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Gene: Sim2 (SIM bHLH transcription factor 2) Rattus norvegicus

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Symbol:

Sim2

Name:

SIM bHLH transcription factor 2

RGD ID:

1308016

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic pattern specification; lung development; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human SIM2 (SIM bHLH transcription factor 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; acrylamide; aldehydo-D-glucose.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC304071; single-minded 2; single-minded family bHLH transcription factor 2; single-minded homolog 2; single-minded homolog 2 (Drosophila)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIM2 (SIM bHLH transcription factor 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Sim2 (single-minded family bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sim2 (SIM bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIM2 (SIM bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIM2 (SIM bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIM2 (SIM bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIM2 (SIM bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sim2 (SIM bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sim2 (SIM bHLH transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SIM2 (SIM bHLH transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sim2 (single-minded family bHLH transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sim2 (SIM bHLH transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	hif-1	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hlh-34	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hlh-34	Alliance	DIOPT (InParanoid\|OrthoFinder\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sim	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sim2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	sim2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	46,883,859 - 46,923,305 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	46,883,859 - 46,923,305 (+)	Ensembl				GRCr8
mRatBN7.2	11	33,414,218 - 33,453,663 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	33,414,218 - 33,453,663 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	42,068,577 - 42,108,000 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	34,739,947 - 34,779,371 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	33,888,780 - 33,928,229 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	34,315,739 - 34,355,183 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	34,316,295 - 34,354,027 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	37,902,943 - 37,942,470 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	34,335,645 - 34,376,925 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	34,996,179 - 35,035,627 (-)	NCBI		Celera
RGSC_v3.1	11	34,392,956 - 34,432,046 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cleft palate (ISO)

Craniofacial Abnormalities (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (EXP)

alpha-Zearalanol (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlorpyrifos (EXP)

choline (ISO)

cisplatin (ISO)

clozapine (ISO)

cocaine (EXP)

CU-O LINKAGE (ISO)

curcumin (EXP)

D-glucose (EXP)

dibenzofuran (EXP)

dorsomorphin (ISO)

ethylparaben (ISO)

folic acid (ISO)

fulvestrant (ISO)

geraniol (ISO)

glucose (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

nickel atom (ISO)

perfluorooctanoic acid (EXP)

potassium chromate (ISO)

retinyl acetate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

streptozocin (EXP)

testosterone (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

DNA-templated transcription (IEA)

embryonic pattern specification (ISO)

lung development (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

nervous system development (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

system development (IEA)

tube development (IEA)

Cellular Component

nuclear body (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (ISO)

protein dimerization activity (IEA)

protein heterodimerization activity (IEA,ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8927054	PMID:11782478	PMID:12024028	PMID:14701734	PMID:23333261	PMID:25319570

Genomics

Comparative Map Data

Sim2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	46,883,859 - 46,923,305 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	46,883,859 - 46,923,305 (+)	Ensembl				GRCr8
mRatBN7.2	11	33,414,218 - 33,453,663 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	33,414,218 - 33,453,663 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	42,068,577 - 42,108,000 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	34,739,947 - 34,779,371 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	33,888,780 - 33,928,229 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	34,315,739 - 34,355,183 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	34,316,295 - 34,354,027 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	37,902,943 - 37,942,470 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	34,335,645 - 34,376,925 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	34,996,179 - 35,035,627 (-)	NCBI		Celera
RGSC_v3.1	11	34,392,956 - 34,432,046 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

SIM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	36,699,115 - 36,749,917 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	36,699,115 - 36,749,917 (+)	Ensembl			hg38	GRCh38
GRCh37	21	38,071,415 - 38,122,218 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	36,993,861 - 37,044,088 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	36,993,860 - 37,040,483	NCBI
Celera	21	23,270,361 - 23,320,891 (+)	NCBI		Celera
Cytogenetic Map	21	q22.13	ENTREZGENE
HuRef	21	23,547,929 - 23,598,327 (+)	NCBI		HuRef
CHM1_1	21	37,633,195 - 37,683,684 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	35,081,302 - 35,132,110 (+)	NCBI		T2T-CHM13v2.0

Sim2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	93,885,963 - 93,927,891 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	93,885,790 - 93,927,891 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	94,085,104 - 94,127,032 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	94,084,931 - 94,127,032 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	94,085,505 - 94,348,638 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	93,973,471 - 94,236,925 (+)	NCBI		MGSCv36	mm8
Celera	16	95,171,465 - 95,213,526 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	55.05	NCBI

Sim2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	35,828,250 - 35,867,620 (+)	Ensembl
ChiLan1.0	NW_004955407	35,828,250 - 35,869,067 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	32,811,175 - 32,864,472 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	27,671,481 - 27,720,202 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	23,060,640 - 23,109,496 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	36,415,945 - 36,462,339 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

SIM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	31,879,483 - 31,929,531 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	31,879,360 - 31,930,359 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	30,940,849 - 30,994,549 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	31,182,551 - 31,236,268 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	31,182,291 - 31,234,643 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	31,050,827 - 31,104,585 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	31,063,591 - 31,118,290 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	31,553,961 - 31,607,783 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

SIM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	200,355,407 - 200,403,247 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	200,354,963 - 200,408,890 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	210,439,397 - 210,483,094 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	80,680,061 - 80,730,331 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	80,680,678 - 80,725,951 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	8,522,886 - 8,570,977 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sim2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	26,852,980 - 26,891,176 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	26,851,423 - 26,891,590 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sim2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	50,512,036 - 50,551,269 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sim2
218 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	175
Count of miRNA genes:	120
Interacting mature miRNAs:	147
Transcripts:	ENSRNOT00000002294
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	46443168	91443168	Rat
1598841	Memor7	Memory QTL 7			exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	11	33306008	78306008	Rat
1598842	Glom10	Glomerulus QTL 10	3.4		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	3818154	48818154	Rat
1598811	Bp291	Blood pressure QTL 291	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	33306008	78306008	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	10806125	55806125	Rat
634341	Bw121	Body weight QTL 121	3.56		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	11	35323199	55805892	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	29958996	57754989	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	31915469	76915469	Rat
2290451	Scl58	Serum cholesterol level QTL 58	3.48		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	11	26318031	55806125	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	36428416	81428416	Rat
1600394	Edcs1	Endometrial carcinoma susceptibility QTL1	2.9	0.04	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	11	12823152	57823152	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	34618760	79618760	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	36749459	81749459	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	36749459	81749459	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
631510	Spl2	Serum phospholipid level QTL 2	4.1		blood phospholipid amount (VT:0006084)	serum phospholipid level (CMO:0001171)	11	27556685	72556685	Rat

Markers in Region

RH138072

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	33,453,357 - 33,453,487 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	34,354,878 - 34,355,007	NCBI	Rnor6.0
Rnor_5.0	11	37,942,167 - 37,942,296	UniSTS	Rnor5.0
RGSC_v3.4	11	34,376,624 - 34,376,753	UniSTS	RGSC3.4
Celera	11	34,996,355 - 34,996,484	UniSTS
Cytogenetic Map	11	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	13	46	138	53	52	21	112	21	5	350	201	21	114	111	92	31	19	19

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000081834 ⟹ ENSRNOP00000069809

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	46,883,859 - 46,923,305 (+)	Ensembl
mRatBN7.2 Ensembl	11	33,414,218 - 33,453,663 (+)	Ensembl
Rnor_6.0 Ensembl	11	34,316,295 - 34,354,027 (+)	Ensembl

RefSeq Acc Id:

NM_001107108 ⟹ NP_001100578

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	46,883,859 - 46,923,305 (+)	NCBI
mRatBN7.2	11	33,414,218 - 33,453,663 (+)	NCBI
Rnor_6.0	11	34,315,739 - 34,355,183 (+)	NCBI
Rnor_5.0	11	37,902,943 - 37,942,470 (+)	NCBI
RGSC_v3.4	11	34,335,645 - 34,376,925 (+)	RGD
Celera	11	34,996,179 - 35,035,627 (-)	NCBI

Sequence:

show sequence

GCCACCGATCGCGGGCTCCGGTCGCCCGGGCTAAGGAAGCAGAACCGCCGAGGAGGGCAGAAGA
GCGCACCGAGCTCAAGCTCGGCTCCAGTCACTGCCACCTCGCTCCGCTCCCGCCCCATGGCTCC
GCGGCGGCCGCCGCCGCTGCCGCCCTTGCCTTCCGAGGGCCCTCGCCGCAGCGGGTAAAAACCC
TCCTTTAAGGACTAAACAGTGTCGCCGACTGCTCGCCTGCCAACCATAGCCCCAGGAAGGTCGG
GGCCCGAGATACCGGAGGCGAGGAGAGCGAGCAGGAAGCAGGTCCACACCGGACTGTCCATCCT
CCAGCCTCAGGCAGAGAGCAGGGCTGCGCAACGGGTTTGCGACGGACTCAGGGCTGGCGCCCGT
GCAGAAACCGTTGGGTGCTCCAGGCCCCGTCCCCCGCACCTGCCCGAGCCCGGCACCCCCCCGA
CTCACCTGACCCCTGGCGTCCCCGTCCCCATCCCGGCTGCCGCAGCCCAAGCGGGACTCCGCGG
GCCTGGAGCGCAGCGAGGTCTAATATGCCCAGAGCCGAGGCGCGATGAAGGAGAAGTCCAAAAA
TGCGGCCAAAACCAGGAGGGAGAAGGAAAATGGCGAGTTTTACGAGCTGGCCAAGCTGCTCCCG
CTGCCTTCGGCCATCACCTCGCAGCTGGACAAAGCTTCCATCATCCGGCTCACCACCAGCTACC
TGAAGATGCGCGCAGTCTTCCCGGAAGGTCTAGGAGATGCGTGGGGACAGCCGAGCAGAACAGG
GCCTCTGGACAGCGTGGCCAAAGAACTAGGATCCCATTTGCTGCAGACTCTAGATGGATTTGTG
TTTGTGGTGGCCTCTGATGGCAAAATCATGTATATATCGGAGACCGCTTCTGTCCATTTAGGCT
TGTCCCAGGTGGAGCTCACAGGCAACAGTATTTACGAATACATCCATCCTTCTGACCACGACGA
GATGACAGCAGTACTGACGGCCCACCCACCGCTCCACCATCACCTGCTCCAAGAGTACGAGATA
GAGCGGTCTTTCTTTCTCCGAATGAAGTGCGTCTTGGCAAAAAGAAATGCAGGCCTGACGTGCA
GTGGATACAAGGTCATTCACTGCAGTGGCTACTTAAAGATCAGGCAGTACATGCTGGACATGTC
CCTGTATGACTCCTGTTACCAGATTGTGGGGCTGGTGGCCGTGGGCCAGTCGCTGCCACCCAGC
GCCATCACGGAGATCAAACTCCACAACAATATGTTCATGTTCAGAGCCAGCCTCGACCTGAAGC
TCATCTTCCTGGATTCCAGGGTGACAGAGCTTACCGGCTATGAGCCACAGGACCTGATTGAAAA
AACACTCTACCATCATGTGCACGGCTGTGACACCTTCCACCTCCGCTATGCACACCACCTCTTG
CTTGTGAAGGGCCAGGTCACCACCAAATACTACCGGCTGCTTTCAAAGCTGGGCGGCTGGGTCT
GGGTGCAGAGCTACGCCACCGTGGTGCACAACAGCCGTTCCTCCCGGCCTCACTGCATCGTGAG
TGTCAATTATGTTCTCACGGAGGTCGAATACAAGGAACTTCAGCTCTCTCTGGACCAGGTATCC
ACCTCTAAGTCCCAGGAGTCCTGGAGAACCACCTTGTCTACCTCACAAGAAACTAGGAAATCAG
CTAAACCCAAAACCACGAAGATGAGGACAAAGCTGAGAACCAACCCATATCCCTCACAGCAATA
CAGCTCGTTCCAAATGGACAAACTGGAGTGCAGCCAGGCGGGAAACTGGAGAACGAGTCCCCCC
ACAAGTGCTGTGGCTCCCCCGGAACAGCAGCTCCATTCAGAAGCCAGCGACCTTTTATATGGGC
CGCCCTACAGCCTCCCCTTCTCCTACCGTTACGGACACTTCCCCCTGGACTCTCATGTCTTCAG
CAGCAAGAAGCCAGGACTGCCCGCCAAGTTCGGGCAGCCCCAAGGATCCCCGTGTGAGGTGGCA
CGCTTTTTCCTGAGCACACTGCCAGCCAGCAGCGAGTGCCAGTGGCATTATGCCAACTCCCTCA
TGCCCAGCAGCCCTTCACCAGCTAAAAACCTTTCTGAGTCTCCTGTGAATGCTGCCCGGCATGG
ACTTGTGCCAAACTATGAAGCGCCCGCCGCCACCGCGCGCAGGTTCGGCGAGGACCCCGCACCC
TCAAGCTTCCCGAGCTGCGGCCACTACCGCGAGGAGCCGACGCTGGGCTCCGCCAAGGCAGCTC
GCCAGGCGTCCCGGGACACAGCCCGACTGGCGCTGGCCCGAGCGACCCCCGAGTGCTGCGCGCC
GCCGGCCCCCGAGCCACAGGCGCCGGCGCAGCTGCCCTTCGTGCTGCTCAACTACCACCGCGTG
CTGGCGCGCCGCGGGCCGCTGGGGAGCGCTGCGCCCGGAGCTCCGGAGGCGGCCGGCTCGCTGC
GGCCCCGACACCCGGGCCCGGTCGCAGCCTCTGCACCCGGCGCGCCCCGGCCACACTACCTGGG
CGCCTCGGTCATCATCACCAACGGCAGGTGACCCGCCAGGGCCGGTCCCGCAGGGCGGCCCACA
AGGGAGAAGCCATAGACCAGGCCTTCTCTGGTTCCTTTTTCACCCCCAAGGTCCAGCAGATGGA
GGGGCGAACTGTATATGCACGATATAAATTAATTTATACAGAGACAACTATTTTAATAGAACTC
CGCAGCCGTCTTTTAGATTTTTACCGTAGATGCCGGTGTAGAGGGTTGGTACTCAGTTGGAGGA
GGACGGGGAGAAGGGACTGACGCCCATCCTTGTCACCAAGGGCCAGTTTTTATGGGGCTGAGCA
TCCGGATGTCAACCTGTGACCTCAAACTGCTATTTCCAGAGTTCTTGGTTTCCTCACCATGAAG
CCAATCAAGCCGAGGTCCAATAATGGGGATTCAAGACAATGCATGCAGCTTGGCAGACGGATGC
CACTTTAAGCTCCAACCCCGTCCCCCACCCCCAGTGGTCCTCTGTTCCCAGGTTGAGACAGGGT
GGAAAGTCCCTTCGGAGTCCTTCTGGACACTTGTAAACGCAAAATGTTATCCTTGTAAGTCCCA
CGAGCAGACAACAGTTTCTGCTGTCTTTGAACTCATGCATCTCATTTTAAAATCCAATCCTTCT
AAAAATACAAAAGCCAACAAGCCGAGGCTGAGGAGGCGAATGTGCAAGACTATTGTGTGAGTGG
ACATGGGTGTGCTTCAGAAGCACATTAACAAGCTCGCTCGTAACTGAGCCCTTAGGAACTGGTT
GACACCCACATGTTGCACCTTCAAAATATGAAGTAGGCATTAAATGCAAAAAGGATATATATAT
ATATATATATATACATATATAGCCAGGCATGTTAGAGAATGGCTCTGTCAAGTGTAATTCCCTG
GCCACATCCTTCCAGCCCACACAGACCTGCTCGTGTCCTACGCTTGTATTTGCTTGCAAGTAGG
AACTACTAAAGCTAGTTAAATTGCATGTGCAATACGGAAACCGGAGCAGACCGCACCTTGTGGA
AGAAAAACAGGCTTAAGGGATGTAAGGAAAGAGGTGTATACATTTAAGCGTTTTCTACACAGCA
AGAGCTTCATACGAACATGTGTGTAACAGGTGAATGGAGACTCTTTTTATAAACTTACCAGCAG
TGTTTAAAAATAAACTCCATTACTTTTCTTTCACA

hide sequence

RefSeq Acc Id:

XM_063270582 ⟹ XP_063126652

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	46,900,535 - 46,923,305 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100578	(Get FASTA)	NCBI Sequence Viewer
	XP_063126652	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76725	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069809
	ENSRNOP00000069809.1

RefSeq Acc Id:

NP_001100578 ⟸ NM_001107108

- UniProtKB:

D4AA36 (UniProtKB/TrEMBL), A6KPY2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAW
GQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYI
HPSDHDEMTAVLTAHPPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIR
QYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHNNMFMFRASLDLKLIFLDSRVTELTGYE
PQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSS
RPHCIVSVNYVLTEVEYKELQLSLDQVSTSKSQESWRTTLSTSQETRKSAKPKTTKMRTKLRTN
PYPSQQYSSFQMDKLECSQAGNWRTSPPTSAVAPPEQQLHSEASDLLYGPPYSLPFSYRYGHFP
LDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHYANSLMPSSPSPAKNLSESP
VNAARHGLVPNYEAPAATARRFGEDPAPSSFPSCGHYREEPTLGSAKAARQASRDTARLALARA
TPECCAPPAPEPQAPAQLPFVLLNYHRVLARRGPLGSAAPGAPEAAGSLRPRHPGPVAASAPGA
PRPHYLGASVIITNGR

hide sequence

Ensembl Acc Id:

ENSRNOP00000069809 ⟸ ENSRNOT00000081834

RefSeq Acc Id:	XP_063126652 ⟸ XM_063270582
- Peptide Label:	isoform X1

Protein Domains

bHLH PAS Single-minded C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AA36-F1-model_v2	AlphaFold	D4AA36	1-656	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308016	AgrOrtholog
BioCyc Gene	G2FUF-21776	BioCyc
Ensembl Genes	ENSRNOG00000054203	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081834	ENTREZGENE
	ENSRNOT00000081834.3	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
	PAS domain	UniProtKB/TrEMBL
InterPro	HLH_DNA-bd	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
	PAC	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
	PAS-like_dom_sf	UniProtKB/TrEMBL
	PAS_fold	UniProtKB/TrEMBL
	PAS_fold_3	UniProtKB/TrEMBL
	SIM_C	UniProtKB/TrEMBL
KEGG Report	rno:304071	UniProtKB/TrEMBL
NCBI Gene	304071	ENTREZGENE
PANTHER	HYPOXIA-INDUCIBLE FACTOR 1 ALPHA	UniProtKB/TrEMBL
	SINGLE-MINDED HOMOLOG 2	UniProtKB/TrEMBL
Pfam	bHLH_HIF1A	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
	PAS_3	UniProtKB/TrEMBL
	SIM_C	UniProtKB/TrEMBL
PhenoGen	Sim2	PhenoGen
PROSITE	HLH	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
	SIM_C	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000054203	RatGTEx
SMART	HLH	UniProtKB/TrEMBL
	PAC	UniProtKB/TrEMBL
	PAS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
	SSF55785	UniProtKB/TrEMBL
UniProt	A6KPY2	ENTREZGENE, UniProtKB/TrEMBL
	D4AA36	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-04-27	Sim2	SIM bHLH transcription factor 2	Sim2	single-minded family bHLH transcription factor 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-11-11	Sim2	single-minded family bHLH transcription factor 2	Sim2	single-minded homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Sim2	single-minded homolog 2 (Drosophila)	Sim2_predicted	single-minded 2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Sim2_predicted	single-minded 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD