Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Fbxo21 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Fbxo21 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of FBXO21 mRNA | CTD | PMID:36331819 | Fbxo21 | Rat | 1,1-dichloroethene | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of FBXO21 mRNA | CTD | PMID:26682919 | Fbxo21 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of FBXO21 mRNA | CTD | PMID:22206623 | Fbxo21 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of FBXO21 mRNA | CTD | PMID:32145629 | Fbxo21 | Rat | 17beta-estradiol | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Estradiol results in increased expression of FBXO21 mRNA | CTD | PMID:39298647 | Fbxo21 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of FBXO21 mRNA | CTD | PMID:21215274|PMID:33387578 | Fbxo21 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Fbxo21 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression more ... | CTD | PMID:25975270 | Fbxo21 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of FBXO21 mRNA | CTD | PMID:23994337|PMID:25975270 | Fbxo21 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of FBXO21 mRNA | CTD | PMID:21570461 | Fbxo21 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of FBXO21 mRNA | CTD | PMID:21346803 | Fbxo21 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of FBXO21 mRNA | CTD | PMID:21346803 | Fbxo21 | Rat | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FBXO21 mRNA | CTD | PMID:23994337 | Fbxo21 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of FBXO21 mRNA | CTD | PMID:25172293 | Fbxo21 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FBXO21 mRNA | CTD | PMID:20188158 | Fbxo21 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of FBXO21 mRNA | CTD | PMID:39298647 | Fbxo21 | Rat | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2,6-dinitrotoluene affects the expression of FBXO21 mRNA | CTD | PMID:21346803 | Fbxo21 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Fenretinide results in increased expression of FBXO21 mRNA | CTD | PMID:28973697 | Fbxo21 | Rat | aflatoxin B1 | decreases methylation | ISO | FBXO21 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of FBXO21 exon | CTD | PMID:30157460 | Fbxo21 | Rat | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of FBXO21 mRNA | CTD | PMID:33354967 | Fbxo21 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of FBXO21 mRNA | CTD | PMID:38685447 | Fbxo21 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of FBXO21 mRNA | CTD | PMID:30779732 | Fbxo21 | Rat | arsenite(3-) | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | arsenite results in increased expression of FBXO21 protein | CTD | PMID:37955338 | Fbxo21 | Rat | benzo[a]pyrene | decreases methylation | ISO | Fbxo21 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of FBXO21 intron | CTD | PMID:27901495 | Fbxo21 | Rat | benzo[a]pyrene | increases methylation | ISO | FBXO21 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of FBXO21 promoter | CTD | PMID:27901495 | Fbxo21 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBXO21 mRNA | CTD | PMID:19150397 | Fbxo21 | Rat | beta-naphthoflavone | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | beta-Naphthoflavone results in increased expression of FBXO21 mRNA | CTD | PMID:23994337 | Fbxo21 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of FBXO21 mRNA | CTD | PMID:21318169 | Fbxo21 | Rat | bisphenol A | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of FBXO21 mRNA | CTD | PMID:21932408 | Fbxo21 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of FBXO21 mRNA | CTD | PMID:30816183|PMID:34947998|PMID:38750585 | Fbxo21 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of FBXO21 gene | CTD | PMID:28505145 | Fbxo21 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of FBXO21 mRNA | CTD | PMID:25181051|PMID:32145629 | Fbxo21 | Rat | cadmium dichloride | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of FBXO21 mRNA | CTD | PMID:38568856 | Fbxo21 | Rat | carbamazepine | affects expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of FBXO21 mRNA | CTD | PMID:25979313 | Fbxo21 | Rat | carbon nanotube | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in decreased expression of FBXO21 mRNA; Nanotubes, Carbon results in decreased more ... | CTD | PMID:25554681|PMID:25620056 | Fbxo21 | Rat | CGP 52608 | multiple interactions | ISO | FBXO21 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to FBXO21 gene] | CTD | PMID:28238834 | Fbxo21 | Rat | chlorpyrifos | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of FBXO21 mRNA | CTD | PMID:37019170 | Fbxo21 | Rat | clofibrate | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Clofibrate results in increased expression of FBXO21 mRNA | CTD | PMID:23811191 | Fbxo21 | Rat | copper(II) sulfate | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of FBXO21 mRNA | CTD | PMID:19549813 | Fbxo21 | Rat | cyclosporin A | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of FBXO21 mRNA | CTD | PMID:25562108|PMID:27989131 | Fbxo21 | Rat | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of FBXO21 mRNA | CTD | PMID:23640034 | Fbxo21 | Rat | Dibutyl phosphate | affects expression | ISO | FBXO21 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of FBXO21 mRNA | CTD | PMID:37042841 | Fbxo21 | Rat | dibutyl phthalate | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of FBXO21 mRNA | CTD | PMID:21266533 | Fbxo21 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of FBXO21 mRNA | CTD | PMID:21266533 | Fbxo21 | Rat | diethylstilbestrol | increases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Diethylstilbestrol results in increased expression of FBXO21 mRNA | CTD | PMID:36621641 | Fbxo21 | Rat | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of FBXO21 mRNA | CTD | PMID:36653537 | Fbxo21 | Rat | fenofibrate | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Fenofibrate results in increased expression of FBXO21 mRNA | CTD | PMID:21318169 | Fbxo21 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of FBXO21 mRNA | CTD | PMID:24136188 | Fbxo21 | Rat | furan | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | furan results in decreased expression of FBXO21 mRNA | CTD | PMID:24183702 | Fbxo21 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of FBXO21 mRNA | CTD | PMID:33387578 | Fbxo21 | Rat | inulin | multiple interactions | ISO | Fbxo21 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of FBXO21 mRNA | CTD | PMID:36331819 | Fbxo21 | Rat | ivermectin | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of FBXO21 protein | CTD | PMID:32959892 | Fbxo21 | Rat | ketoconazole | increases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Ketoconazole results in increased expression of FBXO21 mRNA | CTD | PMID:36621641 | Fbxo21 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of FBXO21 mRNA | CTD | PMID:24136188 | Fbxo21 | Rat | menadione | affects expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of FBXO21 mRNA | CTD | PMID:20044591 | Fbxo21 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of FBXO21 mRNA | CTD | PMID:24136188 | Fbxo21 | Rat | paracetamol | affects expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Acetaminophen affects the expression of FBXO21 mRNA | CTD | PMID:17562736 | Fbxo21 | Rat | paracetamol | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Acetaminophen results in decreased expression of FBXO21 mRNA | CTD | PMID:29246445 | Fbxo21 | Rat | paracetamol | multiple interactions | ISO | Fbxo21 (Mus musculus) | 6480464 | PANX1 gene mutant form promotes the reaction [Acetaminophen results in decreased expression of FBXO21 mRNA] | CTD | PMID:29246445 | Fbxo21 | Rat | parathion | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Parathion results in increased expression of FBXO21 mRNA | CTD | PMID:34813904 | Fbxo21 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Fbxo21 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of FBXO21 mRNA; [perfluorooctane sulfonic more ... | CTD | PMID:36331819 | Fbxo21 | Rat | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of FBXO21 mRNA | CTD | PMID:19162173 | Fbxo21 | Rat | perfluorooctanoic acid | multiple interactions | ISO | Fbxo21 (Mus musculus) | 6480464 | PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of FBXO21 mRNA] | CTD | PMID:21318169 | Fbxo21 | Rat | perfluorooctanoic acid | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | perfluorooctanoic acid results in increased expression of FBXO21 mRNA | CTD | PMID:21318169 | Fbxo21 | Rat | pirinixic acid | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of FBXO21 mRNA | CTD | PMID:18445702 | Fbxo21 | Rat | pirinixic acid | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of FBXO21 mRNA | CTD | PMID:17426115|PMID:18301758|PMID:21318169|PMID:23811191 | Fbxo21 | Rat | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of FBXO21 mRNA | CTD | PMID:19162173 | Fbxo21 | Rat | pirinixic acid | multiple interactions | ISO | Fbxo21 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929|PMID:21318169 | Fbxo21 | Rat | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of FBXO21 mRNA | CTD | PMID:28903501 | Fbxo21 | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of FBXO21 mRNA | CTD | PMID:28374803 | Fbxo21 | Rat | senecionine | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | senecionine results in increased expression of FBXO21 protein | CTD | PMID:35357534 | Fbxo21 | Rat | silicon dioxide | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of FBXO21 mRNA | CTD | PMID:19073995 | Fbxo21 | Rat | sodium arsenate | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of FBXO21 mRNA | CTD | PMID:39847705 | Fbxo21 | Rat | sodium arsenite | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of FBXO21 mRNA | CTD | PMID:38568856 | Fbxo21 | Rat | tamoxifen | affects expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Tamoxifen affects the expression of FBXO21 mRNA | CTD | PMID:20937368 | Fbxo21 | Rat | tetrachloroethene | increases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of FBXO21 mRNA | CTD | PMID:28973375 | Fbxo21 | Rat | tetrachloromethane | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of FBXO21 mRNA | CTD | PMID:27339419|PMID:31919559 | Fbxo21 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of FBXO21 mRNA | CTD | PMID:34492290 | Fbxo21 | Rat | thiram | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Thiram results in decreased expression of FBXO21 mRNA | CTD | PMID:38568856 | Fbxo21 | Rat | triphenyl phosphate | affects expression | ISO | FBXO21 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of FBXO21 mRNA | CTD | PMID:37042841 | Fbxo21 | Rat | troglitazone | decreases expression | ISO | Fbxo21 (Mus musculus) | 6480464 | troglitazone results in decreased expression of FBXO21 mRNA | CTD | PMID:28973697 | Fbxo21 | Rat | valproic acid | affects expression | ISO | Fbxo21 (Mus musculus) | 6480464 | Valproic Acid affects the expression of FBXO21 mRNA | CTD | PMID:17292431|PMID:17963808 | Fbxo21 | Rat | valproic acid | decreases methylation | ISO | FBXO21 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of FBXO21 gene | CTD | PMID:29154799 | Fbxo21 | Rat | valproic acid | decreases expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of FBXO21 mRNA | CTD | PMID:23179753 | Fbxo21 | Rat | valproic acid | affects expression | ISO | FBXO21 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of FBXO21 mRNA | CTD | PMID:25979313 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















