Melk (maternal embryonic leucine zipper kinase) - Rat Genome Database

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Gene: Melk (maternal embryonic leucine zipper kinase) Rattus norvegicus
Analyze
Symbol: Melk
Name: maternal embryonic leucine zipper kinase
RGD ID: 1308974
Description: Predicted to enable calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; neural precursor cell proliferation; and positive regulation of apoptotic process. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Predicted to be located in cell cortex and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human MELK (maternal embryonic leucine zipper kinase); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362510
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,336,151 - 63,396,254 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl563,336,106 - 63,396,247 (+)EnsemblGRCr8
mRatBN7.2558,540,393 - 58,600,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,540,449 - 58,600,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx560,522,076 - 60,582,306 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,340,875 - 62,401,107 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,310,545 - 62,371,306 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,783,835 - 59,844,356 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,783,890 - 59,844,356 (+)Ensemblrn6Rnor6.0
Rnor_5.0564,307,418 - 64,367,854 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,787,123 - 60,848,620 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera557,118,072 - 57,178,790 (+)NCBICelera
RGSC_v3.1560,787,312 - 60,848,021 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Biflorin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
Enterolactone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
isoliquiritigenin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lucanthone  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
Moniliformin  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
potassium chromate  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9305775   PMID:10417823   PMID:12400006   PMID:15908796   PMID:16061694   PMID:16159311   PMID:16216881   PMID:17280616   PMID:18948261   PMID:19946888   PMID:21145462  


Genomics

Comparative Map Data
Melk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,336,151 - 63,396,254 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl563,336,106 - 63,396,247 (+)EnsemblGRCr8
mRatBN7.2558,540,393 - 58,600,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,540,449 - 58,600,937 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx560,522,076 - 60,582,306 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,340,875 - 62,401,107 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,310,545 - 62,371,306 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,783,835 - 59,844,356 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,783,890 - 59,844,356 (+)Ensemblrn6Rnor6.0
Rnor_5.0564,307,418 - 64,367,854 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4560,787,123 - 60,848,620 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera557,118,072 - 57,178,790 (+)NCBICelera
RGSC_v3.1560,787,312 - 60,848,021 (+)NCBI
Cytogenetic Map5q22NCBI
MELK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,572,895 - 36,677,682 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,572,074 - 36,682,131 (+)Ensemblhg38GRCh38
GRCh37936,572,892 - 36,677,679 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,562,905 - 36,667,679 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34936,562,904 - 36,667,678NCBI
Celera936,506,192 - 36,610,971 (+)NCBICelera
Cytogenetic Map9p13.2NCBI
HuRef936,525,297 - 36,629,824 (+)NCBIHuRef
CHM1_1936,573,419 - 36,678,272 (+)NCBICHM1_1
T2T-CHM13v2.0936,595,568 - 36,700,421 (+)NCBIT2T-CHM13v2.0
Melk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39444,300,876 - 44,364,301 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl444,300,876 - 44,364,675 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38444,300,909 - 44,364,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl444,300,876 - 44,364,675 (+)Ensemblmm10GRCm38
MGSCv37444,313,789 - 44,377,547 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36444,322,017 - 44,385,775 (+)NCBIMGSCv36mm8
Celera444,320,472 - 44,384,714 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.46NCBI
Melk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541929,717,978 - 29,815,170 (-)Ensembl
ChiLan1.0NW_00495541929,718,291 - 29,815,163 (-)NCBIChiLan1.0ChiLan1.0
MELK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21187,915,014 - 88,018,519 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1987,920,955 - 88,024,441 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0936,419,974 - 36,522,584 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1937,219,170 - 37,321,318 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl937,219,170 - 37,321,318 (+)EnsemblpanPan2panpan1.1
MELK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,970,699 - 53,067,169 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,977,260 - 53,067,172 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1151,561,713 - 51,658,190 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01154,080,440 - 54,176,384 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1154,080,479 - 54,176,384 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11152,581,152 - 52,676,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01152,608,391 - 52,704,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01153,304,276 - 53,400,894 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Melk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,914,905 - 167,997,045 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,469,256 - 4,544,290 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,479,639 - 4,544,561 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MELK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1237,317,191 - 237,431,589 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11237,317,161 - 237,431,522 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21265,174,996 - 265,288,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MELK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11243,901,840 - 44,007,855 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1243,901,551 - 44,007,266 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603840,975,306 - 41,080,086 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Melk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624930247,018 - 333,240 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Melk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v112,148,942 - 2,209,014 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Melk
344 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:495
Count of miRNA genes:258
Interacting mature miRNAs:319
Transcripts:ENSRNOT00000066277
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH135047  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,600,331 - 58,600,544 (+)MAPPERmRatBN7.2
Rnor_6.0559,843,751 - 59,843,963NCBIRnor6.0
Rnor_5.0564,367,249 - 64,367,461UniSTSRnor5.0
RGSC_v3.4560,848,015 - 60,848,227UniSTSRGSC3.4
Celera557,178,185 - 57,178,397UniSTS
RH 3.4 Map5393.1UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 90 89 58 88 58 6 350 187 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066277   ⟹   ENSRNOP00000059313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,336,106 - 63,396,247 (+)Ensembl
mRatBN7.2 Ensembl558,540,449 - 58,600,937 (+)Ensembl
Rnor_6.0 Ensembl559,783,890 - 59,844,356 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000152121   ⟹   ENSRNOP00000110545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,336,106 - 63,396,247 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162736   ⟹   ENSRNOP00000103229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,336,106 - 63,396,247 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165556   ⟹   ENSRNOP00000106273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl563,336,106 - 63,396,247 (+)Ensembl
RefSeq Acc Id: NM_001395606   ⟹   NP_001382535
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,336,151 - 63,396,254 (+)NCBI
mRatBN7.2558,540,449 - 58,600,562 (+)NCBI
RefSeq Acc Id: XM_063287908   ⟹   XP_063143978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8563,336,739 - 63,396,249 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382535 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143978 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98791 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059313
  ENSRNOP00000059313.4
  ENSRNOP00000103229.1
  ENSRNOP00000106273.1
  ENSRNOP00000110545.1
Ensembl Acc Id: ENSRNOP00000059313   ⟸   ENSRNOT00000066277
RefSeq Acc Id: NP_001382535   ⟸   NM_001395606
- UniProtKB: D4A6T6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143978   ⟸   XM_063287908
- Peptide Label: isoform X1
- UniProtKB: D4A6T6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110545   ⟸   ENSRNOT00000152121
Ensembl Acc Id: ENSRNOP00000106273   ⟸   ENSRNOT00000165556
Ensembl Acc Id: ENSRNOP00000103229   ⟸   ENSRNOT00000162736

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6T6-F1-model_v2 AlphaFold D4A6T6 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693691
Promoter ID:EPDNEW_R4216
Type:initiation region
Name:Melk_1
Description:maternal embryonic leucine zipper kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0559,783,867 - 59,783,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308974 AgrOrtholog
BioCyc Gene G2FUF-41473 BioCyc
Ensembl Genes ENSRNOG00000013598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066277 ENTREZGENE
  ENSRNOT00000066277.4 UniProtKB/TrEMBL
  ENSRNOT00000152121.1 UniProtKB/TrEMBL
  ENSRNOT00000162736.1 UniProtKB/TrEMBL
  ENSRNOT00000165556.1 UniProtKB/TrEMBL
Gene3D-CATH Kinase associated domain 1, KA1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro KA1/Ssp2_C UniProtKB/TrEMBL
  KA1_dom UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  MELK UniProtKB/TrEMBL
  MELK_UBA UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 362510 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE UniProtKB/TrEMBL
Pfam KA1 UniProtKB/TrEMBL
  MELK_UBA UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Melk PhenoGen
PROSITE KA1 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013598 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF103243 UniProtKB/TrEMBL
UniProt A0ABK0LCY9_RAT UniProtKB/TrEMBL
  A0ABK0LZ74_RAT UniProtKB/TrEMBL
  A0ABK0M199_RAT UniProtKB/TrEMBL
  D4A6T6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Melk  maternal embryonic leucine zipper kinase   Melk_predicted  maternal embryonic leucine zipper kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Melk_predicted  maternal embryonic leucine zipper kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED