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Gene: Nlrp9 (NLR family, pyrin domain containing 9) Rattus norvegicus

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Symbol:

Nlrp9

Name:

NLR family, pyrin domain containing 9

RGD ID:

1308981

Description:

Predicted to be involved in several processes, including defense response to virus; positive regulation of interleukin-18 production; and pyroptotic inflammatory response. Predicted to act upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP9 (NLR family pyrin domain containing 9); INTERACTS WITH bisphenol A; N,N-diethyl-m-toluamide; permethrin.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC292577; LOC308329; NACHT, LRR and PYD containing protein 9a; NACHT, LRR and PYD containing protein 9b; NACHT, LRR and PYD domains-containing protein 9; Nalp9a; Nalp9b; NLR family, pyrin domain containing 9B; Nlrp9b

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NLRP9 (NLR family pyrin domain containing 9)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL
Mus musculus (house mouse):	Nlrp9b (NLR family, pyrin domain containing 9B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NLRP9 (NLR family pyrin domain containing 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NLRP9 (NLR family pyrin domain containing 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NLRP9 (NLR family pyrin domain containing 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NLRP9 (NLR family pyrin domain containing 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nlrp9 (NLR family pyrin domain containing 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NLRP9 (NLR family pyrin domain containing 9)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nlrp9b (NLR family, pyrin domain containing 9B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nlrp9a (NLR family, pyrin domain containing 9A)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Mus musculus (house mouse):	Nlrp9c (NLR family, pyrin domain containing 9C)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	si:dkey-121n8.7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder)
Danio rerio (zebrafish):	si:ch211-196h16.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder)
Danio rerio (zebrafish):	LOC110437934 (protein NLRC3-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	LOC108644478	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100493406	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nlrp12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100491706	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100486737	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nlrp12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC108644478	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	77,320,034 - 77,370,366 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	77,319,218 - 77,378,658 (-)	Ensembl				GRCr8
mRatBN7.2	1	68,291,180 - 68,341,512 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	68,291,180 - 68,341,512 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	73,650,894 - 73,701,242 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	82,200,647 - 82,250,993 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	75,381,248 - 75,423,726 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	71,859,390 - 71,917,337 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	71,859,390 - 71,909,138 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	73,246,708 - 73,296,649 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	66,998,708 - 67,067,942 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	68,750,198 - 68,795,339 (+)	NCBI		Celera
RGSC_v3.1	1	67,076,818 - 67,146,053 (-)	NCBI
Cytogenetic Map	1	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital stationary night blindness (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

Aflatoxin B2 alpha (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

dimethylarsinic acid (ISO)

folic acid (ISO)

methapyrilene (ISO)

methylarsonic acid (ISO)

N,N-diethyl-m-toluamide (EXP)

PCB138 (ISO)

permethrin (EXP)

pirinixic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst development (ISO)

defense response to virus (ISO)

immune system process (IEA)

inflammatory response (IEA)

innate immune response (IEA,ISO)

positive regulation of interleukin-18 production (ISO)

pyroptotic inflammatory response (ISO)

regulation of inflammatory response (IBA)

Cellular Component

canonical inflammasome complex (IBA,IEA,ISO)

cytoplasm (IBA)

Molecular Function

ATP binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:28636595

Genomics

Comparative Map Data

Nlrp9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	77,320,034 - 77,370,366 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	77,319,218 - 77,378,658 (-)	Ensembl				GRCr8
mRatBN7.2	1	68,291,180 - 68,341,512 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	68,291,180 - 68,341,512 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	73,650,894 - 73,701,242 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	82,200,647 - 82,250,993 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	75,381,248 - 75,423,726 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	71,859,390 - 71,917,337 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	71,859,390 - 71,909,138 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	73,246,708 - 73,296,649 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	66,998,708 - 67,067,942 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	68,750,198 - 68,795,339 (+)	NCBI		Celera
RGSC_v3.1	1	67,076,818 - 67,146,053 (-)	NCBI
Cytogenetic Map	1	q12	NCBI

NLRP9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	55,708,438 - 55,738,402 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	55,708,438 - 55,738,402 (-)	Ensembl			hg38	GRCh38
GRCh37	19	56,219,804 - 56,249,768 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	60,911,610 - 60,941,580 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	60,911,609 - 60,941,580	NCBI
Celera	19	53,262,092 - 53,294,502 (-)	NCBI		Celera
Cytogenetic Map	19	q13.42	NCBI
HuRef	19	52,530,876 - 52,562,520 (-)	NCBI		HuRef
CHM1_1	19	56,213,523 - 56,243,345 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	58,805,410 - 58,837,757 (-)	NCBI		T2T-CHM13v2.0

Nlrp9b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	19,725,318 - 19,796,867 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	19,725,390 - 19,807,231 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	19,991,393 - 20,062,942 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	19,991,465 - 20,073,306 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	20,593,372 - 20,648,289 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	19,166,545 - 19,221,462 (+)	NCBI		MGSCv36	mm8
Celera	7	17,415,992 - 17,464,267 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	9.96	NCBI

NLRP9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	61,849,963 - 61,882,160 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	63,567,859 - 63,612,116 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	52,755,932 - 52,787,678 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	61,440,710 - 61,473,249 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	61,440,710 - 61,473,249 (-)	Ensembl			panPan2	panpan1.1

NLRP9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	102,013,911 - 102,036,700 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	102,013,909 - 102,036,811 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	102,071,295 - 102,094,081 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	102,667,480 - 102,690,299 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	102,667,478 - 102,690,272 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	102,305,113 - 102,327,903 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	102,017,257 - 102,040,039 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	102,780,047 - 102,802,847 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

NLRP9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	59,949,004 - 59,974,270 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	59,941,318 - 59,974,129 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	54,836,831 - 54,869,831 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NLRP9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	48,297,437 - 48,330,352 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	956,445 - 996,032 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nlrp9
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	180,253,555 - 180,291,942 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nlrp9
450 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	125
Count of miRNA genes:	98
Interacting mature miRNAs:	105
Transcripts:	ENSRNOT00000029591
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	34565726	79565726	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	51909206	91302615	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	ectoderm	endocrine system	endoderm	exocrine system	hepatobiliary system	mesenchyme	mesoderm	nervous system	renal system	reproductive system
1	3	2	1	1	1	5	1	2	2	23

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001169149	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000029591 ⟹ ENSRNOP00000029443

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	77,319,336 - 77,378,658 (-)	Ensembl
mRatBN7.2 Ensembl	1	68,291,180 - 68,341,512 (-)	Ensembl
Rnor_6.0 Ensembl	1	71,859,390 - 71,909,138 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120223 ⟹ ENSRNOP00000088910

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	77,323,699 - 77,378,658 (-)	Ensembl
mRatBN7.2 Ensembl	1	68,294,845 - 68,341,512 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000154629 ⟹ ENSRNOP00000108561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	77,319,218 - 77,378,658 (-)	Ensembl

RefSeq Acc Id:

NM_001169149 ⟹ NP_001162620

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	77,320,034 - 77,370,366 (-)	NCBI
mRatBN7.2	1	68,291,180 - 68,341,512 (-)	NCBI
Rnor_6.0	1	71,859,390 - 71,909,138 (-)	NCBI
Rnor_5.0	1	73,246,708 - 73,296,649 (-)	NCBI
RGSC_v3.4	1	66,998,708 - 67,067,942 (-)	RGD
Celera	1	68,750,198 - 68,795,339 (+)	RGD

Sequence:

show sequence

ATGGTGGACACGTCTGGATATGGCTTGCTGAAGCATCTGCGAAAACTGAGTGACGGGGAGTTCT
GGAGCTTTAAAGAGCTTCTCAGGAAAGAGCCAGAGAAATTTAAGCTCAAACCAATATCCTGGAT
GAAAATTGAGAATGCTTCCAAAGAAGAACTGGTAATGCTATTGAACACACATTATCCAAAACAG
GCATGGGATATGGCGTTGAGCCTGTTTCTACAGGTCAATCGGGAAGACCTCTCAATCATGGCTC
AGAAAAAGAGGAGATATAAACAAACTAAATATAAAAAGTTTATGAAGACTACATTTCAAAGCAT
ATGGACATTGGAGAGCAACATTTGTATACCTGATAGAAGCTACCATTTAATTGTAGAACACCAG
TACAGAAAACTGCAGAACATATTTGATTCTGAATCAGAGCCAGTCACTGCAGTTGTAACAGGTC
CAACAGGAGAAGGAAAAACCGTTTTCCTGAGAAAAGCAATGTTGGATTGGGCATCAGGAATTTT
ATGGCAGAACCGGTTTCAATATGTTTTCTTTTTCTCTGTCCTCTCACTTAACAATACCACAGAG
TTAAGCTTAGCTGAGCTTATCTCAAGTAAGTTACCTGAGTCTTCAGAGACACTGAATGACATTT
TATCTGATCCAAAGAAAATCTTGTTTATCCTGGATGGATTTGATTACCTGAAATTTGACTTGGA
ACTCAGGACAAACTTGTGTAATGACTGGAGGAAGATATTGCCAACACAAATCATCTTGAGTAGT
TTACTACAGAAAATAATGCTCCCAGAATCCTCTTTGCTTCTTGAATTAGGACATATAAGTTTAC
CAAAAATCTTCCCTTTGCTGCAGTATCCAAGGGACATAACTATCCAAGGATTCTCTGAGCGGTG
TCTAAAGACCTATTTTATATCCTTCTTCAATACTGAAAAAGGCATAGAAGTCTTTGAGAATTTG
AAGTCTAATCAAATGCTCAAATTATGCAGCAATCCTTATCTATGCTGGATGTTCTGTAGTTGTT
TAAAGTGGCAGTTTGACAGGGAAGAGGAAGCGTACTTTCAGGCTAAAACAGATTCGGTCTTCTT
CACAAGCTTTATGGTTAGTGCATTCAAATCAGCATATGCCAGTAATCCACCTAAACAAAACAGA
GCCCAATTAAAGAGCCTGTGTACCTTGGCTGTAGAAGGAATGTGGAAACAGTTGTTTGTTTTTG
ACTCTGAAGATCTCAGGAGGAATGGTATATCTGAATCAGATAAGGCAGTGTGGCTGAGAATGAA
ATTTCTCCAGAATCATGATAACCACATTGTGTTTTATCATCCTACACTACAGTTATACTTTGCT
TCCATGTTCTATTTCCTCAAACAAGACAAAGACACGCATGTCCCAGTCATTGGAAGCATACCTC
AACTCCTAAGAAAAATTTATGCTCGTGACCACACACAATGGCTCCAGATAGGGATTTTTTTGTT
TGGACTCGCCACTGAGCAAGTTGCCTCCTTGCTCAAACCATACTTTGGCTTTATACAGCACAGA
GATGTAAGACAGGAAGTCATGAGATACCTTAAGAGTCTCAGTCAACGAGAGTGCTGTGAGAAAT
TGGAAAGACCCCAGAATTTGTTTGCCTGTCTACGTGACAACAAGGAGGAAAAATTTGTAAGAGA
AGTGGTAGATCTATTTGAAGAAATTACTGTTGATATTACTAATTCACATGTATTGTCAATAATT
GCAAACCATCTTCAGAAATCCTCCAAATTAAAGAAACTTCACCTGCATATACAAAAGAGAGTTT
TTTTAGAAATTCATGACCCAGAATATAGTGACTCAGAAACCTTTACACAGGACAAAAAAAATGC
AGCTGAATATTGGAAGAAGTTATGTCATATTTTTGTCAACTTACATGTGTTGGATCTGGACAGC
TGTAATTTCAACAAACAGGTCATAGAGGAACTCTGTAATGTGCTGTCTCCATCACCTAAGATAC
CTCTGATGGCTTTTAAGCTCGAAAGCTTGTTGTGTTCATTCATGACTAACTTTGGAGATGGTTC
ACTATTTCACACCCTTCTTCAGCTACCTCACCTGAAATACCTAAACCTGTATGGCACCAACCTC
TCCAACAGTAGGATTGAGAATCTGTGCTCTGCTCTGAGACGCTCAACATGCAAAGTAGAGGAAC
TACTGTTGGGTAAATGTGACATATCAAGTGAGGCATGTGGCATAATTGCTACTTCCCTTATGAA
CTCTAAAGTGAAACATCTCTCATTGGTTGAAAATCCCTTGAAGAACAAAGGAGTGATGTCACTG
TGTGAAATGCTGAAGGATCCAAGCTGTGTCCTTGAGACACTGATGTTGTCTTACTGCTGTCTCA
CATTCATTGCCTGTGGCCATCTCTATGAAGCCCTTGTGAGCAATAAACACCTCTCCCTGCTTGA
TCTGGGGTCAAATTTCCTGGAAGATACTGGAGTGAACCTTCTGTGTGAAGCTTTGAAAGACCCA
AACTGCATCCTCAAGGAGTTATGGTTGTCAGGTTGCTTTTTAACTTCAGAATGCTGTGAGGAGA
TCTCTGCTGTCCTGACTTGCAATAATAATCTAAAGACCCTGAAACTGGGCAACAATGACATAGA
AGACACTGGTGTCAAACATTTATGTGAAGCCCTGAGTCATCCTAACTGTAAATTAGAATGTCTT
GGGTTAGACCTGTGCAAGTTCACAAGTGACTGTTGTGAAGACCTGGCCTCAGCTCTCACCACCT
GCAAAACACTGAATAGCTTAAATCTGGACTGGAAAACCTTGGAACACTCTGGAGTCGTGGCTCT
CTGTGAGGCTTTGAATCACAAGAAATGTAACTTGAAGATGCTTGGACTGGACAAATCTGCATTT
TCTGTGGAATCGCAGACATTACTGCAAGCTGTGGAAAAGAAAAACAATAATCTGAGTATTTTAC
ATTATCCCTGGGTTGAAGAGGAACGCAAGAAGAGGGGTGTTCGTCTGGTCTGGAACAGCAAGAA
TTGA

hide sequence

RefSeq Acc Id:

XM_039103829 ⟹ XP_038959757

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	77,320,034 - 77,370,366 (-)	NCBI
mRatBN7.2	1	68,291,180 - 68,341,512 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001162620	(Get FASTA)	NCBI Sequence Viewer
	XP_038959757	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000029443.4
	ENSRNOP00000088910
	ENSRNOP00000088910.1
	ENSRNOP00000108561
	ENSRNOP00000108561.1

RefSeq Acc Id:

NP_001162620 ⟸ NM_001169149

- UniProtKB:

D3ZAD9 (UniProtKB/TrEMBL), A0A8I6A735 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVDTSGYGLLKHLRKLSDGEFWSFKELLRKEPEKFKLKPISWMKIENASKEELVMLLNTHYPKQ
AWDMALSLFLQVNREDLSIMAQKKRRYKQTKYKKFMKTTFQSIWTLESNICIPDRSYHLIVEHQ
YRKLQNIFDSESEPVTAVVTGPTGEGKTVFLRKAMLDWASGILWQNRFQYVFFFSVLSLNNTTE
LSLAELISSKLPESSETLNDILSDPKKILFILDGFDYLKFDLELRTNLCNDWRKILPTQIILSS
LLQKIMLPESSLLLELGHISLPKIFPLLQYPRDITIQGFSERCLKTYFISFFNTEKGIEVFENL
KSNQMLKLCSNPYLCWMFCSCLKWQFDREEEAYFQAKTDSVFFTSFMVSAFKSAYASNPPKQNR
AQLKSLCTLAVEGMWKQLFVFDSEDLRRNGISESDKAVWLRMKFLQNHDNHIVFYHPTLQLYFA
SMFYFLKQDKDTHVPVIGSIPQLLRKIYARDHTQWLQIGIFLFGLATEQVASLLKPYFGFIQHR
DVRQEVMRYLKSLSQRECCEKLERPQNLFACLRDNKEEKFVREVVDLFEEITVDITNSHVLSII
ANHLQKSSKLKKLHLHIQKRVFLEIHDPEYSDSETFTQDKKNAAEYWKKLCHIFVNLHVLDLDS
CNFNKQVIEELCNVLSPSPKIPLMAFKLESLLCSFMTNFGDGSLFHTLLQLPHLKYLNLYGTNL
SNSRIENLCSALRRSTCKVEELLLGKCDISSEACGIIATSLMNSKVKHLSLVENPLKNKGVMSL
CEMLKDPSCVLETLMLSYCCLTFIACGHLYEALVSNKHLSLLDLGSNFLEDTGVNLLCEALKDP
NCILKELWLSGCFLTSECCEEISAVLTCNNNLKTLKLGNNDIEDTGVKHLCEALSHPNCKLECL
GLDLCKFTSDCCEDLASALTTCKTLNSLNLDWKTLEHSGVVALCEALNHKKCNLKMLGLDKSAF
SVESQTLLQAVEKKNNNLSILHYPWVEEERKKRGVRLVWNSKN

hide sequence

Ensembl Acc Id:

ENSRNOP00000029443 ⟸ ENSRNOT00000029591

RefSeq Acc Id:	XP_038959757 ⟸ XM_039103829
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A735 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000088910 ⟸ ENSRNOT00000120223

Ensembl Acc Id:

ENSRNOP00000108561 ⟸ ENSRNOT00000154629

Protein Domains

NACHT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZAD9-F1-model_v2	AlphaFold	D3ZAD9	1-1003	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308981	AgrOrtholog
BioCyc Gene	G2FUF-60907	BioCyc
Ensembl Genes	ENSRNOG00000021913	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000029591.5	UniProtKB/TrEMBL
	ENSRNOT00000120223	ENTREZGENE
	ENSRNOT00000120223.2	UniProtKB/TrEMBL
	ENSRNOT00000154629	ENTREZGENE
	ENSRNOT00000154629.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
InterPro	DEATH-like	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	NACHT_NTPase	UniProtKB/TrEMBL
	NLRC_HD2	UniProtKB/TrEMBL
	NLRP_innate_immun_reg	UniProtKB/TrEMBL
	NOD2_WH	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Pyrin	UniProtKB/TrEMBL
KEGG Report	rno:292577	UniProtKB/TrEMBL
NCBI Gene	292577	ENTREZGENE
PANTHER	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12	UniProtKB/TrEMBL
	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9	UniProtKB/TrEMBL
Pfam	NACHT	UniProtKB/TrEMBL
	NLRC4_HD2	UniProtKB/TrEMBL
	NOD2_WH	UniProtKB/TrEMBL
	PAAD_DAPIN	UniProtKB/TrEMBL
PhenoGen	Nlrp9	PhenoGen
PROSITE	NACHT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021913	RatGTEx
SMART	LRR_RI	UniProtKB/TrEMBL
	PYRIN	UniProtKB/TrEMBL
Superfamily-SCOP	DEATH_like	UniProtKB/TrEMBL
	RNI-like	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8I6A735	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LTA6_RAT	UniProtKB/TrEMBL
	D3ZAD9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-19	Nlrp9	NLR family, pyrin domain containing 9	Nalp9a	NACHT, LRR and PYD containing protein 9a	Data merged from RGD:1309734	737654	APPROVED
2008-09-26	Nlrp9	NLR family, pyrin domain containing 9	Nlrp9b	NLR family, pyrin domain containing 9B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Nalp9a	NACHT, LRR and PYD containing protein 9a	Nalp9a_predicted	NACHT, LRR and PYD containing protein 9a (predicted)	'predicted' is removed	2292626	APPROVED
2008-03-04	Nlrp9b	NLR family, pyrin domain containing 9B	Nalp9b_predicted	NACHT, LRR and PYD containing protein 9b (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Nalp9a_predicted	NACHT, LRR and PYD containing protein 9a (predicted)			Symbol and Name status set to approved	70820	APPROVED
2005-01-12	Nalp9b_predicted	NACHT, LRR and PYD containing protein 9b (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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