Asb3 (ankyrin repeat and SOCS box-containing 3) - Rat Genome Database

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Pathways
Gene: Asb3 (ankyrin repeat and SOCS box-containing 3) Rattus norvegicus
Analyze
Symbol: Asb3
Name: ankyrin repeat and SOCS box-containing 3
RGD ID: 1308462
Description: Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to several human genes including ASB3 (ankyrin repeat and SOCS box containing 3); INTERACTS WITH bisphenol A; flutamide; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ankyrin repeat and SOCS box protein 3; ankyrin repeat and SOCS box-containing 3-like; ankyrin repeat and SOCS box-containing protein 3; LOC364227
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,860,318 - 108,988,939 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14108,811,930 - 108,988,942 (+)EnsemblGRCr8
mRatBN7.214104,659,406 - 104,788,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,611,010 - 104,788,028 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14109,005,605 - 109,096,776 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,232,568 - 110,330,841 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,704,999 - 106,803,271 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014115,352,716 - 115,446,618 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,391,609 - 115,446,152 (+)Ensemblrn6Rnor6.0
Rnor_5.014115,009,338 - 115,105,601 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414112,086,518 - 112,175,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera14103,531,205 - 103,622,071 (+)NCBICelera
RGSC_v3.114112,153,594 - 112,201,343 (+)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Asb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814108,860,318 - 108,988,939 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14108,811,930 - 108,988,942 (+)EnsemblGRCr8
mRatBN7.214104,659,406 - 104,788,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14104,611,010 - 104,788,028 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14109,005,605 - 109,096,776 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014110,232,568 - 110,330,841 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014106,704,999 - 106,803,271 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014115,352,716 - 115,446,618 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14115,391,609 - 115,446,152 (+)Ensemblrn6Rnor6.0
Rnor_5.014115,009,338 - 115,105,601 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414112,086,518 - 112,175,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera14103,531,205 - 103,622,071 (+)NCBICelera
RGSC_v3.114112,153,594 - 112,201,343 (+)NCBI
Cytogenetic Map14q22NCBI
ASB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38253,669,980 - 53,786,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl253,532,672 - 53,860,160 (-)Ensemblhg38GRCh38
GRCh37253,897,117 - 54,014,090 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36253,750,622 - 53,867,583 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34253,808,768 - 53,925,730NCBI
Celera253,737,972 - 53,854,933 (-)NCBICelera
Cytogenetic Map2p16.2NCBI
HuRef253,631,423 - 53,748,485 (-)NCBIHuRef
CHM1_1253,828,100 - 53,945,131 (-)NCBICHM1_1
T2T-CHM13v2.0253,666,238 - 53,783,156 (-)NCBIT2T-CHM13v2.0
Asb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,904,398 - 31,052,704 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,835,416 - 31,052,704 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381130,954,392 - 31,102,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,885,416 - 31,102,704 (+)Ensemblmm10GRCm38
MGSCv371130,854,398 - 31,002,704 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361130,854,463 - 31,001,470 (+)NCBIMGSCv36mm8
Celera1133,359,884 - 33,501,950 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.19NCBI
Asb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544119,425,621 - 19,510,723 (-)Ensembl
ChiLan1.0NW_00495544119,427,843 - 19,511,583 (-)NCBIChiLan1.0ChiLan1.0
ASB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21272,498,541 - 72,691,061 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A72,502,405 - 72,695,028 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A53,810,706 - 54,003,099 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A54,723,195 - 54,842,301 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A54,723,195 - 54,820,891 (-)EnsemblpanPan2panpan1.1
ASB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11054,707,815 - 54,815,513 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1054,712,747 - 54,936,838 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1054,664,431 - 54,738,630 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01055,703,328 - 55,814,197 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1055,709,369 - 55,814,154 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11055,404,712 - 55,478,696 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01055,690,487 - 55,764,686 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01055,977,514 - 56,051,739 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101959987
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629228,171,374 - 28,338,175 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936491230,769 - 400,705 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936491233,117 - 351,859 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl387,389,873 - 87,500,977 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1387,389,835 - 87,501,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2392,549,246 - 92,657,488 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11453,112,851 - 53,322,932 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604558,394,291 - 58,517,009 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248337,833,327 - 7,964,708 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248337,830,519 - 7,964,723 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Asb3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11198,489,395 - 98,547,124 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:112
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000067393
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat

Markers in Region
RH134469  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.014115,384,145 - 115,384,327NCBIRnor6.0
Celera14103,558,424 - 103,558,604UniSTS
Cytogenetic Map14q22UniSTS
RH144302  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr814108,923,213 - 108,923,429 (+)Marker Load Pipeline
mRatBN7.214104,722,298 - 104,722,514 (+)MAPPERmRatBN7.2
Rnor_6.014115,385,447 - 115,385,663NCBIRnor6.0
Rnor_5.014115,041,235 - 115,041,451UniSTSRnor5.0
RGSC_v3.414112,116,509 - 112,116,725UniSTSRGSC3.4
Celera14103,559,725 - 103,559,940UniSTS
Cytogenetic Map14q22UniSTS
UniSTS:236546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2117,593,685 - 7,593,949 (+)MAPPERmRatBN7.2
Rnor_6.0116,098,730 - 6,098,993NCBIRnor6.0
Rnor_6.014115,383,934 - 115,384,192NCBIRnor6.0
Rnor_5.0119,798,046 - 9,798,309UniSTSRnor5.0
RGSC_v3.4117,463,398 - 7,463,661UniSTSRGSC3.4
Celera117,546,292 - 7,546,555UniSTS
Celera14103,558,207 - 103,558,471UniSTS
Cytogenetic Map14q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067393   ⟹   ENSRNOP00000060663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14108,811,930 - 108,988,942 (+)Ensembl
mRatBN7.2 Ensembl14104,611,010 - 104,788,028 (+)Ensembl
Rnor_6.0 Ensembl14115,396,017 - 115,446,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079169   ⟹   ENSRNOP00000075281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14108,929,052 - 108,988,917 (+)Ensembl
mRatBN7.2 Ensembl14104,693,595 - 104,788,028 (+)Ensembl
Rnor_6.0 Ensembl14115,391,609 - 115,446,152 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173327   ⟹   ENSRNOP00000107365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14108,894,105 - 108,988,917 (+)Ensembl
RefSeq Acc Id: NM_001108864   ⟹   NP_001102334
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,894,451 - 108,985,555 (+)NCBI
mRatBN7.214104,693,537 - 104,784,644 (+)NCBI
Rnor_6.014115,352,716 - 115,446,618 (+)NCBI
Rnor_5.014115,009,338 - 115,105,601 (+)NCBI
Celera14103,531,205 - 103,622,071 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092257   ⟹   XP_038948185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,929,328 - 108,987,761 (+)NCBI
mRatBN7.214104,728,713 - 104,788,032 (+)NCBI
RefSeq Acc Id: XM_039092258   ⟹   XP_038948186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,860,318 - 108,987,761 (+)NCBI
mRatBN7.214104,659,406 - 104,788,032 (+)NCBI
RefSeq Acc Id: XM_039092259   ⟹   XP_038948187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,929,284 - 108,988,939 (+)NCBI
mRatBN7.214104,728,370 - 104,788,032 (+)NCBI
RefSeq Acc Id: XM_039092261   ⟹   XP_038948189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,929,283 - 108,973,595 (+)NCBI
mRatBN7.214104,728,368 - 104,772,664 (+)NCBI
RefSeq Acc Id: XM_063273443   ⟹   XP_063129513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,929,278 - 108,987,761 (+)NCBI
RefSeq Acc Id: XM_063273444   ⟹   XP_063129514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,894,611 - 108,988,939 (+)NCBI
RefSeq Acc Id: XM_063273445   ⟹   XP_063129515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814108,929,296 - 108,987,761 (+)NCBI
RefSeq Acc Id: NP_001102334   ⟸   NM_001108864
- UniProtKB: A0A0G2KA67 (UniProtKB/TrEMBL),   A6JQD7 (UniProtKB/TrEMBL),   D3ZJN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060663   ⟸   ENSRNOT00000067393
Ensembl Acc Id: ENSRNOP00000075281   ⟸   ENSRNOT00000079169
RefSeq Acc Id: XP_038948186   ⟸   XM_039092258
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KA67 (UniProtKB/TrEMBL),   A6JQD7 (UniProtKB/TrEMBL),   D3ZJN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948189   ⟸   XM_039092261
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038948187   ⟸   XM_039092259
- Peptide Label: isoform X3
- UniProtKB: D3ZJN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948185   ⟸   XM_039092257
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KA67 (UniProtKB/TrEMBL),   A6JQD7 (UniProtKB/TrEMBL),   D3ZJN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129514   ⟸   XM_063273444
- Peptide Label: isoform X4
- UniProtKB: D3ZJN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129513   ⟸   XM_063273443
- Peptide Label: isoform X1
- UniProtKB: D3ZJN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129515   ⟸   XM_063273445
- Peptide Label: isoform X5
- UniProtKB: D3ZJN4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107365   ⟸   ENSRNOT00000173327
Protein Domains
SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJN4-F1-model_v2 AlphaFold D3ZJN4 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308462 AgrOrtholog
BioCyc Gene G2FUF-14625 BioCyc
Ensembl Genes ENSRNOG00000032471 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067393.5 UniProtKB/TrEMBL
  ENSRNOT00000079169 ENTREZGENE
  ENSRNOT00000079169.3 UniProtKB/TrEMBL
  ENSRNOT00000173327 ENTREZGENE
  ENSRNOT00000173327.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  ASB3_SOCS UniProtKB/TrEMBL
  SOCS_box_dom_like UniProtKB/TrEMBL
  SOCS_C UniProtKB/TrEMBL
KEGG Report rno:364227 UniProtKB/TrEMBL
NCBI Gene 364227 ENTREZGENE
PANTHER ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANKYRIN REPEAT AND SOCS BOX CONTAINING 3 UniProtKB/TrEMBL
  ANKYRIN REPEAT AND SOCS BOX PROTEIN 1 UniProtKB/TrEMBL
  ANKYRIN REPEAT CONTAINING UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PhenoGen Asb3 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032471 RatGTEx
SMART ANK UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
UniProt A0A0G2KA67 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LRN0_RAT UniProtKB/TrEMBL
  A6JQD7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJN4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Asb3  ankyrin repeat and SOCS box-containing 3  LOC100361167  ankyrin repeat and SOCS box-containing 3-like  Data merged from RGD:2320694 1643240 APPROVED
2010-05-05 LOC100361167  ankyrin repeat and SOCS box-containing 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Asb3  ankyrin repeat and SOCS box-containing 3  Asb3  ankyrin repeat and SOCS box-containing protein 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Asb3  ankyrin repeat and SOCS box-containing protein 3   Asb3_predicted  ankyrin repeat and SOCS box-containing protein 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Asb3_predicted  ankyrin repeat and SOCS box-containing protein 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED