Kif5c (kinesin family member 5C) - Rat Genome Database

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Gene: Kif5c (kinesin family member 5C) Rattus norvegicus
Analyze
Symbol: Kif5c
Name: kinesin family member 5C
RGD ID: 1308539
Description: Enables ATP hydrolysis activity; apolipoprotein receptor binding activity; and microtubule binding activity. Involved in anterograde axonal protein transport and intracellular mRNA localization. Located in dendrite. Is active in GABA-ergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kinesin heavy chain; kinesin heavy chain isoform 5C; kinesin heavy chain neuron-specific 2; kinesin-1; LOC311024
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8354,441,266 - 54,591,630 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl354,441,310 - 54,594,813 (+)EnsemblGRCr8
mRatBN7.2334,032,082 - 34,185,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx337,402,568 - 37,553,043 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,987,291 - 46,137,761 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,799,352 - 43,950,019 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd352,275,760 - 52,426,371 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive359,240,225 - 59,390,970 (+)NCBILyon_Normotensive
Lyon_Hypertensive351,191,232 - 51,341,542 (+)NCBILyon_Hypertensive
F344_StmMcwi332,430,305 - 32,580,916 (+)NCBIF344_StmMcwi
Rnor_6.0335,014,157 - 35,257,417 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl335,014,538 - 35,257,407 (+)Ensemblrn6Rnor6.0
Rnor_5.0340,150,177 - 40,380,889 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4330,602,210 - 30,755,482 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera332,217,717 - 32,366,850 (+)NCBICelera
RGSC_v3.1330,498,932 - 30,637,511 (+)NCBI
Cytogenetic Map3q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
diethyl phthalate  (EXP,ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
folic acid  (ISO)
haloperidol  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triticonazole  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression profiling of the cellular processes in uterine leiomyomas: omic approaches and IGF-2 association with leiomyosarcomas. Bae SM, etal., Cancer Res Treat. 2004 Feb;36(1):31-42. doi: 10.4143/crt.2004.36.1.31. Epub 2004 Feb 29.
2. Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history. Bergen SE, etal., Schizophr Res. 2014 Apr;154(1-3):48-53. doi: 10.1016/j.schres.2014.01.030. Epub 2014 Feb 26.
3. Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region. Falley K, etal., Traffic. 2009 Jul;10(7):844-57. doi: 10.1111/j.1600-0854.2009.00912.x. Epub 2009 Apr 11.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis. Kuzma-Kozakiewicz M, etal., Neurodegener Dis. 2013;12(2):71-80. doi: 10.1159/000339529. Epub 2012 Sep 21.
7. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
8. Kinesin and ncd bind through a single head to microtubules and compete for a shared MT binding site. Lockhart A, etal., J Mol Biol. 1995 Jun 16;249(4):763-71.
9. Huntingtin mediates dendritic transport of beta-actin mRNA in rat neurons. Ma B, etal., Sci Rep. 2011;1:140. Epub 2011 Nov 3.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. Sepulveda-Falla D, etal., J Clin Invest. 2014 Apr;124(4):1552-67. doi: 10.1172/JCI66407. Epub 2014 Feb 24.
16. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
17. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Twelvetrees AE, etal., Neuron. 2010 Jan 14;65(1):53-65. doi: 10.1016/j.neuron.2009.12.007.
18. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. Verhey KJ, etal., J Cell Biol. 2001 Mar 5;152(5):959-70.
19. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Wang X and Schwarz TL, Cell. 2009 Jan 9;136(1):163-74. doi: 10.1016/j.cell.2008.11.046.
20. The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons. Zivraj KH, etal., J Neurochem. 2013 Mar;124(5):670-84. doi: 10.1111/jnc.12079. Epub 2013 Jan 20.
Additional References at PubMed
PMID:9405049   PMID:9428521   PMID:10964943   PMID:11319135   PMID:15644324   PMID:16018997   PMID:16301330   PMID:17887960   PMID:19608740   PMID:20032309   PMID:21700703   PMID:22871113  
PMID:24286867   PMID:24940781   PMID:26767417   PMID:27699600   PMID:28131823   PMID:28302907   PMID:29476059   PMID:31084716   PMID:34348158   PMID:36675068  


Genomics

Comparative Map Data
Kif5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8354,441,266 - 54,591,630 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl354,441,310 - 54,594,813 (+)EnsemblGRCr8
mRatBN7.2334,032,082 - 34,185,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx337,402,568 - 37,553,043 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,987,291 - 46,137,761 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,799,352 - 43,950,019 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd352,275,760 - 52,426,371 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive359,240,225 - 59,390,970 (+)NCBILyon_Normotensive
Lyon_Hypertensive351,191,232 - 51,341,542 (+)NCBILyon_Hypertensive
F344_StmMcwi332,430,305 - 32,580,916 (+)NCBIF344_StmMcwi
Rnor_6.0335,014,157 - 35,257,417 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl335,014,538 - 35,257,407 (+)Ensemblrn6Rnor6.0
Rnor_5.0340,150,177 - 40,380,889 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4330,602,210 - 30,755,482 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera332,217,717 - 32,366,850 (+)NCBICelera
RGSC_v3.1330,498,932 - 30,637,511 (+)NCBI
Cytogenetic Map3q12NCBI
KIF5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382148,875,227 - 149,026,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2148,875,227 - 149,026,759 (+)Ensemblhg38GRCh38
GRCh372149,632,796 - 149,883,273 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362149,349,289 - 149,396,266 (+)NCBIBuild 36Build 36hg18NCBI36
Build 362149,502,042 - 149,591,519 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2143,347,002 - 143,497,189 (+)NCBICelera
Cytogenetic Map2q23.1-q23.2NCBI
HuRef2141,692,099 - 141,781,519 (+)NCBIHuRef
HuRef2141,630,811 - 141,685,094 (+)NCBIHuRef
CHM1_12149,799,659 - 149,889,137 (+)NCBICHM1_1
CHM1_12149,638,662 - 149,692,791 (+)NCBICHM1_1
T2T-CHM13v2.02149,325,585 - 149,477,131 (+)NCBIT2T-CHM13v2.0
Kif5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39249,509,298 - 49,664,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl249,509,310 - 49,664,790 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38249,619,286 - 49,774,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl249,619,298 - 49,774,778 (+)Ensemblmm10GRCm38
MGSCv37249,474,834 - 49,630,298 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36249,441,323 - 49,596,787 (+)NCBIMGSCv36mm8
Celera251,292,276 - 51,447,919 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.68NCBI
Kif5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544014,754,639 - 14,854,406 (+)Ensembl
ChiLan1.0NW_00495544014,754,931 - 14,854,090 (+)NCBIChiLan1.0ChiLan1.0
KIF5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21325,901,834 - 26,053,898 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B25,916,801 - 26,068,844 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B10,836,356 - 10,987,683 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B153,235,329 - 153,387,221 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B153,235,329 - 153,387,221 (+)EnsemblpanPan2panpan1.1
KIF5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11950,535,622 - 50,684,485 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1950,535,456 - 50,668,738 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1950,659,035 - 50,807,788 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01952,008,886 - 52,158,206 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1952,008,672 - 52,154,871 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11950,652,619 - 50,801,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01950,787,472 - 50,935,851 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01952,186,427 - 52,334,911 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kif5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303113,186,109 - 113,337,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646928,280,095 - 28,431,695 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646928,282,921 - 28,431,638 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,190,343 - 3,361,410 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1153,190,341 - 3,361,470 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2152,730,440 - 2,901,563 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIF5C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11034,285,048 - 34,441,918 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1034,285,037 - 34,444,863 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040165,078,867 - 165,231,441 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif5c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248661,526,638 - 1,698,301 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248661,526,647 - 1,698,113 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kif5c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1527,483,994 - 27,633,566 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kif5c
930 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000006341
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)34542360958601291Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat

Markers in Region
D3Got22  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8354,514,719 - 54,514,855 (+)Marker Load Pipeline
mRatBN7.2334,105,497 - 34,105,633 (+)MAPPERmRatBN7.2
Rnor_6.0335,176,560 - 35,176,695NCBIRnor6.0
Rnor_5.0340,303,203 - 40,303,338UniSTSRnor5.0
RGSC_v3.4330,678,696 - 30,678,832RGDRGSC3.4
RGSC_v3.4330,678,697 - 30,678,832UniSTSRGSC3.4
Celera332,289,943 - 32,290,078UniSTS
RGSC_v3.1330,575,068 - 30,575,204RGD
Cytogenetic Map3q12UniSTS
RH142774  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,182,586 - 34,182,774 (+)MAPPERmRatBN7.2
Rnor_6.0335,254,407 - 35,254,594NCBIRnor6.0
Rnor_5.0340,381,063 - 40,381,250UniSTSRnor5.0
RGSC_v3.4330,755,656 - 30,755,844UniSTSRGSC3.4
Celera332,367,024 - 32,367,211UniSTS
RH 3.4 Map3411.51UniSTS
Cytogenetic Map3q12UniSTS
BE096005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,168,985 - 34,169,159 (+)MAPPERmRatBN7.2
Rnor_6.0335,240,806 - 35,240,979NCBIRnor6.0
Rnor_5.0340,367,462 - 40,367,635UniSTSRnor5.0
RGSC_v3.4330,742,055 - 30,742,228UniSTSRGSC3.4
Celera332,353,423 - 32,353,596UniSTS
RH 3.4 Map3413.71UniSTS
Cytogenetic Map3q12UniSTS
PMC133732P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,106,821 - 34,107,282 (+)MAPPERmRatBN7.2
Rnor_6.0335,177,884 - 35,178,344NCBIRnor6.0
Rnor_5.0340,304,527 - 40,304,987UniSTSRnor5.0
RGSC_v3.4330,680,021 - 30,680,481UniSTSRGSC3.4
Celera332,291,267 - 32,291,727UniSTS
Cytogenetic Map3q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 163 88 87 56 90 56 6 343 188 11 142 75 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006341   ⟹   ENSRNOP00000006341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl354,441,310 - 54,594,813 (+)Ensembl
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)Ensembl
Rnor_6.0 Ensembl335,014,538 - 35,239,888 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081744   ⟹   ENSRNOP00000071329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl354,441,310 - 54,594,813 (+)Ensembl
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)Ensembl
Rnor_6.0 Ensembl335,175,313 - 35,257,407 (+)Ensembl
RefSeq Acc Id: NM_001107730   ⟹   NP_001101200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8354,441,307 - 54,591,630 (+)NCBI
mRatBN7.2334,032,105 - 34,182,413 (+)NCBI
Dahl_SR_JrHsd352,275,760 - 52,426,371 (+)NCBI
Lyon_Normotensive359,240,225 - 59,390,970 (+)NCBI
Lyon_Hypertensive351,191,232 - 51,341,542 (+)NCBI
F344_StmMcwi332,430,305 - 32,580,916 (+)NCBI
Rnor_6.0335,014,187 - 35,254,233 (+)NCBI
Rnor_5.0340,150,177 - 40,380,889 (+)NCBI
RGSC_v3.4330,602,210 - 30,755,482 (+)RGD
Celera332,217,717 - 32,366,850 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283548   ⟹   XP_063139618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8354,441,266 - 54,582,391 (+)NCBI
RefSeq Acc Id: XM_063283549   ⟹   XP_063139619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8354,441,266 - 54,591,138 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101200 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139618 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139619 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00464 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006341
  ENSRNOP00000006341.8
GenBank Protein P56536 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001101200   ⟸   NM_001107730
- UniProtKB: P56536 (UniProtKB/Swiss-Prot),   G3V6L4 (UniProtKB/Swiss-Prot),   A0A0G2K070 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006341   ⟸   ENSRNOT00000006341
Ensembl Acc Id: ENSRNOP00000071329   ⟸   ENSRNOT00000081744
RefSeq Acc Id: XP_063139619   ⟸   XM_063283549
- Peptide Label: isoform X1
- UniProtKB: P56536 (UniProtKB/Swiss-Prot),   G3V6L4 (UniProtKB/Swiss-Prot),   A0A0G2K070 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139618   ⟸   XM_063283548
- Peptide Label: isoform X1
- UniProtKB: P56536 (UniProtKB/Swiss-Prot),   G3V6L4 (UniProtKB/Swiss-Prot),   A0A0G2K070 (UniProtKB/TrEMBL)
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56536-F1-model_v2 AlphaFold P56536 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692069
Promoter ID:EPDNEW_R2594
Type:single initiation site
Name:Kif5c_1
Description:kinesin family member 5C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0335,014,515 - 35,014,575EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308539 AgrOrtholog
BioCyc Gene G2FUF-49761 BioCyc
Ensembl Genes ENSRNOG00000004680 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006341 ENTREZGENE
  ENSRNOT00000006341.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.1590 UniProtKB/Swiss-Prot
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot
  Kinesin_motor_CS UniProtKB/Swiss-Prot
  Kinesin_motor_dom UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:311024 UniProtKB/Swiss-Prot
NCBI Gene 311024 ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/Swiss-Prot
  KINESIN HEAVY CHAIN ISOFORM 5C UniProtKB/Swiss-Prot
Pfam Kinesin UniProtKB/Swiss-Prot
PhenoGen Kif5c PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004680 RatGTEx
SMART KISc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K070 ENTREZGENE, UniProtKB/TrEMBL
  G3V6L4 ENTREZGENE
  KIF5C_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6L4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Kif5c  kinesin family member 5C   Kif5c_predicted  kinesin family member 5C (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kif5c_predicted  kinesin family member 5C (predicted)      Symbol and Name status set to approved 70820 APPROVED