Srxn1 (sulfiredoxin 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Srxn1 (sulfiredoxin 1) Rattus norvegicus
Analyze
Symbol: Srxn1
Name: sulfiredoxin 1
RGD ID: 1307332
Description: Predicted to enable sulfiredoxin activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SRXN1 (sulfiredoxin 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab2-390; LOC296271; neoplastic progression 3; Npn3; sulfiredoxin 1 homolog; sulfiredoxin 1 homolog (S. cerevisiae); sulfiredoxin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,064,812 - 161,070,372 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,059,931 - 161,088,765 (+)EnsemblGRCr8
mRatBN7.23140,604,490 - 140,610,050 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,599,608 - 140,628,448 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,508,993 - 144,514,553 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,092,812 - 153,098,372 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,833,296 - 150,838,855 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3159,168,259 - 159,173,819 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3166,136,506 - 166,142,066 (+)NCBILyon_Normotensive
Lyon_Hypertensive3157,996,355 - 158,001,915 (+)NCBILyon_Hypertensive
F344_StmMcwi3139,006,001 - 139,011,561 (+)NCBIF344_StmMcwi
Rnor_6.03147,608,850 - 147,614,410 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,609,095 - 147,632,801 (+)Ensemblrn6Rnor6.0
Rnor_5.03153,957,677 - 153,963,237 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,457,352 - 142,462,725 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,357,182 - 139,362,742 (+)NCBICelera
RGSC_v3.13142,357,865 - 142,386,609 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (ISO)
2,4-dinitrophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(chloromethyl)pyridine  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-Hydroxybenzo[a]pyrene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
Aflatoxin G2  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amoxicillin  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
aphidicolin  (ISO)
arachidonic acid  (EXP)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
Bardoxolone methyl  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bleomycin A5  (ISO)
brequinar  (ISO)
Bromochloroacetonitrile  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
Chloroacetonitrile  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (EXP)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP)
dicamba  (ISO)
dichloroacetic acid  (ISO)
Dichloroacetonitrile  (ISO)
diclofenac  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
ferric oxide  (EXP)
flucloxacillin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
glyphosate  (ISO)
hexane  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lomustine  (ISO)
lutein  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metam  (ISO)
methapyrilene  (ISO)
methyl methacrylate  (ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
morphine  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
n-propyl gallate  (ISO)
naphthalene  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
nitrososulfamethoxazole  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omaveloxolone  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorone  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
potassium bromate  (ISO)
prednisolone  (ISO)
propan-2-ol  (ISO)
propiconazole  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (EXP)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfisoxazole  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trametinib  (ISO)
trans-isoeugenol  (ISO)
Trichloroacetonitrile  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
XAV939  (ISO)
zearalenone  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15448164   PMID:16565085   PMID:19430206   PMID:22402332   PMID:23553940   PMID:25407820   PMID:25620665   PMID:25955519   PMID:26992405   PMID:28552673   PMID:33173963  
PMID:33421493  


Genomics

Comparative Map Data
Srxn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,064,812 - 161,070,372 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,059,931 - 161,088,765 (+)EnsemblGRCr8
mRatBN7.23140,604,490 - 140,610,050 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,599,608 - 140,628,448 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,508,993 - 144,514,553 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,092,812 - 153,098,372 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03150,833,296 - 150,838,855 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3159,168,259 - 159,173,819 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3166,136,506 - 166,142,066 (+)NCBILyon_Normotensive
Lyon_Hypertensive3157,996,355 - 158,001,915 (+)NCBILyon_Hypertensive
F344_StmMcwi3139,006,001 - 139,011,561 (+)NCBIF344_StmMcwi
Rnor_6.03147,608,850 - 147,614,410 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,609,095 - 147,632,801 (+)Ensemblrn6Rnor6.0
Rnor_5.03153,957,677 - 153,963,237 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,457,352 - 142,462,725 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,357,182 - 139,362,742 (+)NCBICelera
RGSC_v3.13142,357,865 - 142,386,609 (+)NCBI
Cytogenetic Map3q41NCBI
SRXN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3820646,615 - 653,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl20646,615 - 653,378 (-)Ensemblhg38GRCh38
GRCh3720627,259 - 633,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3620575,259 - 581,890 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3420575,269 - 581,890NCBI
Celera20722,084 - 728,715 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef20578,569 - 585,325 (-)NCBIHuRef
CHM1_120627,286 - 634,040 (-)NCBICHM1_1
T2T-CHM13v2.020690,889 - 697,474 (-)NCBIT2T-CHM13v2.0
Srxn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392151,946,738 - 151,953,296 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2151,947,436 - 151,953,296 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382152,105,524 - 152,111,376 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,105,516 - 152,111,376 (+)Ensemblmm10GRCm38
MGSCv372151,931,466 - 151,937,089 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362151,797,171 - 151,802,794 (+)NCBIMGSCv36mm8
Celera2157,921,724 - 157,927,347 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.83NCBI
Srxn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955597483,358 - 487,555 (-)Ensembl
ChiLan1.0NW_004955597483,358 - 487,555 (-)NCBIChiLan1.0ChiLan1.0
SRXN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1201,732,942 - 1,739,638 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v020855,951 - 862,640 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.120625,376 - 631,950 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl20625,376 - 631,950 (-)EnsemblpanPan2panpan1.1
SRXN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,232,608 - 20,238,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,232,607 - 20,237,154 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2419,885,276 - 19,891,640 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02420,923,866 - 20,930,218 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2420,923,866 - 20,930,153 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,199,129 - 20,205,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,304,875 - 20,311,233 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02420,735,939 - 20,742,311 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srxn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640169,441,639 - 169,484,737 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648517,873,286 - 17,877,783 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648517,873,283 - 17,879,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRXN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1734,582,440 - 34,589,300 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11734,582,377 - 34,589,308 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21739,382,631 - 39,389,562 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRXN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1255,866,050 - 55,870,568 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660788,080,707 - 8,087,095 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srxn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247411,724,554 - 1,730,059 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Srxn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15131,461,912 - 131,467,597 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srxn1
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:72
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000041456
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH128232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23140,609,767 - 140,609,981 (+)MAPPERmRatBN7.2
Rnor_6.03147,614,128 - 147,614,341NCBIRnor6.0
Rnor_5.03153,962,955 - 153,963,168UniSTSRnor5.0
RGSC_v3.43142,462,452 - 142,462,665UniSTSRGSC3.4
Celera3139,362,460 - 139,362,673UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 87 59 6 350 187 11 141 80 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041456   ⟹   ENSRNOP00000041813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,059,931 - 161,088,765 (+)Ensembl
mRatBN7.2 Ensembl3140,599,608 - 140,628,448 (+)Ensembl
Rnor_6.0 Ensembl3147,609,095 - 147,632,801 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115549   ⟹   ENSRNOP00000079019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,059,931 - 161,088,765 (+)Ensembl
mRatBN7.2 Ensembl3140,599,608 - 140,628,448 (+)Ensembl
RefSeq Acc Id: NM_001047858   ⟹   NP_001041323
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,064,812 - 161,070,372 (+)NCBI
mRatBN7.23140,604,490 - 140,610,050 (+)NCBI
Dahl_SR_JrHsd3159,168,259 - 159,173,819 (+)NCBI
Lyon_Normotensive3166,136,506 - 166,142,066 (+)NCBI
Lyon_Hypertensive3157,996,355 - 158,001,915 (+)NCBI
F344_StmMcwi3139,006,001 - 139,011,561 (+)NCBI
Rnor_6.03147,608,850 - 147,614,410 (+)NCBI
Rnor_5.03153,957,677 - 153,963,237 (+)NCBI
RGSC_v3.43142,457,352 - 142,462,725 (+)RGD
Celera3139,357,182 - 139,362,742 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001041323 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI67743 (Get FASTA)   NCBI Sequence Viewer  
  AAP92606 (Get FASTA)   NCBI Sequence Viewer  
  EDL86084 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041813.3
  ENSRNOP00000079019.1
RefSeq Acc Id: NP_001041323   ⟸   NM_001047858
- UniProtKB: A6KHM1 (UniProtKB/TrEMBL),   B3DM86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041813   ⟸   ENSRNOT00000041456
Ensembl Acc Id: ENSRNOP00000079019   ⟸   ENSRNOT00000115549
Protein Domains
ParB-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TP44-F1-model_v2 AlphaFold Q7TP44 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307332 AgrOrtholog
BioCyc Gene G2FUF-47281 BioCyc
Ensembl Genes ENSRNOG00000031167 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041456.6 UniProtKB/TrEMBL
  ENSRNOT00000115549.2 UniProtKB/TrEMBL
Gene3D-CATH Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455497 IMAGE-MGC_LOAD
InterPro ParB/Sulfiredoxin_dom UniProtKB/TrEMBL
  ParB/Sulfiredoxin_sf UniProtKB/TrEMBL
  Sulfiredoxin UniProtKB/TrEMBL
KEGG Report rno:296271 UniProtKB/TrEMBL
MGC_CLONE MGC:187204 IMAGE-MGC_LOAD
NCBI Gene 296271 ENTREZGENE
PANTHER PTHR21348 UniProtKB/TrEMBL
  SULFIREDOXIN-1 UniProtKB/TrEMBL
PhenoGen Srxn1 PhenoGen
PIRSF Sulfiredoxin UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031167 RatGTEx
SMART ParB UniProtKB/TrEMBL
Superfamily-SCOP SSF110849 UniProtKB/TrEMBL
UniProt A0A8I5ZLX4_RAT UniProtKB/TrEMBL
  A6KHM1 ENTREZGENE, UniProtKB/TrEMBL
  B3DM86 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP44_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Srxn1  sulfiredoxin 1  Srxn1  sulfiredoxin 1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Srxn1  sulfiredoxin 1 homolog (S. cerevisiae)  Npn3  neoplastic progression 3  Symbol and Name updated 1299863 APPROVED
2005-12-06 Npn3  neoplastic progression 3  Npn3_predicted  neoplastic progression 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Npn3_predicted  neoplastic progression 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED