Cep68 (centrosomal protein 68) - Rat Genome Database

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Gene: Cep68 (centrosomal protein 68) Rattus norvegicus
Analyze
Symbol: Cep68
Name: centrosomal protein 68
RGD ID: 1309101
Description: Predicted to enable protein domain specific binding activity and protein kinase binding activity. Predicted to be involved in centriole-centriole cohesion. Predicted to be located in centrosome. Orthologous to human CEP68 (centrosomal protein 68); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: centrosomal protein 68kDa; centrosomal protein of 68 kDa; LOC289822; RGD1309101; similar to KIAA0582 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,649,993 - 98,671,892 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1498,649,993 - 98,671,868 (-)EnsemblGRCr8
mRatBN7.21494,447,973 - 94,470,533 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,449,055 - 94,470,517 (-)EnsemblmRatBN7.2
Rnor_6.014104,501,759 - 104,523,330 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,505,319 - 104,523,297 (-)Ensemblrn6Rnor6.0
Rnor_5.014104,236,508 - 104,258,520 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414101,031,918 - 101,051,380 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1493,474,639 - 93,493,251 (-)NCBICelera
RGSC_v3.114101,052,249 - 101,064,017 (-)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriolar satellite  (IEA,ISO)
centrosome  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18042621   PMID:21399614   PMID:24554434  


Genomics

Comparative Map Data
Cep68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81498,649,993 - 98,671,892 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1498,649,993 - 98,671,868 (-)EnsemblGRCr8
mRatBN7.21494,447,973 - 94,470,533 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1494,449,055 - 94,470,517 (-)EnsemblmRatBN7.2
Rnor_6.014104,501,759 - 104,523,330 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14104,505,319 - 104,523,297 (-)Ensemblrn6Rnor6.0
Rnor_5.014104,236,508 - 104,258,520 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414101,031,918 - 101,051,380 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1493,474,639 - 93,493,251 (-)NCBICelera
RGSC_v3.114101,052,249 - 101,064,017 (-)NCBI
Cytogenetic Map14q22NCBI
CEP68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38265,056,416 - 65,087,004 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl265,056,350 - 65,087,010 (+)Ensemblhg38GRCh38
GRCh37265,283,550 - 65,314,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36265,136,999 - 65,167,646 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34265,195,249 - 65,222,622NCBI
Celera265,129,881 - 65,160,529 (+)NCBICelera
Cytogenetic Map2p14NCBI
HuRef265,017,251 - 65,048,120 (+)NCBIHuRef
CHM1_1265,214,440 - 65,245,100 (+)NCBICHM1_1
T2T-CHM13v2.0265,066,038 - 65,096,632 (+)NCBIT2T-CHM13v2.0
Cep68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391120,177,037 - 20,199,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1120,177,037 - 20,199,429 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381120,227,037 - 20,249,424 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1120,227,037 - 20,249,429 (-)Ensemblmm10GRCm38
MGSCv371120,127,040 - 20,149,427 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361120,128,509 - 20,149,420 (-)NCBIMGSCv36mm8
Celera1122,376,409 - 22,398,791 (-)NCBICelera
Cytogenetic Map11A3.1NCBI
cM Map1112.92NCBI
Cep68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542419,426,642 - 19,439,126 (-)Ensembl
ChiLan1.0NW_00495542419,424,088 - 19,439,126 (-)NCBIChiLan1.0ChiLan1.0
CEP68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21261,313,471 - 61,344,167 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A61,317,422 - 61,348,117 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A65,119,388 - 65,147,624 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A66,244,826 - 66,274,963 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A66,244,826 - 66,274,963 (+)EnsemblpanPan2panpan1.1
CEP68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11064,545,010 - 64,561,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1064,538,166 - 64,561,684 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1064,423,849 - 64,449,309 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01065,546,500 - 65,571,954 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1065,546,538 - 65,570,469 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11065,225,349 - 65,250,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01065,534,030 - 65,559,472 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01065,827,634 - 65,853,098 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cep68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629218,714,431 - 18,741,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364919,829,721 - 9,854,966 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364919,829,746 - 9,858,409 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CEP68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl376,869,622 - 76,901,126 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1376,869,350 - 76,932,673 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2380,712,106 - 80,728,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CEP68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11441,934,740 - 41,961,853 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1441,935,996 - 41,949,335 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604569,919,167 - 69,946,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cep68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247628,454,117 - 8,476,053 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247628,449,759 - 8,476,001 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cep68
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11188,508,341 - 88,529,974 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cep68
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:28
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000039523
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582201Sffal2Serum free fatty acids level QTL 240.0002blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)1496755448100078267Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1486271332100078267Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat

Markers in Region
BI275913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21494,460,602 - 94,460,695 (+)MAPPERmRatBN7.2
Rnor_6.014104,513,130 - 104,513,222NCBIRnor6.0
Rnor_5.014104,248,331 - 104,248,423UniSTSRnor5.0
RGSC_v3.414101,041,479 - 101,041,571UniSTSRGSC3.4
Celera1493,483,328 - 93,483,420UniSTS
RH 3.4 Map14746.5UniSTS
Cytogenetic Map14q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000039523   ⟹   ENSRNOP00000035901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,649,993 - 98,671,868 (-)Ensembl
mRatBN7.2 Ensembl1494,449,055 - 94,470,479 (-)Ensembl
Rnor_6.0 Ensembl14104,505,319 - 104,523,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098413   ⟹   ENSRNOP00000082067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,657,654 - 98,671,868 (-)Ensembl
mRatBN7.2 Ensembl1494,449,055 - 94,470,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122101   ⟹   ENSRNOP00000100093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1498,655,152 - 98,671,868 (-)Ensembl
RefSeq Acc Id: NM_001427307   ⟹   NP_001414236
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81498,649,993 - 98,671,868 (-)NCBI
RefSeq Acc Id: XM_039092868   ⟹   XP_038948796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81498,654,089 - 98,671,892 (-)NCBI
mRatBN7.21494,452,727 - 94,470,533 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414236 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948796 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97937 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035901
  ENSRNOP00000035901.4
  ENSRNOP00000082067.2
  ENSRNOP00000100093
  ENSRNOP00000100093.1
Ensembl Acc Id: ENSRNOP00000035901   ⟸   ENSRNOT00000039523
RefSeq Acc Id: XP_038948796   ⟸   XM_039092868
- Peptide Label: isoform X1
- UniProtKB: A6JQ20 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082067   ⟸   ENSRNOT00000098413
RefSeq Acc Id: NP_001414236   ⟸   NM_001427307
- UniProtKB: D3ZZ61 (UniProtKB/TrEMBL),   A6JQ20 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100093   ⟸   ENSRNOT00000122101

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZ61-F1-model_v2 AlphaFold D3ZZ61 1-734 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699513
Promoter ID:EPDNEW_R10033
Type:initiation region
Name:Cep68_1
Description:centrosomal protein 68
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014104,523,305 - 104,523,365EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309101 AgrOrtholog
BioCyc Gene G2FUF-14886 BioCyc
Ensembl Genes ENSRNOG00000027282 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039523 ENTREZGENE
  ENSRNOT00000039523.8 UniProtKB/TrEMBL
  ENSRNOT00000098413.2 UniProtKB/TrEMBL
  ENSRNOT00000122101 ENTREZGENE
  ENSRNOT00000122101.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.60 UniProtKB/TrEMBL
NCBI Gene 289822 ENTREZGENE
PhenoGen Cep68 PhenoGen
RatGTEx ENSRNOG00000027282 RatGTEx
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
UniProt A0A8I5ZSZ1_RAT UniProtKB/TrEMBL
  A0ABK0KYS7_RAT UniProtKB/TrEMBL
  A6JQ20 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZ61 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-27 Cep68  centrosomal protein 68  Cep68  centrosomal protein 68kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Cep68  centrosomal protein 68kDa  Cep68  centrosomal protein 68   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cep68  centrosomal protein 68   Cep68_predicted  centrosomal protein 68 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Cep68_predicted  centrosomal protein 68 (predicted)  RGD1309101_predicted  similar to KIAA0582 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1309101_predicted  similar to KIAA0582 protein (predicted)  LOC289822_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289822_predicted  similar to KIAA0582 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL