Samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) - Rat Genome Database

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Gene: Samhd1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1) Rattus norvegicus
Analyze
Symbol: Samhd1
Name: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
RGD ID: 1308369
Description: Predicted to enable several functions, including dGTP binding activity; triphosphoric monoester hydrolase activity; and zinc ion binding activity. Predicted to be involved in several processes, including DNA metabolic process; host-mediated perturbation of viral RNA genome replication; and purine deoxyribonucleoside triphosphate catabolic process. Predicted to be located in site of double-strand break and tetraspanin-enriched microdomain. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; acute myeloid leukemia; hepatitis B; and hepatitis C. Orthologous to human SAMHD1 (SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deoxynucleoside triphosphate triphosphohydrolase SAMHD1; LOC311580; SAM domain and HD domain, 1; SAM domain and HD domain-containing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,179,742 - 166,214,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3166,181,588 - 166,214,410 (-)EnsemblGRCr8
mRatBN7.23145,761,549 - 145,794,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3149,586,957 - 149,619,774 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,084,906 - 158,117,628 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,825,467 - 155,858,563 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,210,829 - 153,250,705 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)Ensemblrn6Rnor6.0
Rnor_5.03158,468,644 - 158,504,183 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43147,689,421 - 147,727,429 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3144,468,270 - 144,500,913 (-)NCBICelera
RGSC_v3.13147,595,329 - 147,627,065 (-)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dGTP  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1. Deutschmann J, etal., Nat Microbiol. 2019 Dec;4(12):2273-2284. doi: 10.1038/s41564-019-0529-z. Epub 2019 Sep 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice. Kodigepalli KM, etal., Cell Cycle. 2018;17(23):2564-2576. doi: 10.1080/15384101.2018.1550955. Epub 2018 Dec 4.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Identification of natural splice variants of SAMHD1 in virus-infected HCC. Shi Y, etal., Oncol Rep. 2014 Feb;31(2):687-92. doi: 10.3892/or.2013.2895. Epub 2013 Dec 5.
Additional References at PubMed
PMID:19525956   PMID:22056990   PMID:22069334   PMID:22461318   PMID:23601106   PMID:23972988   PMID:24141705   PMID:24217394   PMID:25038827   PMID:26294762   PMID:27920203   PMID:28834754  
PMID:28871089   PMID:29379009   PMID:29669924   PMID:29670289  


Genomics

Comparative Map Data
Samhd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,179,742 - 166,214,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3166,181,588 - 166,214,410 (-)EnsemblGRCr8
mRatBN7.23145,761,549 - 145,794,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3149,586,957 - 149,619,774 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,084,906 - 158,117,628 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,825,467 - 155,858,563 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,210,829 - 153,250,705 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)Ensemblrn6Rnor6.0
Rnor_5.03158,468,644 - 158,504,183 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43147,689,421 - 147,727,429 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3144,468,270 - 144,500,913 (-)NCBICelera
RGSC_v3.13147,595,329 - 147,627,065 (-)NCBI
Cytogenetic Map3q42NCBI
SAMHD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,889,773 - 36,951,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,890,229 - 36,951,893 (-)Ensemblhg38GRCh38
GRCh372035,518,176 - 35,580,111 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362034,954,059 - 35,013,590 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342034,954,058 - 35,013,590NCBI
Celera2032,227,775 - 32,287,786 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,255,951 - 32,316,085 (-)NCBIHuRef
CHM1_12035,421,787 - 35,482,498 (-)NCBICHM1_1
T2T-CHM13v2.02038,614,121 - 38,676,051 (-)NCBIT2T-CHM13v2.0
Samhd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,939,454 - 156,977,016 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,939,453 - 156,977,185 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382157,097,534 - 157,135,096 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,097,533 - 157,135,265 (-)Ensemblmm10GRCm38
MGSCv372156,923,265 - 156,960,958 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362156,788,970 - 156,826,663 (-)NCBIMGSCv36mm8
Celera2163,030,928 - 163,069,082 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.0NCBI
Samhd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,735,161 - 24,778,830 (+)Ensembl
ChiLan1.0NW_00495542224,714,103 - 24,780,672 (+)NCBIChiLan1.0ChiLan1.0
SAMHD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,629,145 - 42,687,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,622,243 - 42,680,550 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,224,200 - 33,282,018 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,341,367 - 34,398,514 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,341,367 - 34,398,314 (-)EnsemblpanPan2panpan1.1
SAMHD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,623,997 - 25,676,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,626,134 - 25,680,902 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2425,269,008 - 25,324,975 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02426,321,372 - 26,377,665 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,322,848 - 26,373,771 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,599,032 - 25,655,273 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,699,545 - 25,755,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,189,021 - 26,245,159 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Samhd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,510,839 - 174,568,927 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,180,546 - 4,229,036 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,180,607 - 4,238,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAMHD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,107,462 - 40,171,878 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11740,117,348 - 40,171,935 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,558,314 - 45,611,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SAMHD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1257,641,634 - 57,699,685 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl257,639,046 - 57,699,525 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666054357,564 - 415,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Samhd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,591,148 - 2,647,742 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248422,591,016 - 2,649,746 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Samhd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15136,440,504 - 136,475,943 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Samhd1
303 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:47
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000008961, ENSRNOT00000067748
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
RH139202  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map31341.1UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 355 192 11 142 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008961   ⟹   ENSRNOP00000008961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3166,181,588 - 166,214,410 (-)Ensembl
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)Ensembl
Rnor_6.0 Ensembl3153,210,829 - 153,250,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067748   ⟹   ENSRNOP00000059210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3145,761,558 - 145,789,602 (-)Ensembl
Rnor_6.0 Ensembl3153,211,004 - 153,246,433 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103535   ⟹   ENSRNOP00000087823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3166,183,999 - 166,214,410 (-)Ensembl
mRatBN7.2 Ensembl3145,761,973 - 145,794,386 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116624   ⟹   ENSRNOP00000090074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3166,181,588 - 166,214,410 (-)Ensembl
mRatBN7.2 Ensembl3145,761,558 - 145,794,386 (-)Ensembl
RefSeq Acc Id: NM_001191743   ⟹   NP_001178672
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,181,588 - 166,214,410 (-)NCBI
mRatBN7.23145,761,558 - 145,794,386 (-)NCBI
Rnor_6.03153,210,829 - 153,250,641 (-)NCBI
Rnor_5.03158,468,644 - 158,504,183 (+)NCBI
Celera3144,468,270 - 144,500,913 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105087   ⟹   XP_038961015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,179,742 - 166,214,448 (-)NCBI
mRatBN7.23145,761,549 - 145,794,420 (-)NCBI
RefSeq Acc Id: XM_039105088   ⟹   XP_038961016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,179,742 - 166,202,555 (-)NCBI
mRatBN7.23145,761,549 - 145,782,530 (-)NCBI
RefSeq Acc Id: NP_001178672   ⟸   NM_001191743
- UniProtKB: D3Z898 (UniProtKB/TrEMBL),   A0A8I6ACW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008961   ⟸   ENSRNOT00000008961
Ensembl Acc Id: ENSRNOP00000059210   ⟸   ENSRNOT00000067748
RefSeq Acc Id: XP_038961015   ⟸   XM_039105087
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3V5 (UniProtKB/TrEMBL),   A0A8I6ACW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961016   ⟸   XM_039105088
- Peptide Label: isoform X2
- UniProtKB: A6JWR1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087823   ⟸   ENSRNOT00000103535
Ensembl Acc Id: ENSRNOP00000090074   ⟸   ENSRNOT00000116624
Protein Domains
HD   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z898-F1-model_v2 AlphaFold D3Z898 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692608
Promoter ID:EPDNEW_R3133
Type:multiple initiation site
Name:Samhd1_1
Description:SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03153,250,624 - 153,250,684EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308369 AgrOrtholog
BioCyc Gene G2FUF-47065 BioCyc
Ensembl Genes ENSRNOG00000006418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008961 ENTREZGENE
  ENSRNOT00000008961.9 UniProtKB/TrEMBL
  ENSRNOT00000103535 ENTREZGENE
  ENSRNOT00000103535.2 UniProtKB/TrEMBL
  ENSRNOT00000116624.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  3.30.70.2760 UniProtKB/TrEMBL
  Hypothetical protein af1432 UniProtKB/TrEMBL
InterPro dGTPase UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  Metal-dep_PHydrolase_HD_sub UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed UniProtKB/TrEMBL
KEGG Report rno:311580 UniProtKB/TrEMBL
NCBI Gene 311580 ENTREZGENE
PANTHER DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE UniProtKB/TrEMBL
  DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 UniProtKB/TrEMBL
Pfam PF01966 UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PhenoGen Samhd1 PhenoGen
PROSITE PS51831 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006418 RatGTEx
SMART HDc UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
UniProt A0A8I6A3V5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACW3 ENTREZGENE, UniProtKB/TrEMBL
  A6JWR1 ENTREZGENE, UniProtKB/TrEMBL
  D3Z898 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Samhd1  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1  Samhd1  SAM domain and HD domain, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Samhd1  SAM domain and HD domain, 1   Samhd1_predicted  SAM domain and HD domain, 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Samhd1_predicted  SAM domain and HD domain, 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED