Plekhg3 (pleckstrin homology and RhoGEF domain containing G3) - Rat Genome Database

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Pathways
Gene: Plekhg3 (pleckstrin homology and RhoGEF domain containing G3) Rattus norvegicus
Analyze
Symbol: Plekhg3
Name: pleckstrin homology and RhoGEF domain containing G3
RGD ID: 1308089
Description: Predicted to enable actin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytosol. Orthologous to human PLEKHG3 (pleckstrin homology and RhoGEF domain containing G3); INTERACTS WITH bisphenol A; Cuprizon; diuron.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314249; pleckstrin homology domain containing, family G (with RhoGef domain) member 3; pleckstrin homology domain-containing family G member 3; RGD1308089; similar to common-site lymphoma leukemia guanine nucleotide exchange factor like (5N754)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,998,965 - 101,042,120 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6100,994,417 - 101,042,118 (+)EnsemblGRCr8
mRatBN7.2695,265,756 - 95,308,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,266,058 - 95,310,359 (+)EnsemblmRatBN7.2
Rnor_6.0699,612,993 - 99,655,753 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,625,306 - 99,655,362 (+)Ensemblrn6Rnor6.0
Rnor_5.06109,011,027 - 109,053,773 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4699,157,196 - 99,175,135 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera693,686,450 - 93,729,361 (+)NCBICelera
RGSC_v3.1699,113,163 - 99,177,734 (+)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Plekhg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,998,965 - 101,042,120 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6100,994,417 - 101,042,118 (+)EnsemblGRCr8
mRatBN7.2695,265,756 - 95,308,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,266,058 - 95,310,359 (+)EnsemblmRatBN7.2
Rnor_6.0699,612,993 - 99,655,753 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,625,306 - 99,655,362 (+)Ensemblrn6Rnor6.0
Rnor_5.06109,011,027 - 109,053,773 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4699,157,196 - 99,175,135 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera693,686,450 - 93,729,361 (+)NCBICelera
RGSC_v3.1699,113,163 - 99,177,734 (+)NCBI
Cytogenetic Map6q24NCBI
PLEKHG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,704,424 - 64,750,249 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,704,102 - 64,750,249 (+)Ensemblhg38GRCh38
GRCh371465,171,142 - 65,216,967 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,240,946 - 64,280,813 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341464,240,945 - 64,280,813NCBI
Celera1445,228,934 - 45,268,795 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,343,172 - 45,383,026 (+)NCBIHuRef
CHM1_11465,110,787 - 65,150,655 (+)NCBICHM1_1
T2T-CHM13v2.01458,912,267 - 58,958,084 (+)NCBIT2T-CHM13v2.0
Plekhg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,580,330 - 76,627,265 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,577,665 - 76,627,262 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381276,533,303 - 76,580,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,530,891 - 76,580,488 (+)Ensemblmm10GRCm38
MGSCv371277,634,547 - 77,680,026 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361277,452,422 - 77,497,882 (+)NCBIMGSCv36mm8
Celera1277,625,687 - 77,671,276 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Plekhg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,173,213 - 5,188,381 (-)Ensembl
ChiLan1.0NW_0049554665,172,603 - 5,212,518 (-)NCBIChiLan1.0ChiLan1.0
PLEKHG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,818,261 - 65,858,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11465,034,800 - 65,074,644 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,287,879 - 45,327,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11464,167,692 - 64,207,508 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1464,167,692 - 64,207,509 (+)EnsemblpanPan2panpan1.1
PLEKHG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1839,112,613 - 39,155,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl839,072,389 - 39,155,173 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha838,803,035 - 38,845,343 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0839,333,799 - 39,376,008 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,346,702 - 39,375,994 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,955,081 - 38,997,311 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0839,028,037 - 39,070,227 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,387,088 - 39,429,124 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plekhg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,777,084 - 65,817,714 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,398,397 - 8,414,006 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,373,985 - 8,414,616 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl788,764,471 - 88,810,994 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1788,764,476 - 88,810,996 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2795,145,099 - 95,191,598 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,915,817 - 41,955,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,938,514 - 41,955,834 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605330,085,138 - 30,127,544 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekhg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,274,662 - 36,321,826 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473436,274,053 - 36,321,809 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Plekhg3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1790,691,482 - 90,734,455 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plekhg3
193 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:81
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000008573, ENSRNOT00000008721
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6100704576101593851Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
AI463170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,278,643 - 95,278,778 (+)MAPPERmRatBN7.2
Rnor_6.0699,625,349 - 99,625,483NCBIRnor6.0
Rnor_5.06109,023,369 - 109,023,503UniSTSRnor5.0
RGSC_v3.4699,144,561 - 99,144,695UniSTSRGSC3.4
Celera693,699,073 - 93,699,207UniSTS
RH133516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,308,586 - 95,308,798 (+)MAPPERmRatBN7.2
Rnor_6.0699,655,388 - 99,655,599NCBIRnor6.0
Rnor_5.06109,053,408 - 109,053,619UniSTSRnor5.0
RGSC_v3.4699,174,502 - 99,174,713UniSTSRGSC3.4
Celera693,728,996 - 93,729,207UniSTS
RH 3.4 Map6672.4UniSTS
Cytogenetic Map6q24UniSTS
AW530059  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86101,000,900 - 101,001,051 (+)Marker Load Pipeline
mRatBN7.2695,267,723 - 95,267,875 (+)MAPPERmRatBN7.2
Rnor_6.0699,614,710 - 99,614,860NCBIRnor6.0
Rnor_5.06109,012,730 - 109,012,880UniSTSRnor5.0
RGSC_v3.4699,133,925 - 99,134,075UniSTSRGSC3.4
Celera693,688,164 - 93,688,315UniSTS
RH 3.4 Map6674.7UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039113273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008573   ⟹   ENSRNOP00000008573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6101,011,816 - 101,042,118 (+)Ensembl
mRatBN7.2 Ensembl695,278,637 - 95,310,359 (+)Ensembl
Rnor_6.0 Ensembl699,625,306 - 99,655,362 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095415   ⟹   ENSRNOP00000086263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,999,349 - 101,042,118 (+)Ensembl
mRatBN7.2 Ensembl695,290,825 - 95,310,359 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105013   ⟹   ENSRNOP00000097983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,999,349 - 101,042,118 (+)Ensembl
mRatBN7.2 Ensembl695,266,058 - 95,310,359 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143902   ⟹   ENSRNOP00000111983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,994,417 - 101,042,118 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156659   ⟹   ENSRNOP00000108696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6101,012,841 - 101,042,118 (+)Ensembl
RefSeq Acc Id: XM_017594464   ⟹   XP_017449953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,658 - 101,042,120 (+)NCBI
mRatBN7.2695,277,826 - 95,308,952 (+)NCBI
Rnor_6.0699,638,043 - 99,655,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594465   ⟹   XP_017449954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,658 - 101,042,120 (+)NCBI
mRatBN7.2695,277,825 - 95,308,952 (+)NCBI
Rnor_6.0699,623,384 - 99,655,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594466   ⟹   XP_017449955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,998,965 - 101,042,120 (+)NCBI
mRatBN7.2695,265,757 - 95,308,952 (+)NCBI
Rnor_6.0699,612,993 - 99,655,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594469   ⟹   XP_017449958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,657 - 101,042,120 (+)NCBI
mRatBN7.2695,277,825 - 95,308,952 (+)NCBI
Rnor_6.0699,638,043 - 99,655,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594471   ⟹   XP_017449960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,658 - 101,042,120 (+)NCBI
mRatBN7.2695,277,825 - 95,308,952 (+)NCBI
Rnor_6.0699,638,043 - 99,655,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594472   ⟹   XP_017449961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,661 - 101,042,120 (+)NCBI
mRatBN7.2695,277,827 - 95,308,952 (+)NCBI
Rnor_6.0699,638,043 - 99,655,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594473   ⟹   XP_017449962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,027,076 - 101,042,120 (+)NCBI
mRatBN7.2695,293,970 - 95,308,952 (+)NCBI
Rnor_6.0699,640,829 - 99,655,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039113273   ⟹   XP_038969201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,659 - 101,042,120 (+)NCBI
mRatBN7.2695,277,826 - 95,308,952 (+)NCBI
RefSeq Acc Id: XM_063262761   ⟹   XP_063118831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,658 - 101,042,120 (+)NCBI
RefSeq Acc Id: XM_063262762   ⟹   XP_063118832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,998,967 - 101,042,120 (+)NCBI
RefSeq Acc Id: XM_063262763   ⟹   XP_063118833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,998,969 - 101,042,120 (+)NCBI
RefSeq Acc Id: XM_063262764   ⟹   XP_063118834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,999,660 - 101,042,120 (+)NCBI
RefSeq Acc Id: XM_063262765   ⟹   XP_063118835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,998,967 - 101,042,120 (+)NCBI
RefSeq Acc Id: XM_063262766   ⟹   XP_063118836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,998,969 - 101,042,120 (+)NCBI
RefSeq Acc Id: XP_017449955   ⟸   XM_017594466
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449954   ⟸   XM_017594465
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449958   ⟸   XM_017594469
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449953   ⟸   XM_017594464
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449960   ⟸   XM_017594471
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449961   ⟸   XM_017594472
- Peptide Label: isoform X7
- UniProtKB: D3ZA21 (UniProtKB/TrEMBL),   A0A8I6A394 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449962   ⟸   XM_017594473
- Peptide Label: isoform X13
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008573   ⟸   ENSRNOT00000008573
RefSeq Acc Id: XP_038969201   ⟸   XM_039113273
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097983   ⟸   ENSRNOT00000105013
Ensembl Acc Id: ENSRNOP00000086263   ⟸   ENSRNOT00000095415
RefSeq Acc Id: XP_063118832   ⟸   XM_063262762
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118835   ⟸   XM_063262765
- Peptide Label: isoform X11
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118833   ⟸   XM_063262763
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063118836   ⟸   XM_063262766
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063118831   ⟸   XM_063262761
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118834   ⟸   XM_063262764
- Peptide Label: isoform X10
- UniProtKB: A0A8I6A394 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108696   ⟸   ENSRNOT00000156659
Ensembl Acc Id: ENSRNOP00000111983   ⟸   ENSRNOT00000143902
Protein Domains
DH   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZA21-F1-model_v2 AlphaFold D3ZA21 1-1368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308089 AgrOrtholog
BioCyc Gene G2FUF-37052 BioCyc
Ensembl Genes ENSRNOG00000006570 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008573 ENTREZGENE
  ENSRNOT00000008573.9 UniProtKB/TrEMBL
  ENSRNOT00000095415.2 UniProtKB/TrEMBL
  ENSRNOT00000105013 ENTREZGENE
  ENSRNOT00000105013.2 UniProtKB/TrEMBL
  ENSRNOT00000143902.1 UniProtKB/TrEMBL
  ENSRNOT00000156659 ENTREZGENE
  ENSRNOT00000156659.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH_PLEKHG1_G2_G3 UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
NCBI Gene 314249 ENTREZGENE
PANTHER FI17866P1 UniProtKB/TrEMBL
  PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 3 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Plekhg3 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006570 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A8I6A394 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATN8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LLV4_RAT UniProtKB/TrEMBL
  A0ABK0LYG0_RAT UniProtKB/TrEMBL
  D3ZA21 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Plekhg3  pleckstrin homology and RhoGEF domain containing G3  Plekhg3  pleckstrin homology domain containing, family G (with RhoGef domain) member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Plekhg3  pleckstrin homology domain containing, family G (with RhoGef domain) member 3  RGD1308089_predicted  similar to common-site lymphoma leukemia guanine nucleotide exchange factor like (5N754) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308089_predicted  similar to common-site lymphoma leukemia guanine nucleotide exchange factor like (5N754) (predicted)  LOC314249_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314249_predicted  similar to common-site lymphoma leukemia guanine nucleotide exchange factor like (5N754) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL