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Gene: Adamts12 (ADAM metallopeptidase with thrombospondin type 1 motif, 12) Rattus norvegicus

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Symbol:

Adamts12

Name:

ADAM metallopeptidase with thrombospondin type 1 motif, 12

RGD ID:

1307323

Description:

Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of cellular response to growth factor stimulus; protein catabolic process; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; LOC294809

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	61,759,975 - 62,054,716 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	61,759,987 - 62,054,716 (+)	Ensembl				GRCr8
mRatBN7.2	2	60,032,873 - 60,327,629 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	60,032,873 - 60,327,629 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	67,143,918 - 67,451,709 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	65,265,431 - 65,573,247 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	60,266,812 - 60,574,625 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	61,039,072 - 61,340,687 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	61,039,053 - 61,340,697 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	83,352,798 - 83,650,251 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	60,427,824 - 60,717,617 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	58,357,418 - 58,652,079 (-)	NCBI		Celera
RGSC_v3.1	2	60,349,718 - 60,645,857 (+)	NCBI
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

stroke (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

amphotericin B (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP)

CGP 52608 (ISO)

choline (ISO)

clotrimazole (EXP)

clozapine (ISO)

Cuprizon (EXP,ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

hexadecanoic acid (ISO)

L-methionine (ISO)

lead(0) (ISO)

malathion (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dibromide (ISO)

methimazole (EXP)

methoxychlor (EXP)

microcystin-LR (EXP)

nickel sulfate (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

testosterone (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

triclosan (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell migration (IEA,ISO)

cell-matrix adhesion (IEA,ISO)

cellular response to BMP stimulus (IEA,ISO)

cellular response to interleukin-1 (IEA,ISO)

cellular response to tumor necrosis factor (IEA,ISO)

chondrocyte differentiation (IEA,ISO)

collagen fibril organization (IEA,ISO)

extracellular matrix organization (IBA,IEA)

negative regulation of cellular response to hepatocyte growth factor stimulus (IEA,ISO)

negative regulation of cellular response to vascular endothelial growth factor stimulus (IEA,ISO)

negative regulation of chondrocyte differentiation (IEA,ISO)

negative regulation of hepatocyte growth factor receptor signaling pathway (IEA,ISO)

ossification (IEA,ISO)

ossification involved in bone maturation (IEA,ISO)

proteoglycan catabolic process (IEA,ISO)

proteoglycan metabolic process (IEA,ISO)

proteolysis (IBA,IEA)

proteolysis involved in protein catabolic process (IEA,ISO)

regulation of endothelial tube morphogenesis (IEA,ISO)

regulation of inflammatory response (IEA,ISO)

Cellular Component

extracellular matrix (IBA)

Molecular Function

hydrolase activity (IEA)

metal ion binding (IEA)

metalloendopeptidase activity (IBA,IEA,ISO)

metallopeptidase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.	Arning A, etal., Blood. 2012 Dec 20;120(26):5231-6. doi: 10.1182/blood-2012-07-442038. Epub 2012 Sep 18.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:16611630	PMID:17895370	PMID:18485748	PMID:21494557	PMID:21869572	PMID:22247065	PMID:23019333	PMID:37400752

Genomics

Comparative Map Data

Adamts12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	61,759,975 - 62,054,716 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	61,759,987 - 62,054,716 (+)	Ensembl				GRCr8
mRatBN7.2	2	60,032,873 - 60,327,629 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	60,032,873 - 60,327,629 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	67,143,918 - 67,451,709 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	65,265,431 - 65,573,247 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	60,266,812 - 60,574,625 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	61,039,072 - 61,340,687 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	61,039,053 - 61,340,697 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	83,352,798 - 83,650,251 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	60,427,824 - 60,717,617 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	58,357,418 - 58,652,079 (-)	NCBI		Celera
RGSC_v3.1	2	60,349,718 - 60,645,857 (+)	NCBI
Cytogenetic Map	2	q16	NCBI

ADAMTS12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	33,523,535 - 33,891,990 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	33,523,535 - 33,892,019 (-)	Ensembl			hg38	GRCh38
GRCh37	5	33,523,640 - 33,892,095 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	33,563,043 - 33,927,881 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	33,563,042 - 33,927,881	NCBI
Celera	5	33,408,303 - 33,780,613 (-)	NCBI		Celera
Cytogenetic Map	5	p13.3-p13.2	NCBI
HuRef	5	33,495,595 - 33,870,040 (-)	NCBI		HuRef
CHM1_1	5	33,528,883 - 33,893,746 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	33,638,143 - 34,013,900 (-)	NCBI		T2T-CHM13v2.0

Adamts12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	11,064,781 - 11,349,321 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	11,064,876 - 11,349,317 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	11,064,773 - 11,349,232 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	11,064,790 - 11,349,231 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	10,994,545 - 11,276,622 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	11,009,756 - 11,290,402 (+)	NCBI		MGSCv36	mm8
Celera	15	10,855,060 - 11,130,577 (+)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	5.43	NCBI

Adamts12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	19,150,343 - 19,471,534 (-)	Ensembl
ChiLan1.0	NW_004955426	19,146,288 - 19,471,880 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADAMTS12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	76,399,984 - 76,784,157 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	74,561,166 - 74,937,839 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	76,442,053 - 76,818,726 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	81,828,264 - 82,203,497 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	81,827,560 - 82,199,840 (+)	Ensembl			panPan2	panpan1.1

ADAMTS12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	73,887,959 - 74,188,909 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	73,887,924 - 74,001,984 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	73,503,678 - 73,767,544 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
Dog10K_Boxer_Tasha	4	73,777,238 - 73,812,152 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	74,394,459 - 74,697,683 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	74,379,341 - 74,696,853 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	74,140,285 - 74,398,310 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	74,264,326 - 74,571,548 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	74,798,493 - 75,101,600 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adamts12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	223,889,032 - 224,191,694 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	7,180,428 - 7,480,802 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	7,180,262 - 7,483,416 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAMTS12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	19,547,011 - 19,920,513 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	19,547,003 - 19,920,780 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	20,237,769 - 20,454,645 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAMTS12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	32,757,699 - 33,129,116 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	32,757,684 - 33,129,059 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666071	23,035,326 - 23,424,713 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adamts12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	20,898,761 - 21,088,838 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624759	20,749,548 - 21,092,816 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Adamts12
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	169,485,235 - 169,697,427 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Adamts12
1787 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	713
Count of miRNA genes:	306
Interacting mature miRNAs:	381
Transcripts:	ENSRNOT00000025693
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	61556902	106556902	Rat
6480225	Gdil1	Gastrointestinal dilation QTL 1			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	58388201	77302351	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	61051883	104684275	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	61051541	105724065	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	61051541	105724065	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	60861391	105861391	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

D2Rat271

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	60,305,234 - 60,305,371 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	61,318,079 - 61,318,215	NCBI	Rnor6.0
Rnor_5.0	2	83,375,215 - 83,375,351	UniSTS	Rnor5.0
RGSC_v3.4	2	60,697,816 - 60,697,953	RGD	RGSC3.4
RGSC_v3.4	2	60,697,817 - 60,697,953	UniSTS	RGSC3.4
Celera	2	58,379,219 - 58,379,355	UniSTS
RGSC_v3.1	2	60,625,871 - 60,626,340	RGD
SHRSP x BN Map	2	27.4398	RGD
SHRSP x BN Map	2	27.4398	UniSTS
Cytogenetic Map	2	q16	UniSTS

D2Got315

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	60,277,511 - 60,277,618 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	61,290,038 - 61,290,144	NCBI	Rnor6.0
Rnor_5.0	2	83,403,286 - 83,403,392	UniSTS	Rnor5.0
RGSC_v3.4	2	60,670,084 - 60,670,190	UniSTS	RGSC3.4
Celera	2	58,406,792 - 58,406,898	UniSTS
Cytogenetic Map	2	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	61	59	6	320	161	11	140	76	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025693 ⟹ ENSRNOP00000025693

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	61,759,987 - 62,054,716 (+)	Ensembl
mRatBN7.2 Ensembl	2	60,032,873 - 60,327,629 (+)	Ensembl
Rnor_6.0 Ensembl	2	61,039,053 - 61,340,697 (+)	Ensembl

RefSeq Acc Id:

NM_001106420 ⟹ NP_001099890

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	61,759,987 - 62,054,716 (+)	NCBI
mRatBN7.2	2	60,032,873 - 60,327,629 (+)	NCBI
Rnor_6.0	2	61,039,072 - 61,340,687 (+)	NCBI
Rnor_5.0	2	83,352,798 - 83,650,251 (-)	NCBI
RGSC_v3.4	2	60,427,824 - 60,717,617 (+)	RGD
Celera	2	58,357,418 - 58,652,079 (-)	NCBI

Sequence:

show sequence

CAGAAAGCAGAAGCTGTCAGCTCATTCACTCCCCTTTCAGGAAAGGGAGAGCAGAGAAGTTCTC
TGGTCCTGTCTACTTCAAAAGGCCACTAGAGCTCTTGGGCAGCTAGCGGGCCGCTCCCTTCCCA
CGCCTGGACCATGCTCCGCTGCGGCTTCCTGCGCGGCCACGGGCGAGGACTCGGTATCTGCAGC
TGAGAGCTAACACTGTTTTGACTTTTCTTCTCCCCAACAACCGAACCATGCCATGTGCTCAGGG
GAACTGGATGGCAAAGCTCTCCATGGTGGCCCAGCTTCTTAACTTTGGGGCTTTTTGCCATGGG
AGACAAGCTCAGCCCTGGCCGGTTCGCTTCCCAGACCCGAAGCAAGAACATTTTATCAAGTCCC
TGCCAGAATACCACATAGTGAGTCCTGTCCAAGTAGATGCCAGTGGCCACTTTCTGTCCTATGG
CCTGCATCACCCTGTCACTGGCAGCAGGAAGAAGAGAGCTGCAGGTGGTTCTGGGGACCAGGTG
TACTACAGGATTTCACACGAAGAAAAAAACCTGTTTTTCAATCTGACAGTCAACTGGGAATTTC
TTTCCAATGGCTATGTCGTGGAGAGGAGATATGGGAACCTTTCCCATGTGAAGATGGCGGCTTC
CTCAGGGCAGCCCTGCCATCTCAGGGGCACAGTTCTGCAACAGGGCCCCACAATCAGGATGGGG
ACAGCAGCTCTTAGTGCCTGCCAAGGACTGACTGGATTTTTCCATCTACCACATGGAGACTTTT
TCATTGAGCCTGTTAAAAAGCATCCACTGACCGAGGAAGGTTACCAGCCTCATGTCATATACAG
GAGGCAGAGCTACAGAGTTCCAGAGACAAAGGAGCCCACCTGCGGATTAAAGGACAGCCTTGAT
AACTCTGTGAAGCAAGAGCTCCAGCGGGAGAAGTGGGAGAGGAAGAACTGGCCAAGCAGAAGCC
TCTCCCGACGCTCCATAAGCAAGGAGAGATGGGTGGAGACCCTCGTGGTAGCTGACACGAAGAT
GGTAGAGTACCATGGAAGTGAGAACGTGGAGTCGTACATCCTCACTATCATGAATATGGTCACT
GGGTTGTTTCATAACCCAAGCATTGGAAACGCAGTGCACATTGTTGTGGTTCGGCTCATTCTAC
TTGAAGAAGAGGAGCAAGGATTGAAAATAGTTCACCATGCAGAGAAGACACTGTCCAGCTTCTG
CAAGTGGCAGAAGAGCATCAATCCCAAGAGTGACCTCAACCCTGTCCATCATGATGTGGCTGTC
CTTATCACCAGAAAGGACATCTGTGCTGGTGTCAATCGCCCTTGTGAGACTCTGGGGCTGTCCC
AGCTGTCAGGAATGTGCCAGCCTCACAGGAGCTGTAACATCAACGAAGACTCCGGTCTCCCCCT
GGCTTTCACCATTGCGCATGAACTTGGGCACAGCTTCGGCATCCAACATGATGGGAAGGAAAAT
GACTGTGAGCCCGTGGGCAGACACCCATACATCATGTCCCAACAAATTCAGTATGACCCAACTC
CACTGACATGGTCGAAATGCAGCAAGGAGTACATCACTCGCTTCTTGGACCGAGGCAGGGGGTT
CTGTCTTGATGACGTCCCCAGAAAGAAAGGCTTAAAGTCCAATGTCATTGCCCCTGGAGTGATT
TATGATGTTCATCACCAGTGCCAGCTCCAATACGGCCCAAATGCTACATTCTGCCAGGAAGTGG
AAAATGTTTGCCAGACACTGTGGTGCTCAGTGAAAGGCTTCTGTCGCTCTAAGCTGGATGCTGC
TGCAGATGGGACACGTTGTGGTGAGAAGAAGTGGTGTATGGCTGGAAAGTGTATCACAGTGGGG
AAGAAACCAGAGAGCATCCCTGGAGGCTGGGGACGCTGGTCACCCTGGTCACACTGTTCGAGGA
CATGTGGGGCAGGAGCTCAGAGCGCAGAGAGGCTCTGCAACAACCCAGAACCAAAGTTTGGAGG
GAAATACTGCACCGGAGAAAGAAAACGCTATCGCTTATGCAATGTCCACCCCTGCCGCTCAGAC
ACTCCAACTTTCCGACAGATGCAGTGCAGTGAATTTGACACAGTCCCCTACAAAAACCAATTCT
ACCGCTGGTTCCCAGTGTTTAATCCAGCACATCCTTGTGAGCTGTACTGCAGACCCATAGATGA
ACAGTTTTCTGAGAGAATGCTGGAAGCCGTCATTGATGGCACCCCGTGCTTTGAAGGTGGCAAC
AGCAGAAATGTCTGTATTAATGGCATATGTAAGAGGGTTGGCTGTGACTATGAGATTGATTCCA
ATGCTACAGAGGATCGCTGTGGCGTGTGCCTTGGAGATGGCTCTGCCTGCCAGACTGTGAAGAA
GGTGTTTAGACAGAAGGAAGGATCCGGTTACATTGACATCGGACTTATTCCCAAAGGTGCAAGG
GATATAAGAGTGATGGAAATCAAGGCAGCCGGCAATTTCCTGGCCATTAGGAGTGAAGATCCAG
AAAAATATTACCTCAACGGAGGATTTATCATCCAGTGGAATGGAAACTATAAACTGGCAGGGAC
CGTCTTCCAGTATGACAGGAAAGGAGATCTGGAGAGACTTATGGCTCCAGGCCCCACCAACGAG
TCAGTGTGGCTCCAGCTACTATTCCAGGTGACTAACCCCGGTATCAAGTATGAGTACACAGTCC
GGAAAGATGGCCTTGACAATGATGTGGAGAAGTTGCTGTACTTCTGGCAATTTGGCCGCTGGAC
AGAGTGCAGTGTAACATGTGGAACAGGTATCCGCCGGCAGACTGCTCATTGTGTCAAGAAGGGC
CATGGGATAGTGAAAACTACCTTCTGCAACCCAGAAACACAGCCCAGCGTGAGACAGAAAAAGT
GCTATGAAAAGGACTGTCCACCCAGGTGGTGGGCCGGAGAGTGGGAAGCATGTTCAATGACATG
TGGGCCGTACGGAGAAAAAAAGAGAACAGTGCTGTGCATCCAGACCATGGGCTCTGATGAGCAG
GCTCTCCCAGCTACAGACTGCCAGCACCTGCTGAAGCCCAAGACACTGGTTTCCTGCAACAGAG
ACATTCTGTGTCCATCAGATTGGACAGTAGGCAACTGGAGTGAGTGCTCTGTTTCCTGTGGTGG
TGGAGTGCGGATTCGCAGTGTCACATGTGCCAAGAACCTTAATGAACCCTGTGACAAGACACGG
AAACCCAACAGTCGAGCTCTGTGTGGCCTCCAGCAGTGCCCATTCAGCCGTAGAGTTCTGAAAC
CCAATAAAGATACAGTTCCCAGTGGGAAAAATCCAACAACATCAGAACATGACCACTTCAAGCC
CATCCCAGCATCTACATCCAGGCCCACGCCACTGTCCACACCCACAGTGCCTGAGTCTGTGAGC
ACAAGTACCCCCACAATCAACAGCCTTGGCTCCACCATAACATCCCAAGAAGAACCAGATGGGA
TAGGATGGCAGAATAATTCAACCCAAGCTGAAGAGGACTCCCACATCCCTACTTCTGTTGGAAG
CACTTCCCAGACTCCCCTCACTTCCTGGTCTTGGAGTATGCAGCCTGATGATGAAAACGTTTCC
AGTTCAGCTATAGGTCCAACTTCAGAGAGTGACTTTTGGGCAACCACAAGTGATTCTGGCTTAT
CATCTAGCAATGCTATGACTTGGCAGGTAACTCCATTTTATAGCACTGCGACCACAGAACCGGA
AGTGGAGATACATAGTGGCTCAGGGGAAGACAGTGACCAGCCTTTGAACAAGGAGGAAAACAAC
TCTGTGCTATGGAACAAGATCAGAGTACCTGAACGTGATGCTCCCATGGAGATGGATGCAGAAA
TACCACTTGGACCTCCACCAACATCTTATGTGACAGAAGAGTCCTCATGGCCTCCCTTCAGTAC
AATGATGAAAAGCTCACTACCTGCCTGGTCCTTCAAAAATGAGACACCCAGGGATGAGGGGATG
ATCACTGAAAAATCAGGGAATATTCCACTCCCTCTTGGAGGAGACCACCAGACAACATCCCCAG
AGAAGTTAGGAAACAATGACCAACTGGCATCAGCAAATAGTACAAATCCAACCCAAGGCTCTGG
GCCTGTCCTGACTGAGGAAGATGCCTCCACTCTGATTGAGGAGGGATTTTTGCTAAATGCTTCC
AATTACAAGCATCTCATGAAGGACCACAGCCCTGCACACTGGATTGTTGGAAATTGGAGTAAAT
GCTCTACCACCTGTGGGCTGGGGGCCTACTGGAGGAGTGTGGAGTGTAGCACCGGGATGAACGC
TGACTGCGCCGCCATTCAGAGGCCAGACCCTGCTAAGAAGTGCCACCTGCGCCCCTGTGCTGGC
TGGCGAGTGGGAAACTGGAGCAAGTGCTCTCGAAACTGCAGTGGAGGTTTCAAGATTCGTGAGG
TTCAGTGCATGGACGGCGTGGACCATCACCGGAGCCTGAGGCCATTTCACTGTCAGTTCCTGGC
CGGCGTTCCTCCTCCGCTGAGTATGAGCTGTAATCTGGAGCCTTGCGAAGAGTGGAAAGTGGAA
CCCTGGAGCCAGTGTTCTAGGTCCTGTGGAGGCGGTGTTCAGGAGAGAGGAGTGTTTTGCCCAG
GAGGTCTCTGCGACTGGACAAAAAGACCTGCATCCACTGTGCCCTGCAACAGACACCTTTGCTG
TCACTGGGCCACTGGGAACTGGGAACTGTGCACCACTTCCTGTGGTGGTGGCTCTCAGAAGAGG
ACCGTTCATTGCATCCCTTCAGAAAACAGTACAACTGAAGATCAAGACCAGTGTTTCTGTGACC
ACCAAGCCAGACCCCCAGAATTCCAAAACTGCAACCAGCAAGCCTGCCGGAAGAGTGCTGATTT
AACTTGCACGAAGGACAGACTTTCAACCAGCTTCTGCCAGACACTAAAATCCATGAAGAAGTGC
TCGGTGCCATCAGTACGAGTCCAGTGCTGTCTCTCGTGTCCACAGACACAGAGCATCCACACCC
AGAGGCAAAGAAAACAGCAGATGCTCCAAAATCATGACACGCTCTAGGTTCAGAAAGAAGCCAC
CATCATGGGCTTCCACAGCCTGATACCCAAGAACATGGTCCAGAAGGCCACTTCACTAATATTT
CACTTTGTACATTCTAGGTTCAACTTTGGGTCATAACAAAACAAAACGCAATGTGTGTGTCTAG
TCACTAAATGTTTCTCACAGAAAGCTTGGGGCTGGCTGCTCCCCAATAGGAAGACGAAGTATTT
GAGAGAATGATGCTGCAGCAGTTGAGATGAGTTCCTTGGGAAAGTGCCAGATTAGGCAAGTCTG
TGAAAATATGTCTTTCCCCCTTTAAAGATGAAAATAGAAACCTGTTTTTTTCCCAAACTACCTC
AAGAAACAGAGACACACTTACCCAGGAAACAGATAATCTTTTAAATTTGTCTTCATGAATATAT
CCCCCTTAGGTGCCTTGGGTAGCCACTGTTTAAAAGCCATGAGGCAAGTTTTAGGACCATCTAT
CTCAGTAGTCAATAAGGACAGGAAAAAGATGCTAGCTATGGTGCCCTGTCTGTTCTCCATCACT
GTAGGACTTCACAACTGGAAACCTAGAATCTTGGGACAAACCATGGAGATTTGAGATTAAGGAG
ACAGGGGCATCAGATGCAGCCTAGGGGCATTAGATTGGCGGTCAAGAAGTCATTTTTTACTTTA
CTTCAATTTCTATTAAAAGTCCTTAAAATGCAAATGAACAGAATCAACTTCTAGCTAGCATAAG
AAAGAAAATGGTCCTTGTCCCTCAAACTTTACTGGCTTTGTTAGCTTGTCACAGAACAAATGTG
TGTTCCTGTCTGCCAGTGCCCTGTCCCTTTCGGAGTCATGACCTCAGGTCTTCCCATCATCCCT
GTGCAGAAAGATTACACACAAACCTGCTACAAGTAGGGTTAGGGCTGTCTGCACACCCTGTTTC
TCTCCTGAGAGAAAAAGTGAAGTTATAGGCCAAACCACTTTTAAAAATCAGGTAAATTGTACTA
AGTCTAGGAATTTAGTAGAAATTTATAGTTTAGAAGAAAAAAGTTCTAAAAAGTGTGCCTTAGT
GTGTCTATTAGTAACTTTTAAAAGAGATAAAGAGCTGGGGTAGAATGCATATTTATCACAGTTG
TGCAAGGCTGTAAGTTTGGTGTCTAGCAACACACGTGCATGCGTATACACATACACACAGAATC
AAAAATGGAGGCTAACTAACCTTATGGAGAGCAAGCAAGTCAAGAGGGTCCAGAACACTGAAAC
AGAAGTGAAATAGAACACTAAAACATGCTTGTTTTAGAATCACCCCGCCTCACTGATGTCAGTA
GGCTGTGAGCACAAACGCAGAGCAGATTTCCAGGTGAGCCTGTAGACTGAACCTTGAGTGAAAA
ATGGATGTGTGGAGAGATGCAAGCCCCAGGGAAAGACCCCAGAACCAGCTCTTGACAGGATAGG
AGGCAATGTATGTCTTCCGGTGGGACTCAAGGCTTATGCACCAATATGAATCTTCATTCTGGAG
TGCAGTGTCCCTCAGCTCCCTGTAGTTATCTGTCCATTCAGCAGAATGGTGCTATTGAACTTGG
TGCTAATATCTAGATGGTGGCAAAGCTAACAGAATGTTAACAAATAGTCATGTGAAAGGCTAGG
TGTCTATGAACTTCCTTATAGACATATGCTTTGTGTGAGATGGTATTGCTGGCCAATGCCAGTT
TTATTTGTTCTGAGACCATGAACATAGCATTATATAGGATGCACTTTTAAACTCTTTCAAGACA
CTAGCATGGATTATTCTGATCGATTCCTGTGGAAAGTAAAACACTGGGATTTGGATAAAATTCA
AGGTATACCAGAAATAGGAGAAAATACACATTTACTGAAGCCAGGGAATTATGTATAGTTAAGC
ATACATTCTTGCATTCTGTCTTTACATAAACACATTGCTGGCCAATGACAATCTCTGATGAAAT
AGCTATTTTAGAGAAATGCTTACATTAATCTGTTAGTGGCAGAAATGGAGAAAAAAGTAGAGGA
GAACTTGACCTTCTAATGAGGAATTTTGCAAGGGCTAGTAGTATAGGCTTTCAAAAGTGTTAAT
TAATAAGCCATGTGTACTGTTCTACAGCAGAATAAAGAACATGACACCAGAGTCCTGGGTATGA
CCAGGCTTACAAAACTCAGGAACAAACTTGGATTTCTACTGACCTCAACAAACTAAAAGTAGGC
CAGATTTTCCAGTGCAAAAAAAATAGACCATGTCATTTGGGACCCATGTGGTTGAGCACAACAT
GAGCCTCGGGGGAGAGTCTGGCCAGGTGCTCCATTCTAGATCTTTCTCCATTTTCTTAAGTACA
GGAAATAGGTCTCTGATCATGCATCATGGACATCCTCTTCTTCTACCACGGTGAGACTGTCCTA
TGCCATGTGTCATTAGTGTTTGCTGTAGGAGTCATTGGTCAGCTGCTCAGCTGTGGGCTATCAG
TGTTTCCATGGATCTTTAATGCTTGAGATGCTGGAAGAACCTTGAATAGCAGGATGACACTGAC
AGCAAGAGCTGGATAGTATCTTCACGGGGTCAAATGTGAAGGCTTGGTTTATTTCATCCATCTC
CTCCTTCACATCAACACCTTGAAGGTGTGAACAAGAAGCTCAGCAAGAGACACTAGAGTCGTAC
TCTGAGCCAGACAGATCCACCATGGAGCCTTGTACTTACATTCATCATGTTGGGTTTACATTGC
TTTTCAGAGTGATAGACTTAGTTCTTCTCCAAAAAGTTATAAGCTACTTAATTTTAACATCAGA
AAAGTGTTATGCCATAAGAAAACAATATTCCTAGAAACTTTATAGTGAACACTTTGTTCAAGTC
ATGAATCATGTCCTGTAACAAAGGATTGCTTTCCTTTGCAGGAATAACTATTGAGTCATAGGTC
TTCCTAAACAAGAGCACAGGCACTTTCCTCTGGTCTCCTGAGACAGCATGTCTTCGCTGGCTGT
CCAATGCAATGCTCTGAGAGTCTTTTGAGCAACCGCCACCAAGAATCTGAAGCAATTTGAGAGA
TTACATAATTTCAGACCCTAATTTCCCATCCAGTTAGCTGAAGTTCTCTGACAGCTACATATTG
CAAACCTAGAAAAGTGCAAAGTCTTAGTTTTCTCCTTTCTCACTTCAAGATGAAGCTCTGGGAC
AGCTTTTCTGGTGCTCAATCCACAGTGATCCACTCTCACAGGCCACATGTCTTGAGTTTCCTGG
TGCTATAACCAATCTAATACATTTGATGCTACTCCTGTTGTTAATGCAAGTATTTTTTTTAATT
CAAGTATTTTTTTAAGTTCTGTCACTAAAAATAATGTGATGGGGGAAAATGCATTTCTCCCTAC
CATTGTCCTCCAAAATAATGGCGTGACATAACATGGCTAACTCATTGTCTCCCCTGTGTTTCTA
TATTGCTGCTTCACCAGCTGATTCCTACACTCCTCCTGTACCCCATTAGTAAGTACCTCAGTAT
TAAAACCAGATTGTAATCACAGGCTGTCTCTGTGTGGCATCAATAAATGGCCAAACCCA

hide sequence

RefSeq Acc Id:

XM_039101948 ⟹ XP_038957876

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	61,759,975 - 62,025,462 (+)	NCBI
mRatBN7.2	2	60,032,885 - 60,298,374 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099890	(Get FASTA)	NCBI Sequence Viewer
	XP_038957876	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82979	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025693
	ENSRNOP00000025693.6

RefSeq Acc Id:	NP_001099890 ⟸ NM_001106420
- Peptide Label:	precursor
- UniProtKB:	D3ZTJ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPCAQGNWMAKLSMVAQLLNFGAFCHGRQAQPWPVRFPDPKQEHFIKSLPEYHIVSPVQVDASG HFLSYGLHHPVTGSRKKRAAGGSGDQVYYRISHEEKNLFFNLTVNWEFLSNGYVVERRYGNLSH VKMAASSGQPCHLRGTVLQQGPTIRMGTAALSACQGLTGFFHLPHGDFFIEPVKKHPLTEEGYQ PHVIYRRQSYRVPETKEPTCGLKDSLDNSVKQELQREKWERKNWPSRSLSRRSISKERWVETLV VADTKMVEYHGSENVESYILTIMNMVTGLFHNPSIGNAVHIVVVRLILLEEEEQGLKIVHHAEK TLSSFCKWQKSINPKSDLNPVHHDVAVLITRKDICAGVNRPCETLGLSQLSGMCQPHRSCNINE DSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSQQIQYDPTPLTWSKCSKEYITRFL DRGRGFCLDDVPRKKGLKSNVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCR SKLDAAADGTRCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGAQSAERLCNNP EPKFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCSEFDTVPYKNQFYRWFPVFNPAHPCELY CRPIDEQFSERMLEAVIDGTPCFEGGNSRNVCINGICKRVGCDYEIDSNATEDRCGVCLGDGSA CQTVKKVFRQKEGSGYIDIGLIPKGARDIRVMEIKAAGNFLAIRSEDPEKYYLNGGFIIQWNGN YKLAGTVFQYDRKGDLERLMAPGPTNESVWLQLLFQVTNPGIKYEYTVRKDGLDNDVEKLLYFW QFGRWTECSVTCGTGIRRQTAHCVKKGHGIVKTTFCNPETQPSVRQKKCYEKDCPPRWWAGEWE ACSMTCGPYGEKKRTVLCIQTMGSDEQALPATDCQHLLKPKTLVSCNRDILCPSDWTVGNWSEC SVSCGGGVRIRSVTCAKNLNEPCDKTRKPNSRALCGLQQCPFSRRVLKPNKDTVPSGKNPTTSE HDHFKPIPASTSRPTPLSTPTVPESVSTSTPTINSLGSTITSQEEPDGIGWQNNSTQAEEDSHI PTSVGSTSQTPLTSWSWSMQPDDENVSSSAIGPTSESDFWATTSDSGLSSSNAMTWQVTPFYST ATTEPEVEIHSGSGEDSDQPLNKEENNSVLWNKIRVPERDAPMEMDAEIPLGPPPTSYVTEESS WPPFSTMMKSSLPAWSFKNETPRDEGMITEKSGNIPLPLGGDHQTTSPEKLGNNDQLASANSTN PTQGSGPVLTEEDASTLIEEGFLLNASNYKHLMKDHSPAHWIVGNWSKCSTTCGLGAYWRSVEC STGMNADCAAIQRPDPAKKCHLRPCAGWRVGNWSKCSRNCSGGFKIREVQCMDGVDHHRSLRPF HCQFLAGVPPPLSMSCNLEPCEEWKVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPASTVPC NRHLCCHWATGNWELCTTSCGGGSQKRTVHCIPSENSTTEDQDQCFCDHQARPPEFQNCNQQAC RKSADLTCTKDRLSTSFCQTLKSMKKCSVPSVRVQCCLSCPQTQSIHTQRQRKQQMLQNHDTL hide sequence

Ensembl Acc Id:

ENSRNOP00000025693 ⟸ ENSRNOT00000025693

RefSeq Acc Id:	XP_038957876 ⟸ XM_039101948
- Peptide Label:	isoform X1

Protein Domains

Peptidase M12B PLAC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTJ3-F1-model_v2	AlphaFold	D3ZTJ3	1-1599	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691189

Promoter ID:

EPDNEW_R1714

Type:

initiation region

Name:

Adamts12_1

Description:

ADAM metallopeptidase with thrombospondin type 1 motif, 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	61,039,073 - 61,039,133	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307323	AgrOrtholog
BioCyc Gene	G2FUF-54063	BioCyc
Ensembl Genes	ENSRNOG00000018865	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025693	ENTREZGENE
	ENSRNOT00000025693.9	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/TrEMBL
	2.60.120.830	UniProtKB/TrEMBL
	3.40.1620.60	UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/TrEMBL
InterPro	ADAM_CR_2	UniProtKB/TrEMBL
	ADAM_spacer1	UniProtKB/TrEMBL
	ADAMTS/ADAMTS-like	UniProtKB/TrEMBL
	ADAMTS_ADAMTS-like	UniProtKB/TrEMBL
	ADAMTS_CR_3	UniProtKB/TrEMBL
	MetalloPept_cat_dom	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	PLAC	UniProtKB/TrEMBL
	Thrombospondin_1_rpt	UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/TrEMBL
KEGG Report	rno:294809	UniProtKB/TrEMBL
NCBI Gene	294809	ENTREZGENE
PANTHER	A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 12	UniProtKB/TrEMBL
	ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE	UniProtKB/TrEMBL
Pfam	ADAM_CR_2	UniProtKB/TrEMBL
	ADAM_CR_3	UniProtKB/TrEMBL
	ADAM_spacer1	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
	TSP1_ADAMTS	UniProtKB/TrEMBL
	TSP_1	UniProtKB/TrEMBL
PhenoGen	Adamts12	PhenoGen
PRINTS	ADAMTSFAMILY	UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	PLAC	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018865	RatGTEx
SMART	TSP1	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
UniProt	D3ZTJ3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Adamts12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	Adamts12	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Adamts12	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12	Adamts12_predicted	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Adamts12_predicted	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)		a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Adamts12_predicted	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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