Hibch (3-hydroxyisobutyryl-CoA hydrolase) - Rat Genome Database

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Gene: Hibch (3-hydroxyisobutyryl-CoA hydrolase) Rattus norvegicus
Analyze
Symbol: Hibch
Name: 3-hydroxyisobutyryl-CoA hydrolase
RGD ID: 1308392
Description: Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in L-valine catabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-hydroxyisobutryl-CoA hydrolase deficiency. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-Coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H; LOC301384
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,082,082 - 56,161,796 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl956,082,091 - 56,161,886 (-)EnsemblGRCr8
mRatBN7.2948,590,097 - 48,669,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,590,099 - 48,669,824 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx957,131,763 - 57,211,849 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,254,592 - 62,334,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,550,578 - 60,630,667 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd959,875,997 - 59,956,085 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive955,651,398 - 55,731,481 (-)NCBILyon_Normotensive
Lyon_Hypertensive955,786,819 - 55,866,903 (-)NCBILyon_Hypertensive
F344_StmMcwi957,702,867 - 57,782,951 (-)NCBIF344_StmMcwi
Rnor_6.0953,446,185 - 53,526,727 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,446,194 - 53,526,728 (-)Ensemblrn6Rnor6.0
Rnor_5.0953,112,579 - 53,193,190 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4945,564,702 - 45,645,252 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera946,259,906 - 46,339,124 (-)NCBICelera
RGSC_v3.1945,566,124 - 45,624,624 (-)NCBI
Cytogenetic Map9q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acryloyl-CoA  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glyphosate  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
kojic acid  (ISO)
leflunomide  (EXP)
methacrylyl-CoA  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
Muraglitazar  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8188708   PMID:8824301   PMID:18614015   PMID:23376485  


Genomics

Comparative Map Data
Hibch
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,082,082 - 56,161,796 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl956,082,091 - 56,161,886 (-)EnsemblGRCr8
mRatBN7.2948,590,097 - 48,669,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,590,099 - 48,669,824 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx957,131,763 - 57,211,849 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,254,592 - 62,334,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,550,578 - 60,630,667 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd959,875,997 - 59,956,085 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive955,651,398 - 55,731,481 (-)NCBILyon_Normotensive
Lyon_Hypertensive955,786,819 - 55,866,903 (-)NCBILyon_Hypertensive
F344_StmMcwi957,702,867 - 57,782,951 (-)NCBIF344_StmMcwi
Rnor_6.0953,446,185 - 53,526,727 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,446,194 - 53,526,728 (-)Ensemblrn6Rnor6.0
Rnor_5.0953,112,579 - 53,193,190 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4945,564,702 - 45,645,252 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera946,259,906 - 46,339,124 (-)NCBICelera
RGSC_v3.1945,566,124 - 45,624,624 (-)NCBI
Cytogenetic Map9q22NCBI
HIBCH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,189,735 - 190,319,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,189,735 - 190,344,193 (-)Ensemblhg38GRCh38
GRCh372191,068,646 - 191,184,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,777,605 - 190,892,804 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342190,894,866 - 191,010,065NCBI
Celera2184,664,402 - 184,779,775 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,929,253 - 183,044,631 (-)NCBIHuRef
CHM1_12191,075,217 - 191,190,581 (-)NCBICHM1_1
T2T-CHM13v2.02190,693,510 - 190,809,397 (-)NCBIT2T-CHM13v2.0
Hibch
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,884,197 - 52,960,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,884,088 - 52,960,145 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38152,845,038 - 52,920,986 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,844,929 - 52,920,986 (+)Ensemblmm10GRCm38
MGSCv37152,901,890 - 52,977,704 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36152,789,591 - 52,865,405 (+)NCBIMGSCv36mm8
Celera153,386,006 - 53,461,488 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Hibch
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,752,309 - 8,792,927 (+)Ensembl
ChiLan1.0NW_0049554038,752,339 - 8,796,693 (+)NCBIChiLan1.0ChiLan1.0
HIBCH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,896,951 - 93,041,587 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,911,935 - 93,053,182 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,510,938 - 77,652,911 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,429,787 - 195,544,564 (-)NCBIPanPan1.1PanPan1.1panPan2
HIBCH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137841,385 - 943,972 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37841,414 - 943,941 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha371,797,343 - 1,893,653 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.037735,664 - 832,314 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37735,666 - 832,320 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137746,020 - 842,670 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037713,636 - 809,463 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037742,338 - 838,606 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hibch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,955,211 - 149,026,449 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,811,600 - 7,882,642 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,811,624 - 7,882,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIBCH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,792,985 - 94,941,266 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11594,795,744 - 94,941,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,964,875 - 105,973,529 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HIBCH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,711,829 - 75,852,055 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,715,996 - 75,828,310 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040123,643,515 - 123,757,713 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hibch
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,705,044 - 5,769,628 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248545,705,067 - 5,770,145 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hibch
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14122,324,443 - 122,489,080 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hibch
631 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:214
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000029677, ENSRNOT00000040650
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000029677   ⟹   ENSRNOP00000032041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,082,091 - 56,161,796 (-)Ensembl
mRatBN7.2 Ensembl948,590,101 - 48,669,798 (-)Ensembl
Rnor_6.0 Ensembl953,446,593 - 53,526,728 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000040650   ⟹   ENSRNOP00000046370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,082,091 - 56,161,796 (-)Ensembl
mRatBN7.2 Ensembl948,590,099 - 48,669,824 (-)Ensembl
Rnor_6.0 Ensembl953,446,194 - 53,526,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111639   ⟹   ENSRNOP00000078527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,082,091 - 56,151,229 (-)Ensembl
mRatBN7.2 Ensembl948,590,101 - 48,663,172 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116077   ⟹   ENSRNOP00000084082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,082,091 - 56,161,886 (-)Ensembl
mRatBN7.2 Ensembl948,590,101 - 48,656,597 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133361   ⟹   ENSRNOP00000109504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,082,091 - 56,151,229 (-)Ensembl
RefSeq Acc Id: NM_001013112   ⟹   NP_001013130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,161,796 (-)NCBI
mRatBN7.2948,590,097 - 48,669,815 (-)NCBI
Dahl_SR_JrHsd959,875,997 - 59,956,085 (-)NCBI
Lyon_Normotensive955,651,398 - 55,731,481 (-)NCBI
Lyon_Hypertensive955,786,819 - 55,866,903 (-)NCBI
F344_StmMcwi957,702,867 - 57,782,951 (-)NCBI
Rnor_6.0953,446,185 - 53,526,641 (-)NCBI
Rnor_5.0953,112,579 - 53,193,190 (-)NCBI
RGSC_v3.4945,564,702 - 45,645,252 (-)RGD
Celera946,259,906 - 46,339,124 (-)RGD
Sequence:
RefSeq Acc Id: NM_001398668   ⟹   NP_001385597
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,161,796 (-)NCBI
mRatBN7.2948,590,097 - 48,669,815 (-)NCBI
Dahl_SR_JrHsd959,875,997 - 59,956,085 (-)NCBI
Lyon_Normotensive955,651,398 - 55,731,481 (-)NCBI
Lyon_Hypertensive955,786,819 - 55,866,903 (-)NCBI
F344_StmMcwi957,702,867 - 57,782,951 (-)NCBI
RefSeq Acc Id: XM_039083288   ⟹   XP_038939216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,148,344 (-)NCBI
mRatBN7.2948,590,121 - 48,656,290 (-)NCBI
RefSeq Acc Id: XM_039083289   ⟹   XP_038939217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,151,645 (-)NCBI
mRatBN7.2948,590,121 - 48,662,740 (-)NCBI
RefSeq Acc Id: XM_063266936   ⟹   XP_063123006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,082 - 56,148,344 (-)NCBI
RefSeq Acc Id: XM_063266937   ⟹   XP_063123007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,088,967 - 56,148,344 (-)NCBI
RefSeq Acc Id: XM_063266938   ⟹   XP_063123008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,082,667 - 56,148,344 (-)NCBI
RefSeq Acc Id: XM_063266939   ⟹   XP_063123009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,092,615 - 56,161,792 (-)NCBI
RefSeq Acc Id: NP_001013130   ⟸   NM_001013112
- Peptide Label: isoform 2
- UniProtKB: Q5XIE6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032041   ⟸   ENSRNOT00000029677
Ensembl Acc Id: ENSRNOP00000046370   ⟸   ENSRNOT00000040650
RefSeq Acc Id: XP_038939217   ⟸   XM_039083289
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZL23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939216   ⟸   XM_039083288
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0J8 (UniProtKB/TrEMBL),   A0A8I5ZL23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084082   ⟸   ENSRNOT00000116077
Ensembl Acc Id: ENSRNOP00000078527   ⟸   ENSRNOT00000111639
RefSeq Acc Id: NP_001385597   ⟸   NM_001398668
- Peptide Label: isoform 1
- UniProtKB: Q5XIE6 (UniProtKB/Swiss-Prot),   A6INV5 (UniProtKB/TrEMBL),   A0A8I5ZL23 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123006   ⟸   XM_063266936
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063123008   ⟸   XM_063266938
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063123007   ⟸   XM_063266937
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063123009   ⟸   XM_063266939
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000109504   ⟸   ENSRNOT00000133361
Protein Domains
Enoyl-CoA hydratase/isomerase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIE6-F1-model_v2 AlphaFold Q5XIE6 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696652
Promoter ID:EPDNEW_R7176
Type:initiation region
Name:Hibch_1
Description:3-hydroxyisobutyryl-CoA hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0953,526,668 - 53,526,728EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308392 AgrOrtholog
BioCyc Gene G2FUF-27618 BioCyc
BioCyc Pathway VALDEG-PWY [L-valine degradation I] BioCyc
BioCyc Pathway Image VALDEG-PWY BioCyc
Ensembl Genes ENSRNOG00000028557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029677 ENTREZGENE
  ENSRNOT00000029677.7 UniProtKB/Swiss-Prot
  ENSRNOT00000040650 ENTREZGENE
  ENSRNOT00000040650.4 UniProtKB/Swiss-Prot
  ENSRNOT00000116077 ENTREZGENE
Gene3D-CATH 2-enoyl-CoA Hydratase, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191666 IMAGE-MGC_LOAD
InterPro ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot
  ECH_dom UniProtKB/Swiss-Prot
  HIBYL-CoA-H UniProtKB/Swiss-Prot
KEGG Report rno:301384 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94647 IMAGE-MGC_LOAD
NCBI Gene 301384 ENTREZGENE
PANTHER 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR43176 UniProtKB/Swiss-Prot
Pfam ECH_2 UniProtKB/Swiss-Prot
PhenoGen Hibch PhenoGen
RatGTEx ENSRNOG00000028557 RatGTEx
Superfamily-SCOP SSF52096 UniProtKB/Swiss-Prot
UniProt A0A8I5ZL23 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0J8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M4C9_RAT UniProtKB/TrEMBL
  A6INV5 ENTREZGENE, UniProtKB/TrEMBL
  HIBCH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hibch  3-hydroxyisobutyryl-CoA hydrolase  Hibch  3-hydroxyisobutyryl-Coenzyme A hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Hibch  3-hydroxyisobutyryl-Coenzyme A hydrolase  Hibch_predicted  3-hydroxyisobutyryl-Coenzyme A hydrolase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Hibch_predicted  3-hydroxyisobutyryl-Coenzyme A hydrolase (predicted)      Symbol and Name status set to approved 70820 APPROVED