Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cdkl2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of CDKL2 mRNA | CTD | PMID:22206623 | Cdkl2 | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of CDKL2 mRNA | CTD | PMID:30723492 | Cdkl2 | Rat | 1H-pyrazole | increases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | pyrazole results in increased expression of CDKL2 mRNA | CTD | PMID:17945193 | Cdkl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CDKL2 promoter] | CTD | PMID:19654925 | Cdkl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CDKL2 mRNA | CTD | PMID:32109520 | Cdkl2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CDKL2 mRNA | CTD | PMID:21570461 | Cdkl2 | Rat | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of CDKL2 mRNA | CTD | PMID:30723492 | Cdkl2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of CDKL2 mRNA | CTD | PMID:30951980 | Cdkl2 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of CDKL2 mRNA | CTD | PMID:28973697 | Cdkl2 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of CDKL2 mRNA | CTD | PMID:31881176 | Cdkl2 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of CDKL2 mRNA | CTD | PMID:28959563 | Cdkl2 | Rat | aflatoxin B1 | decreases methylation | ISO | CDKL2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of CDKL2 gene | CTD | PMID:27153756 | Cdkl2 | Rat | benzo[a]pyrene | increases methylation | ISO | CDKL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CDKL2 5' UTR; Benzo(a)pyrene results in increased methylation of more ... | CTD | PMID:27901495 | Cdkl2 | Rat | benzo[a]pyrene | affects methylation | ISO | CDKL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CDKL2 3' UTR | CTD | PMID:27901495 | Cdkl2 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of CDKL2 mRNA | CTD | PMID:19850644 | Cdkl2 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CDKL2 mRNA] | CTD | PMID:19850644 | Cdkl2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CDKL2 mRNA | CTD | PMID:30816183|PMID:32528016|PMID:34947998 | Cdkl2 | Rat | bisphenol F | increases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of CDKL2 mRNA | CTD | PMID:30951980 | Cdkl2 | Rat | cadmium atom | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKL2 more ... | CTD | PMID:28111341 | Cdkl2 | Rat | cadmium dichloride | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKL2 more ... | CTD | PMID:28111341 | Cdkl2 | Rat | carbon nanotube | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of CDKL2 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681 | Cdkl2 | Rat | choline | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Cdkl2 | Rat | cisplatin | decreases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CDKL2 mRNA | CTD | PMID:27392435 | Cdkl2 | Rat | clofibrate | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of CDKL2 mRNA; PPARA affects the reaction [[Clofibrate more ... | CTD | PMID:17585979 | Cdkl2 | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of CDKL2 mRNA | CTD | PMID:26577399 | Cdkl2 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CDKL2 mRNA | CTD | PMID:29391264 | Cdkl2 | Rat | entinostat | increases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | entinostat results in increased expression of CDKL2 mRNA | CTD | PMID:26272509|PMID:27188386 | Cdkl2 | Rat | folic acid | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Cdkl2 | Rat | L-methionine | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Cdkl2 | Rat | lead(0) | affects expression | ISO | CDKL2 (Homo sapiens) | 6480464 | Lead affects the expression of CDKL2 mRNA | CTD | PMID:28903495 | Cdkl2 | Rat | mercury atom | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Mercury analog results in decreased expression of CDKL2 mRNA | CTD | PMID:25056781 | Cdkl2 | Rat | mercury(0) | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Mercury analog results in decreased expression of CDKL2 mRNA | CTD | PMID:25056781 | Cdkl2 | Rat | methotrexate | affects expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Methotrexate affects the expression of CDKL2 mRNA | CTD | PMID:18502557 | Cdkl2 | Rat | nickel atom | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Nickel results in decreased expression of CDKL2 mRNA | CTD | PMID:12540486 | Cdkl2 | Rat | nickel atom | decreases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | Nickel results in decreased expression of CDKL2 mRNA | CTD | PMID:24768652|PMID:25583101 | Cdkl2 | Rat | nickel sulfate | increases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of CDKL2 mRNA | CTD | PMID:22714537 | Cdkl2 | Rat | paracetamol | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of CDKL2 mRNA; PPARA affects the reaction [[Clofibrate more ... | CTD | PMID:17585979 | Cdkl2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CDKL2 mRNA | CTD | PMID:33387578 | Cdkl2 | Rat | pirinixic acid | increases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of CDKL2 mRNA | CTD | PMID:18301758|PMID:23811191 | Cdkl2 | Rat | potassium chromate | decreases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of CDKL2 mRNA | CTD | PMID:22714537 | Cdkl2 | Rat | progesterone | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Progesterone results in decreased expression of CDKL2 mRNA | CTD | PMID:16966611 | Cdkl2 | Rat | rimonabant | multiple interactions | ISO | Cdkl2 (Mus musculus) | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in increased expression of CDKL2 mRNA] | CTD | PMID:19030233 | Cdkl2 | Rat | sodium arsenite | increases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CDKL2 mRNA | CTD | PMID:38568856 | Cdkl2 | Rat | sodium arsenite | decreases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CDKL2 mRNA | CTD | PMID:34032870|PMID:39719251 | Cdkl2 | Rat | sunitinib | increases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of CDKL2 mRNA | CTD | PMID:31533062 | Cdkl2 | Rat | temozolomide | decreases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of CDKL2 mRNA | CTD | PMID:31758290 | Cdkl2 | Rat | tetrachloromethane | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of CDKL2 mRNA | CTD | PMID:17484886 | Cdkl2 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CDKL2 mRNA | CTD | PMID:23411599 | Cdkl2 | Rat | titanium dioxide | decreases methylation | ISO | Cdkl2 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of CDKL2 gene | CTD | PMID:35295148 | Cdkl2 | Rat | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of CDKL2 mRNA | CTD | PMID:30589522 | Cdkl2 | Rat | triptonide | decreases expression | ISO | Cdkl2 (Mus musculus) | 6480464 | triptonide results in decreased expression of CDKL2 mRNA | CTD | PMID:33045310 | Cdkl2 | Rat | valproic acid | increases expression | ISO | CDKL2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of CDKL2 mRNA | CTD | PMID:19101580|PMID:23179753|PMID:28001369 | Cdkl2 | Rat | valproic acid | affects expression | ISO | CDKL2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CDKL2 mRNA | CTD | PMID:25979313 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















