount (VT:0000184) serum high density lipoprotein cholesterol level (CMO:0000361) 18 54490801 86134022 Rat 12904067 Cm122 Cardiac mass QTL 122 0.001 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 18 33379158 78379158 Rat 61384 Bp48 Blood pressure QTL 48 19.4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 18 62892257 79484461 Rat 1331741 Bp232 Blood pressure QTL 232 3.59112 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 18 23494057 85487725 Rat 1331742 Bp228 Blood pressure QTL 228 3.88752 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31610505 77371277 Rat 2301417 Bp319 Blood pressure QTL 319 0.002 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 33379158 78379158 Rat 1298072 Cia26 Collagen induced arthritis QTL 26 3.6 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 18 64383762 79484311 Rat 12904073 Kidm71 Kidney mass QTL 71 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 18 33379158 78379158 Rat 631834 Sach3 Saccharin preference QTL 3 3.9 0.01 consumption behavior trait (VT:0002069) calculated saccharin drink intake volume (CMO:0001600) 18 38575919 83575919 Rat 738008 Hcar14 Hepatocarcinoma resistance QTL 14 4.3 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion number (CMO:0001462) 18 57825243 85493247 Rat 1331776 Bp225 Blood pressure QTL 225 2.829 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 18 31610505 77371277 Rat 634333 Pia19 Pristane induced arthritis QTL 19 3.4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 18 76272104 81806852 Rat 631518 Bw11 Body weight QTL 11 2.8 body mass (VT:0001259) body weight (CMO:0000012) 18 36121626 81121626 Rat 1641923 Colcr8 Colorectal carcinoma resistance QTL 8 3.1 0.0014 intestine integrity trait (VT:0010554) poorly differentiated malignant colorectal tumor number (CMO:0002076) 18 31990891 76990891 Rat 6893683 Bw110 Body weight QTL 110 2.7 0.002 body mass (VT:0001259) body weight (CMO:0000012) 18 45620306 86134022 Rat 8694366 Abfw8 Abdominal fat weight QTL 8 6.38 0.001 visceral adipose mass (VT:0010063) abdominal fat pad weight to body weight ratio (CMO:0000095) 18 48915737 86134022 Rat 7794793 Mcs34 Mammary carcinoma susceptibility QTL 34 1.54 mammary gland integrity trait (VT:0010552) mammary tumor incidence/prevalence measurement (CMO:0000946) 18 65635567 85897775 Rat 631274 Sprol1 Serum protein level QTL 1 5.3 blood total protein amount (VT:0005567) serum total protein level (CMO:0000661) 18 31644508 79484311 Rat 9589041 Epfw12 Epididymal fat weight QTL 12 17.08 0.001 epididymal fat pad mass (VT:0010421) epididymal fat pad weight to body weight ratio (CMO:0000658) 18 48915737 86134022 Rat 8694432 Bw165 Body weight QTL 165 3.81 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 18 48915737 86134022 Rat 1358193 Emca2 Estrogen-induced mammary cancer QTL 2 1.6 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 18 65846447 86134022 Rat 1598832 Glom11 Glomerulus QTL 11 2.9 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 18 53266671 86134022 Rat 1331774 Bp226 Blood pressure QTL 226 4.41065 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 31610505 77371277 Rat 9589816 Gluco68 Glucose level QTL 68 7.25 0.001 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 18 31990891 76990891 Rat 1600373 Mamtr6 Mammary tumor resistance QTL 6 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 18 19553532 85493247 Rat 8694378 Bw157 Body weight QTL 157 3.59 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 18 31990891 76990891 Rat 1331770 Bp234 Blood pressure QTL 234 3.807 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 45620306 86134022 Rat 2303571 Bw92 Body weight QTL 92 3 body mass (VT:0001259) body weight (CMO:0000012) 18 50795212 86134022 Rat 631675 Iddm15 Insulin dependent diabetes mellitus QTL 15 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) 18 62892257 79484461 Rat 1578667 Bss21 Bone structure and strength QTL 21 3.5 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 18 12066482 85493247 Rat 2303120 Mamtr8 Mammary tumor resistance QTL 8 0.001 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) 18 31610505 85493247 Rat 12880368 Bw187 Body weight QTL 187 0.045 body mass (VT:0001259) body weight (CMO:0000012) 18 33379158 78379158 Rat 724542 Kidm2 Kidney mass QTL 2 2.6 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) 18 61446853 86134022 Rat 61367 Iddm4 Insulin dependent diabetes mellitus QTL 4 2.33 0.0074 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 18 40462383 85462383 Rat 9590318 Scort22 Serum corticosterone level QTL 22 7.64 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 18 31990891 76990891 Rat 1578661 Bss20 Bone structure and strength QTL 20 3.7 femur morphology trait (VT:0000559) femoral neck cross-sectional area (CMO:0001697) 18 12066482 85493247 Rat 1331754 Bp230 Blood pressure QTL 230 4.61609 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 18 15642280 86134022 Rat