Aff1 (ALF transcription elongation factor 1) - Rat Genome Database

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Gene: Aff1 (ALF transcription elongation factor 1) Rattus norvegicus
Analyze
Symbol: Aff1
Name: ALF transcription elongation factor 1
RGD ID: 1307940
Description: Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of super elongation complex. Orthologous to human AFF1 (ALF transcription elongation factor 1); PARTICIPATES IN RNA polymerase II transcription elongation pathway; INTERACTS WITH atrazine; bisphenol A; bisphenol AF.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AF4/FMR2 family member 1; AF4/FMR2 family, member 1; LOC305152; Mllt2; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,165,864 - 6,328,848 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl146,169,562 - 6,328,879 (-)EnsemblGRCr8
mRatBN7.2145,861,188 - 6,024,196 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,863,961 - 6,024,729 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx145,832,479 - 5,931,188 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,132,711 - 7,231,419 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,830,707 - 5,929,568 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,222,883 - 7,384,916 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,226,586 - 7,384,876 (-)Ensemblrn6Rnor6.0
Rnor_5.0147,212,805 - 7,353,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,015,191 - 7,114,671 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera146,003,631 - 6,102,711 (-)NCBICelera
RGSC_v3.1147,004,997 - 7,155,484 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
teratoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
malathion  (ISO)
manganese(II) chloride  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
ozone  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
potassium chromate  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thiram  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The super elongation complex (SEC) family in transcriptional control. Luo Z, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):543-7. doi: 10.1038/nrm3417. Epub 2012 Aug 16.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9365243   PMID:22195968  


Genomics

Comparative Map Data
Aff1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,165,864 - 6,328,848 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl146,169,562 - 6,328,879 (-)EnsemblGRCr8
mRatBN7.2145,861,188 - 6,024,196 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,863,961 - 6,024,729 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx145,832,479 - 5,931,188 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,132,711 - 7,231,419 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,830,707 - 5,929,568 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0147,222,883 - 7,384,916 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,226,586 - 7,384,876 (-)Ensemblrn6Rnor6.0
Rnor_5.0147,212,805 - 7,353,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4147,015,191 - 7,114,671 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera146,003,631 - 6,102,711 (-)NCBICelera
RGSC_v3.1147,004,997 - 7,155,484 (-)NCBI
Cytogenetic Map14p22NCBI
AFF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38486,935,011 - 87,141,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl486,934,237 - 87,141,073 (+)Ensemblhg38GRCh38
GRCh37487,856,163 - 88,062,191 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,147,177 - 88,281,215 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34488,285,318 - 88,419,369NCBI
Celera485,145,587 - 85,351,225 (+)NCBICelera
Cytogenetic Map4q21.3-q22.1NCBI
HuRef483,600,862 - 83,808,030 (+)NCBIHuRef
CHM1_1487,833,687 - 88,039,595 (+)NCBICHM1_1
T2T-CHM13v2.0490,264,015 - 90,470,100 (+)NCBIT2T-CHM13v2.0
Aff1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395103,840,307 - 104,003,188 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5103,840,240 - 104,003,188 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385103,692,362 - 103,855,322 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5103,692,374 - 103,855,322 (+)Ensemblmm10GRCm38
MGSCv375104,183,181 - 104,284,341 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365104,023,426 - 104,091,425 (+)NCBIMGSCv36mm8
Celera5101,059,857 - 101,161,382 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.45NCBI
Aff1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554742,751,809 - 2,896,311 (-)Ensembl
ChiLan1.0NW_0049554742,748,438 - 2,899,094 (-)NCBIChiLan1.0ChiLan1.0
AFF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2384,910,830 - 85,168,476 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,172,840 - 85,438,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,197,196 - 79,443,485 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1489,968,502 - 90,171,478 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl489,969,675 - 90,166,160 (+)EnsemblpanPan2panpan1.1
AFF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13210,430,159 - 10,631,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3210,430,090 - 10,632,172 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3231,326,682 - 31,523,790 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03210,453,888 - 10,679,293 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3210,453,810 - 10,678,879 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13210,564,467 - 10,761,370 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,391,189 - 10,588,764 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03229,366,225 - 29,563,373 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aff1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405285353,215 - 537,615 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493692043,338 - 227,522 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493692043,047 - 227,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,728,873 - 131,924,819 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18131,728,819 - 131,924,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28141,000,099 - 141,105,435 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1735,309,172 - 35,516,777 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl735,380,578 - 35,511,446 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603714,000,731 - 14,207,897 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aff1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248723,486,135 - 3,651,098 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248723,486,242 - 3,656,089 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aff1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11113,783,109 - 13,942,749 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aff1
1876 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:351
Count of miRNA genes:202
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000066071
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1439578789393298Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
D14Got10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,889,548 - 5,889,720 (+)MAPPERmRatBN7.2
Rnor_6.0147,251,239 - 7,251,410NCBIRnor6.0
Rnor_5.0147,241,163 - 7,241,334UniSTSRnor5.0
RGSC_v3.4147,040,107 - 7,040,278RGDRGSC3.4
RGSC_v3.4147,040,107 - 7,040,278UniSTSRGSC3.4
Celera146,028,327 - 6,028,498UniSTS
RGSC_v3.1147,040,107 - 7,040,278RGD
RH 3.4 Map14120.7RGD
RH 3.4 Map14120.7UniSTS
RH 2.0 Map14122.3RGD
Cytogenetic Map14p22UniSTS
D14Got11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,935,643 - 5,935,760 (+)MAPPERmRatBN7.2
Rnor_6.0147,297,320 - 7,297,436NCBIRnor6.0
Rnor_5.0147,286,982 - 7,287,098UniSTSRnor5.0
RGSC_v3.4147,086,074 - 7,086,190RGDRGSC3.4
RGSC_v3.4147,086,075 - 7,086,191UniSTSRGSC3.4
Celera146,074,392 - 6,074,510UniSTS
RGSC_v3.1147,086,074 - 7,086,190RGD
RH 3.4 Map14102.7RGD
RH 3.4 Map14102.7UniSTS
Cytogenetic Map14p22UniSTS
BE119930  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,927,218 - 5,927,376 (+)MAPPERmRatBN7.2
Rnor_6.0147,288,901 - 7,289,058NCBIRnor6.0
Rnor_5.0147,278,561 - 7,278,718UniSTSRnor5.0
RGSC_v3.4147,077,654 - 7,077,811UniSTSRGSC3.4
Celera146,065,959 - 6,066,116UniSTS
RH 3.4 Map14114.9UniSTS
Cytogenetic Map14p22UniSTS
Aff1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,930,027 - 5,931,624 (+)MAPPERmRatBN7.2
Rnor_6.0147,291,709 - 7,293,305NCBIRnor6.0
Rnor_5.0147,281,371 - 7,282,967UniSTSRnor5.0
RGSC_v3.4147,080,464 - 7,082,060UniSTSRGSC3.4
Celera146,068,765 - 6,070,358UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 82 205 91 90 59 149 59 6 481 274 22 183 117 122 31 29 29

Sequence


Ensembl Acc Id: ENSRNOT00000066071   ⟹   ENSRNOP00000062389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl146,169,562 - 6,328,879 (-)Ensembl
mRatBN7.2 Ensembl145,864,886 - 6,024,729 (-)Ensembl
Rnor_6.0 Ensembl147,226,586 - 7,325,645 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086694   ⟹   ENSRNOP00000071392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl146,169,562 - 6,268,613 (-)Ensembl
mRatBN7.2 Ensembl145,864,886 - 5,963,951 (-)Ensembl
Rnor_6.0 Ensembl147,227,224 - 7,384,876 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100672   ⟹   ENSRNOP00000085398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,864,853 - 5,964,314 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101670   ⟹   ENSRNOP00000096227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl146,169,562 - 6,269,056 (-)Ensembl
mRatBN7.2 Ensembl145,864,886 - 5,931,751 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107578   ⟹   ENSRNOP00000096010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,863,961 - 5,964,314 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116173   ⟹   ENSRNOP00000096988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,864,886 - 5,931,918 (-)Ensembl
RefSeq Acc Id: NM_001107206   ⟹   NP_001100676
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,169,562 - 6,268,613 (-)NCBI
mRatBN7.2145,864,886 - 5,963,951 (-)NCBI
Rnor_6.0147,226,586 - 7,325,645 (-)NCBI
Rnor_5.0147,212,805 - 7,353,561 (-)NCBI
RGSC_v3.4147,015,191 - 7,114,671 (-)RGD
Celera146,003,631 - 6,102,711 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250632   ⟹   XP_006250694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,165,864 - 6,328,848 (-)NCBI
mRatBN7.2145,865,426 - 6,024,196 (-)NCBI
Rnor_6.0147,222,883 - 7,384,916 (-)NCBI
Rnor_5.0147,212,805 - 7,353,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250633   ⟹   XP_006250695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,165,864 - 6,269,037 (-)NCBI
mRatBN7.2145,865,426 - 5,964,376 (-)NCBI
Rnor_6.0147,226,586 - 7,326,034 (-)NCBI
Rnor_5.0147,212,805 - 7,353,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091821   ⟹   XP_038947749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,165,864 - 6,268,749 (-)NCBI
mRatBN7.2145,861,188 - 5,964,089 (-)NCBI
RefSeq Acc Id: NP_001100676   ⟸   NM_001107206
- UniProtKB: A6K5U8 (UniProtKB/TrEMBL),   A0A0G2K0C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250694   ⟸   XM_006250632
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006250695   ⟸   XM_006250633
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000062389   ⟸   ENSRNOT00000066071
Ensembl Acc Id: ENSRNOP00000071392   ⟸   ENSRNOT00000086694
RefSeq Acc Id: XP_038947749   ⟸   XM_039091821
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096227   ⟸   ENSRNOT00000101670
Ensembl Acc Id: ENSRNOP00000096010   ⟸   ENSRNOT00000107578
Ensembl Acc Id: ENSRNOP00000085398   ⟸   ENSRNOT00000100672
Ensembl Acc Id: ENSRNOP00000096988   ⟸   ENSRNOT00000116173
Protein Domains
AF4/FMR2 C-terminal homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0C8-F1-model_v2 AlphaFold A0A0G2K0C8 1-1223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699184
Promoter ID:EPDNEW_R9704
Type:initiation region
Name:Aff1_1
Description:AF4/FMR2 family, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0147,384,887 - 7,384,947EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307940 AgrOrtholog
BioCyc Gene G2FUF-16488 BioCyc
Ensembl Genes ENSRNOG00000002232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066071 ENTREZGENE
  ENSRNOT00000066071.4 UniProtKB/TrEMBL
  ENSRNOT00000086694 ENTREZGENE
  ENSRNOT00000086694.3 UniProtKB/TrEMBL
  ENSRNOT00000101670 ENTREZGENE
  ENSRNOT00000101670.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2670 UniProtKB/TrEMBL
InterPro AF-4 UniProtKB/TrEMBL
  AF4/FMR2_C UniProtKB/TrEMBL
  AF4_int UniProtKB/TrEMBL
KEGG Report rno:305152 UniProtKB/TrEMBL
NCBI Gene 305152 ENTREZGENE
PANTHER AF-4 UniProtKB/TrEMBL
  AF4/FMR2 FAMILY MEMBER 1 UniProtKB/TrEMBL
Pfam AF-4 UniProtKB/TrEMBL
  AF-4_C UniProtKB/TrEMBL
  AF4_int UniProtKB/TrEMBL
PhenoGen Aff1 PhenoGen
RatGTEx ENSRNOG00000002232 RatGTEx
UniProt A0A0G2K0C8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B3L8 ENTREZGENE
  A6K5U8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBU5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-05 Aff1  ALF transcription elongation factor 1  Aff1  AF4/FMR2 family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Aff1  AF4/FMR2 family, member 1   Aff1_predicted  AF4/FMR2 family, member 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Aff1_predicted  AF4/FMR2 family, member 1 (predicted)  Mllt2_predicted  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Mllt2_predicted  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED