Ice1 (interactor of little elongation complex ELL subunit 1) - Rat Genome Database

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Gene: Ice1 (interactor of little elongation complex ELL subunit 1) Rattus norvegicus
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Symbol: Ice1
Name: interactor of little elongation complex ELL subunit 1
RGD ID: 1309747
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Predicted to be located in Cajal body; euchromatin; and histone locus body. Predicted to be part of transcription elongation factor complex. Orthologous to human ICE1 (interactor of little elongation complex ELL subunit 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: interactor of little elongator complex ELL subunit 1; little elongation complex subunit 1; LOC306665; RGD1309747; similar to KIAA0947 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp344
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8134,468,839 - 34,508,346 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl134,468,659 - 34,508,346 (+)EnsemblGRCr8
mRatBN7.2132,640,372 - 32,682,669 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl132,640,407 - 32,679,898 (+)EnsemblmRatBN7.2
Rnor_6.0135,280,481 - 35,322,769 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl135,280,701 - 35,319,182 (+)Ensemblrn6Rnor6.0
Rnor_5.0136,680,159 - 36,722,468 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4172,771,969 - 2,811,255 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera131,257,531 - 31,299,819 (+)NCBICelera
RGSC_v3.1172,755,059 - 2,810,243 (+)NCBI
Cytogenetic Map1p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:22195968   PMID:23932780  


Genomics

Comparative Map Data
Ice1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8134,468,839 - 34,508,346 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl134,468,659 - 34,508,346 (+)EnsemblGRCr8
mRatBN7.2132,640,372 - 32,682,669 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl132,640,407 - 32,679,898 (+)EnsemblmRatBN7.2
Rnor_6.0135,280,481 - 35,322,769 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl135,280,701 - 35,319,182 (+)Ensemblrn6Rnor6.0
Rnor_5.0136,680,159 - 36,722,468 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4172,771,969 - 2,811,255 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera131,257,531 - 31,299,819 (+)NCBICelera
RGSC_v3.1172,755,059 - 2,810,243 (+)NCBI
Cytogenetic Map1p11NCBI
ICE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3855,422,677 - 5,490,220 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl55,420,664 - 5,490,220 (+)Ensemblhg38GRCh38
GRCh3755,422,790 - 5,490,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3655,475,807 - 5,543,338 (+)NCBIBuild 36Build 36hg18NCBI36
Celera55,448,998 - 5,516,538 (+)NCBICelera
Cytogenetic Map5p15.32NCBI
HuRef55,396,259 - 5,463,831 (+)NCBIHuRef
CHM1_155,422,775 - 5,490,347 (+)NCBICHM1_1
T2T-CHM13v2.055,350,239 - 5,417,793 (+)NCBIT2T-CHM13v2.0
Ice1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391370,736,808 - 70,785,958 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1370,699,826 - 70,785,753 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381370,588,688 - 70,637,839 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1370,551,707 - 70,637,634 (-)Ensemblmm10GRCm38
MGSCv371370,727,567 - 70,776,512 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361371,019,314 - 71,073,934 (-)NCBIMGSCv36mm8
Celera1372,931,505 - 72,980,649 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1335.97NCBI
Ice1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555043,427,612 - 3,465,313 (+)Ensembl
ChiLan1.0NW_0049555043,409,431 - 3,465,245 (+)NCBIChiLan1.0ChiLan1.0
ICE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v245,683,652 - 5,751,353 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan153,837,257 - 3,904,960 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v055,756,574 - 5,824,227 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.155,435,482 - 5,503,437 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl55,435,482 - 5,503,437 (+)EnsemblpanPan2panpan1.1
ICE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1348,052,211 - 8,110,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl348,052,993 - 8,110,785 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3412,560,242 - 12,622,744 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0347,953,943 - 8,016,394 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,957,662 - 8,016,393 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1348,001,593 - 8,063,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,981,278 - 8,043,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0348,194,300 - 8,256,672 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ice1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213241,099,820 - 241,154,642 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366341,690,814 - 1,745,901 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366341,691,039 - 1,745,842 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ICE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1676,195,361 - 76,254,318 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11676,195,357 - 76,254,365 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21682,397,966 - 82,413,944 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ICE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.145,150,090 - 5,216,864 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl45,167,199 - 5,216,933 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606423,579,944 - 23,646,179 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ice1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247513,334,380 - 3,383,573 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247513,321,999 - 3,383,462 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ice1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12201,973,514 - 202,015,485 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ice1
143 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:74
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000061873
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
731169Bp153Blood pressure QTL 1530.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13287937235320571Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat

Markers in Region
D1Mco114  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8134,500,340 - 34,500,515 (+)Marker Load Pipeline
mRatBN7.2132,671,887 - 32,672,062 (+)MAPPERmRatBN7.2
Rnor_6.0135,311,991 - 35,312,165NCBIRnor6.0
Rnor_5.0136,711,661 - 36,711,835UniSTSRnor5.0
RGSC_v3.4172,803,250 - 2,803,424UniSTSRGSC3.4
Celera131,289,041 - 31,289,215UniSTS
Cytogenetic Map17p14UniSTS
RH142250  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000061873   ⟹   ENSRNOP00000058589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl134,469,060 - 34,508,346 (+)Ensembl
mRatBN7.2 Ensembl132,640,607 - 32,679,898 (+)Ensembl
Rnor_6.0 Ensembl135,280,701 - 35,319,182 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099989   ⟹   ENSRNOP00000091423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl134,468,659 - 34,508,346 (+)Ensembl
mRatBN7.2 Ensembl132,640,407 - 32,679,898 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112308   ⟹   ENSRNOP00000095586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl132,640,600 - 32,679,303 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119576   ⟹   ENSRNOP00000082427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl132,644,855 - 32,679,898 (+)Ensembl
RefSeq Acc Id: NM_001427643   ⟹   NP_001414572
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8134,468,839 - 34,508,346 (+)NCBI
RefSeq Acc Id: XM_039099380   ⟹   XP_038955308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8134,483,457 - 34,508,346 (+)NCBI
mRatBN7.2132,654,998 - 32,682,669 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414572 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955308 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058589.5
  ENSRNOP00000091423
  ENSRNOP00000091423.2
Ensembl Acc Id: ENSRNOP00000058589   ⟸   ENSRNOT00000061873
RefSeq Acc Id: XP_038955308   ⟸   XM_039099380
- Peptide Label: isoform X1
- UniProtKB: D3ZK16 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082427   ⟸   ENSRNOT00000119576
Ensembl Acc Id: ENSRNOP00000091423   ⟸   ENSRNOT00000099989
Ensembl Acc Id: ENSRNOP00000095586   ⟸   ENSRNOT00000112308
RefSeq Acc Id: NP_001414572   ⟸   NM_001427643
- UniProtKB: A0A8I5ZXX1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZK16-F1-model_v2 AlphaFold D3ZK16 1-2225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309747 AgrOrtholog
BioCyc Gene G2FUF-61891 BioCyc
Ensembl Genes ENSRNOG00000023053 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061873.6 UniProtKB/TrEMBL
  ENSRNOT00000099989 ENTREZGENE
  ENSRNOT00000099989.2 UniProtKB/TrEMBL
NCBI Gene 306665 ENTREZGENE
PANTHER LITTLE ELONGATION COMPLEX SUBUNIT 1 UniProtKB/TrEMBL
  PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE UniProtKB/TrEMBL
Pfam ICE1_C UniProtKB/TrEMBL
PhenoGen Ice1 PhenoGen
RatGTEx ENSRNOG00000023053 RatGTEx
UniProt A0A8I5ZXX1 ENTREZGENE
  A0A8I6AEG0_RAT UniProtKB/TrEMBL
  D3ZK16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-13 Ice1  interactor of little elongation complex ELL subunit 1  Ice1  interactor of little elongator complex ELL subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-06-11 Ice1  interactor of little elongator complex ELL subunit 1  RGD1309747  similar to KIAA0947 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309747  similar to KIAA0947 protein   RGD1309747_predicted  similar to KIAA0947 protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309747_predicted  similar to KIAA0947 protein (predicted)  LOC306665_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306665_predicted  similar to KIAA0947 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL