Eea1 (early endosome antigen 1) - Rat Genome Database

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Gene: Eea1 (early endosome antigen 1) Rattus norvegicus
Analyze
Symbol: Eea1
Name: early endosome antigen 1
RGD ID: 1310167
Description: Predicted to enable 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in chemical postsynaptic transmission; endocytosis; and vesicle fusion. Located in recycling endosome. Is active in presynaptic endosome. Orthologous to human EEA1 (early endosome antigen 1); PARTICIPATES IN endocytosis pathway; phagocytosis pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314764
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8732,441,281 - 32,608,808 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl732,441,272 - 32,608,476 (+)EnsemblGRCr8
mRatBN7.2730,554,686 - 30,722,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,554,552 - 30,718,487 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd734,617,927 - 34,734,862 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive735,443,900 - 35,560,845 (+)NCBILyon_Normotensive
Lyon_Hypertensive735,595,811 - 35,712,776 (+)NCBILyon_Hypertensive
F344_StmMcwi734,174,919 - 34,303,978 (+)NCBIF344_StmMcwi
Rnor_6.0737,101,415 - 37,186,534 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl737,018,459 - 37,186,732 (+)Ensemblrn6Rnor6.0
Rnor_5.0737,144,373 - 37,233,282 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4733,294,184 - 33,396,666 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera727,696,956 - 27,782,232 (+)NCBICelera
RGSC_v3.1733,311,103 - 33,413,833 (+)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
FR900359  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
Nivalenol  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, etal., Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. Mao L, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43. doi: 10.1073/pnas.1013494107. Epub 2010 Oct 18.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51.
11. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. Wan J, etal., J Neurosci. 2008 Sep 3;28(36):9002-12. doi: 10.1523/JNEUROSCI.0767-08.2008.
Additional References at PubMed
PMID:7768953   PMID:9697774   PMID:10491193   PMID:11256955   PMID:11741531   PMID:12536145   PMID:12746448   PMID:12890772   PMID:14668490   PMID:14718562   PMID:15078902   PMID:15229288  
PMID:15588329   PMID:15792797   PMID:15880641   PMID:15975910   PMID:16204232   PMID:16399794   PMID:16542649   PMID:16923123   PMID:17003038   PMID:17620357   PMID:17716972   PMID:17728463  
PMID:17765678   PMID:18388320   PMID:18523162   PMID:18767904   PMID:18838382   PMID:19056867   PMID:19376974   PMID:19535332   PMID:20943658   PMID:21081650   PMID:21097843   PMID:21502359  
PMID:22719997   PMID:23303939   PMID:23553667   PMID:23918928   PMID:23926254   PMID:24029230   PMID:24239381   PMID:24334765   PMID:24760869   PMID:25327288   PMID:25662281   PMID:26582200  
PMID:26965651   PMID:28176461   PMID:31505169  


Genomics

Comparative Map Data
Eea1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8732,441,281 - 32,608,808 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl732,441,272 - 32,608,476 (+)EnsemblGRCr8
mRatBN7.2730,554,686 - 30,722,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,554,552 - 30,718,487 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd734,617,927 - 34,734,862 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive735,443,900 - 35,560,845 (+)NCBILyon_Normotensive
Lyon_Hypertensive735,595,811 - 35,712,776 (+)NCBILyon_Hypertensive
F344_StmMcwi734,174,919 - 34,303,978 (+)NCBIF344_StmMcwi
Rnor_6.0737,101,415 - 37,186,534 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl737,018,459 - 37,186,732 (+)Ensemblrn6Rnor6.0
Rnor_5.0737,144,373 - 37,233,282 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4733,294,184 - 33,396,666 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera727,696,956 - 27,782,232 (+)NCBICelera
RGSC_v3.1733,311,103 - 33,413,833 (+)NCBI
Cytogenetic Map7q13NCBI
EEA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381292,770,637 - 92,929,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1292,770,637 - 92,929,350 (-)Ensemblhg38GRCh38
GRCh371293,164,413 - 93,323,071 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361291,690,416 - 91,847,238 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341291,671,790 - 91,825,475NCBI
Celera1292,837,376 - 92,994,185 (-)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1290,233,695 - 90,352,959 (-)NCBIHuRef
CHM1_11293,130,989 - 93,288,076 (-)NCBICHM1_1
T2T-CHM13v2.01292,748,215 - 92,957,284 (-)NCBIT2T-CHM13v2.0
Eea1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391095,776,525 - 95,881,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1095,776,512 - 95,881,380 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381095,940,663 - 96,045,518 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1095,940,650 - 96,045,518 (+)Ensemblmm10GRCm38
MGSCv371095,403,297 - 95,508,152 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361095,370,351 - 95,474,820 (+)NCBIMGSCv36mm8
Celera1097,916,805 - 98,021,533 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1049.59NCBI
Eea1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540529,760,332 - 29,868,755 (-)Ensembl
ChiLan1.0NW_00495540529,760,332 - 29,959,553 (-)NCBIChiLan1.0ChiLan1.0
EEA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210100,799,346 - 100,957,036 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112100,795,736 - 100,953,409 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01290,299,582 - 90,457,109 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11293,611,628 - 93,767,583 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1293,611,628 - 93,767,583 (-)EnsemblpanPan2panpan1.1
EEA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11533,145,250 - 33,234,899 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1533,148,637 - 33,256,669 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1533,597,838 - 33,709,848 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01533,814,867 - 33,927,149 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1533,816,143 - 33,927,195 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11533,094,790 - 33,206,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01533,183,253 - 33,295,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01533,447,116 - 33,559,225 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eea1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494526,769,728 - 26,903,979 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365079,331,455 - 9,424,835 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365079,331,572 - 9,465,708 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl590,168,242 - 90,257,241 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1590,131,707 - 90,257,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2594,369,958 - 94,492,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EEA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11188,164,064 - 88,318,305 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1188,167,550 - 88,318,218 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037156,846,305 - 157,001,660 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eea1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475013,848,833 - 13,968,552 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475013,773,127 - 13,969,438 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Eea1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11175,176,540 - 175,281,404 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eea1
1785 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:316
Count of miRNA genes:195
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000029764
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH130077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,721,729 - 30,721,914 (+)MAPPERmRatBN7.2
Rnor_6.0737,189,851 - 37,190,035NCBIRnor6.0
Rnor_5.0737,233,180 - 37,233,364UniSTSRnor5.0
RGSC_v3.4733,396,564 - 33,396,748UniSTSRGSC3.4
Celera727,785,549 - 27,785,733UniSTS
RH 3.4 Map7241.5UniSTS
Cytogenetic Map7q13UniSTS
RH130537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,637,818 - 30,638,031 (+)MAPPERmRatBN7.2
Rnor_6.0737,106,496 - 37,106,708NCBIRnor6.0
Rnor_5.0737,149,907 - 37,150,119UniSTSRnor5.0
RGSC_v3.4733,308,383 - 33,308,595UniSTSRGSC3.4
Celera727,702,030 - 27,702,242UniSTS
RH 3.4 Map7241.0UniSTS
Cytogenetic Map7q13UniSTS
BF389134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,689,763 - 30,689,886 (+)MAPPERmRatBN7.2
Rnor_6.0737,158,417 - 37,158,539NCBIRnor6.0
Rnor_5.0737,201,405 - 37,201,527UniSTSRnor5.0
RGSC_v3.4733,363,397 - 33,363,519UniSTSRGSC3.4
Celera727,754,447 - 27,754,569UniSTS
RH 3.4 Map7241.5UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000029764   ⟹   ENSRNOP00000029575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl732,491,686 - 32,608,476 (+)Ensembl
mRatBN7.2 Ensembl730,632,334 - 30,718,487 (+)Ensembl
Rnor_6.0 Ensembl737,101,391 - 37,186,534 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087297   ⟹   ENSRNOP00000071305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl732,441,272 - 32,608,476 (+)Ensembl
mRatBN7.2 Ensembl730,554,552 - 30,718,487 (+)Ensembl
Rnor_6.0 Ensembl737,018,459 - 37,186,732 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095444   ⟹   ENSRNOP00000092690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl732,491,280 - 32,608,476 (+)Ensembl
mRatBN7.2 Ensembl730,604,739 - 30,718,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103157   ⟹   ENSRNOP00000087995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl732,491,524 - 32,608,476 (+)Ensembl
mRatBN7.2 Ensembl730,604,739 - 30,718,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107821   ⟹   ENSRNOP00000094814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl732,491,280 - 32,608,476 (+)Ensembl
mRatBN7.2 Ensembl730,604,770 - 30,718,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117665   ⟹   ENSRNOP00000083105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl732,491,280 - 32,608,476 (+)Ensembl
mRatBN7.2 Ensembl730,604,739 - 30,718,487 (+)Ensembl
RefSeq Acc Id: NM_001427400   ⟹   NP_001414329
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,491,558 - 32,608,476 (+)NCBI
Dahl_SR_JrHsd734,617,927 - 34,734,862 (+)NCBI
Lyon_Normotensive735,443,900 - 35,560,845 (+)NCBI
Lyon_Hypertensive735,595,811 - 35,712,776 (+)NCBI
F344_StmMcwi734,174,919 - 34,303,978 (+)NCBI
RefSeq Acc Id: XM_039080104   ⟹   XP_038936032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,491,542 - 32,608,808 (+)NCBI
mRatBN7.2730,604,663 - 30,722,186 (+)NCBI
RefSeq Acc Id: XM_039080106   ⟹   XP_038936034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,441,490 - 32,608,808 (+)NCBI
mRatBN7.2730,554,686 - 30,722,186 (+)NCBI
RefSeq Acc Id: XM_039080107   ⟹   XP_038936035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,441,281 - 32,608,808 (+)NCBI
mRatBN7.2730,554,686 - 30,722,186 (+)NCBI
RefSeq Acc Id: XM_063263460   ⟹   XP_063119530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,491,542 - 32,608,808 (+)NCBI
RefSeq Acc Id: XM_063263461   ⟹   XP_063119531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,484,866 - 32,608,808 (+)NCBI
RefSeq Acc Id: XM_063263462   ⟹   XP_063119532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,519,538 - 32,608,808 (+)NCBI
RefSeq Acc Id: XM_063263463   ⟹   XP_063119533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8732,574,274 - 32,608,808 (+)NCBI
Ensembl Acc Id: ENSRNOP00000071305   ⟸   ENSRNOT00000087297
Ensembl Acc Id: ENSRNOP00000029575   ⟸   ENSRNOT00000029764
RefSeq Acc Id: XP_038936034   ⟸   XM_039080106
- Peptide Label: isoform X4
- UniProtKB: F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936035   ⟸   XM_039080107
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K051 (UniProtKB/TrEMBL),   F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936032   ⟸   XM_039080104
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIN6 (UniProtKB/TrEMBL),   F1LUA1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083105   ⟸   ENSRNOT00000117665
Ensembl Acc Id: ENSRNOP00000087995   ⟸   ENSRNOT00000103157
Ensembl Acc Id: ENSRNOP00000094814   ⟸   ENSRNOT00000107821
Ensembl Acc Id: ENSRNOP00000092690   ⟸   ENSRNOT00000095444
RefSeq Acc Id: XP_063119531   ⟸   XM_063263461
- Peptide Label: isoform X3
- UniProtKB: F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119530   ⟸   XM_063263460
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A8E0 (UniProtKB/TrEMBL),   F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414329   ⟸   NM_001427400
- UniProtKB: A0A8I5ZV67 (UniProtKB/TrEMBL),   A6IG51 (UniProtKB/TrEMBL),   F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119532   ⟸   XM_063263462
- Peptide Label: isoform X6
- UniProtKB: F1LUA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119533   ⟸   XM_063263463
- Peptide Label: isoform X7
Protein Domains
C2H2-type   FYVE-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K051-F1-model_v2 AlphaFold A0A0G2K051 1-1449 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310167 AgrOrtholog
BioCyc Gene G2FUF-34314 BioCyc
Ensembl Genes ENSRNOG00000021681 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029764.7 UniProtKB/TrEMBL
  ENSRNOT00000087297 ENTREZGENE
  ENSRNOT00000087297.3 UniProtKB/TrEMBL
  ENSRNOT00000095444 ENTREZGENE
  ENSRNOT00000095444.2 UniProtKB/TrEMBL
  ENSRNOT00000103157 ENTREZGENE
  ENSRNOT00000103157.2 UniProtKB/TrEMBL
  ENSRNOT00000107821 ENTREZGENE
  ENSRNOT00000107821.2 UniProtKB/TrEMBL
  ENSRNOT00000117665 ENTREZGENE
  ENSRNOT00000117665.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
  L1 transposable element, trimerization domain UniProtKB/TrEMBL
InterPro Znf_C2H2_type UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 314764 ENTREZGENE
PANTHER EARLY ENDOSOME ANTIGEN 1 UniProtKB/TrEMBL
  EARLY ENDOSOME ANTIGEN 1 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
PhenoGen Eea1 PhenoGen
PROSITE ZF_FYVE UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021681 RatGTEx
SMART FYVE UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  Tropomyosin UniProtKB/TrEMBL
UniProt A0A0G2K051 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8E0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIH5_RAT UniProtKB/TrEMBL
  A0A8I6AIN6 ENTREZGENE, UniProtKB/TrEMBL
  A6IG51 ENTREZGENE, UniProtKB/TrEMBL
  F1LUA1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Eea1  early endosome antigen 1   Eea1_predicted  early endosome antigen 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eea1_predicted  early endosome antigen 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED