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Gene: Tbcb (tubulin folding cofactor B) Rattus norvegicus

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Symbol:

Tbcb

Name:

tubulin folding cofactor B

RGD ID:

1309965

Description:

Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be located in cytoplasm. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Orthologous to human TBCB (tubulin folding cofactor B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ckap1; cytoskeleton-associated protein 1; liver cancer related protein; LOC100911774; LOC103690005; LOC292777; tubulin-folding cofactor B; tubulin-folding cofactor B-like; ZH14

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TBCB (tubulin folding cofactor B)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Tbcb (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tbcb (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TBCB (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TBCB (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tbcb (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TBCB (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TBCB (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tbcb (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tbcb (tubulin folding cofactor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TBCB (tubulin folding cofactor B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tbcb (tubulin folding cofactor B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tbcb (tubulin folding cofactor B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ALF1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	ALF1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	TBCB	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tbcb-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tbcb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	94,605,100 - 94,610,949 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	94,605,101 - 94,610,949 (-)	Ensembl				GRCr8
mRatBN7.2	1	85,477,639 - 85,483,488 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,477,640 - 85,483,488 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	90,893,904 - 90,900,083 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,361,605 - 99,367,453 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	92,652,165 - 92,658,344 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	88,680,936 - 88,686,785 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	88,680,856 - 88,686,615 (-)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	1	91,042,635 - 91,048,483 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	92,179,817 - 92,185,666 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,490,553 - 85,496,402 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	79,852,078 - 79,857,927 (-)	NCBI		Celera
RGSC_v3.1	1	85,568,618 - 85,574,513 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neoplasm Metastasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol AF (ISO)

Bisphenol B (ISO)

caffeine (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

choline (ISO)

clofibrate (ISO)

clozapine (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diuron (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

furfural (ISO)

gallic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

hexane (EXP)

ivermectin (ISO)

L-methionine (ISO)

lead diacetate (EXP)

methimazole (EXP)

microcystin RR (ISO)

nefazodone (EXP)

nimesulide (EXP)

nitrates (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (EXP)

pirinixic acid (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium chloride (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cytoplasmic microtubule organization (IBA)

nervous system development (IEA)

post-chaperonin tubulin folding pathway (IEA)

tubulin complex assembly (IEA)

Cellular Component

cell cortex (IBA)

cytoplasm (IEA,ISO)

cytoskeleton (IEA)

cytosol (IEA,ISO)

microtubule (IEA)

microtubule plus-end (IBA)

nucleus (IBA)

Molecular Function

alpha-tubulin binding (IEA)

microtubule plus-end binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:22777741

Genomics

Comparative Map Data

Tbcb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	94,605,100 - 94,610,949 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	94,605,101 - 94,610,949 (-)	Ensembl				GRCr8
mRatBN7.2	1	85,477,639 - 85,483,488 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	85,477,640 - 85,483,488 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	90,893,904 - 90,900,083 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	99,361,605 - 99,367,453 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	92,652,165 - 92,658,344 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	88,680,936 - 88,686,785 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	88,680,856 - 88,686,615 (-)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	1	91,042,635 - 91,048,483 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	92,179,817 - 92,185,666 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	85,490,553 - 85,496,402 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	79,852,078 - 79,857,927 (-)	NCBI		Celera
RGSC_v3.1	1	85,568,618 - 85,574,513 (+)	NCBI
Cytogenetic Map	1	q21	NCBI

TBCB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	36,114,967 - 36,125,941 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	36,114,289 - 36,125,947 (+)	Ensembl			hg38	GRCh38
GRCh37	19	36,605,869 - 36,616,843 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	41,297,728 - 41,308,689 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	41,297,727 - 41,308,689	NCBI
Celera	19	33,320,069 - 33,331,031 (+)	NCBI		Celera
Cytogenetic Map	19	q13.12	NCBI
HuRef	19	33,111,374 - 33,122,336 (+)	NCBI		HuRef
CHM1_1	19	36,607,230 - 36,618,203 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	38,660,785 - 38,671,758 (+)	NCBI		T2T-CHM13v2.0

Tbcb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	29,923,554 - 29,931,622 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	29,923,556 - 29,931,697 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	30,224,129 - 30,232,197 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	30,224,131 - 30,232,272 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	31,009,150 - 31,017,048 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	29,932,898 - 29,940,546 (-)	NCBI		MGSCv36	mm8
Celera	7	24,824,947 - 24,836,426 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	17.33	NCBI

Tbcb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	2,477,682 - 2,494,242 (-)	Ensembl
ChiLan1.0	NW_004955468	2,477,682 - 2,494,122 (-)	NCBI	ChiLan1.0	ChiLan1.0

TBCB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	42,117,563 - 42,127,987 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	44,101,113 - 44,111,542 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	33,034,583 - 33,045,253 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	41,781,404 - 41,792,375 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	41,781,404 - 41,792,375 (+)	Ensembl			panPan2	panpan1.1

TBCB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	116,576,222 - 116,585,788 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	116,576,219 - 116,586,021 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	115,982,219 - 115,991,816 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	117,179,708 - 117,189,206 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	117,179,000 - 117,188,992 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	116,747,053 - 116,756,600 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	116,367,269 - 116,376,768 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	117,422,445 - 117,431,951 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tbcb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	11,361,864 - 11,369,846 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936922	132,015 - 144,556 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936922	131,998 - 139,912 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TBCB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	45,482,371 - 45,492,627 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	45,482,542 - 45,492,627 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	40,884,741 - 40,894,825 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TBCB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	31,021,363 - 31,033,354 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	31,021,913 - 31,033,188 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	8,821,855 - 8,833,215 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tbcb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	10,361,942 - 10,370,231 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	10,361,567 - 10,370,228 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tbcb
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	165,777,056 - 165,782,900 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tbcb
35 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	89
Count of miRNA genes:	81
Interacting mature miRNAs:	83
Transcripts:	ENSRNOT00000028211
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat

Markers in Region

D1Bda12

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	94,611,767 - 94,611,992 (+)	Marker Load Pipeline
mRatBN7.2	1	85,484,307 - 85,484,531 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	85,484,307 - 85,484,531 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	91,041,592 - 91,041,815	NCBI	Rnor6.0
Rnor_6.0	1	88,687,605 - 88,687,828	NCBI	Rnor6.0
Rnor_5.0	1	92,178,774 - 92,178,997	UniSTS	Rnor5.0
Rnor_5.0	1	89,845,011 - 89,845,234	UniSTS	Rnor5.0
RGSC_v3.4	1	85,489,510 - 85,489,733	UniSTS	RGSC3.4
Celera	1	79,858,747 - 79,858,970	UniSTS
Cytogenetic Map	1	q21	UniSTS

RH137061

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	94,605,181 - 94,605,500 (+)	Marker Load Pipeline
mRatBN7.2	1	85,477,720 - 85,478,039 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	85,477,720 - 85,478,039 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	88,681,018 - 88,681,336	NCBI	Rnor6.0
Rnor_6.0	1	91,048,084 - 91,048,402	NCBI	Rnor6.0
Rnor_5.0	1	92,185,266 - 92,185,584	UniSTS	Rnor5.0
Rnor_5.0	1	89,838,424 - 89,838,742	UniSTS	Rnor5.0
RGSC_v3.4	1	85,496,002 - 85,496,320	UniSTS	RGSC3.4
Celera	1	79,852,160 - 79,852,478	UniSTS
RH 3.4 Map	1	848.3	UniSTS
Cytogenetic Map	1	q21	UniSTS

RH139378

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	85,484,547 - 85,484,619 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	85,484,547 - 85,484,619 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	91,041,504 - 91,041,575	NCBI	Rnor6.0
Rnor_6.0	1	88,687,845 - 88,687,916	NCBI	Rnor6.0
Rnor_5.0	1	89,845,251 - 89,845,322	UniSTS	Rnor5.0
Rnor_5.0	1	92,178,686 - 92,178,757	UniSTS	Rnor5.0
RGSC_v3.4	1	85,489,422 - 85,489,493	UniSTS	RGSC3.4
Celera	1	79,858,987 - 79,859,058	UniSTS
RH 3.4 Map	1	847.0	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
19	1	30	113	68	60	36	79	36	12	254	143	11	88	56	70	24	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001040180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB256046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AM258961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC126061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ447885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028211 ⟹ ENSRNOP00000028211

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	94,605,101 - 94,610,949 (-)	Ensembl
mRatBN7.2 Ensembl	1	85,477,640 - 85,483,488 (-)	Ensembl
Rnor_6.0 Ensembl	1	91,042,635 - 91,048,483 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000070921 ⟹ ENSRNOP00000066828

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	88,680,856 - 88,686,615 (-)	Ensembl

RefSeq Acc Id:

NM_001040180 ⟹ NP_001035270

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	94,605,100 - 94,610,949 (-)	NCBI
mRatBN7.2	1	85,477,639 - 85,483,488 (-)	NCBI
Rnor_6.0	1	88,680,936 - 88,686,785 (-)	NCBI
Rnor_5.0	1	92,179,817 - 92,185,666 (+)	NCBI
RGSC_v3.4	1	85,490,553 - 85,496,402 (+)	RGD
Celera	1	79,852,078 - 79,857,927 (-)	RGD

Sequence:

show sequence

CAGCTATTGGAAGAACCGAGAGCCACGGAAGGCCTCTCGGGATTGGTTGGACGCAACGGAGGAT
CCGCCTGTCCGTGGAGAAAGGGCGACAGCGATTGGCTGGTCATGTTAGGTGGAGAGCTTACATT
GGTCAACTCCGGGACGAGGGCGGGACTTATATCCCAGAAGCAGCGGCGGCCACTGCGGAGCCGG
TGTGAGACGGCTGAAGCGGACCGCGGGCCACTACAGGGCGCGGCGAGATGGAGGTGTCGGGGAC
ATCGGCGCCCACCGTGACGGTTTTCATCAGCAGCTCCCTCAACAGCTTCCGTTCGGAGAAGCGA
TACAGTCGTAGCCTCACCATCGCAGAGTTCAAGTGTAAACTGGAACTGGTGGTGGGCAGCCCTG
CTTCCTGCATGGAACTGGAGCTGTATGGAGCTGACGACCAGTTCTACAGCAAGTTGGATCAGGA
GGATGCACTGCTGGGCTCCTATCCTGTGGATGATGGCTGCCGAATCCATGTCATTGACCACAGT
GGTGTCCGGCTCGGAGAATATGAGGACGTGTCCAAAGTGGAGAAATACGAGATCTCACCAGAAG
CTTACGAACGGAGACAGAACACAGTTCGATCCTTCATGAAGCGCAGCAAGTTAGGCCCGTACAA
TGAAGAACTCCGGGCCCAGCAAGAGGCAGAGGCTGCCCAGCGTCTCAGTGAGGAGGAGGCCCAA
GCCAGTGCCATCTCTGTGGGGAGCCGTTGTGAGGTGCGGGCACCCGGCCAGTCCCTTCGCAGGG
GCACTGTCATGTATGTAGGACTCACAGATTTCAAGCCAGGCTACTGGGTTGGTGTCCGATATGA
TGAGCCATTAGGAAAAAACGATGGCAGTGTGAATGGGAAACGCTACTTTGAATGCCAGGCCAAG
TACGGTGCCTTTGTGAAGCCAGCGGCTGTCACGGTGGGAGATTTCCCAGAGGAAGATTACGGAT
TGGACGAGATGTGACACTGATGGACATGTGACCCTATCCCTTCCGGCCCCATCCCTGACACAGC
CCCTCTGAATGCCAGTGGCACCTTTCCTCTGAGATTTGTGCATTAAATTAAGCAGATCGAAAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001035270	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI26062	(Get FASTA)	NCBI Sequence Viewer
	ABD93210	(Get FASTA)	NCBI Sequence Viewer
	BAE94256	(Get FASTA)	NCBI Sequence Viewer
	CAJ88857	(Get FASTA)	NCBI Sequence Viewer
	EDM07781	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028211
	ENSRNOP00000028211.4

RefSeq Acc Id:

NP_001035270 ⟸ NM_001040180

- UniProtKB:

Q1RP74 (UniProtKB/TrEMBL), A0JMZ5 (UniProtKB/TrEMBL), Q1W1V7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEVSGTSAPTVTVFISSSLNSFRSEKRYSRSLTIAEFKCKLELVVGSPASCMELELYGADDQFY
SKLDQEDALLGSYPVDDGCRIHVIDHSGVRLGEYEDVSKVEKYEISPEAYERRQNTVRSFMKRS
KLGPYNEELRAQQEAEAAQRLSEEEAQASAISVGSRCEVRAPGQSLRRGTVMYVGLTDFKPGYW
VGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPAAVTVGDFPEEDYGLDEM

hide sequence

Ensembl Acc Id:

ENSRNOP00000028211 ⟸ ENSRNOT00000028211

Ensembl Acc Id:

ENSRNOP00000066828 ⟸ ENSRNOT00000070921

Protein Domains

CAP-Gly

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q1RP74-F1-model_v2	AlphaFold	Q1RP74	1-244	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689906

Promoter ID:

EPDNEW_R431

Type:

initiation region

Name:

Tbcb_1

Description:

tubulin folding cofactor B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	88,686,592 - 88,686,652	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309965	AgrOrtholog
BioCyc Gene	G2FUF-60136	BioCyc
Ensembl Genes	ENSRNOG00000020781	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000045655	Ensembl
Ensembl Transcript	ENSRNOT00000028211	ENTREZGENE
	ENSRNOT00000028211.7	UniProtKB/TrEMBL
Gene3D-CATH	2.30.30.190	UniProtKB/TrEMBL
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113234	IMAGE-MGC_LOAD
InterPro	CAP-Gly_dom_sf	UniProtKB/TrEMBL
	Cytoskel-assoc-prot_CAP-Gly	UniProtKB/TrEMBL
	TBCB_N_Ubl	UniProtKB/TrEMBL
	Ubiquitin-like	UniProtKB/TrEMBL
	Ubiquitin-rel_dom	UniProtKB/TrEMBL
KEGG Report	rno:292777	UniProtKB/TrEMBL
MGC_CLONE	MGC:156460	IMAGE-MGC_LOAD
NCBI Gene	292777	ENTREZGENE
PANTHER	DYNACTIN 1-RELATED MICROTUBULE-BINDING	UniProtKB/TrEMBL
	TUBULIN-FOLDING COFACTOR B	UniProtKB/TrEMBL
Pfam	CAP_GLY	UniProtKB/TrEMBL
	Ubiquitin_2	UniProtKB/TrEMBL
PhenoGen	Tbcb	PhenoGen
PROSITE	CAP_GLY_1	UniProtKB/TrEMBL
	CAP_GLY_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020781	RatGTEx
	ENSRNOG00000045655	RatGTEx
SMART	CAP_GLY	UniProtKB/TrEMBL
Superfamily-SCOP	CAP-Gly_domain	UniProtKB/TrEMBL
	SSF54236	UniProtKB/TrEMBL
UniProt	A0JMZ5	ENTREZGENE, UniProtKB/TrEMBL
	Q1RP74	ENTREZGENE, UniProtKB/TrEMBL
	Q1W1V7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Tbcb	tubulin folding cofactor B	LOC103690005	tubulin-folding cofactor B	Data merged from RGD:9365423	737654	PROVISIONAL
2015-07-29	Tbcb	tubulin folding cofactor B	LOC100911774	tubulin-folding cofactor B-like	Data merged from RGD:6490962	737654	PROVISIONAL
2014-08-25	LOC103690005	tubulin-folding cofactor B			Symbol and Name status set to provisional	70820	PROVISIONAL
2012-07-05	LOC100911774	tubulin-folding cofactor B-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-03	Tbcb	tubulin folding cofactor B	Ckap1_predicted	cytoskeleton-associated protein 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Ckap1_predicted	cytoskeleton-associated protein 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD