Adamdec1 (ADAM-like, decysin 1) - Rat Genome Database

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Gene: Adamdec1 (ADAM-like, decysin 1) Rattus norvegicus
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Symbol: Adamdec1
Name: ADAM-like, decysin 1
RGD ID: 1309861
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ADAMDEC1 (ADAM like decysin 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADAM DEC1; LOC290338
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81547,076,011 - 47,097,065 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1547,076,019 - 47,097,065 (-)EnsemblGRCr8
mRatBN7.21542,900,629 - 42,921,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,900,636 - 42,921,712 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1544,765,281 - 44,786,328 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,915,508 - 45,936,555 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01544,360,879 - 44,381,942 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01549,485,604 - 49,521,638 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1549,485,611 - 49,505,553 (-)Ensemblrn6Rnor6.0
Rnor_5.01553,218,715 - 53,238,690 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41548,250,970 - 48,272,395 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1542,534,343 - 42,555,121 (-)NCBICelera
RGSC_v3.11548,267,607 - 48,288,140 (-)NCBI
Cytogenetic Map15p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Adamdec1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81547,076,011 - 47,097,065 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1547,076,019 - 47,097,065 (-)EnsemblGRCr8
mRatBN7.21542,900,629 - 42,921,684 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,900,636 - 42,921,712 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1544,765,281 - 44,786,328 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,915,508 - 45,936,555 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01544,360,879 - 44,381,942 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01549,485,604 - 49,521,638 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1549,485,611 - 49,505,553 (-)Ensemblrn6Rnor6.0
Rnor_5.01553,218,715 - 53,238,690 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41548,250,970 - 48,272,395 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1542,534,343 - 42,555,121 (-)NCBICelera
RGSC_v3.11548,267,607 - 48,288,140 (-)NCBI
Cytogenetic Map15p11NCBI
ADAMDEC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38824,384,285 - 24,406,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl824,384,285 - 24,406,013 (+)Ensemblhg38GRCh38
GRCh37824,241,798 - 24,263,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,297,916 - 24,319,471 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34824,297,915 - 24,319,471NCBI
Celera823,205,384 - 23,227,107 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef822,786,429 - 22,808,152 (+)NCBIHuRef
CHM1_1824,443,956 - 24,465,678 (+)NCBICHM1_1
T2T-CHM13v2.0824,659,416 - 24,681,139 (+)NCBIT2T-CHM13v2.0
Adamdec1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,800,829 - 68,819,535 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,800,829 - 68,819,544 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381468,563,387 - 68,582,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,563,380 - 68,582,095 (-)Ensemblmm10GRCm38
MGSCv371469,181,444 - 69,200,129 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361467,516,717 - 67,535,402 (-)NCBIMGSCv36mm8
Celera1466,331,214 - 66,349,962 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.69NCBI
Adamdec1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540347,421,102 - 47,439,501 (+)NCBIChiLan1.0ChiLan1.0
ADAMDEC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2742,892,991 - 42,914,657 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1818,627,118 - 18,648,797 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0823,653,257 - 23,674,893 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1820,570,606 - 20,590,177 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl820,570,606 - 20,591,383 (+)EnsemblpanPan2panpan1.1
ADAMDEC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12533,046,404 - 33,061,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2533,046,312 - 33,061,731 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2533,630,692 - 33,646,155 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02533,252,217 - 33,267,658 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2533,252,441 - 33,267,811 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12533,200,387 - 33,215,843 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02533,056,965 - 33,072,405 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02533,215,149 - 33,230,607 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adamdec1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,873,411 - 10,883,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365557,686,841 - 7,697,078 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365557,686,841 - 7,697,084 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMDEC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,456,134 - 8,471,088 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1148,455,964 - 8,483,308 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2149,498,092 - 9,512,852 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMDEC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1822,516,511 - 22,537,706 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl822,516,639 - 22,537,731 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605219,647,053 - 19,668,264 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamdec1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475819,519,526 - 19,534,259 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475819,519,526 - 19,534,409 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Adamdec1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11255,798,350 - 55,815,551 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adamdec1
110 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:401
Count of miRNA genes:221
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000028974
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154480677352597086Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154446544756583797Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
16 1 19 59 72 53 9 53 5 92 12 12 11 56 19

Sequence


Ensembl Acc Id: ENSRNOT00000028974   ⟹   ENSRNOP00000037152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1547,076,019 - 47,097,065 (-)Ensembl
mRatBN7.2 Ensembl1542,900,636 - 42,921,712 (-)Ensembl
Rnor_6.0 Ensembl1549,485,611 - 49,505,553 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117651   ⟹   ENSRNOP00000081269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1542,902,963 - 42,921,712 (-)Ensembl
RefSeq Acc Id: NM_001401660   ⟹   NP_001388589
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81547,076,011 - 47,097,065 (-)NCBI
mRatBN7.21542,900,629 - 42,921,684 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388589 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85426 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037152
  ENSRNOP00000037152.4
Ensembl Acc Id: ENSRNOP00000037152   ⟸   ENSRNOT00000028974
Ensembl Acc Id: ENSRNOP00000081269   ⟸   ENSRNOT00000117651
RefSeq Acc Id: NP_001388589   ⟸   NM_001401660
- Peptide Label: precursor
- UniProtKB: D3ZW34 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZW34-F1-model_v2 AlphaFold D3ZW34 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699792
Promoter ID:EPDNEW_R10315
Type:multiple initiation site
Name:Adamdec1_1
Description:ADAM-like, decysin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01549,505,525 - 49,505,585EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309861 AgrOrtholog
BioCyc Gene G2FUF-13283 BioCyc
Ensembl Genes ENSRNOG00000030724 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028974 ENTREZGENE
  ENSRNOT00000028974.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene 290338 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  PTHR11905:SF125 UniProtKB/TrEMBL
Pfam Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adamdec1 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030724 RatGTEx
SMART DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt D3ZW34 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Adamdec1  ADAM-like, decysin 1   Adamdec1_predicted  ADAM-like, decysin 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Adamdec1_predicted  ADAM-like, decysin 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED