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Gene: Bco2 (beta-carotene oxygenase 2) Rattus norvegicus

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Symbol:

Bco2 (Ensembl: Rps13)

Name:

beta-carotene oxygenase 2 (Ensembl:ribosomal protein S13)

RGD ID:

1309022

Description:

Predicted to enable beta-carotene 15,15'-dioxygenase activity and carotenoid dioxygenase activity. Predicted to be involved in carotene catabolic process and retinal metabolic process. Predicted to be active in mitochondrion. Orthologous to human BCO2 (beta-carotene oxygenase 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ab2-079; Bcdo2; beta,beta-carotene 9',10'-oxygenase; beta-carotene 9', 10'-dioxygenase 2; carotenoid 9',10' monooxygenase II; carotenoid 9',10' monoxygenase II; carotenoid-cleaving dioxygenase, mitochondrial; LOC315644

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BCO2 (beta-carotene oxygenase 2)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Bco2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bco2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BCO2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BCO2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bco2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BCO2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BCO2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bco2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Bco2 (beta-carotene oxygenase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RPS13 (ribosomal protein S13)	HGNC	PhylomeDB, Treefam
Homo sapiens (human):	TBPL1 (TATA-box binding protein like 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	BCO2 (beta-carotene oxygenase 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Bco2 (beta-carotene oxygenase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bco2l (beta-carotene 15, 15-dioxygenase 2, like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bco2a (beta-carotene oxygenase 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bco2b (beta-carotene oxygenase 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bcmo-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bcmo-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ninaB	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ninaB	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bcmo-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	bcmo-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bco2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	bco2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	bco2l	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	59,778,571 - 59,803,597 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	59,778,575 - 59,799,168 (-)	Ensembl				GRCr8
mRatBN7.2	8	50,882,174 - 50,907,676 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	50,882,181 - 50,915,467 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	56,387,689 - 56,412,994 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	54,666,588 - 54,691,892 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	52,530,858 - 52,556,168 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	54,965,577 - 54,990,604 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	54,965,583 - 54,998,864 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	53,562,900 - 53,587,926 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	53,892,017 - 53,917,522 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	50,430,781 - 50,455,782 (-)	NCBI		Celera
RGSC_v3.1	8	53,911,481 - 53,932,108 (-)	NCBI
Cytogenetic Map	8	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-tert-butylhydroquinone (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

8'-apo-beta,psi-caroten-8'-al (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP,ISO)

beta-carotene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

carotenoid (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

endosulfan (EXP)

ethanol (ISO)

lead diacetate (ISO)

lutein (ISO)

methylmercury chloride (ISO)

N-nitrosodiethylamine (ISO)

nitrofen (EXP)

orphenadrine (EXP)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

propiconazole (ISO)

rotenone (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

succimer (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trametinib (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

trovafloxacin (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carotene catabolic process (IBA,IEA,ISO)

carotene metabolic process (IEA,ISO)

carotenoid metabolic process (IEA,ISO)

lipid metabolic process (IEA)

regulation of mitochondrial membrane potential (IEA,ISO)

regulation of reactive oxygen species metabolic process (IEA,ISO)

retinal metabolic process (IBA,ISO)

xanthophyll catabolic process (IEA,ISO)

xanthophyll metabolic process (ISO)

Cellular Component

mitochondrion (IBA,IEA,ISO)

Molecular Function

beta,beta-carotene-9',10'-cleaving oxygenase activity (IEA,ISO)

beta-carotene 15,15'-dioxygenase activity (IBA)

carotenoid dioxygenase activity (IBA)

dioxygenase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11278918	PMID:12477932	PMID:21106934	PMID:21302131	PMID:25575786	PMID:25701869	PMID:25931508

Genomics

Comparative Map Data

Bco2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	59,778,571 - 59,803,597 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	59,778,575 - 59,799,168 (-)	Ensembl				GRCr8
mRatBN7.2	8	50,882,174 - 50,907,676 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	50,882,181 - 50,915,467 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	56,387,689 - 56,412,994 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	54,666,588 - 54,691,892 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	52,530,858 - 52,556,168 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	54,965,577 - 54,990,604 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	54,965,583 - 54,998,864 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	53,562,900 - 53,587,926 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	53,892,017 - 53,917,522 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	50,430,781 - 50,455,782 (-)	NCBI		Celera
RGSC_v3.1	8	53,911,481 - 53,932,108 (-)	NCBI
Cytogenetic Map	8	q23	NCBI

BCO2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	112,175,512 - 112,218,946 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	112,175,472 - 112,225,877 (+)	Ensembl			hg38	GRCh38
GRCh37	11	112,046,235 - 112,089,669 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	111,551,418 - 111,594,862 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	111,551,567 - 111,594,072	NCBI
Celera	11	109,199,441 - 109,242,886 (+)	NCBI		Celera
Cytogenetic Map	11	q23.1	NCBI
HuRef	11	107,970,380 - 108,015,210 (+)	NCBI		HuRef
CHM1_1	11	111,929,662 - 111,973,106 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	112,185,841 - 112,229,285 (+)	NCBI		T2T-CHM13v2.0

Bco2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	50,444,387 - 50,466,513 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	50,444,387 - 50,466,481 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	50,533,087 - 50,555,214 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	50,533,087 - 50,555,181 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	50,341,192 - 50,363,243 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	50,285,381 - 50,302,932 (-)	NCBI		MGSCv36	mm8
Celera	9	47,822,891 - 47,850,079 (-)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	27.74	NCBI

Bco2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	13,837,782 - 13,872,886 (+)	Ensembl
ChiLan1.0	NW_004955412	13,838,260 - 13,872,886 (+)	NCBI	ChiLan1.0	ChiLan1.0

BCO2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	112,920,417 - 112,971,307 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	114,015,150 - 114,065,619 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	107,056,525 - 107,105,358 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	110,899,703 - 110,942,556 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	110,899,703 - 110,942,547 (+)	Ensembl			panPan2	panpan1.1

BCO2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	20,914,658 - 20,969,847 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	20,915,647 - 20,964,177 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	20,838,144 - 20,892,509 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	20,937,599 - 20,992,072 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	20,919,161 - 20,987,893 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	21,000,542 - 21,054,904 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	20,900,812 - 20,955,168 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	20,948,956 - 20,998,527 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Bco2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	94,411,396 - 94,443,419 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	2,262,066 - 2,294,255 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	2,262,115 - 2,294,287 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BCO2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	39,872,645 - 39,917,263 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	39,864,136 - 39,916,491 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	44,716,295 - 44,767,961 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BCO2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	103,511,730 - 103,566,526 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	103,521,658 - 103,565,659 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	22,419,766 - 22,475,321 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bco2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	7,334,472 - 7,353,802 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624784	7,324,312 - 7,353,733 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Bco2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	45,003,727 - 45,029,432 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Bco2
113 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	332
Count of miRNA genes:	208
Interacting mature miRNAs:	250
Transcripts:	ENSRNOT00000059191, ENSRNOT00000059192, ENSRNOT00000070894
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	58991697	91341052	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	58991697	91341052	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	50763951	67219641	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	58991697	91341052	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat

Markers in Region

BQ204515

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	59,778,913 - 59,779,117 (+)	Marker Load Pipeline
mRatBN7.2	8	50,882,519 - 50,882,723 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	54,965,920 - 54,966,123	NCBI	Rnor6.0
Rnor_5.0	8	53,563,243 - 53,563,446	UniSTS	Rnor5.0
RGSC_v3.4	8	53,892,360 - 53,892,563	UniSTS	RGSC3.4
Celera	8	50,431,124 - 50,431,327	UniSTS
RH 3.4 Map	8	544.0	UniSTS
Cytogenetic Map	8	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	90	59	6	350	190	11	143	77	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY325176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC133725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ083174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000034694 ⟹ ENSRNOP00000036690

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	59,780,489 - 59,781,134 (-)	Ensembl
mRatBN7.2 Ensembl	8	50,884,095 - 50,884,743 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000059191 ⟹ ENSRNOP00000055964

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	50,884,627 - 50,915,467 (-)	Ensembl
Rnor_6.0 Ensembl	8	54,968,028 - 54,998,864 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000059192 ⟹ ENSRNOP00000055965

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	59,778,575 - 59,799,168 (-)	Ensembl
mRatBN7.2 Ensembl	8	50,882,181 - 50,907,207 (-)	Ensembl
Rnor_6.0 Ensembl	8	54,965,583 - 54,990,604 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099090 ⟹ ENSRNOP00000080449

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	50,884,627 - 50,913,360 (-)	Ensembl

RefSeq Acc Id:

NM_001127712 ⟹ NP_001121184

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	59,778,571 - 59,803,597 (-)	NCBI
mRatBN7.2	8	50,882,177 - 50,907,207 (-)	NCBI
Rnor_6.0	8	54,965,577 - 54,990,604 (-)	NCBI
Rnor_5.0	8	53,562,900 - 53,587,926 (-)	NCBI
RGSC_v3.4	8	53,892,017 - 53,917,522 (-)	RGD
Celera	8	50,430,781 - 50,455,782 (-)	RGD

Sequence:

show sequence

CAGCAACCTTCCTGACGCTGTGCTGCAGGGGTTCTTTCTGTGACAGTGTACCATCTCCCAGTTT
TGAAGAACTACGTGGGGGAATATTCACCGGAAAACCATGTTGGGACCACAGCAGAGTCTGCCGT
GCATTGCCCCGCTGTTGACCACGGTGGAGGAGACGCTGAGCACTGTCTCCGCTCGGGTCCGAGG
ACACATTCCTGAATGGCTCAATGGCTATCTACTTCGAGTTGGACCTGGGAAATTTGAGTTTGGA
AAGGATAGATACAATCATTGGTTTGATGGAATGGCTTTGCTTCACCAGTTCAAAATGGAGAAGG
GTACAGTGACATACAAGAGCAAGTTTCTACAGAGTGATACATACAAGGCCAACAGTGCGGGAGA
TAGAATCGTGATCTCAGAATTTGGCACGCTGGCCCTTCCTGACCCATGCAAGAGCATCTTTGAA
CGTTTCATGTCAAGGTTTGAGCCACCTACTATGACCGACAACACCAGCGTCAACTTTGTGCAGT
ACAAAGGTGATTACTACATGAGCACAGAGACCAATTTTATGAATAAAGTGGACATTGAAACACT
GGAAAGAACAGAAAAGGTGGACTGGAGCAAATTCGTTGCTGTGAATGGAGCGACCGCACACCCT
CACTATGACCCAGACGGGACAGCATACAATATGGGGAACACCTATGGACCAAGAGGTTCTTGCT
ATAATATTATTCGTGTTCCTCCAAAAAAGAAAGAACCCGGGGAGACGATTCATGGGGCGCAGGT
AGTATGTTCTATAGCTTCCTCTGAGAAGATGAAGCCTTCTTACTACCATAGCTTTGGAATGACA
AAAAACTACATAGTCTTTGTCGAACAGCCTCTAAAGATGAAGCTGTGGAAAATAATTACTTCTA
AAATCCGGGGAAAGTCCTTCGCCGATGGCATAAGCTGGGAACCCCAGTATAACACGCGATTTCA
CGTGGTGGATAAGCACACTGGACAGCCTCTCCCAGGAGTGTACTACAGCAAGCCTTTTCTTACC
TATCATCAAATCAATGCCTTCGAGGACCAGGGCTGTATTGTGATTGACCTGTGCTGTGAGGATG
ATGGGAGAAGCCTAGACATTTACCAACTACAGAATCTCAGGAAAGCCGGAGAAGAGCTCGATCA
GGTCTATAAGGCAAAGGCAAAGTCTTTCCCTCGAAGATTTGTCTTGCCCTTGGATATCAGTGTG
GGTGCCCCCGAGGGAGAGAACCTCAGACCCCTGCCCTATTCTTCAGCCAGTGTCGTGAAACAGG
GTGACAGAGAGATCTGGTGCTCTCCTGAAAATCTACACCAAGAGGACCTGGAAGAGGAAGGGGG
AATTGAATTTCCTCAGATCAACTATGGCCGATTCAGTGGCAAAAAGTATAGTTTCTTCTATGGC
TGCGGTTTTCGACATTTGGTGGGGGATTCTCTGATTAAGGTTGACGTGGTGAACAAGACACTAA
GGGTTTGGAGAGAAGAAGGCTGTTATCCTTCGGAGCCCGTTTTTGTTCCGGTGCCAGGAGCCGA
TGAGGAAGACAGTGGGGCTATACTCTCTGTGGTGATCACTCCCAACCAGGGTGAAAGCAACTTT
CTCCTTGTCTTGGATGCCAAGAACTTTACAGAACTGGGGCGAGCAGAGGTACCTGTGCGGATGC
CTTATGGGTTCCACGGCACATTTGTGCCTATCTGATGGCAAAAGCTTAAGGAAGGACTCAGATA
AGGCTTCAATGAGCACATTTCTATGGAAAAGAGAAAATGGTGGGCGTCTTAGGGTTTTACTGCT
GTGAACAGATACCATGACCAGGGCACGTCTTAAAAGGACATTTAATTGAGGCTGGCTTACAAGT
TCAGAGGTTCAGTCCATTATCATCGAGGTGAGAGCATGGTGGCGTCCAGGCAGGCATGGTGCAC
GCAGAGCTGAGAGTTCAACATCATCATCTGAAGGCTGCTAGTGGAAGACTGGCTTCTTAAAGCC
CTCACAGTCATACACCTACTTCAACAAGGCCACAACTCCTAACAGTGCCACTCCCTGGCCCAAG
CATATTCAAACCATGCCAGTGGGTCTCACCCAAAAGCTACTGTAGTTTGGCCCCGACCCTGACC
CTGACCCTGACCCTGACCACCATGGGCTCATATTTTACATGATTGTTCCCAGGTTGTGGCACCA
CTTTGGGAGGCTGTGTAAACTTTTGGGGGTGATGCCCCACAGGCACCAGGAGCCAGCCTTTGAG
GTCCCTGGTTCTCTCATGCTCTCTCTCTGCTTCCTGGTCCACTACTATGTGGACAGCCTTCATT
CCATGTTCTCAGCCTTGTGGCTGATGGGGTTTCTCCTCCATGCCTCCCTACTGAGTCCCCTCAG
TCTGTGGGCCAAGGATATATTTGCACCTTAAGTTGTTCTGTCAGTTTGAGTTTGCTTTTGGTTT
GCAGCAGTGGTGAAATAATTAATAAAAAAGAACCCCGATGTATGGCTTTACATTTCTATTAAAA
CATAATTTGTGAGATAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039081446 ⟹ XP_038937374

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	59,778,571 - 59,800,905 (-)	NCBI
mRatBN7.2	8	50,882,174 - 50,904,508 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001121184	(Get FASTA)	NCBI Sequence Viewer
	XP_038937374	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI33726	(Get FASTA)	NCBI Sequence Viewer
	AAP92577	(Get FASTA)	NCBI Sequence Viewer
	AAY85350	(Get FASTA)	NCBI Sequence Viewer
	EDL95460	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000055965
	ENSRNOP00000055965.2

RefSeq Acc Id:

NP_001121184 ⟸ NM_001127712

- UniProtKB:

A3KN98 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLGPQQSLPCIAPLLTTVEETLSTVSARVRGHIPEWLNGYLLRVGPGKFEFGKDRYNHWFDGMA
LLHQFKMEKGTVTYKSKFLQSDTYKANSAGDRIVISEFGTLALPDPCKSIFERFMSRFEPPTMT
DNTSVNFVQYKGDYYMSTETNFMNKVDIETLERTEKVDWSKFVAVNGATAHPHYDPDGTAYNMG
NTYGPRGSCYNIIRVPPKKKEPGETIHGAQVVCSIASSEKMKPSYYHSFGMTKNYIVFVEQPLK
MKLWKIITSKIRGKSFADGISWEPQYNTRFHVVDKHTGQPLPGVYYSKPFLTYHQINAFEDQGC
IVIDLCCEDDGRSLDIYQLQNLRKAGEELDQVYKAKAKSFPRRFVLPLDISVGAPEGENLRPLP
YSSASVVKQGDREIWCSPENLHQEDLEEEGGIEFPQINYGRFSGKKYSFFYGCGFRHLVGDSLI
KVDVVNKTLRVWREEGCYPSEPVFVPVPGADEEDSGAILSVVITPNQGESNFLLVLDAKNFTEL
GRAEVPVRMPYGFHGTFVPI

hide sequence

Ensembl Acc Id:

ENSRNOP00000055964 ⟸ ENSRNOT00000059191

Ensembl Acc Id:

ENSRNOP00000055965 ⟸ ENSRNOT00000059192

RefSeq Acc Id:	XP_038937374 ⟸ XM_039081446
- Peptide Label:	isoform X1
- UniProtKB:	A3KN98 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000080449 ⟸ ENSRNOT00000099090

Ensembl Acc Id:

ENSRNOP00000036690 ⟸ ENSRNOT00000034694

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A3KN98-F1-model_v2	AlphaFold	A3KN98	1-532	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695944

Promoter ID:

EPDNEW_R6469

Type:

initiation region

Name:

Bco2_1

Description:

beta-carotene oxygenase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	54,990,663 - 54,990,723	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309022	AgrOrtholog
BioCyc Gene	G2FUF-30563	BioCyc
Ensembl Genes	ENSRNOG00000038746	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000059192	ENTREZGENE
	ENSRNOT00000059192.6	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7100438	IMAGE-MGC_LOAD
InterPro	Carotenoid_Oase	UniProtKB/TrEMBL
KEGG Report	rno:315644	UniProtKB/TrEMBL
MGC_CLONE	MGC:156714	IMAGE-MGC_LOAD
NCBI Gene	315644	ENTREZGENE
PANTHER	BETA,BETA-CAROTENE 9',10'-OXYGENASE	UniProtKB/TrEMBL
	PTHR10543	UniProtKB/TrEMBL
Pfam	RPE65	UniProtKB/TrEMBL
PhenoGen	Bco2	PhenoGen
RatGTEx	ENSRNOG00000038746	RatGTEx
UniProt	A3KN98	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-15	Bco2	beta-carotene oxygenase 2	Bcdo2	beta-carotene 9', 10'-dioxygenase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Bcdo2	beta-carotene 9', 10'-dioxygenase 2	Bcdo2_predicted	beta-carotene 9', 10'-dioxygenase 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Bcdo2_predicted	beta-carotene 9', 10'-dioxygenase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD