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Gene: Pnpla5 (patatin like domain 5, triacylglycerol lipase) Rattus norvegicus

Analyze

Symbol:

Pnpla5

Name:

patatin like domain 5, triacylglycerol lipase (Ensembl:patatin-like phospholipase domain containing 5)

RGD ID:

1307495

Description:

Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid homeostasis and triglyceride catabolic process. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA5 (patatin like phospholipase domain containing 5); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC300108; patatin-like phospholipase domain containing 5; patatin-like phospholipase domain-containing protein 5; RGD1307495; similar to GS2 like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PNPLA5 (patatin like domain 5, triacylglycerol lipase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pnpla5 (patatin-like phospholipase domain containing 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pnpla5 (patatin like domain 5, triacylglycerol lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PNPLA5 (patatin like domain 5, triacylglycerol lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PNPLA5 (patatin like phospholipase domain containing 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pnpla5 (patatin like domain 5, triacylglycerol lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PNPLA5 (patatin like domain 5, triacylglycerol lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pnpla5 (patatin like domain 5, triacylglycerol lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pnpla5 (patatin like domain 5, triacylglycerol lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PNPLA5 (patatin like domain 5, triacylglycerol lipase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pnpla5 (patatin-like phospholipase domain containing 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pnpla3 (patatin-like phospholipase domain containing 3)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	bmm	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	bmm	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	dob	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	atgl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	atgl-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pnpla3	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,126,046 - 117,137,036 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	117,126,046 - 117,137,036 (-)	Ensembl				GRCr8
mRatBN7.2	7	115,246,050 - 115,257,039 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,246,050 - 115,257,039 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	116,993,931 - 117,004,916 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,219,637 - 119,230,641 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,189,103 - 119,200,104 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,988,524 - 124,999,137 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,988,524 - 124,999,137 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	124,976,939 - 124,987,552 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	122,105,019 - 122,116,003 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	111,552,006 - 111,562,981 (-)	NCBI		Celera
RGSC_v3.1	7	122,132,963 - 122,186,351 (-)	NCBI
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

dichloroacetic acid (ISO)

fipronil (EXP)

fulvestrant (ISO)

indole-3-methanol (EXP)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP,ISO)

PCB138 (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

quercetin (EXP)

resveratrol (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

thioacetamide (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid catabolic process (IEA)

lipid homeostasis (IBA)

lipid metabolic process (IEA)

triglyceride catabolic process (IBA)

Cellular Component

cytoplasm (IBA)

lipid droplet (IBA)

membrane (IBA)

Molecular Function

hydrolase activity (IEA)

protein binding (ISO)

triacylglycerol lipase activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17603008

Genomics

Comparative Map Data

Pnpla5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,126,046 - 117,137,036 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	117,126,046 - 117,137,036 (-)	Ensembl				GRCr8
mRatBN7.2	7	115,246,050 - 115,257,039 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,246,050 - 115,257,039 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	116,993,931 - 117,004,916 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,219,637 - 119,230,641 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,189,103 - 119,200,104 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,988,524 - 124,999,137 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,988,524 - 124,999,137 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	124,976,939 - 124,987,552 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	122,105,019 - 122,116,003 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	111,552,006 - 111,562,981 (-)	NCBI		Celera
RGSC_v3.1	7	122,132,963 - 122,186,351 (-)	NCBI
Cytogenetic Map	7	q34	NCBI

PNPLA5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,879,678 - 43,892,013 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,878,568 - 43,892,494 (-)	Ensembl			hg38	GRCh38
GRCh37	22	44,275,558 - 44,287,893 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	42,606,891 - 42,619,190 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	42,600,459 - 42,612,758	NCBI
Celera	22	28,186,079 - 28,198,414 (-)	NCBI		Celera
Cytogenetic Map	22	q13.31	NCBI
HuRef	22	27,229,762 - 27,241,992 (-)	NCBI		HuRef
CHM1_1	22	44,233,798 - 44,246,118 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	44,362,256 - 44,374,585 (-)	NCBI		T2T-CHM13v2.0

Pnpla5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	83,996,631 - 84,007,567 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	83,996,557 - 84,007,376 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	84,112,621 - 84,123,175 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	84,112,356 - 84,123,175 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	83,943,051 - 83,953,605 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,940,114 - 83,950,941 (-)	NCBI		MGSCv36	mm8
Celera	15	86,242,746 - 86,253,354 (-)	NCBI		Celera
Cytogenetic Map	15	E2	NCBI
cM Map	15	39.78	NCBI

Pnpla5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,825,319 - 28,835,751 (-)	Ensembl
ChiLan1.0	NW_004955413	28,825,673 - 28,835,476 (-)	NCBI	ChiLan1.0	ChiLan1.0

PNPLA5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	53,690,774 - 53,720,256 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	56,383,107 - 56,412,675 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,753,811 - 24,780,581 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	42,958,161 - 42,972,328 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	42,959,988 - 42,972,328 (-)	Ensembl			panPan2	panpan1.1

PNPLA5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	21,761,069 - 21,773,521 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	21,760,563 - 21,773,531 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	21,701,773 - 21,714,227 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	22,509,933 - 22,522,375 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	22,509,895 - 22,522,385 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,229,308 - 22,241,737 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	22,549,389 - 22,561,857 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	22,723,514 - 22,735,949 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pnpla5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,402,413 - 5,411,244 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	1,568,339 - 1,577,701 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	1,568,339 - 1,577,701 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PNPLA5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	26,396,040 - 26,408,553 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	26,397,163 - 26,408,126 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	98,996,958 - 99,009,236 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pnpla5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	5,256,060 - 5,266,071 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	5,256,060 - 5,266,061 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pnpla5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	253,507,896 - 253,518,596 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pnpla5
100 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	137
Count of miRNA genes:	106
Interacting mature miRNAs:	123
Transcripts:	ENSRNOT00000039228
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	92388565	119280177	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	73618702	118618702	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	73557047	118557047	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	96700404	118618702	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
10450862	Kidm55	Kidney mass QTL 55	4.9		kidney mass (VT:0002707)	kidney weight (CMO:0000081)	7	72725037	117725037	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
10450856	Livw4	Liver weight QTL 4	3.8		liver mass (VT:0003402)	liver weight (CMO:0000092)	7	72725037	117725037	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	116269196	132020414	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	71621154	119349044	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
5	5	34	69	68	49	34	49	6	112	49	22	9	45	19	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001130497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000039228 ⟹ ENSRNOP00000032256

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	117,126,046 - 117,137,036 (-)	Ensembl
mRatBN7.2 Ensembl	7	115,246,050 - 115,257,039 (-)	Ensembl
Rnor_6.0 Ensembl	7	124,988,524 - 124,999,137 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103466 ⟹ ENSRNOP00000080131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	117,126,635 - 117,137,036 (-)	Ensembl
mRatBN7.2 Ensembl	7	115,246,639 - 115,257,039 (-)	Ensembl

RefSeq Acc Id:

NM_001130497 ⟹ NP_001123969

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,126,046 - 117,137,036 (-)	NCBI
mRatBN7.2	7	115,246,050 - 115,257,039 (-)	NCBI
Rnor_6.0	7	124,988,524 - 124,999,137 (-)	NCBI
Rnor_5.0	7	124,976,939 - 124,987,552 (-)	NCBI
RGSC_v3.4	7	122,105,019 - 122,116,003 (-)	RGD
Celera	7	111,552,006 - 111,562,981 (-)	RGD

Sequence:

show sequence

TGAACATTCCTTCATGCTCCAGCGCAGCACCAAGGCTGAGGAGTCTGCAGTCCCGCGTCCCAAG
CGCCCAATTATGGACTTCCTGGAGGTAGAGGGCGGTTGGAGCCTGTCCTTCTCAGGCTCTGGCT
ACCTGGGCCTCTACCACGTGGGTGCCACCGAGTGTCTGCGCCAGCGCGCGCCGCGCCTCATCCA
GGGTGCCCGCCGTTTCTACGGCTCTTCCTCGGGCGCGCTCAACGCCCTGAGCATCATCTGTGGC
AAGTCCGCAGACTTCACCTGCTCCAATCTCCTGGCCATGGTGAAACACGTGGAGCGGCTGAGCC
TGGGCATCTTCCATCCGGCCTATGGACCCATTGAGCACATCAAGAAAAAGCTGCAAGACGACTT
ACCCGACAACAGCCATATTGTGGCCTCCCAGAGGCTGGGCATCTCCCTGACCCGATGGCCTGAT
GGTCAGAACTTCATAGTCACTGATTTTGCCACTCGGGATGAACTCATCCAGGCTCTGGTCTGCA
CCTTGTATTTTCCCTTTTACTGTGGGACGATACCCCCGGCATTCAGAGGGGAGCGCTTCATTGA
CGGGGCCCTGAGCAACAACCTGCCCTTCTCCAACTGTCCTACCACCATCACCGTCTCTCCTTTC
AACGGGACAGTGGACATCTGTCCCCAGAGCACCTCATCCAGCCTTTTTGAGCTAACTGCCTTCA
ATGCCAGTTTCCAGATCTCTACCAGGAACTTCTTTCTGGGGTTCAAATCCCTGTTTCCCCCCAA
GCCTGAGGTGGTGGCTGACTATTGCAGACAAGGTTACCTGGATGCCCTGAGGTTCTTGGAGAGA
CGGGGACTTACCAAGGAGCCAGTGCTGTGGTCGCTGGTTTCTAAGGAGCCTCCAGCCCTCGTGG
AGGGGCCCAGGGGAACTGACCATAACCAGGGTCAGGAGGCTGGTCTGATTGTCAGGTGGGACAT
CCCCAATGTGCTGGTAAAGGACGTGCCCAACTTCGAGCTGCTGTCACCGGAGCTGGAGGCTGCA
TTGAAAAAGGCATGCAAGAGAGACTTCTGGGCCCAAATCCAGTGTTCAGTGCCAGGGAAGGTGC
TGACCTACCTGCTTTTGCCCTGTACGCTGCCCTTTGAGTATGCCTATTTCCGGAGCAGGAGGCT
GATGCAATGGTTGCCGGAGGTGCCAGATGACTTGTATTGGATGCAGGGCCTACTGAAGACTACC
ACCCTCAAGGTCTACTCCATGGCGAAGTCATGGCTTCTCAGCTTGGGCAGCCCACTTGTCACCA
GTGCAGACGCTGGTCTCCTCTGGCAGCAGCAGGGGACAGCTGCTGCTGGGAACAGGCCCTTGAA
CCACAGGTTGGCGGATTGTGCACTGGGCTAGGCCAGCCACATGTGTGACCCTCTGAACTCTGTC
CTTGCCCTCGTCTTGTGTGCTTACGCCTGCTGGAGTGACTCTGGCAGGTGGCCTGTGTTGGAGC
ATCCCCCAGGATCTCTGAGCTCAGCTCCTAACTCAGAGAGGTTGCTGAATTACTGGCATAAAGA
CCTGGCTTCCTGTCCATGCTGTGTCATGTGCTTCTTGTGTGGGCAGGTGGTTTCCTGGCACGGA
ACAAGGGCTCTCTGCAGCTGTTCCTGGGACCTTGATCCCCCAGGTCCTCTCTGGAAGCTTCTAG
CCTACTGTGTGCTCAGGCCACTGCCTTTCTTCTTGTCAGTTTTGTCAGAGAAGAAAAGACAGAA
CAAGCTAAGACACATCTCAGTTCCGGGTCTCCATGTGAGGGACACAGAAGGCATAGGTGTCTAG
CAGACGTGTGTTCTGAGCTAGGCTGGGACTGGAGATGGTACCCCAAGGCTATGATCACGGTACT
GACTGCTCTGACAGGGCTCCCCGCCTCCTTTCTCTGATCCACACTTACCTAAGGGGTTAATGCC
CGTGACAAGTACAGATGGAAGGTGGTTGGCTGGGGAGTTCATTCTAGGGGAAATCCTGGTCATA
GATGCTTCTCATGGGGATGGGGCCTACTGCCACTGCAGCCTGGTTTCTAGGGAAGGTTTCTGGG
TGGCACACGTACCAAAGGTCCTCTGGCCTCTCCTCTGTTCTTCCTATCCCTAAAGATAGGGTTG
GGGACACTCTGCCAAGTGGGGATGGTACTGTAGAGAAGTGGAGGTGCCGGTGAGAGAAGAGATT
ATGTAATAAATGCCGAG

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Protein Sequences


Protein RefSeqs	NP_001123969	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM15610	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000032256
	ENSRNOP00000032256.3
	ENSRNOP00000080131.1

RefSeq Acc Id:

NP_001123969 ⟸ NM_001130497

- UniProtKB:

D3ZXU1 (UniProtKB/TrEMBL), A6HTB2 (UniProtKB/TrEMBL), A0A8I5ZPL6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLQRSTKAEESAVPRPKRPIMDFLEVEGGWSLSFSGSGYLGLYHVGATECLRQRAPRLIQGARR
FYGSSSGALNALSIICGKSADFTCSNLLAMVKHVERLSLGIFHPAYGPIEHIKKKLQDDLPDNS
HIVASQRLGISLTRWPDGQNFIVTDFATRDELIQALVCTLYFPFYCGTIPPAFRGERFIDGALS
NNLPFSNCPTTITVSPFNGTVDICPQSTSSSLFELTAFNASFQISTRNFFLGFKSLFPPKPEVV
ADYCRQGYLDALRFLERRGLTKEPVLWSLVSKEPPALVEGPRGTDHNQGQEAGLIVRWDIPNVL
VKDVPNFELLSPELEAALKKACKRDFWAQIQCSVPGKVLTYLLLPCTLPFEYAYFRSRRLMQWL
PEVPDDLYWMQGLLKTTTLKVYSMAKSWLLSLGSPLVTSADAGLLWQQQGTAAAGNRPLNHRLA
DCALG

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Ensembl Acc Id:

ENSRNOP00000032256 ⟸ ENSRNOT00000039228

Ensembl Acc Id:

ENSRNOP00000080131 ⟸ ENSRNOT00000103466

Protein Domains

PNPLA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZXU1-F1-model_v2	AlphaFold	D3ZXU1	1-453	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307495	AgrOrtholog
BioCyc Gene	G2FUF-32583	BioCyc
Ensembl Genes	ENSRNOG00000022296	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039228	ENTREZGENE
	ENSRNOT00000039228.5	UniProtKB/TrEMBL
	ENSRNOT00000103466.2	UniProtKB/TrEMBL
Gene3D-CATH	Cytosolic phospholipase A2 catalytic domain	UniProtKB/TrEMBL
InterPro	Acyl_Trfase/lysoPlipase	UniProtKB/TrEMBL
	Patatin	UniProtKB/TrEMBL
	PLPL	UniProtKB/TrEMBL
KEGG Report	rno:300108	UniProtKB/TrEMBL
NCBI Gene	300108	ENTREZGENE
PANTHER	PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 5	UniProtKB/TrEMBL
	PTHR12406	UniProtKB/TrEMBL
Pfam	Patatin	UniProtKB/TrEMBL
PhenoGen	Pnpla5	PhenoGen
PROSITE	PNPLA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022296	RatGTEx
Superfamily-SCOP	Acyl_Trfase/lysoPlipase	UniProtKB/TrEMBL
UniProt	A0A8I5ZPL6	ENTREZGENE, UniProtKB/TrEMBL
	A6HTB2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZXU1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Pnpla5	patatin like domain 5, triacylglycerol lipase	Pnpla5	patatin-like phospholipase domain containing 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Pnpla5	patatin-like phospholipase domain containing 5	Pnpla5_predicted	patatin-like phospholipase domain containing 5 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Pnpla5_predicted	patatin-like phospholipase domain containing 5 (predicted)	RGD1307495_predicted	similar to GS2 like (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1307495_predicted	similar to GS2 like (predicted)	LOC300108_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC300108_predicted	similar to GS2 like (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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