Tdh (L-threonine dehydrogenase) - Rat Genome Database

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Gene: Tdh (L-threonine dehydrogenase) Rattus norvegicus
Analyze
Symbol: Tdh
Name: L-threonine dehydrogenase
RGD ID: 1310214
Description: Predicted to enable L-threonine 3-dehydrogenase activity and identical protein binding activity. Predicted to be involved in L-threonine catabolic process. Predicted to be located in mitochondrion. Orthologous to human TDH (L-threonine dehydrogenase (pseudogene)); PARTICIPATES IN glycine, serine and threonine metabolic pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: L-threonine 3-dehydrogenase, mitochondrial; LOC290315
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,915,766 - 41,929,307 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,915,766 - 41,929,307 (-)EnsemblGRCr8
mRatBN7.21537,739,823 - 37,753,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,739,823 - 37,753,365 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,592,291 - 39,605,865 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,742,954 - 40,756,528 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,200,434 - 39,213,980 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1540,447,368 - 40,460,830 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1540,165,108 - 40,178,570 (-)NCBILyon_Normotensive
Lyon_Hypertensive1540,446,248 - 40,459,676 (-)NCBILyon_Hypertensive
F344_StmMcwi1539,455,726 - 39,469,188 (-)NCBIF344_StmMcwi
Rnor_6.01546,667,926 - 46,682,752 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,667,926 - 46,681,467 (-)Ensemblrn6Rnor6.0
Rnor_5.01550,429,955 - 50,443,496 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,758,308 - 42,771,849 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,422,646 - 37,436,207 (-)NCBICelera
RGSC_v3.11542,774,121 - 42,787,473 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:21896756   PMID:26492815  


Genomics

Comparative Map Data
Tdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,915,766 - 41,929,307 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1541,915,766 - 41,929,307 (-)EnsemblGRCr8
mRatBN7.21537,739,823 - 37,753,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,739,823 - 37,753,365 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,592,291 - 39,605,865 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,742,954 - 40,756,528 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,200,434 - 39,213,980 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1540,447,368 - 40,460,830 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1540,165,108 - 40,178,570 (-)NCBILyon_Normotensive
Lyon_Hypertensive1540,446,248 - 40,459,676 (-)NCBILyon_Hypertensive
F344_StmMcwi1539,455,726 - 39,469,188 (-)NCBIF344_StmMcwi
Rnor_6.01546,667,926 - 46,682,752 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,667,926 - 46,681,467 (-)Ensemblrn6Rnor6.0
Rnor_5.01550,429,955 - 50,443,496 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,758,308 - 42,771,849 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,422,646 - 37,436,207 (-)NCBICelera
RGSC_v3.11542,774,121 - 42,787,473 (-)NCBI
Cytogenetic Map15p12NCBI
TDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38811,339,637 - 11,368,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl811,356,120 - 11,365,722 (+)Ensemblhg38GRCh38
GRCh38.p14 Ensembl811,339,637 - 11,368,452 (+)Ensemblhg38GRCh38
GRCh37811,197,146 - 11,225,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,234,556 - 11,263,371 (+)NCBIBuild 36Build 36hg18NCBI36
Celera810,325,172 - 10,353,989 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,127,309 - 10,156,094 (+)NCBIHuRef
CHM1_1811,262,440 - 11,291,368 (+)NCBICHM1_1
T2T-CHM13v2.088,370,590 - 8,399,377 (-)NCBIT2T-CHM13v2.0
Tdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,729,796 - 63,746,541 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,729,796 - 63,746,541 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381463,492,347 - 63,509,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,492,347 - 63,509,092 (-)Ensemblmm10GRCm38
MGSCv371464,111,184 - 64,127,929 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361462,446,457 - 62,463,202 (-)NCBIMGSCv36mm8
Celera1461,261,977 - 61,278,715 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.31NCBI
TDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,541,717 - 26,560,366 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2527,197,247 - 27,215,878 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02526,694,959 - 26,713,603 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,693,854 - 26,713,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,649,525 - 26,668,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,544,921 - 26,563,545 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,696,859 - 26,715,551 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11414,577,009 - 14,597,695 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Tdh
15 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:97
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000015353
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH130602  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,739,959 - 37,740,140 (+)MAPPERmRatBN7.2
Rnor_6.01546,668,063 - 46,668,243NCBIRnor6.0
Rnor_5.01550,430,092 - 50,430,272UniSTSRnor5.0
RGSC_v3.41542,758,445 - 42,758,625UniSTSRGSC3.4
Celera1537,422,783 - 37,422,963UniSTS
RH 3.4 Map15276.5UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 57 137 84 83 52 73 52 6 305 157 5 113 73 80 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000015353   ⟹   ENSRNOP00000015353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1541,915,766 - 41,929,307 (-)Ensembl
mRatBN7.2 Ensembl1537,739,823 - 37,753,365 (-)Ensembl
Rnor_6.0 Ensembl1546,667,926 - 46,681,467 (-)Ensembl
RefSeq Acc Id: NM_001106044   ⟹   NP_001099514
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81541,915,766 - 41,929,307 (-)NCBI
mRatBN7.21537,739,823 - 37,753,365 (-)NCBI
Dahl_SR_JrHsd1540,447,368 - 40,460,830 (-)NCBI
Lyon_Normotensive1540,165,108 - 40,178,570 (-)NCBI
Lyon_Hypertensive1540,446,248 - 40,459,676 (-)NCBI
F344_StmMcwi1539,455,726 - 39,469,188 (-)NCBI
Rnor_6.01546,667,926 - 46,681,467 (-)NCBI
Rnor_5.01550,429,955 - 50,443,496 (-)NCBI
RGSC_v3.41542,758,308 - 42,771,849 (-)RGD
Celera1537,422,646 - 37,436,207 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099514 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85323 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015353
  ENSRNOP00000015353.4
RefSeq Acc Id: NP_001099514   ⟸   NM_001106044
- UniProtKB: D3ZN15 (UniProtKB/TrEMBL),   A6K6G3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015353   ⟸   ENSRNOT00000015353
Protein Domains
NAD-dependent epimerase/dehydratase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN15-F1-model_v2 AlphaFold D3ZN15 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310214 AgrOrtholog
BioCyc Gene G2FUF-13421 BioCyc
BioCyc Pathway THREONINE-DEG2-PWY [L-threonine degradation II] BioCyc
BioCyc Pathway Image THREONINE-DEG2-PWY BioCyc
Ensembl Genes ENSRNOG00000011342 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015353 ENTREZGENE
  ENSRNOT00000015353.7 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Epimerase_deHydtase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  NAD(P)_epim/dehydratase UniProtKB/TrEMBL
KEGG Report rno:290315 UniProtKB/TrEMBL
NCBI Gene 290315 ENTREZGENE
PANTHER L-THREONINE 3-DEHYDROGENASE UniProtKB/TrEMBL
  L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Epimerase UniProtKB/TrEMBL
PhenoGen Tdh PhenoGen
RatGTEx ENSRNOG00000011342 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A6K6G3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN15 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tdh  L-threonine dehydrogenase   Tdh_predicted  L-threonine dehydrogenase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tdh_predicted  L-threonine dehydrogenase (predicted)      Symbol and Name status set to approved 70820 APPROVED