Mfhas1 (multifunctional ROCO family signaling regulator 1) - Rat Genome Database

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Pathways
Gene: Mfhas1 (multifunctional ROCO family signaling regulator 1) Rattus norvegicus
Analyze
Symbol: Mfhas1
Name: multifunctional ROCO family signaling regulator 1
RGD ID: 1308812
Description: Predicted to enable GTP binding activity; protein phosphatase 2A binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including erythrocyte differentiation; regulation of macrophage activation; and regulation of signal transduction. Predicted to be located in cytoplasm. Orthologous to human MFHAS1 (multifunctional ROCO family signaling regulator 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC306508; malignant fibrous histiocytoma amplified sequence 1; malignant fibrous histiocytoma-amplified sequence 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81663,248,833 - 63,336,441 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1663,250,455 - 63,336,602 (-)EnsemblGRCr8
mRatBN7.21656,545,462 - 56,633,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,546,207 - 56,633,743 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1661,871,278 - 61,951,249 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01665,285,260 - 65,365,229 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01660,505,245 - 60,585,208 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01660,120,457 - 60,208,550 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,128,201 - 60,208,462 (-)Ensemblrn6Rnor6.0
Rnor_5.01659,795,263 - 59,882,664 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41660,251,500 - 60,330,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1654,605,099 - 54,684,103 (-)NCBICelera
RGSC_v3.11660,258,856 - 60,330,906 (-)NCBI
Cytogenetic Map16q12.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibric acid  (EXP)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
indoles  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytoskeleton  (ISO)
lysosome  (ISO)
mitochondrion  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
4. Identification of a novel gene, MASL1, within an amplicon at 8p23.1 detected in malignant fibrous histiocytomas by comparative genomic hybridization. Sakabe T, etal., Cancer Res. 1999 Feb 1;59(3):511-5.
Additional References at PubMed
PMID:20616063   PMID:23327923   PMID:24286120   PMID:26599367   PMID:28471450   PMID:28609714   PMID:29168081  


Genomics

Comparative Map Data
Mfhas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81663,248,833 - 63,336,441 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1663,250,455 - 63,336,602 (-)EnsemblGRCr8
mRatBN7.21656,545,462 - 56,633,649 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,546,207 - 56,633,743 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1661,871,278 - 61,951,249 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01665,285,260 - 65,365,229 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01660,505,245 - 60,585,208 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01660,120,457 - 60,208,550 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,128,201 - 60,208,462 (-)Ensemblrn6Rnor6.0
Rnor_5.01659,795,263 - 59,882,664 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41660,251,500 - 60,330,831 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1654,605,099 - 54,684,103 (-)NCBICelera
RGSC_v3.11660,258,856 - 60,330,906 (-)NCBI
Cytogenetic Map16q12.2NCBI
MFHAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3888,783,354 - 8,893,630 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl88,783,354 - 8,893,630 (-)Ensemblhg38GRCh38
GRCh3788,640,864 - 8,751,140 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3688,679,409 - 8,788,541 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3488,680,941 - 8,787,978NCBI
Celera87,770,247 - 7,879,341 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef87,566,885 - 7,675,726 (-)NCBIHuRef
CHM1_188,707,354 - 8,816,498 (-)NCBICHM1_1
T2T-CHM13v2.0810,850,500 - 10,960,846 (+)NCBIT2T-CHM13v2.0
Mfhas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39836,054,922 - 36,146,603 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl836,054,952 - 36,146,603 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38835,587,789 - 35,679,449 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl835,587,798 - 35,679,449 (+)Ensemblmm10GRCm38
MGSCv37836,650,852 - 36,742,503 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36837,056,315 - 37,147,966 (+)NCBIMGSCv36mm8
Celera838,233,298 - 38,323,358 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map821.16NCBI
Mfhas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554634,900,060 - 4,993,793 (-)Ensembl
ChiLan1.0NW_0049554634,900,115 - 4,993,793 (-)NCBIChiLan1.0ChiLan1.0
MFHAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2725,239,514 - 25,349,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan181,266,572 - 1,376,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0810,318,455 - 10,428,469 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MFHAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11635,579,531 - 35,676,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1635,579,585 - 35,674,063 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1636,043,903 - 36,140,864 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01637,611,966 - 37,715,247 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1637,611,037 - 37,724,094 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11635,717,994 - 35,814,591 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01636,280,244 - 36,377,395 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01636,399,273 - 36,496,290 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mfhas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494343,482,035 - 43,574,638 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365731,567,798 - 1,662,525 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365731,567,798 - 1,662,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFHAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1556,200,455 - 56,295,064 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11556,200,455 - 56,296,151 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MFHAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1810,158,951 - 10,268,286 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl810,159,421 - 10,268,323 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605232,127,152 - 32,236,483 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfhas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248394,908,639 - 5,000,677 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248394,908,861 - 5,000,218 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mfhas1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11351,382,041 - 51,472,555 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mfhas1
594 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000015203
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)166241446475736480Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
RH131104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21656,621,697 - 56,621,911 (+)MAPPERmRatBN7.2
Rnor_6.01660,197,057 - 60,197,270NCBIRnor6.0
Rnor_5.01659,871,172 - 59,871,385UniSTSRnor5.0
RGSC_v3.41660,319,426 - 60,319,639UniSTSRGSC3.4
Celera1654,672,698 - 54,672,911UniSTS
RH 3.4 Map16559.4UniSTS
Cytogenetic Map16q12.2UniSTS
RH134391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21656,545,529 - 56,545,743 (+)MAPPERmRatBN7.2
Rnor_6.01660,120,525 - 60,120,738NCBIRnor6.0
Rnor_5.01659,795,331 - 59,795,544UniSTSRnor5.0
RGSC_v3.41660,243,824 - 60,244,037UniSTSRGSC3.4
Celera1654,597,423 - 54,597,636UniSTS
RH 3.4 Map16557.1UniSTS
Cytogenetic Map16q12.2UniSTS
RH143897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21656,616,692 - 56,616,815 (+)MAPPERmRatBN7.2
Rnor_6.01660,191,935 - 60,192,057NCBIRnor6.0
Rnor_5.01659,866,050 - 59,866,172UniSTSRnor5.0
RGSC_v3.41660,314,476 - 60,314,598UniSTSRGSC3.4
Celera1654,668,328 - 54,668,450UniSTS
RH 3.4 Map16559.2UniSTS
Cytogenetic Map16q12.2UniSTS
BF399307  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21656,550,923 - 56,551,093 (+)MAPPERmRatBN7.2
Rnor_6.01660,125,919 - 60,126,088NCBIRnor6.0
Rnor_5.01659,800,725 - 59,800,894UniSTSRnor5.0
RGSC_v3.41660,249,218 - 60,249,387UniSTSRGSC3.4
Celera1654,602,817 - 54,602,986UniSTS
RH 3.4 Map16559.7UniSTS
Cytogenetic Map16q12.2UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015203   ⟹   ENSRNOP00000015203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1663,256,577 - 63,336,602 (-)Ensembl
mRatBN7.2 Ensembl1656,553,206 - 56,633,743 (-)Ensembl
Rnor_6.0 Ensembl1660,128,201 - 60,208,462 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098060   ⟹   ENSRNOP00000081189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1663,250,455 - 63,336,602 (-)Ensembl
mRatBN7.2 Ensembl1656,546,207 - 56,633,743 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108535   ⟹   ENSRNOP00000080425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1663,325,252 - 63,336,602 (-)Ensembl
mRatBN7.2 Ensembl1656,621,259 - 56,633,743 (-)Ensembl
RefSeq Acc Id: NM_001107316   ⟹   NP_001100786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81663,256,577 - 63,336,403 (-)NCBI
mRatBN7.21656,553,206 - 56,633,105 (-)NCBI
Rnor_6.01660,128,201 - 60,208,462 (-)NCBI
Rnor_5.01659,795,263 - 59,882,664 (-)NCBI
RGSC_v3.41660,251,500 - 60,330,831 (-)RGD
Celera1654,605,099 - 54,684,103 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253224   ⟹   XP_006253286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81663,248,833 - 63,336,441 (-)NCBI
mRatBN7.21656,545,462 - 56,633,646 (-)NCBI
Rnor_6.01660,120,457 - 60,208,550 (-)NCBI
Rnor_5.01659,795,263 - 59,882,664 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253227   ⟹   XP_006253289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81663,319,486 - 63,336,441 (-)NCBI
mRatBN7.21656,621,609 - 56,633,649 (-)NCBI
Rnor_6.01660,196,968 - 60,208,550 (-)NCBI
Rnor_5.01659,795,263 - 59,882,664 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001841536
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81663,248,833 - 63,336,441 (-)NCBI
mRatBN7.21656,545,462 - 56,633,648 (-)NCBI
Rnor_6.01660,120,457 - 60,208,550 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001100786   ⟸   NM_001107316
- Sequence:
RefSeq Acc Id: XP_006253286   ⟸   XM_006253224
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253289   ⟸   XM_006253227
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000015203   ⟸   ENSRNOT00000015203
Ensembl Acc Id: ENSRNOP00000080425   ⟸   ENSRNOT00000108535
Ensembl Acc Id: ENSRNOP00000081189   ⟸   ENSRNOT00000098060
Protein Domains
Roc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJL1-F1-model_v2 AlphaFold D3ZJL1 1-1046 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308812 AgrOrtholog
BioCyc Gene G2FUF-11171 BioCyc
Ensembl Genes ENSRNOG00000011431 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015203.6 UniProtKB/TrEMBL
  ENSRNOT00000098060 ENTREZGENE
  ENSRNOT00000098060.2 UniProtKB/TrEMBL
  ENSRNOT00000108535 ENTREZGENE
  ENSRNOT00000108535.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_domain-containing UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  ROC_GTPase UniProtKB/TrEMBL
KEGG Report rno:306508 UniProtKB/TrEMBL
NCBI Gene 306508 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR48051 UniProtKB/TrEMBL
  RAS SUPPRESSOR PROTEIN 1 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  Roc UniProtKB/TrEMBL
PhenoGen Mfhas1 PhenoGen
PRINTS LEURICHRPT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  ROC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011431 RatGTEx
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  Polo-box domain UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZRZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZT22 ENTREZGENE, UniProtKB/TrEMBL
  A6IVM5 ENTREZGENE, UniProtKB/TrEMBL
  A6IVM6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJL1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-06-07 Mfhas1  multifunctional ROCO family signaling regulator 1  Mfhas1  malignant fibrous histiocytoma amplified sequence 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mfhas1  malignant fibrous histiocytoma amplified sequence 1   Mfhas1_predicted  malignant fibrous histiocytoma amplified sequence 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mfhas1_predicted  malignant fibrous histiocytoma amplified sequence 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED