Mfsd2a (MFSD2 lysolipid transporter A, lysophospholipid) - Rat Genome Database

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Gene: Mfsd2a (MFSD2 lysolipid transporter A, lysophospholipid) Rattus norvegicus
Analyze
Symbol: Mfsd2a
Name: MFSD2 lysolipid transporter A, lysophospholipid
RGD ID: 1310174
Description: Predicted to enable lysophosphatidylcholine flippase activity; lysophospholipid:sodium symporter activity; and oleate transmembrane transporter activity. Predicted to be involved in several processes, including central nervous system development; lipid transport across blood-brain barrier; and lysophospholipid translocation. Predicted to act upstream of or within several processes, including photoreceptor cell development; regulation of lipid metabolic process; and retina development in camera-type eye. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 15. Orthologous to human MFSD2A (MFSD2 lysolipid transporter A, lysophospholipid); INTERACTS WITH 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical LOC298504; LOC298504; major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2A; Mfsd2; RGD1310174; sodium-dependent lysophosphatidylcholine symporter 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,510,933 - 140,525,828 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5140,510,953 - 140,525,916 (-)EnsemblGRCr8
mRatBN7.25135,225,801 - 135,240,744 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,225,816 - 135,240,690 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5137,932,684 - 137,947,368 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,702,687 - 139,717,377 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,709,784 - 139,724,468 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,642,865 - 140,657,759 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,642,885 - 140,657,745 (-)Ensemblrn6Rnor6.0
Rnor_5.05144,433,445 - 144,448,324 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45142,260,560 - 142,275,435 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5133,764,543 - 133,779,074 (-)NCBICelera
RGSC_v3.15142,265,780 - 142,280,604 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[b]fluorene  (EXP)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
Harpagoside  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lysophosphatidylcholine  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naled  (ISO)
naphthalene  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sevoflurane  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:23209793   PMID:24828040   PMID:24828044   PMID:26005865   PMID:26005868   PMID:26945070   PMID:27008858   PMID:30074985   PMID:31907728   PMID:36631446   PMID:37458379  


Genomics

Comparative Map Data
Mfsd2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,510,933 - 140,525,828 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5140,510,953 - 140,525,916 (-)EnsemblGRCr8
mRatBN7.25135,225,801 - 135,240,744 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5135,225,816 - 135,240,690 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5137,932,684 - 137,947,368 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,702,687 - 139,717,377 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,709,784 - 139,724,468 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,642,865 - 140,657,759 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5140,642,885 - 140,657,745 (-)Ensemblrn6Rnor6.0
Rnor_5.05144,433,445 - 144,448,324 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45142,260,560 - 142,275,435 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5133,764,543 - 133,779,074 (-)NCBICelera
RGSC_v3.15142,265,780 - 142,280,604 (-)NCBI
Cytogenetic Map5q36NCBI
MFSD2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38139,955,145 - 39,969,956 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl139,955,112 - 39,969,968 (+)Ensemblhg38GRCh38
GRCh37140,420,817 - 40,435,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,193,397 - 40,208,215 (+)NCBIBuild 36Build 36hg18NCBI36
Celera138,702,422 - 38,717,260 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,539,329 - 38,554,171 (+)NCBIHuRef
CHM1_1140,536,427 - 40,551,270 (+)NCBICHM1_1
T2T-CHM13v2.0139,824,591 - 39,839,402 (+)NCBIT2T-CHM13v2.0
Mfsd2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394122,840,643 - 122,855,844 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4122,840,643 - 122,854,981 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384122,946,850 - 122,961,194 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4122,946,850 - 122,961,188 (-)Ensemblmm10GRCm38
MGSCv374122,624,093 - 122,638,431 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364122,449,153 - 122,463,473 (-)NCBIMGSCv36mm8
Celera4121,276,713 - 121,291,009 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.34NCBI
Mfsd2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545217,430,219 - 17,443,830 (+)Ensembl
ChiLan1.0NW_00495545217,430,850 - 17,443,830 (+)NCBIChiLan1.0ChiLan1.0
MFSD2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21186,853,107 - 186,867,856 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11185,990,715 - 186,005,462 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,244,438 - 39,259,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,569,706 - 40,584,438 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl140,569,706 - 40,584,438 (+)EnsemblpanPan2panpan1.1
MFSD2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1152,966,433 - 2,979,030 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl152,966,461 - 2,978,968 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha153,223,537 - 3,236,132 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0153,053,922 - 3,066,514 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl153,053,950 - 3,066,453 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1152,960,820 - 2,973,412 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0153,020,725 - 3,033,317 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0153,037,135 - 3,049,729 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mfsd2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505855,966,002 - 55,978,559 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647421,790,747 - 21,803,360 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647421,790,807 - 21,803,336 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFSD2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl695,738,969 - 95,753,245 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1695,738,961 - 95,753,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2688,931,112 - 88,945,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFSD2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12092,926,217 - 92,941,191 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2092,926,067 - 92,941,159 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603323,896,232 - 23,911,104 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfsd2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,422,423 - 22,435,416 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476422,422,520 - 22,435,332 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mfsd2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1135,294,077 - 35,308,679 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mfsd2a
171 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:58
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000019080
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5140258140143398122Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
BF400287  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,239,524 - 135,239,728 (+)MAPPERmRatBN7.2
Rnor_6.05140,656,586 - 140,656,789NCBIRnor6.0
Rnor_5.05144,447,166 - 144,447,369UniSTSRnor5.0
RGSC_v3.45142,274,276 - 142,274,479UniSTSRGSC3.4
Celera5133,777,915 - 133,778,118UniSTS
RH 3.4 Map5890.0UniSTS
Cytogenetic Map5q36UniSTS
BF387250  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,239,532 - 135,239,728 (+)MAPPERmRatBN7.2
Rnor_6.05140,656,594 - 140,656,789NCBIRnor6.0
Rnor_5.05144,447,174 - 144,447,369UniSTSRnor5.0
RGSC_v3.45142,274,284 - 142,274,479UniSTSRGSC3.4
Celera5133,777,923 - 133,778,118UniSTS
Cytogenetic Map5q36UniSTS
BF404032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,239,268 - 135,239,420 (+)MAPPERmRatBN7.2
Rnor_6.05140,656,330 - 140,656,481NCBIRnor6.0
Rnor_5.05144,446,910 - 144,447,061UniSTSRnor5.0
RGSC_v3.45142,274,020 - 142,274,171UniSTSRGSC3.4
Celera5133,777,659 - 133,777,810UniSTS
RH 3.4 Map5874.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 42 154 91 90 59 71 59 6 282 140 7 137 60 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000019080   ⟹   ENSRNOP00000019080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5140,510,953 - 140,525,916 (-)Ensembl
mRatBN7.2 Ensembl5135,225,816 - 135,240,690 (-)Ensembl
Rnor_6.0 Ensembl5140,642,885 - 140,657,745 (-)Ensembl
RefSeq Acc Id: NM_001106683   ⟹   NP_001100153
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,510,938 - 140,525,817 (-)NCBI
mRatBN7.25135,225,801 - 135,240,690 (-)NCBI
Rnor_6.05140,642,870 - 140,657,745 (-)NCBI
Rnor_5.05144,433,445 - 144,448,324 (-)NCBI
RGSC_v3.45142,260,560 - 142,275,435 (-)RGD
Celera5133,764,543 - 133,779,074 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238792   ⟹   XP_006238854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,510,933 - 140,525,826 (-)NCBI
mRatBN7.25135,225,948 - 135,240,697 (-)NCBI
Rnor_6.05140,642,865 - 140,657,759 (-)NCBI
Rnor_5.05144,433,445 - 144,448,324 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109607   ⟹   XP_038965535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,510,933 - 140,525,826 (-)NCBI
mRatBN7.25135,225,948 - 135,240,697 (-)NCBI
RefSeq Acc Id: XM_039109609   ⟹   XP_038965537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,514,694 - 140,525,828 (-)NCBI
mRatBN7.25135,229,558 - 135,240,744 (-)NCBI
RefSeq Acc Id: NP_001100153   ⟸   NM_001106683
- UniProtKB: B1WBW6 (UniProtKB/TrEMBL),   F7F9H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238854   ⟸   XM_006238792
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000019080   ⟸   ENSRNOT00000019080
RefSeq Acc Id: XP_038965535   ⟸   XM_039109607
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965537   ⟸   XM_039109609
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WBW6-F1-model_v2 AlphaFold B1WBW6 1-534 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694000
Promoter ID:EPDNEW_R4525
Type:multiple initiation site
Name:Mfsd2a_1
Description:major facilitator superfamily domain containing 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05140,657,746 - 140,657,806EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310174 AgrOrtholog
BioCyc Gene G2FUF-40027 BioCyc
Ensembl Genes ENSRNOG00000014008 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019080 ENTREZGENE
  ENSRNOT00000019080.9 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8369688 IMAGE-MGC_LOAD
InterPro MFS_2 UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
KEGG Report rno:298504 UniProtKB/TrEMBL
MGC_CLONE MGC:187650 IMAGE-MGC_LOAD
NCBI Gene 298504 ENTREZGENE
PANTHER PTHR11328 UniProtKB/TrEMBL
  SODIUM-DEPENDENT LYSOPHOSPHATIDYLCHOLINE SYMPORTER 1 UniProtKB/TrEMBL
Pfam MFS_2 UniProtKB/TrEMBL
PhenoGen Mfsd2a PhenoGen
RatGTEx ENSRNOG00000014008 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt B1WBW6 ENTREZGENE, UniProtKB/TrEMBL
  F7F9H0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-27 Mfsd2a  MFSD2 lysolipid transporter A, lysophospholipid  Mfsd2a  major facilitator superfamily domain containing 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Mfsd2a  major facilitator superfamily domain containing 2A  Mfsd2  major facilitator superfamily domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Mfsd2  major facilitator superfamily domain containing 2  RGD1310174_predicted  hypothetical LOC298504 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310174_predicted  hypothetical LOC298504 (predicted)  LOC298504_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC298504_predicted  hypothetical LOC298504 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL