Ephx4 (epoxide hydrolase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ephx4 (epoxide hydrolase 4) Rattus norvegicus
Analyze
Symbol: Ephx4
Name: epoxide hydrolase 4
RGD ID: 1308891
Description: Predicted to enable hydrolase activity. Predicted to be located in membrane. Orthologous to human EPHX4 (epoxide hydrolase 4); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abhd7; abhydrolase domain containing 7; LOC289440
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,488,282 - 2,517,558 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl142,488,290 - 2,517,757 (-)EnsemblGRCr8
mRatBN7.2142,343,376 - 2,372,680 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,340,248 - 2,373,022 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx142,224,957 - 2,254,649 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,526,765 - 3,556,443 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,220,530 - 2,250,028 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,360,680 - 3,389,996 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,360,712 - 3,389,943 (-)Ensemblrn6Rnor6.0
Rnor_5.0143,364,185 - 3,393,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,902,381 - 2,932,820 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera142,360,897 - 2,390,947 (-)NCBICelera
RGSC_v3.1142,902,517 - 2,943,238 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ephx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,488,282 - 2,517,558 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl142,488,290 - 2,517,757 (-)EnsemblGRCr8
mRatBN7.2142,343,376 - 2,372,680 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl142,340,248 - 2,373,022 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx142,224,957 - 2,254,649 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0143,526,765 - 3,556,443 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0142,220,530 - 2,250,028 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0143,360,680 - 3,389,996 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl143,360,712 - 3,389,943 (-)Ensemblrn6Rnor6.0
Rnor_5.0143,364,185 - 3,393,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,902,381 - 2,932,820 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera142,360,897 - 2,390,947 (-)NCBICelera
RGSC_v3.1142,902,517 - 2,943,238 (-)NCBI
Cytogenetic Map14p22NCBI
EPHX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,029,985 - 92,063,538 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,029,475 - 92,063,538 (+)Ensemblhg38GRCh38
GRCh37192,495,542 - 92,529,095 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,268,146 - 92,301,681 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34192,207,578 - 92,241,114NCBI
Celera190,741,979 - 90,775,554 (+)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef190,615,750 - 90,649,341 (+)NCBIHuRef
CHM1_1192,610,387 - 92,643,948 (+)NCBICHM1_1
T2T-CHM13v2.0191,874,824 - 91,908,391 (+)NCBIT2T-CHM13v2.0
Ephx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395107,551,379 - 107,577,901 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5107,550,602 - 107,577,901 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385107,403,513 - 107,430,035 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5107,402,736 - 107,430,035 (+)Ensemblmm10GRCm38
MGSCv375107,832,532 - 107,859,054 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365107,643,853 - 107,670,193 (+)NCBIMGSCv36mm8
Celera5104,516,877 - 104,543,312 (+)NCBICelera
Cytogenetic Map5E5- FNCBI
cM Map552.23NCBI
Ephx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554232,386,888 - 2,425,036 (-)Ensembl
ChiLan1.0NW_0049554232,389,745 - 2,425,036 (-)NCBIChiLan1.0ChiLan1.0
EPHX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21134,962,862 - 134,999,348 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11134,114,506 - 134,150,925 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0194,686,577 - 94,722,985 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,430,641 - 93,467,072 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,430,647 - 93,467,072 (+)EnsemblpanPan2panpan1.1
EPHX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1656,863,779 - 56,900,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha659,569,682 - 59,608,451 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0657,246,279 - 57,284,786 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl657,246,283 - 57,285,192 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1656,923,342 - 56,962,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0656,899,728 - 56,938,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0657,362,441 - 57,400,969 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ephx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058101,916,019 - 101,957,457 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365376,990,512 - 7,031,760 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365376,990,854 - 7,031,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4124,960,189 - 124,992,749 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14124,961,246 - 124,992,789 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EPHX4
(Chlorocebus sabaeus - green monkey)		 No map positions available.
Ephx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247425,695,912 - 5,722,597 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247425,695,776 - 5,722,645 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ephx4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11117,170,481 - 17,200,196 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ephx4
133 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:82
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000037101
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
BE120124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,366,797 - 2,367,006 (+)MAPPERmRatBN7.2
Rnor_6.0143,384,126 - 3,384,334NCBIRnor6.0
Rnor_5.0143,387,771 - 3,387,979UniSTSRnor5.0
RGSC_v3.4142,927,004 - 2,927,212UniSTSRGSC3.4
Celera142,385,130 - 2,385,338UniSTS
RH 3.4 Map1441.9UniSTS
Cytogenetic Map14p22UniSTS
BF415499  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,357,572 - 2,357,717 (+)MAPPERmRatBN7.2
Rnor_6.0143,374,901 - 3,375,045NCBIRnor6.0
Rnor_5.0143,378,546 - 3,378,690UniSTSRnor5.0
RGSC_v3.4142,917,779 - 2,917,923UniSTSRGSC3.4
Celera142,375,878 - 2,376,022UniSTS
RH 3.4 Map1442.4UniSTS
Cytogenetic Map14p22UniSTS
D5Mit239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,360,217 - 2,360,934 (+)MAPPERmRatBN7.2
Rnor_6.0143,377,546 - 3,378,262NCBIRnor6.0
Rnor_5.0143,381,191 - 3,381,907UniSTSRnor5.0
RGSC_v3.4142,920,424 - 2,921,140UniSTSRGSC3.4
Celera142,378,523 - 2,379,266UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 8 46 133 62 66 35 11 35 6 181 70 126 61 78 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000037101   ⟹   ENSRNOP00000034573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,488,290 - 2,517,757 (-)Ensembl
mRatBN7.2 Ensembl142,343,384 - 2,373,022 (-)Ensembl
Rnor_6.0 Ensembl143,360,712 - 3,389,943 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100966   ⟹   ENSRNOP00000083130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl142,488,290 - 2,515,457 (-)Ensembl
mRatBN7.2 Ensembl142,340,248 - 2,373,022 (-)Ensembl
RefSeq Acc Id: NM_001105994   ⟹   NP_001099464
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,488,290 - 2,517,521 (-)NCBI
mRatBN7.2142,343,384 - 2,372,615 (-)NCBI
Rnor_6.0143,360,712 - 3,389,943 (-)NCBI
Rnor_5.0143,364,185 - 3,393,641 (-)NCBI
RGSC_v3.4142,902,381 - 2,932,820 (-)RGD
Celera142,360,897 - 2,390,947 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769927   ⟹   XP_008768149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,488,282 - 2,515,220 (-)NCBI
mRatBN7.2142,343,376 - 2,370,294 (-)NCBI
Rnor_6.0143,360,680 - 3,388,650 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091658   ⟹   XP_038947586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,488,282 - 2,515,210 (-)NCBI
mRatBN7.2142,343,376 - 2,370,353 (-)NCBI
RefSeq Acc Id: XM_039091659   ⟹   XP_038947587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,502,368 - 2,517,558 (-)NCBI
mRatBN7.2142,357,462 - 2,372,680 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099464 (Get FASTA)   NCBI Sequence Viewer  
  XP_008768149 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947586 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947587 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83968 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034573.7
  ENSRNOP00000083130
  ENSRNOP00000083130.2
RefSeq Acc Id: NP_001099464   ⟸   NM_001105994
- UniProtKB: A6KPJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768149   ⟸   XM_008769927
- Peptide Label: isoform X1
- UniProtKB: A6KPJ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034573   ⟸   ENSRNOT00000037101
RefSeq Acc Id: XP_038947586   ⟸   XM_039091658
- Peptide Label: isoform X1
- UniProtKB: A6KPJ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947587   ⟸   XM_039091659
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000083130   ⟸   ENSRNOT00000100966
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKP8-F1-model_v2 AlphaFold D3ZKP8 1-266 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308891 AgrOrtholog
BioCyc Gene G2FUF-16618 BioCyc
Ensembl Genes ENSRNOG00000023389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037101.8 UniProtKB/TrEMBL
  ENSRNOT00000100966 ENTREZGENE
  ENSRNOT00000100966.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/TrEMBL
  Epox_hydrolase-like UniProtKB/TrEMBL
KEGG Report rno:289440 UniProtKB/TrEMBL
NCBI Gene 289440 ENTREZGENE
PANTHER EPOXIDE HYDROLASE UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/TrEMBL
PhenoGen Ephx4 PhenoGen
PRINTS ABHYDROLASE UniProtKB/TrEMBL
  EPOXHYDRLASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023389 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8I5ZZC4_RAT UniProtKB/TrEMBL
  A6KPJ6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKP8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-05-06 Ephx4  epoxide hydrolase 4  Abhd7  abhydrolase domain containing 7   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Abhd7  abhydrolase domain containing 7   Abhd7_predicted  abhydrolase domain containing 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Abhd7_predicted  abhydrolase domain containing 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED