Htra3 (HtrA serine peptidase 3) - Rat Genome Database

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Gene: Htra3 (HtrA serine peptidase 3) Rattus norvegicus
Analyze
Symbol: Htra3
Name: HtrA serine peptidase 3
RGD ID: 1308120
Description: Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; and proteolysis. Predicted to be located in extracellular region. Orthologous to human HTRA3 (HtrA serine peptidase 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: high-temperature requirement factor A3; LOC360959; pregnancy-related serine protease; probable serine protease HTRA3; RGD1308120; serine protease HTRA3; similar to toll-associated serine protease
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,293,535 - 79,321,936 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,293,541 - 79,321,936 (+)EnsemblGRCr8
mRatBN7.21475,068,917 - 75,097,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,068,917 - 75,097,315 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,510,244 - 79,538,637 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,751,106 - 80,779,496 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,196,098 - 77,224,488 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,248,140 - 80,276,534 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,248,140 - 80,276,534 (+)Ensemblrn6Rnor6.0
Rnor_5.01479,875,405 - 79,903,558 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,702,016 - 80,730,742 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,999,661 - 74,027,836 (+)NCBICelera
RGSC_v3.11480,704,572 - 80,732,620 (+)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
cantharidin  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
choline  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fipronil  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
glucose  (ISO)
hexadecanoic acid  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
mercaptopurine  (EXP)
methapyrilene  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
purine-6-thiol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15206957   PMID:18387192   PMID:22229724   PMID:26110759   PMID:35764130  


Genomics

Comparative Map Data
Htra3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,293,535 - 79,321,936 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1479,293,541 - 79,321,936 (+)EnsemblGRCr8
mRatBN7.21475,068,917 - 75,097,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,068,917 - 75,097,315 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,510,244 - 79,538,637 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,751,106 - 80,779,496 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,196,098 - 77,224,488 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,248,140 - 80,276,534 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,248,140 - 80,276,534 (+)Ensemblrn6Rnor6.0
Rnor_5.01479,875,405 - 79,903,558 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,702,016 - 80,730,742 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,999,661 - 74,027,836 (+)NCBICelera
RGSC_v3.11480,704,572 - 80,732,620 (+)NCBI
Cytogenetic Map14q21NCBI
HTRA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3848,269,754 - 8,307,098 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl48,269,749 - 8,307,110 (+)Ensemblhg38GRCh38
GRCh3748,271,481 - 8,308,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3648,322,392 - 8,359,734 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3448,389,562 - 8,426,901NCBI
Celera48,163,395 - 8,202,090 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef48,191,265 - 8,229,449 (+)NCBIHuRef
CHM1_148,269,374 - 8,307,228 (+)NCBICHM1_1
T2T-CHM13v2.048,248,531 - 8,287,062 (+)NCBIT2T-CHM13v2.0
Htra3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,809,370 - 35,837,157 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,809,367 - 35,837,126 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38535,652,026 - 35,679,813 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,652,023 - 35,679,782 (-)Ensemblmm10GRCm38
MGSCv37535,994,682 - 36,022,431 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36535,968,902 - 35,996,426 (-)NCBIMGSCv36mm8
Celera533,125,477 - 33,153,277 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map518.49NCBI
Htra3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,717,290 - 2,737,288 (-)Ensembl
ChiLan1.0NW_0049555142,716,448 - 2,740,590 (-)NCBIChiLan1.0ChiLan1.0
HTRA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v238,555,658 - 8,594,262 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan148,482,892 - 8,521,742 (+)NCBINHGRI_mPanPan1
PanPan1.148,335,529 - 8,374,509 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl48,335,529 - 8,374,510 (+)EnsemblpanPan2panpan1.1
HTRA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,081,087 - 60,111,847 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,081,087 - 60,111,170 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha362,729,083 - 62,759,944 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0360,553,415 - 60,587,493 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl360,553,106 - 60,586,818 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,048,935 - 60,079,759 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0360,252,174 - 60,283,033 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0360,610,012 - 60,640,894 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Htra3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,923,787 - 65,960,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647719,646,047 - 19,661,632 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647719,625,479 - 19,662,532 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTRA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,793,799 - 2,820,184 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.182,794,780 - 2,819,686 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.284,457,177 - 4,482,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTRA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12744,214,635 - 44,252,673 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2744,214,874 - 44,252,732 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666051545,096 - 583,900 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htra3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,951,134 - 23,969,774 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475523,950,972 - 23,969,700 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Htra3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11169,399,183 - 69,417,781 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Htra3
201 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:271
Count of miRNA genes:156
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000010852, ENSRNOT00000050993, ENSRNOT00000073624
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH136858  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,097,022 - 75,097,237 (+)MAPPERmRatBN7.2
Rnor_6.01480,276,242 - 80,276,456NCBIRnor6.0
Rnor_5.01479,903,266 - 79,903,480UniSTSRnor5.0
RGSC_v3.41480,730,452 - 80,730,666UniSTSRGSC3.4
Celera1474,027,544 - 74,027,758UniSTS
Cytogenetic Map14q21UniSTS
AA800135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,090,287 - 75,090,462 (+)MAPPERmRatBN7.2
Rnor_6.01480,269,507 - 80,269,681NCBIRnor6.0
Rnor_5.01479,896,531 - 79,896,705UniSTSRnor5.0
RGSC_v3.41480,723,717 - 80,723,891UniSTSRGSC3.4
Celera1474,020,809 - 74,020,983UniSTS
RH 3.4 Map14455.57UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 91 59 6 353 191 11 141 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010852   ⟹   ENSRNOP00000010852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,293,541 - 79,321,936 (+)Ensembl
mRatBN7.2 Ensembl1475,068,917 - 75,097,315 (+)Ensembl
Rnor_6.0 Ensembl1480,248,140 - 80,276,534 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103981   ⟹   ENSRNOP00000093047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1479,293,541 - 79,311,846 (+)Ensembl
mRatBN7.2 Ensembl1475,068,917 - 75,087,464 (+)Ensembl
RefSeq Acc Id: NM_001271027   ⟹   NP_001257956
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,293,541 - 79,321,936 (+)NCBI
mRatBN7.21475,068,917 - 75,097,315 (+)NCBI
Rnor_6.01480,248,140 - 80,276,534 (+)NCBI
Rnor_5.01479,875,405 - 79,903,558 (+)NCBI
Celera1473,999,661 - 74,027,836 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599315   ⟹   XP_017454804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,293,535 - 79,317,800 (+)NCBI
mRatBN7.21475,068,922 - 75,093,196 (+)NCBI
Rnor_6.01480,248,145 - 80,267,238 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001257956   ⟸   NM_001271027
- Peptide Label: precursor
- UniProtKB: D3ZLW3 (UniProtKB/Swiss-Prot),   D3ZA76 (UniProtKB/Swiss-Prot),   A6IJZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454804   ⟸   XM_017599315
- Peptide Label: isoform X1
- UniProtKB: D3ZA76 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010852   ⟸   ENSRNOT00000010852
Ensembl Acc Id: ENSRNOP00000093047   ⟸   ENSRNOT00000103981
Protein Domains
IGFBP N-terminal   Kazal-like   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZA76-F1-model_v2 AlphaFold D3ZA76 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699388
Promoter ID:EPDNEW_R9913
Type:initiation region
Name:Htra3_1
Description:HtrA serine peptidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01480,248,169 - 80,248,229EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308120 AgrOrtholog
BioCyc Gene G2FUF-15327 BioCyc
Ensembl Genes ENSRNOG00000008182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010852 ENTREZGENE
  ENSRNOT00000010852.9 UniProtKB/Swiss-Prot
  ENSRNOT00000103981 ENTREZGENE
  ENSRNOT00000103981.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  2.40.10.120 UniProtKB/Swiss-Prot
  3.30.60.30 UniProtKB/Swiss-Prot
  4.10.40.20 UniProtKB/Swiss-Prot
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  IGFBP-like UniProtKB/Swiss-Prot
  Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1C UniProtKB/Swiss-Prot
KEGG Report rno:360959 UniProtKB/Swiss-Prot
NCBI Gene 360959 ENTREZGENE
PANTHER SERINE PROTEASE FAMILY S1C HTRA-RELATED UniProtKB/Swiss-Prot
  SERINE PROTEASE HTRA3 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot
  Kazal_2 UniProtKB/Swiss-Prot
  PDZ_2 UniProtKB/Swiss-Prot
  Trypsin_2 UniProtKB/Swiss-Prot
PhenoGen Htra3 PhenoGen
PRINTS PROTEASES2C UniProtKB/Swiss-Prot
PROSITE IGFBP_N_2 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008182 RatGTEx
SMART KAZAL UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SM00121 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF50494 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A6IJZ1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZA76 ENTREZGENE
  D3ZLW3 ENTREZGENE
  HTRA3_RAT UniProtKB/Swiss-Prot
UniProt Secondary D3ZLW3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Htra3  HtrA serine peptidase 3   Htra3_predicted  HtrA serine peptidase 3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Htra3_predicted  HtrA serine peptidase 3 (predicted)  RGD1308120_predicted  similar to toll-associated serine protease (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308120_predicted  similar to toll-associated serine protease (predicted)  LOC360959_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360959_predicted  similar to toll-associated serine protease (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL