Gene: Ska3 (spindle and kinetochore associated complex subunit 3) Rattus norvegicus
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Symbol:
Ska3
Name:
spindle and kinetochore associated complex subunit 3
RGD ID:
1307201
Description:
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including establishment of meiotic spindle orientation; negative regulation of mitotic spindle assembly checkpoint signaling; and nuclear chromosome segregation. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to be part of SKA complex. Predicted to be active in kinetochore and spindle microtubule. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC361047; RGD1307201; similar to chromosome 13 open reading frame 3; SKA complex subunit 3; spindle and kinetochore-associated protein 3
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
SKA3 (spindle and kinetochore associated complex subunit 3)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SKA3 (spindle and kinetochore associated complex subunit 3)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Ska3 (spindle and kinetochore associated complex subunit 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
ska3 (spindle and kinetochore associated complex subunit 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
ska3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 15 36,067,372 - 36,086,563 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 15 36,067,373 - 36,086,563 (-) Ensembl GRCr8 mRatBN7.2 15 31,951,812 - 31,971,010 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 15 31,951,825 - 31,971,010 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 15 33,944,005 - 33,962,337 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 15 35,094,675 - 35,113,007 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 15 33,352,759 - 33,371,092 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Dahl_SR_JrHsd 15 34,786,141 - 34,805,106 (-) NCBI Dahl_SR_JrHsd Lyon_Normotensive 15 34,490,792 - 34,509,756 (-) NCBI Lyon_Normotensive Lyon_Hypertensive 15 34,597,364 - 34,616,328 (-) NCBI Lyon_Hypertensive F344_StmMcwi 15 33,782,833 - 33,801,797 (-) NCBI F344_StmMcwi Rnor_6.0 15 38,077,903 - 38,097,100 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 15 38,077,909 - 38,096,875 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 15 41,918,694 - 41,937,891 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 15 36,848,694 - 36,867,026 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 15 31,663,336 - 31,681,669 (-) NCBI Celera RGSC_v3.1 15 36,864,972 - 36,877,317 (-) NCBI Cytogenetic Map 15 p12 NCBI
JBrowse:
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Ska3 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of SKA3 mRNA CTD PMID:30723492 Ska3 Rat 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of SKA3 mRNA CTD PMID:32145629 Ska3 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO SKA3 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of SKA3 mRNA CTD PMID:22574217 Ska3 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SKA3 mRNA CTD PMID:34747641 Ska3 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 2-palmitoylglycerol increases expression ISO SKA3 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of SKA3 mRNA CTD PMID:37199045 Ska3 Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of SKA3 mRNA CTD PMID:31881176 Ska3 Rat acrylamide decreases expression ISO SKA3 (Homo sapiens) 6480464 Acrylamide results in decreased expression of SKA3 mRNA CTD PMID:32763439 Ska3 Rat aflatoxin B1 increases expression ISO SKA3 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of SKA3 mRNA CTD PMID:22100608 Ska3 Rat aflatoxin B1 increases methylation ISO SKA3 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of SKA3 gene CTD PMID:27153756 Ska3 Rat all-trans-retinoic acid decreases expression ISO SKA3 (Homo sapiens) 6480464 Tretinoin results in decreased expression of SKA3 mRNA CTD PMID:33167477 Ska3 Rat arsenous acid increases expression ISO Ska3 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of SKA3 mRNA CTD PMID:35676786 Ska3 Rat atrazine decreases expression ISO SKA3 (Homo sapiens) 6480464 Atrazine results in decreased expression of SKA3 mRNA CTD PMID:22378314 Ska3 Rat benzo[a]pyrene increases methylation ISO SKA3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SKA3 3' UTR CTD PMID:27901495 Ska3 Rat benzo[a]pyrene increases expression ISO SKA3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of SKA3 mRNA CTD PMID:32234424 Ska3 Rat benzo[a]pyrene diol epoxide I decreases expression ISO SKA3 (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SKA3 mRNA CTD PMID:20382639 Ska3 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SKA3 mRNA CTD PMID:25181051 Ska3 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SKA3 mRNA CTD PMID:32145629 Ska3 Rat bisphenol A decreases expression ISO SKA3 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SKA3 mRNA CTD PMID:29275510 Ska3 Rat cadmium atom multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SKA3 more ... CTD PMID:35301059 Ska3 Rat cadmium dichloride decreases expression ISO SKA3 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of SKA3 mRNA CTD PMID:38174414|PMID:38568856 Ska3 Rat cadmium dichloride multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SKA3 more ... CTD PMID:35301059 Ska3 Rat caffeine increases phosphorylation ISO SKA3 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of SKA3 protein CTD PMID:35688186 Ska3 Rat calcitriol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat calcitriol decreases expression ISO SKA3 (Homo sapiens) 6480464 Calcitriol results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat carbon nanotube increases expression ISO Ska3 (Mus musculus) 6480464 Nanotubes, Carbon analog results in increased expression of SKA3 mRNA; Nanotubes, Carbon results in increased more ... CTD PMID:25554681 Ska3 Rat chlorpyrifos decreases expression ISO Ska3 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SKA3 mRNA CTD PMID:37019170 Ska3 Rat chromium(6+) affects expression ISO Ska3 (Mus musculus) 6480464 chromium hexavalent ion affects the expression of SKA3 mRNA CTD PMID:28472532 Ska3 Rat chromium(6+) multiple interactions ISO SKA3 (Homo sapiens) 6480464 [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ... CTD PMID:38479592 Ska3 Rat copper(II) sulfate decreases expression ISO SKA3 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of SKA3 mRNA CTD PMID:19549813 Ska3 Rat coumestrol increases expression ISO SKA3 (Homo sapiens) 6480464 Coumestrol results in increased expression of SKA3 mRNA CTD PMID:19167446 Ska3 Rat coumestrol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SKA3 mRNA; [Coumestrol co-treated with resveratrol] more ... CTD PMID:19167446 Ska3 Rat DDE increases expression ISO SKA3 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of SKA3 mRNA CTD PMID:38568856 Ska3 Rat diarsenic trioxide increases expression ISO Ska3 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of SKA3 mRNA CTD PMID:35676786 Ska3 Rat Enterolactone multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SKA3 mRNA CTD PMID:19167446 Ska3 Rat enzyme inhibitor multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... CTD PMID:23301498 Ska3 Rat ethanol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... CTD PMID:29432896 Ska3 Rat folic acid multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SKA3 mRNA CTD PMID:24657277 Ska3 Rat FR900359 affects phosphorylation ISO SKA3 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of SKA3 protein CTD PMID:37730182 Ska3 Rat hydrogen peroxide affects expression ISO SKA3 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of SKA3 mRNA CTD PMID:23410634 Ska3 Rat lead(0) affects expression ISO SKA3 (Homo sapiens) 6480464 Lead affects the expression of SKA3 mRNA CTD PMID:28903495 Ska3 Rat lidocaine increases expression EXP 6480464 Lidocaine results in increased expression of SKA3 mRNA CTD PMID:35283115 Ska3 Rat manganese atom multiple interactions ISO SKA3 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased expression of SKA3 more ... CTD PMID:39836092 Ska3 Rat manganese(0) multiple interactions ISO SKA3 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased expression of SKA3 more ... CTD PMID:39836092 Ska3 Rat manganese(II) chloride multiple interactions ISO SKA3 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased expression of SKA3 more ... CTD PMID:39836092 Ska3 Rat menadione affects expression ISO SKA3 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of SKA3 mRNA CTD PMID:23410634 Ska3 Rat methotrexate decreases expression ISO SKA3 (Homo sapiens) 6480464 Methotrexate results in decreased expression of SKA3 mRNA CTD PMID:17400583|PMID:24657277 Ska3 Rat methotrexate multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SKA3 mRNA CTD PMID:24657277 Ska3 Rat N-Nitrosopyrrolidine decreases expression ISO SKA3 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of SKA3 mRNA CTD PMID:32234424 Ska3 Rat okadaic acid increases expression ISO SKA3 (Homo sapiens) 6480464 Okadaic Acid results in increased expression of SKA3 mRNA CTD PMID:38832940 Ska3 Rat oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat ozone multiple interactions ISO Ska3 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... CTD PMID:34911549 Ska3 Rat paracetamol increases expression ISO SKA3 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SKA3 mRNA CTD PMID:22230336 Ska3 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SKA3 mRNA CTD PMID:33387578 Ska3 Rat paracetamol decreases expression ISO SKA3 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of SKA3 mRNA CTD PMID:29067470 Ska3 Rat PCB138 multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat perfluorooctanoic acid decreases expression ISO SKA3 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of SKA3 mRNA CTD PMID:36326898 Ska3 Rat phenethyl isothiocyanate decreases expression ISO SKA3 (Homo sapiens) 6480464 phenethyl isothiocyanate results in decreased expression of SKA3 mRNA CTD PMID:26678675 Ska3 Rat resveratrol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of SKA3 mRNA CTD PMID:19167446 Ska3 Rat silicon dioxide decreases expression ISO SKA3 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of SKA3 mRNA CTD PMID:23806026 Ska3 Rat silicon dioxide increases expression ISO Ska3 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of SKA3 mRNA CTD PMID:29341224 Ska3 Rat sodium arsenite increases expression ISO SKA3 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SKA3 mRNA CTD PMID:25493608|PMID:29301061|PMID:39719251 Ska3 Rat sodium arsenite increases expression ISO Ska3 (Mus musculus) 6480464 sodium arsenite results in increased expression of SKA3 mRNA CTD PMID:37682722 Ska3 Rat sodium arsenite decreases expression ISO SKA3 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of SKA3 mRNA CTD PMID:38568856 Ska3 Rat sunitinib decreases expression ISO SKA3 (Homo sapiens) 6480464 Sunitinib results in decreased expression of SKA3 mRNA CTD PMID:31533062 Ska3 Rat temozolomide increases expression ISO SKA3 (Homo sapiens) 6480464 Temozolomide results in increased expression of SKA3 mRNA CTD PMID:31758290 Ska3 Rat tert-butyl hydroperoxide affects expression ISO SKA3 (Homo sapiens) 6480464 tert-Butylhydroperoxide affects the expression of SKA3 mRNA CTD PMID:23410634 Ska3 Rat testosterone decreases expression ISO SKA3 (Homo sapiens) 6480464 Testosterone results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat testosterone multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SKA3 mRNA CTD PMID:34492290 Ska3 Rat thiram decreases expression ISO SKA3 (Homo sapiens) 6480464 Thiram results in decreased expression of SKA3 mRNA CTD PMID:38568856 Ska3 Rat topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat trovafloxacin decreases expression ISO Ska3 (Mus musculus) 6480464 trovafloxacin results in decreased expression of SKA3 mRNA CTD PMID:35537566 Ska3 Rat valproic acid decreases expression ISO SKA3 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of SKA3 mRNA CTD PMID:23179753|PMID:27188386