Yars1 (tyrosyl-tRNA synthetase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Yars1 (tyrosyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Yars1
Name: tyrosyl-tRNA synthetase 1
RGD ID: 1307616
Description: Predicted to enable small molecule binding activity and tyrosine-tRNA ligase activity. Predicted to be involved in response to starvation. Predicted to act upstream of or within protein poly-ADP-ribosylation and tyrosyl-tRNA aminoacylation. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate C. Orthologous to human YARS1 (tyrosyl-tRNA synthetase 1); PARTICIPATES IN phenylketonuria pathway; tyrosinemia type II pathway; tyrosinemia type III pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313047; MGC112837; tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase, cytoplasmic; tyrRS; Yars
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,820,163 - 146,848,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5146,819,358 - 146,848,377 (+)EnsemblGRCr8
mRatBN7.25141,535,815 - 141,564,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,535,759 - 141,563,833 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5144,233,688 - 144,262,170 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,003,509 - 146,031,990 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,003,105 - 146,031,352 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,375,350 - 147,403,578 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,375,350 - 147,403,571 (+)Ensemblrn6Rnor6.0
Rnor_5.05151,109,967 - 151,138,479 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45148,350,363 - 148,378,989 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5140,015,592 - 140,043,428 (+)NCBICelera
RGSC_v3.15148,360,401 - 148,389,028 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methylmercury chloride  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorone  (EXP)
potassium chromate  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tanespimycin  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (ISO,ISS)
nuclear body  (ISO)
nucleus  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16854843   PMID:22658674   PMID:29289698   PMID:31505169  


Genomics

Comparative Map Data
Yars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,820,163 - 146,848,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5146,819,358 - 146,848,377 (+)EnsemblGRCr8
mRatBN7.25141,535,815 - 141,564,029 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,535,759 - 141,563,833 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5144,233,688 - 144,262,170 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05146,003,509 - 146,031,990 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,003,105 - 146,031,352 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,375,350 - 147,403,578 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,375,350 - 147,403,571 (+)Ensemblrn6Rnor6.0
Rnor_5.05151,109,967 - 151,138,479 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45148,350,363 - 148,378,989 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5140,015,592 - 140,043,428 (+)NCBICelera
RGSC_v3.15148,360,401 - 148,389,028 (+)NCBI
Cytogenetic Map5q36NCBI
YARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,775,239 - 32,817,358 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,775,237 - 32,818,031 (-)Ensemblhg38GRCh38
GRCh37133,240,840 - 33,282,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,013,427 - 33,056,220 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34132,909,932 - 32,952,726NCBI
Celera131,509,662 - 31,552,283 (-)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,356,139 - 31,399,200 (-)NCBIHuRef
CHM1_1133,356,247 - 33,399,028 (-)NCBICHM1_1
T2T-CHM13v2.0132,635,023 - 32,677,140 (-)NCBIT2T-CHM13v2.0
Yars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,083,595 - 129,113,033 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,083,553 - 129,113,400 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384129,189,734 - 129,219,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,189,760 - 129,219,607 (+)Ensemblmm10GRCm38
MGSCv374128,867,039 - 128,896,851 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364128,692,255 - 128,721,911 (+)NCBIMGSCv36mm8
Celera4127,529,758 - 127,559,623 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.05NCBI
Yars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,046,047 - 11,078,016 (-)Ensembl
ChiLan1.0NW_00495545211,046,047 - 11,078,016 (-)NCBIChiLan1.0ChiLan1.0
YARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21194,004,825 - 194,044,614 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,126,810 - 193,166,838 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,068,202 - 32,108,664 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,232,163 - 33,295,347 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,232,905 - 33,294,558 (-)EnsemblpanPan2panpan1.1
YARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,535,402 - 68,566,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,535,447 - 68,565,439 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha265,115,258 - 65,146,054 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0269,100,498 - 69,131,463 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,100,535 - 69,132,060 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,912,002 - 65,942,953 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,934,433 - 66,965,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,926,368 - 67,957,551 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Yars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,867,056 - 49,896,532 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,691,842 - 15,721,953 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,691,838 - 15,721,308 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,088,544 - 89,119,592 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1689,088,122 - 89,118,837 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,115,016 - 83,145,732 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,050,717 - 100,096,719 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20100,052,535 - 100,095,980 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603316,595,637 - 16,639,571 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,898,646 - 15,933,400 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476415,898,648 - 15,933,386 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Yars1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1128,923,364 - 28,952,262 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Yars1
104 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:63
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000010674
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Rat97  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85146,838,530 - 146,838,760 (+)Marker Load Pipeline
mRatBN7.25141,554,182 - 141,554,412 (+)MAPPERmRatBN7.2
Rnor_6.05147,393,732 - 147,393,961NCBIRnor6.0
Rnor_5.05151,128,633 - 151,128,862UniSTSRnor5.0
RGSC_v3.45148,369,142 - 148,369,372RGDRGSC3.4
RGSC_v3.45148,369,143 - 148,369,372UniSTSRGSC3.4
Celera5140,033,582 - 140,033,811UniSTS
RGSC_v3.15148,379,182 - 148,379,411RGD
RH 3.4 Map5958.0RGD
RH 3.4 Map5958.0UniSTS
RH 2.0 Map5163.9RGD
SHRSP x BN Map579.6799RGD
FHH x ACI Map578.8RGD
Cytogenetic Map5q36UniSTS
RH130408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,563,717 - 141,563,922 (+)MAPPERmRatBN7.2
Rnor_6.05147,403,267 - 147,403,471NCBIRnor6.0
Rnor_5.05151,138,168 - 151,138,372UniSTSRnor5.0
RGSC_v3.45148,378,678 - 148,378,882UniSTSRGSC3.4
Celera5140,043,117 - 140,043,321UniSTS
Cytogenetic Map5q36UniSTS
RH142596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25141,536,271 - 141,536,381 (+)MAPPERmRatBN7.2
Rnor_6.05147,375,807 - 147,375,916NCBIRnor6.0
Rnor_5.05151,110,424 - 151,110,533UniSTSRnor5.0
RGSC_v3.45148,350,820 - 148,350,929UniSTSRGSC3.4
Celera5140,016,049 - 140,016,158UniSTS
RH 3.4 Map5957.6UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010674   ⟹   ENSRNOP00000010674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5146,820,139 - 146,848,377 (+)Ensembl
mRatBN7.2 Ensembl5141,535,759 - 141,563,833 (+)Ensembl
Rnor_6.0 Ensembl5147,375,350 - 147,403,571 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129477   ⟹   ENSRNOP00000107228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5146,819,358 - 146,848,370 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138685   ⟹   ENSRNOP00000099048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5146,819,358 - 146,846,963 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169180   ⟹   ENSRNOP00000103209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5146,819,358 - 146,846,892 (+)Ensembl
RefSeq Acc Id: NM_001025696   ⟹   NP_001020867
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85146,820,163 - 146,848,377 (+)NCBI
mRatBN7.25141,535,815 - 141,564,029 (+)NCBI
Rnor_6.05147,375,350 - 147,403,578 (+)NCBI
Rnor_5.05151,109,967 - 151,138,479 (+)NCBI
RGSC_v3.45148,350,363 - 148,378,989 (+)RGD
Celera5140,015,592 - 140,043,428 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020867 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98795 (Get FASTA)   NCBI Sequence Viewer  
  EDL80530 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000107228
GenBank Protein Q4KM49 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020867   ⟸   NM_001025696
- UniProtKB: Q4KM49 (UniProtKB/Swiss-Prot),   A6ISH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010674   ⟸   ENSRNOT00000010674
Ensembl Acc Id: ENSRNOP00000103209   ⟸   ENSRNOT00000169180
Ensembl Acc Id: ENSRNOP00000099048   ⟸   ENSRNOT00000138685
Ensembl Acc Id: ENSRNOP00000107228   ⟸   ENSRNOT00000129477
Protein Domains
tRNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KM49-F1-model_v2 AlphaFold Q4KM49 1-528 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694057
Promoter ID:EPDNEW_R4582
Type:initiation region
Name:Yars_1
Description:tyrosyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05147,375,385 - 147,375,445EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307616 AgrOrtholog
BioCyc Gene G2FUF-39815 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000007213 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000129477 ENTREZGENE
Gene3D-CATH 2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.620 UniProtKB/Swiss-Prot
  Tyrosyl-Transfer RNA Synthetase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7375769 IMAGE-MGC_LOAD
InterPro aa-tRNA-synth_Ic UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
  tRNA-bd_dom UniProtKB/Swiss-Prot
  Tyr-tRNA-ligase UniProtKB/Swiss-Prot
  Tyrosine-tRNA_ligase_regulator UniProtKB/Swiss-Prot
KEGG Report rno:313047 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112837 IMAGE-MGC_LOAD
NCBI Gene 313047 ENTREZGENE
PANTHER TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER UniProtKB/Swiss-Prot
  TYROSINE--TRNA LIGASE, CYTOPLASMIC UniProtKB/Swiss-Prot
Pfam tRNA-synt_1b UniProtKB/Swiss-Prot
  tRNA_bind UniProtKB/Swiss-Prot
PhenoGen Yars1 PhenoGen
PRINTS TRNASYNTHTYR UniProtKB/Swiss-Prot
PROSITE TRBD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007213 RatGTEx
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/Swiss-Prot
  SSF50249 UniProtKB/Swiss-Prot
UniProt A0A0H2UHG0_RAT UniProtKB/TrEMBL
  A0ABK0LE44_RAT UniProtKB/TrEMBL
  A0ABK0LML7_RAT UniProtKB/TrEMBL
  A0ABK0LT71_RAT UniProtKB/TrEMBL
  A6ISH9 ENTREZGENE, UniProtKB/TrEMBL
  Q4KM49 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Yars1  tyrosyl-tRNA synthetase 1  Yars  tyrosyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Yars  tyrosyl-tRNA synthetase  Yars_predicted  tyrosyl-tRNA synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Yars_predicted  tyrosyl-tRNA synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED