Dusp23 (dual specificity phosphatase 23) - Rat Genome Database

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Gene: Dusp23 (dual specificity phosphatase 23) Rattus norvegicus
Analyze
Symbol: Dusp23
Name: dual specificity phosphatase 23
RGD ID: 1309202
Description: Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in cilium assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human DUSP23 (dual specificity phosphatase 23); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity phosphatase 23-like; dual specificity protein phosphatase 23; LOC360881
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,630,245 - 87,632,400 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,630,245 - 87,632,400 (-)EnsemblGRCr8
mRatBN7.21385,097,899 - 85,100,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,097,899 - 85,100,093 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,602,026 - 87,603,219 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,002,297 - 89,003,490 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,187,031 - 86,188,224 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,018,670 - 91,019,862 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,018,510 - 91,020,112 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,537,373 - 95,538,565 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,637,671 - 88,638,863 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,707,861 - 84,708,048 (-)NCBICelera
RGSC_v3.11388,826,435 - 88,827,841 (-)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17498703   PMID:23376485   PMID:24531476  


Genomics

Comparative Map Data
Dusp23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,630,245 - 87,632,400 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,630,245 - 87,632,400 (-)EnsemblGRCr8
mRatBN7.21385,097,899 - 85,100,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,097,899 - 85,100,093 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,602,026 - 87,603,219 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,002,297 - 89,003,490 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,187,031 - 86,188,224 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,018,670 - 91,019,862 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,018,510 - 91,020,112 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,537,373 - 95,538,565 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,637,671 - 88,638,863 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,707,861 - 84,708,048 (-)NCBICelera
RGSC_v3.11388,826,435 - 88,827,841 (-)NCBI
Cytogenetic Map13q24NCBI
DUSP23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,780,962 - 159,782,543 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,780,932 - 159,782,543 (+)Ensemblhg38GRCh38
GRCh371159,750,752 - 159,752,333 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,017,383 - 158,018,957 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341156,563,831 - 156,565,406NCBI
Celera1132,819,186 - 132,820,760 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,107,191 - 131,108,765 (+)NCBIHuRef
CHM1_11161,146,109 - 161,147,683 (+)NCBICHM1_1
T2T-CHM13v2.01158,917,974 - 158,919,555 (+)NCBIT2T-CHM13v2.0
Dusp23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,458,336 - 172,460,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,458,331 - 172,460,529 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,630,769 - 172,632,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,630,764 - 172,632,962 (-)Ensemblmm10GRCm38
MGSCv371174,560,900 - 174,563,105 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361174,468,045 - 174,469,637 (-)NCBIMGSCv36mm8
Celera1175,487,228 - 175,489,448 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.05NCBI
Dusp23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,579,817 - 11,581,174 (+)Ensembl
ChiLan1.0NW_00495546811,579,624 - 11,581,975 (+)NCBIChiLan1.0ChiLan1.0
DUSP23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,071,900 - 90,073,604 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,811,935 - 89,813,618 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,132,451 - 135,134,101 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,053,238 - 139,054,865 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,053,238 - 139,054,865 (+)EnsemblpanPan2panpan1.1
DUSP23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,341,052 - 22,344,861 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,417,809 - 22,423,310 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03822,463,300 - 22,469,314 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,462,976 - 22,469,317 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,235,838 - 22,236,110 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,762,744 - 22,768,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,173,732 - 23,179,864 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dusp23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408299257 - 1,735 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049439431 - 1,800 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00494394331 - 1,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,720,696 - 90,721,946 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1490,720,655 - 90,722,675 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,692,567 - 98,695,616 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,169,422 - 4,171,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,169,418 - 4,170,947 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660383,274,497 - 3,276,202 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,467,692 - 1,469,857 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247941,462,782 - 1,469,881 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dusp23
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11051,745,755 - 51,747,757 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dusp23
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:84
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000030449
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 88 59 6 352 188 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000030449   ⟹   ENSRNOP00000028912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,630,245 - 87,632,400 (-)Ensembl
mRatBN7.2 Ensembl1385,097,899 - 85,100,093 (-)Ensembl
Rnor_6.0 Ensembl1391,018,510 - 91,020,112 (-)Ensembl
RefSeq Acc Id: NM_001191830   ⟹   NP_001178759
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,630,245 - 87,632,400 (-)NCBI
mRatBN7.21385,097,899 - 85,100,054 (-)NCBI
Rnor_6.01391,018,670 - 91,019,862 (-)NCBI
Rnor_5.01395,537,373 - 95,538,565 (-)NCBI
Celera1384,707,861 - 84,708,048 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028912
  ENSRNOP00000028912.4
RefSeq Acc Id: NP_001178759   ⟸   NM_001191830
- UniProtKB: D3ZRL3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028912   ⟸   ENSRNOT00000030449
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRL3-F1-model_v2 AlphaFold D3ZRL3 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699030
Promoter ID:EPDNEW_R9555
Type:initiation region
Name:Dusp23_1
Description:dual specificity phosphatase 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01391,019,932 - 91,019,992EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309202 AgrOrtholog
BioCyc Gene G2FUF-17297 BioCyc
Ensembl Genes ENSRNOG00000022143 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030449 ENTREZGENE
  ENSRNOT00000030449.8 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp/Tyr_phosphatase UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP UniProtKB/TrEMBL
  PTP-SAK UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
KEGG Report rno:360881 UniProtKB/TrEMBL
NCBI Gene 360881 ENTREZGENE
PANTHER TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/TrEMBL
Pfam PTP-SAK UniProtKB/TrEMBL
PhenoGen Dusp23 PhenoGen
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022143 RatGTEx
SMART DSPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt D3ZRL3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Dusp23  dual specificity phosphatase 23  LOC100366094  dual specificity phosphatase 23-like  Data merged from RGD:2324364 1643240 APPROVED
2010-05-06 LOC100366094  dual specificity phosphatase 23-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Dusp23  dual specificity phosphatase 23   Dusp23_predicted  dual specificity phosphatase 23 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dusp23_predicted  dual specificity phosphatase 23 (predicted)      Symbol and Name status set to approved 70820 APPROVED