Peds1 (plasmanylethanolamine desaturase 1) - Rat Genome Database

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Gene: Peds1 (plasmanylethanolamine desaturase 1) Rattus norvegicus
Analyze
Symbol: Peds1
Name: plasmanylethanolamine desaturase 1
RGD ID: 1309093
Description: Predicted to enable plasmanylethanolamine desaturase activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to several human genes including PEDS1 (plasmanylethanolamine desaturase 1); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Kua; Kua homolog; plasmanylethanolamine desaturase; Tmem189; transmembrane protein 189
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,769,111 - 176,788,278 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.23156,350,135 - 156,369,309 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,349,526 - 156,369,314 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,145,203 - 160,164,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,644,269 - 168,663,535 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,385,974 - 166,405,245 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,376,621 - 164,388,213 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,376,630 - 164,388,492 (-)Ensemblrn6Rnor6.0
Rnor_5.03170,527,447 - 170,539,038 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43158,778,662 - 158,790,278 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3154,928,354 - 154,939,946 (-)NCBICelera
RGSC_v3.13158,684,108 - 158,712,837 (-)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:31604315  


Genomics

Comparative Map Data
Peds1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,769,111 - 176,788,278 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.23156,350,135 - 156,369,309 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,349,526 - 156,369,314 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,145,203 - 160,164,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,644,269 - 168,663,535 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,385,974 - 166,405,245 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,376,621 - 164,388,213 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,376,630 - 164,388,492 (-)Ensemblrn6Rnor6.0
Rnor_5.03170,527,447 - 170,539,038 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43158,778,662 - 158,790,278 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3154,928,354 - 154,939,946 (-)NCBICelera
RGSC_v3.13158,684,108 - 158,712,837 (-)NCBI
Cytogenetic Map3q42NCBI
PEDS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,118,254 - 50,153,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2050,118,254 - 50,153,754 (-)Ensemblhg38GRCh38
GRCh372048,734,791 - 48,770,260 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,173,714 - 48,203,667 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2045,444,831 - 45,474,884 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,488,872 - 45,518,923 (-)NCBIHuRef
CHM1_12048,644,933 - 48,674,989 (-)NCBICHM1_1
T2T-CHM13v2.02051,888,041 - 51,923,515 (-)NCBIT2T-CHM13v2.0
Peds1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,485,145 - 167,503,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,484,528 - 167,531,742 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382167,643,225 - 167,661,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,642,608 - 167,689,822 (-)Ensemblmm10GRCm38
MGSCv372167,468,725 - 167,487,044 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362167,334,430 - 167,352,749 (-)NCBIMGSCv36mm8
MGSCv362168,627,513 - 168,645,837 (-)NCBIMGSCv36mm8
Celera2173,583,467 - 173,617,406 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.5NCBI
PEDS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,869,391 - 55,900,476 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,862,499 - 55,893,555 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02046,465,126 - 46,496,553 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12047,582,519 - 47,613,194 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2047,582,519 - 47,613,200 (-)EnsemblpanPan2panpan1.1
LOC611401
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,610,640 - 36,633,768 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,611,449 - 36,633,686 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2435,853,922 - 35,877,398 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02437,316,904 - 37,340,359 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,317,308 - 37,340,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,557,653 - 36,581,113 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,690,902 - 36,714,361 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,234,592 - 37,258,071 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Peds1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,908,801 - 188,912,756 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,362,479 - 4,366,416 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,361,283 - 4,366,399 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEDS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,672,757 - 51,697,981 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11751,674,099 - 51,697,985 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,826,782 - 57,850,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PEDS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,814,811 - 13,844,604 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605062,247,181 - 62,277,326 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000089040   ⟹   ENSRNOP00000075639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3156,349,526 - 156,369,314 (-)Ensembl
Rnor_6.0 Ensembl3164,376,630 - 164,388,281 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090493   ⟹   ENSRNOP00000069029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3156,349,614 - 156,362,470 (-)Ensembl
Rnor_6.0 Ensembl3164,376,643 - 164,388,492 (-)Ensembl
RefSeq Acc Id: NM_001113752   ⟹   NP_001107224
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83176,769,111 - 176,788,278 (-)NCBI
mRatBN7.23156,350,135 - 156,369,309 (-)NCBI
Rnor_6.03164,376,621 - 164,388,213 (-)NCBI
Rnor_5.03170,527,447 - 170,539,038 (-)NCBI
RGSC_v3.43158,778,662 - 158,790,278 (-)RGD
Celera3154,928,354 - 154,939,946 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001107224 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58661 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001107224   ⟸   NM_001113752
- UniProtKB: B0BN29 (UniProtKB/TrEMBL),   A0A0G2KB37 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075639   ⟸   ENSRNOT00000089040
Ensembl Acc Id: ENSRNOP00000069029   ⟸   ENSRNOT00000090493
Protein Domains
Lipid desaturase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUA8-F1-model_v2 AlphaFold A0A0G2JUA8 1-258 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309093 AgrOrtholog
BioCyc Gene G2FUF-46721 BioCyc
BioCyc Pathway PWY-7782 [plasmalogen biosynthesis] BioCyc
BioCyc Pathway Image PWY-7782 BioCyc
Ensembl Genes ENSRNOG00000060571 Ensembl
IMAGE_CLONE IMAGE:8369614 IMAGE-MGC_LOAD
InterPro KuaUb-conj-enz_UEV1 UniProtKB/TrEMBL
  Plasmalogen_desaturase UniProtKB/TrEMBL
KEGG Report rno:362278 UniProtKB/TrEMBL
MGC_CLONE MGC:187649 IMAGE-MGC_LOAD
NCBI Gene 362278 ENTREZGENE
PANTHER PLASMANYLETHANOLAMINE DESATURASE UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 189 UniProtKB/TrEMBL
Pfam Kua-UEV1_localn UniProtKB/TrEMBL
PhenoGen Peds1 PhenoGen
RatGTEx ENSRNOG00000060571 RatGTEx
UniProt A0A0G2KB37 ENTREZGENE
  B0BN29 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-22 Peds1  plasmanylethanolamine desaturase 1  Tmem189  transmembrane protein 189  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tmem189  transmembrane protein 189  Kua_predicted  Kua homolog (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Kua_predicted  Kua homolog (predicted)  LOC686344  similar to ubiquitin-conjugating enzyme E2 Kua-UEV isoform 1  Data merged from RGD:1583159 1643240 APPROVED
2006-11-19 LOC686344  similar to ubiquitin-conjugating enzyme E2 Kua-UEV isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Kua_predicted  Kua homolog (predicted)      Symbol and Name status set to approved 70820 APPROVED