Muc16 (mucin 16, cell surface associated) - Rat Genome Database

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Gene: Muc16 (mucin 16, cell surface associated) Rattus norvegicus
Analyze
Symbol: Muc16
Name: mucin 16, cell surface associated
RGD ID: 1308422
Description: Biomarker of ovarian carcinoma. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated); INTERACTS WITH 17beta-estradiol; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC315451; Muc16l; mucin 16; mucin 16 like; mucin-16; RGD1308422; similar to ovarian cancer related tumor marker CA125
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8824,440,840 - 24,644,494 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2816,164,531 - 16,323,126 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.0818,438,838 - 18,639,777 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0818,505,745 - 18,678,475 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4816,552,167 - 16,726,561 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera817,583,127 - 17,786,039 (-)NCBICelera
RGSC_v3.1816,552,166 - 16,813,582 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MUC16 expression in Sjogren's syndrome, KCS, and control subjects. Caffery B, etal., Mol Vis. 2008;14:2547-55. Epub 2008 Dec 30.
2. Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. Dogru M, etal., Allergy. 2008 Oct;63(10):1324-34. doi: 10.1111/j.1398-9995.2008.01781.x.
3. Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye. Gipson IK, etal., Cornea. 2011 Dec;30(12):1346-52. doi: 10.1097/ICO.0b013e31820d852a.
4. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Junutula JR, etal., Nat Biotechnol. 2008 Aug;26(8):925-32. doi: 10.1038/nbt.1480. Epub 2008 Jul 20.
5. Assessment of serum and bile levels of CA19-9 and CA125 in cholangitis and bile duct carcinoma. Ker CG, etal., J Gastroenterol Hepatol. 1991 Sep-Oct;6(5):505-8.
6. Tumour markers in the detection of opisthorchiasis-associated cholangiocarcinoma. Pungpak S, etal., Trans R Soc Trop Med Hyg. 1991 Mar-Apr;85(2):277-9.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Identification and characterization of a spontaneous ovarian carcinoma in Lewis rats. Sharrow AC, etal., J Ovarian Res. 2010 Mar 31;3:9.
12. Diagnostic value of serum CA242, CA 19-9, CA 15-3 and CA 125 in patients with carcinoma of the gallbladder. Shukla VK, etal., Trop Gastroenterol. 2006 Oct-Dec;27(4):160-5.
13. The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Yue T, etal., Mol Cell Proteomics. 2009 Jul;8(7):1697-707. Epub 2009 Apr 17.
14. Extracts of salvia miltiorrhiza bunge on the cytokines of rat endometriosis models. Zhou ZH, etal., Afr J Tradit Complement Altern Med. 2012 Apr 2;9(3):303-14.
Additional References at PubMed
PMID:8889548   PMID:12766047   PMID:18637025   PMID:19190083   PMID:19199708   PMID:21873635   PMID:24812549  


Genomics

Comparative Map Data
Muc16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8824,440,840 - 24,644,494 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2816,164,531 - 16,323,126 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.0818,438,838 - 18,639,777 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0818,505,745 - 18,678,475 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4816,552,167 - 16,726,561 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera817,583,127 - 17,786,039 (-)NCBICelera
RGSC_v3.1816,552,166 - 16,813,582 (-)NCBI
Cytogenetic Map8q13NCBI
MUC16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,848,844 - 9,065,751 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,848,844 - 9,010,390 (-)Ensemblhg38GRCh38
GRCh37198,959,520 - 9,176,427 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,820,520 - 8,953,018 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34198,820,519 - 8,923,563NCBI
Cytogenetic Map19p13.2NCBI
HuRef198,536,945 - 8,584,059 (-)NCBIHuRef
HuRef198,584,670 - 8,673,562 (-)NCBIHuRef
CHM1_1198,959,010 - 9,091,710 (-)NCBICHM1_1
T2T-CHM13v2.0198,959,807 - 9,191,530 (-)NCBIT2T-CHM13v2.0
Muc16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39918,406,741 - 18,586,117 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl918,406,751 - 18,585,826 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38918,495,445 - 18,674,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl918,495,455 - 18,674,530 (-)Ensemblmm10GRCm38
MGSCv37918,299,899 - 18,317,332 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36918,245,857 - 18,472,198 (-)NCBIMGSCv36mm8
Celera915,778,999 - 15,796,681 (-)NCBICelera
Cytogenetic Map9A2NCBI
cM Map97.06NCBI
Muc16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955563432,160 - 581,330 (+)NCBIChiLan1.0ChiLan1.0
MUC16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22013,797,498 - 14,036,604 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11912,779,869 - 12,965,004 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0198,416,393 - 8,568,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1199,109,917 - 9,260,669 (-)NCBIPanPan1.1PanPan1.1panPan2
MUC16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12051,790,036 - 51,876,801 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2051,637,206 - 51,746,304 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02052,293,754 - 52,404,418 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12051,498,618 - 51,608,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,980,166 - 52,054,572 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,170,387 - 52,282,686 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Muc16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,222,666 - 212,328,106 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365885,506,683 - 5,586,450 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103233851
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.168,110,087 - 8,256,015 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607411,930,596 - 12,078,366 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248281,510,104 - 1,579,727 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Muc16
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1814,573,554 - 14,742,596 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Muc16
912 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:70
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000061339
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
12 2 29 13 1 1 16 26

Sequence


RefSeq Acc Id: XM_063266294   ⟹   XP_063122364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8824,440,840 - 24,644,494 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001415682 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122364 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000110601.1
RefSeq Acc Id: XP_063122364   ⟸   XM_063266294

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308422 AgrOrtholog
BioCyc Gene G2FUF-31573 BioCyc
Ensembl Genes ENSRNOG00000072977 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000172603.1 UniProtKB/TrEMBL
NCBI Gene 315451 ENTREZGENE
PhenoGen Muc16 PhenoGen
RatGTEx ENSRNOG00000072977 RatGTEx
UniProt A0ABK0M105_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Muc16  mucin 16, cell surface associated  Muc16  mucin 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Muc16  mucin 16  RGD1308422  similar to ovarian cancer related tumor marker CA125  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 RGD1308422  similar to ovarian cancer related tumor marker CA125  LOC686731  similar to mucin 17  Data merged from RGD:1593730 1643240 APPROVED
2006-11-20 LOC686731  similar to mucin 17      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 RGD1308422  similar to ovarian cancer related tumor marker CA125  RGD1308422_predicted  similar to ovarian cancer related tumor marker CA125 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308422_predicted  similar to ovarian cancer related tumor marker CA125 (predicted)  LOC315451_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315451_predicted  similar to ovarian cancer related tumor marker CA125 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL