Tdp1 (tyrosyl-DNA phosphodiesterase 1) - Rat Genome Database

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Gene: Tdp1 (tyrosyl-DNA phosphodiesterase 1) Rattus norvegicus
Analyze
Symbol: Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
RGD ID: 1309618
Description: Predicted to enable 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair. Predicted to act upstream of or within single strand break repair. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy 1. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314380; MGC112732; tyr-DNA phosphodiesterase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86124,892,821 - 124,960,646 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6124,881,574 - 124,960,642 (+)EnsemblGRCr8
mRatBN7.26119,163,192 - 119,231,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6119,163,166 - 119,231,021 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6119,314,236 - 119,388,547 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06119,611,041 - 119,685,353 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06118,945,900 - 119,020,218 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06123,895,860 - 123,963,688 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6123,897,956 - 123,963,675 (+)Ensemblrn6Rnor6.0
Rnor_5.06133,109,211 - 133,187,083 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46124,095,259 - 124,162,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6116,696,845 - 116,764,588 (+)NCBICelera
RGSC_v3.16124,105,017 - 124,166,344 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amantadine  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
citronellal  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
myrtenal  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
veliparib  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12023295   PMID:12477932   PMID:15811850   PMID:17118488   PMID:17576665   PMID:17600775   PMID:17914460   PMID:17948061   PMID:21390131   PMID:22822062  


Genomics

Comparative Map Data
Tdp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86124,892,821 - 124,960,646 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6124,881,574 - 124,960,642 (+)EnsemblGRCr8
mRatBN7.26119,163,192 - 119,231,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6119,163,166 - 119,231,021 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6119,314,236 - 119,388,547 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06119,611,041 - 119,685,353 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06118,945,900 - 119,020,218 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06123,895,860 - 123,963,688 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6123,897,956 - 123,963,675 (+)Ensemblrn6Rnor6.0
Rnor_5.06133,109,211 - 133,187,083 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46124,095,259 - 124,162,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6116,696,845 - 116,764,588 (+)NCBICelera
RGSC_v3.16124,105,017 - 124,166,344 (+)NCBI
Cytogenetic Map6q32NCBI
TDP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381489,954,968 - 90,044,764 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1489,954,939 - 90,044,820 (+)Ensemblhg38GRCh38
GRCh371490,422,271 - 90,511,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361489,491,999 - 89,580,861 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341489,491,998 - 89,580,859NCBI
Celera1470,469,447 - 70,558,298 (+)NCBICelera
Cytogenetic Map14q32.11NCBI
HuRef1470,596,174 - 70,685,067 (+)NCBIHuRef
CHM1_11490,360,149 - 90,448,932 (+)NCBICHM1_1
T2T-CHM13v2.01484,179,088 - 84,268,965 (+)NCBIT2T-CHM13v2.0
Tdp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391299,850,767 - 99,921,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1299,850,776 - 99,921,478 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381299,884,515 - 99,955,223 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1299,884,517 - 99,955,219 (+)Ensemblmm10GRCm38
MGSCv3712101,122,725 - 101,193,429 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612100,285,568 - 100,338,412 (+)NCBIMGSCv36mm8
Celera12101,107,017 - 101,181,494 (+)NCBICelera
Cytogenetic Map12ENCBI
Tdp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543812,421,005 - 12,511,493 (+)Ensembl
ChiLan1.0NW_00495543812,421,790 - 12,510,243 (+)NCBIChiLan1.0ChiLan1.0
TDP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21591,099,597 - 91,189,302 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11490,316,103 - 90,408,984 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01470,574,066 - 70,662,562 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11489,926,462 - 90,014,802 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1489,926,462 - 90,014,802 (+)EnsemblpanPan2panpan1.1
TDP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1861,023,564 - 61,107,599 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl861,024,084 - 61,107,506 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha860,602,950 - 60,687,315 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0861,295,027 - 61,379,934 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl861,295,370 - 61,379,841 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1860,976,795 - 61,061,437 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0861,025,579 - 61,109,935 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0861,353,607 - 61,438,500 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tdp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864014,757,696 - 14,831,981 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648817,236,703 - 17,311,310 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648817,237,002 - 17,311,325 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TDP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7111,767,089 - 111,853,249 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17111,767,094 - 111,853,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27118,331,680 - 118,417,900 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TDP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12467,672,178 - 67,762,340 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605354,975,611 - 55,064,238 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tdp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473412,331,710 - 12,414,784 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473412,319,499 - 12,414,815 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tdp1
276 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:126
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000005167
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH129987  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26119,230,758 - 119,230,945 (+)MAPPERmRatBN7.2
Rnor_6.06123,963,418 - 123,963,604NCBIRnor6.0
Rnor_5.06133,186,817 - 133,187,003UniSTSRnor5.0
RGSC_v3.46124,162,549 - 124,162,735UniSTSRGSC3.4
Celera6116,764,322 - 116,764,508UniSTS
RH 3.4 Map6871.2UniSTS
Cytogenetic Map6q32UniSTS
RH142247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26119,230,753 - 119,230,933 (+)MAPPERmRatBN7.2
Rnor_6.06123,963,413 - 123,963,592NCBIRnor6.0
Rnor_5.06133,186,812 - 133,186,991UniSTSRnor5.0
RGSC_v3.46124,162,544 - 124,162,723UniSTSRGSC3.4
Celera6116,764,317 - 116,764,496UniSTS
RH 3.4 Map6871.2UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005167   ⟹   ENSRNOP00000005167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6124,895,199 - 124,960,642 (+)Ensembl
mRatBN7.2 Ensembl6119,165,463 - 119,231,021 (+)Ensembl
Rnor_6.0 Ensembl6123,897,956 - 123,963,675 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111469   ⟹   ENSRNOP00000092684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6124,881,574 - 124,960,642 (+)Ensembl
mRatBN7.2 Ensembl6119,163,166 - 119,231,019 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115515   ⟹   ENSRNOP00000093319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6124,894,587 - 124,960,642 (+)Ensembl
mRatBN7.2 Ensembl6119,169,119 - 119,231,021 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122813   ⟹   ENSRNOP00000110966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6124,891,595 - 124,946,305 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126423   ⟹   ENSRNOP00000111409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6124,891,595 - 124,960,641 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157506   ⟹   ENSRNOP00000110852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6124,891,595 - 124,960,641 (+)Ensembl
RefSeq Acc Id: NM_001031657   ⟹   NP_001026827
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86124,892,821 - 124,960,646 (+)NCBI
mRatBN7.26119,163,192 - 119,231,025 (+)NCBI
Rnor_6.06123,895,860 - 123,963,684 (+)NCBI
Rnor_5.06133,109,211 - 133,187,083 (+)NCBI
RGSC_v3.46124,095,259 - 124,162,815 (+)RGD
Celera6116,696,845 - 116,764,588 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240432   ⟹   XP_006240494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86124,895,043 - 124,960,646 (+)NCBI
mRatBN7.26119,165,628 - 119,231,029 (+)NCBI
Rnor_6.06123,898,131 - 123,963,688 (+)NCBI
Rnor_5.06133,109,211 - 133,187,083 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112347   ⟹   XP_038968275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86124,894,952 - 124,960,646 (+)NCBI
mRatBN7.26119,165,324 - 119,231,025 (+)NCBI
RefSeq Acc Id: XM_039112349   ⟹   XP_038968277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86124,899,334 - 124,960,646 (+)NCBI
mRatBN7.26119,169,704 - 119,231,025 (+)NCBI
RefSeq Acc Id: NP_001026827   ⟸   NM_001031657
- UniProtKB: Q4G056 (UniProtKB/Swiss-Prot),   A6JEG4 (UniProtKB/TrEMBL),   A0A8I6AVZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240494   ⟸   XM_006240432
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHC3 (UniProtKB/TrEMBL),   A0A8I6AFL5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005167   ⟸   ENSRNOT00000005167
RefSeq Acc Id: XP_038968275   ⟸   XM_039112347
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AVZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968277   ⟸   XM_039112349
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000092684   ⟸   ENSRNOT00000111469
Ensembl Acc Id: ENSRNOP00000093319   ⟸   ENSRNOT00000115515
Ensembl Acc Id: ENSRNOP00000110852   ⟸   ENSRNOT00000157506
Ensembl Acc Id: ENSRNOP00000111409   ⟸   ENSRNOT00000126423
Ensembl Acc Id: ENSRNOP00000110966   ⟸   ENSRNOT00000122813

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4G056-F1-model_v2 AlphaFold Q4G056 1-609 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309618 AgrOrtholog
BioCyc Gene G2FUF-36507 BioCyc
Ensembl Genes ENSRNOG00000003831 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005167 ENTREZGENE
  ENSRNOT00000115515 ENTREZGENE
  ENSRNOT00000157506 ENTREZGENE
Gene3D-CATH Endonuclease Chain A UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7385935 IMAGE-MGC_LOAD
InterPro Tdp1 UniProtKB/Swiss-Prot
KEGG Report rno:314380 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112732 IMAGE-MGC_LOAD
NCBI Gene 314380 ENTREZGENE
PANTHER PTHR12415 UniProtKB/Swiss-Prot
  TYROSYL-DNA PHOSPHODIESTERASE 1 UniProtKB/Swiss-Prot
Pfam Tyr-DNA_phospho UniProtKB/Swiss-Prot
PharmGKB TDP1 RGD
PhenoGen Tdp1 PhenoGen
RatGTEx ENSRNOG00000003831 RatGTEx
Superfamily-SCOP Phospholipase D/nuclease UniProtKB/Swiss-Prot
UniProt A0A0H2UHC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AVZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LKI3_RAT UniProtKB/TrEMBL
  A0ABK0M721_RAT UniProtKB/TrEMBL
  A6JEG4 ENTREZGENE, UniProtKB/TrEMBL
  A6JEG5_RAT UniProtKB/TrEMBL
  Q4G056 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Tdp1  tyrosyl-DNA phosphodiesterase 1  Tdp1_predicted  tyrosyl-DNA phosphodiesterase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tdp1_predicted  tyrosyl-DNA phosphodiesterase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED