Gars1 (glycyl-tRNA synthetase 1) - Rat Genome Database

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Gene: Gars1 (glycyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Gars1
Name: glycyl-tRNA synthetase 1
RGD ID: 1307856
Description: Predicted to enable several functions, including bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; glycine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in diadenosine tetraphosphate biosynthetic process and mitochondrial glycyl-tRNA aminoacylation. Predicted to act upstream of or within glycyl-tRNA aminoacylation. Predicted to be located in axon; extracellular exosome; and secretory granule. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; nonketotic hyperglycinemia pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AP-4-A synthetase; ap4A synthetase; diadenosine tetraphosphate synthetase; Gars; glycine--tRNA ligase; glycyl-tRNA synthetase; GlyRS; LOC297113; RGD1559871
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,484,939 - 85,542,876 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl485,493,753 - 85,542,876 (+)EnsemblGRCr8
mRatBN7.2484,171,596 - 84,212,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,171,596 - 84,212,609 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx489,394,653 - 89,435,634 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,170,068 - 85,211,053 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,582,545 - 83,623,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,235,122 - 85,276,085 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,235,172 - 85,276,044 (+)Ensemblrn6Rnor6.0
Rnor_5.04149,884,600 - 149,933,329 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4483,718,584 - 83,759,591 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera479,038,903 - 79,079,749 (+)NCBICelera
RGSC_v3.1484,123,817 - 84,165,539 (-)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
gefitinib  (ISO)
ifosfamide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lamivudine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
metformin  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omega-6 fatty acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
progesterone  (ISO)
pyrethrins  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
extracellular exosome  (IEA,ISO,ISS)
extracellular region  (IEA)
mitochondrion  (IBA,IEA)
secretory granule  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8939962   PMID:12477932   PMID:16854843   PMID:17035524   PMID:17544401   PMID:17545306   PMID:17595294   PMID:18614015   PMID:19470612   PMID:19710017   PMID:22082260   PMID:22871113  
PMID:23376485   PMID:24625528   PMID:26503042   PMID:28675565   PMID:30053369   PMID:34800366  


Genomics

Comparative Map Data
Gars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,484,939 - 85,542,876 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl485,493,753 - 85,542,876 (+)EnsemblGRCr8
mRatBN7.2484,171,596 - 84,212,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,171,596 - 84,212,609 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx489,394,653 - 89,435,634 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,170,068 - 85,211,053 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,582,545 - 83,623,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,235,122 - 85,276,085 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,235,172 - 85,276,044 (+)Ensemblrn6Rnor6.0
Rnor_5.04149,884,600 - 149,933,329 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4483,718,584 - 83,759,591 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera479,038,903 - 79,079,749 (+)NCBICelera
RGSC_v3.1484,123,817 - 84,165,539 (-)NCBI
Cytogenetic Map4q24NCBI
GARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,594,735 - 30,634,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,580,533 - 30,634,033 (+)Ensemblhg38GRCh38
GRCh37730,634,351 - 30,673,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,600,706 - 30,640,174 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34730,407,420 - 30,446,884NCBI
Celera730,623,360 - 30,662,827 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,516,030 - 30,555,489 (+)NCBIHuRef
CHM1_1730,634,438 - 30,673,905 (+)NCBICHM1_1
T2T-CHM13v2.0730,732,340 - 30,771,637 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2730,683,834 - 30,723,301 (+)NCBI
Gars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,014,986 - 55,056,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,014,992 - 55,056,485 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38655,038,001 - 55,079,504 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,038,007 - 55,079,500 (+)Ensemblmm10GRCm38
MGSCv37654,987,995 - 55,029,498 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36654,967,598 - 55,009,078 (+)NCBIMGSCv36mm8
Celera655,573,683 - 55,614,743 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.29NCBI
Gars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541031,779,543 - 31,819,113 (+)Ensembl
ChiLan1.0NW_00495541031,778,654 - 31,819,287 (+)NCBIChiLan1.0ChiLan1.0
GARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,406,501 - 35,445,814 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1783,731,131 - 83,770,542 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,208,351 - 31,247,841 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,329,572 - 31,368,719 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,329,456 - 31,368,582 (+)EnsemblpanPan2panpan1.1
GARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,308,274 - 43,351,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,308,152 - 43,396,487 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1442,741,012 - 42,784,674 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01443,249,452 - 43,293,125 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,249,308 - 43,295,729 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,365,329 - 43,408,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,041,322 - 43,084,982 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,402,683 - 43,446,352 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,636,717 - 87,677,496 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364786,848,322 - 6,889,045 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364786,848,448 - 6,889,103 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,311,576 - 42,352,162 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11842,311,711 - 42,352,201 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,675,442 - 46,768,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,750,532 - 27,791,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,749,514 - 27,790,881 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604276,909,963 - 76,953,465 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624739171,777 - 211,164 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624739172,111 - 211,229 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gars1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1685,995,703 - 86,035,485 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gars1
400 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:27
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000014780
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
RH133826  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,210,880 - 84,212,302 (+)MAPPERmRatBN7.2
Rnor_6.0485,274,357 - 85,275,778NCBIRnor6.0
Rnor_5.04149,931,601 - 149,933,022UniSTSRnor5.0
RGSC_v3.4483,718,891 - 83,720,312UniSTSRGSC3.4
Celera479,078,021 - 79,079,442UniSTS
RH 3.4 Map4523.2UniSTS
Cytogenetic Map4q24UniSTS
RH142694  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,177,684 - 84,177,785 (+)MAPPERmRatBN7.2
mRatBN7.2234,201,033 - 34,201,134 (+)MAPPERmRatBN7.2
Rnor_6.0233,165,333 - 33,165,433NCBIRnor6.0
Rnor_6.0485,241,212 - 85,241,312NCBIRnor6.0
Rnor_5.0252,301,473 - 52,301,573UniSTSRnor5.0
Rnor_5.04149,898,456 - 149,898,556UniSTSRnor5.0
Celera479,044,993 - 79,045,093UniSTS
Celera230,185,400 - 30,185,500UniSTS
RH 3.4 Map1819.5UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map4q24UniSTS
BM384835  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,204,987 - 84,205,197 (+)MAPPERmRatBN7.2
Rnor_6.0485,268,465 - 85,268,674NCBIRnor6.0
Rnor_5.04149,925,709 - 149,925,918UniSTSRnor5.0
RGSC_v3.4483,725,995 - 83,726,204UniSTSRGSC3.4
Celera479,072,157 - 79,072,366UniSTS
RH 3.4 Map4522.3UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014780   ⟹   ENSRNOP00000014780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl485,501,865 - 85,542,876 (+)Ensembl
mRatBN7.2 Ensembl484,171,596 - 84,212,609 (+)Ensembl
Rnor_6.0 Ensembl485,235,172 - 85,276,044 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000127639   ⟹   ENSRNOP00000111813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl485,493,753 - 85,542,832 (+)Ensembl
RefSeq Acc Id: NM_001271139   ⟹   NP_001258068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,501,865 - 85,542,876 (+)NCBI
mRatBN7.2484,171,596 - 84,212,609 (+)NCBI
Rnor_6.0485,235,122 - 85,276,085 (+)NCBI
Rnor_5.04149,884,600 - 149,933,329 (+)NCBI
Celera479,038,903 - 79,079,749 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285771   ⟹   XP_063141841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,501,864 - 85,542,823 (+)NCBI
RefSeq Acc Id: XM_063285772   ⟹   XP_063141842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,484,939 - 85,542,823 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001258068 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141841 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141842 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88347 (Get FASTA)   NCBI Sequence Viewer  
  EDL88100 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014780
  ENSRNOP00000111813
GenBank Protein Q5I0G4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258068   ⟸   NM_001271139
- UniProtKB: Q5I0G4 (UniProtKB/Swiss-Prot),   G3V7G8 (UniProtKB/TrEMBL),   A0A8L2Q7W8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014780   ⟸   ENSRNOT00000014780
RefSeq Acc Id: XP_063141842   ⟸   XM_063285772
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063141841   ⟸   XM_063285771
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q7W8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111813   ⟸   ENSRNOT00000127639
Protein Domains
Aminoacyl-transfer RNA synthetases class-II family   WHEP-TRS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5I0G4-F1-model_v2 AlphaFold Q5I0G4 1-728 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693072
Promoter ID:EPDNEW_R3596
Type:initiation region
Name:Gars_1
Description:glycyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0485,235,220 - 85,235,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307856 AgrOrtholog
BioCyc Gene G2FUF-44743 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000011052 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014780 ENTREZGENE
  ENSRNOT00000127639 ENTREZGENE
Gene3D-CATH 3.30.40.230 UniProtKB/Swiss-Prot
  3.30.720.200 UniProtKB/Swiss-Prot
  3.40.50.800 UniProtKB/Swiss-Prot
  Bira Bifunctional Protein, Domain 2 UniProtKB/Swiss-Prot
  S15/NS1, RNA-binding UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368341 IMAGE-MGC_LOAD
InterPro aa-tRNA-synt_IIb UniProtKB/Swiss-Prot
  aa-tRNA-synth_II UniProtKB/Swiss-Prot
  aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot
  Anticodon-bd UniProtKB/Swiss-Prot
  Anticodon-bd_dom_sf UniProtKB/Swiss-Prot
  Gly-tRNA_synthase/POLG2 UniProtKB/Swiss-Prot
  GlyRS-like_core UniProtKB/Swiss-Prot
  S15_NS1_RNA-bd UniProtKB/Swiss-Prot
  tRNA-synt_gly UniProtKB/Swiss-Prot
  WHEP-TRS_dom UniProtKB/Swiss-Prot
KEGG Report rno:297113 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109655 IMAGE-MGC_LOAD
NCBI Gene 297113 ENTREZGENE
PANTHER GLYCINE--TRNA LIGASE UniProtKB/Swiss-Prot
  PTHR10745 UniProtKB/Swiss-Prot
Pfam HGTP_anticodon UniProtKB/Swiss-Prot
  tRNA-synt_2b UniProtKB/Swiss-Prot
  WHEP-TRS UniProtKB/Swiss-Prot
PhenoGen Gars1 PhenoGen
PRINTS TRNASYNTHGLY UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_II UniProtKB/Swiss-Prot
  WHEP_TRS_1 UniProtKB/Swiss-Prot
  WHEP_TRS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011052 RatGTEx
SMART WHEP-TRS UniProtKB/Swiss-Prot
Superfamily-SCOP Class II aaRS ABD-related UniProtKB/Swiss-Prot
  SSF47060 UniProtKB/Swiss-Prot
  SSF55681 UniProtKB/Swiss-Prot
UniProt A0A8L2Q7W8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M7J7_RAT UniProtKB/TrEMBL
  G3V7G8 ENTREZGENE
  GARS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V7G8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-14 Gars1  glycyl-tRNA synthetase 1  Gars  glycyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gars  glycyl-tRNA synthetase  Gars_predicted  glycyl-tRNA synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gars_predicted  glycyl-tRNA synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED