Gene: Ska3 (spindle and kinetochore associated complex subunit 3) Rattus norvegicus
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Symbol:
Ska3
Name:
spindle and kinetochore associated complex subunit 3
RGD ID:
1307201
Description:
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including establishment of meiotic spindle orientation; negative regulation of mitotic spindle assembly checkpoint signaling; and nuclear chromosome segregation. Predicted to be located in centrosome; meiotic spindle; and mitotic spindle. Predicted to be part of SKA complex. Predicted to be active in kinetochore and spindle microtubule. Orthologous to human SKA3 (spindle and kinetochore associated complex subunit 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC361047; RGD1307201; similar to chromosome 13 open reading frame 3; SKA complex subunit 3; spindle and kinetochore-associated protein 3
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
SKA3 (spindle and kinetochore associated complex subunit 3)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SKA3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Ska3 (spindle and kinetochore associated complex subunit 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
SKA3 (spindle and kinetochore associated complex subunit 3)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Ska3 (spindle and kinetochore associated complex subunit 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
ska3 (spindle and kinetochore associated complex subunit 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
ska3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 15 36,067,372 - 36,086,563 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 15 36,067,373 - 36,086,563 (-) Ensembl GRCr8 mRatBN7.2 15 31,951,812 - 31,971,010 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 15 31,951,825 - 31,971,010 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 15 33,944,005 - 33,962,337 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 15 35,094,675 - 35,113,007 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 15 33,352,759 - 33,371,092 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 15 38,077,903 - 38,097,100 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 15 38,077,909 - 38,096,875 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 15 41,918,694 - 41,937,891 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 15 36,848,694 - 36,867,026 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 15 31,663,336 - 31,681,669 (-) NCBI Celera RGSC_v3.1 15 36,864,972 - 36,877,317 (-) NCBI Cytogenetic Map 15 p12 NCBI
JBrowse:
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Ska3 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of SKA3 mRNA CTD PMID:30723492 Ska3 Rat 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of SKA3 mRNA CTD PMID:32145629 Ska3 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO SKA3 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of SKA3 mRNA CTD PMID:22574217 Ska3 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SKA3 mRNA CTD PMID:34747641 Ska3 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat 2-palmitoylglycerol increases expression ISO SKA3 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of SKA3 mRNA CTD PMID:37199045 Ska3 Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of SKA3 mRNA CTD PMID:31881176 Ska3 Rat acrylamide decreases expression ISO SKA3 (Homo sapiens) 6480464 Acrylamide results in decreased expression of SKA3 mRNA CTD PMID:32763439 Ska3 Rat aflatoxin B1 increases expression ISO SKA3 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of SKA3 mRNA CTD PMID:22100608 Ska3 Rat aflatoxin B1 increases methylation ISO SKA3 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of SKA3 gene CTD PMID:27153756 Ska3 Rat all-trans-retinoic acid decreases expression ISO SKA3 (Homo sapiens) 6480464 Tretinoin results in decreased expression of SKA3 mRNA CTD PMID:33167477 Ska3 Rat arsenous acid increases expression ISO Ska3 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of SKA3 mRNA CTD PMID:35676786 Ska3 Rat atrazine decreases expression ISO SKA3 (Homo sapiens) 6480464 Atrazine results in decreased expression of SKA3 mRNA CTD PMID:22378314 Ska3 Rat benzo[a]pyrene increases methylation ISO SKA3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SKA3 3' UTR CTD PMID:27901495 Ska3 Rat benzo[a]pyrene increases expression ISO SKA3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of SKA3 mRNA CTD PMID:32234424 Ska3 Rat benzo[a]pyrene diol epoxide I decreases expression ISO SKA3 (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SKA3 mRNA CTD PMID:20382639 Ska3 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SKA3 mRNA CTD PMID:25181051 Ska3 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SKA3 mRNA CTD PMID:32145629 Ska3 Rat bisphenol A decreases expression ISO SKA3 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SKA3 mRNA CTD PMID:29275510 Ska3 Rat cadmium atom multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SKA3 more ... CTD PMID:35301059 Ska3 Rat cadmium dichloride decreases expression ISO SKA3 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of SKA3 mRNA CTD PMID:38174414|PMID:38568856 Ska3 Rat cadmium dichloride multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SKA3 more ... CTD PMID:35301059 Ska3 Rat caffeine increases phosphorylation ISO SKA3 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of SKA3 protein CTD PMID:35688186 Ska3 Rat calcitriol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat calcitriol decreases expression ISO SKA3 (Homo sapiens) 6480464 Calcitriol results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat carbon nanotube increases expression ISO Ska3 (Mus musculus) 6480464 Nanotubes, Carbon analog results in increased expression of SKA3 mRNA; Nanotubes, Carbon results in increased more ... CTD PMID:25554681 Ska3 Rat chlorpyrifos decreases expression ISO Ska3 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SKA3 mRNA CTD PMID:37019170 Ska3 Rat chromium(6+) affects expression ISO Ska3 (Mus musculus) 6480464 chromium hexavalent ion affects the expression of SKA3 mRNA CTD PMID:28472532 Ska3 Rat chromium(6+) multiple interactions ISO SKA3 (Homo sapiens) 6480464 [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ... CTD PMID:38479592 Ska3 Rat copper(II) sulfate decreases expression ISO SKA3 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of SKA3 mRNA CTD PMID:19549813 Ska3 Rat coumestrol increases expression ISO SKA3 (Homo sapiens) 6480464 Coumestrol results in increased expression of SKA3 mRNA CTD PMID:19167446 Ska3 Rat coumestrol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SKA3 mRNA; [Coumestrol co-treated with resveratrol] more ... CTD PMID:19167446 Ska3 Rat DDE increases expression ISO SKA3 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of SKA3 mRNA CTD PMID:38568856 Ska3 Rat diarsenic trioxide increases expression ISO Ska3 (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of SKA3 mRNA CTD PMID:35676786 Ska3 Rat Enterolactone multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SKA3 mRNA CTD PMID:19167446 Ska3 Rat enzyme inhibitor multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... CTD PMID:23301498 Ska3 Rat ethanol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... CTD PMID:29432896 Ska3 Rat folic acid multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SKA3 mRNA CTD PMID:24657277 Ska3 Rat FR900359 affects phosphorylation ISO SKA3 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of SKA3 protein CTD PMID:37730182 Ska3 Rat hydrogen peroxide affects expression ISO SKA3 (Homo sapiens) 6480464 Hydrogen Peroxide affects the expression of SKA3 mRNA CTD PMID:23410634 Ska3 Rat lead(0) affects expression ISO SKA3 (Homo sapiens) 6480464 Lead affects the expression of SKA3 mRNA CTD PMID:28903495 Ska3 Rat lidocaine increases expression EXP 6480464 Lidocaine results in increased expression of SKA3 mRNA CTD PMID:35283115 Ska3 Rat manganese atom multiple interactions ISO SKA3 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased expression of SKA3 more ... CTD PMID:39836092 Ska3 Rat manganese(0) multiple interactions ISO SKA3 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased expression of SKA3 more ... CTD PMID:39836092 Ska3 Rat manganese(II) chloride multiple interactions ISO SKA3 (Homo sapiens) 6480464 [manganese chloride results in increased abundance of Manganese] which results in increased expression of SKA3 more ... CTD PMID:39836092 Ska3 Rat menadione affects expression ISO SKA3 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of SKA3 mRNA CTD PMID:23410634 Ska3 Rat methotrexate decreases expression ISO SKA3 (Homo sapiens) 6480464 Methotrexate results in decreased expression of SKA3 mRNA CTD PMID:17400583|PMID:24657277 Ska3 Rat methotrexate multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of SKA3 mRNA CTD PMID:24657277 Ska3 Rat N-Nitrosopyrrolidine decreases expression ISO SKA3 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of SKA3 mRNA CTD PMID:32234424 Ska3 Rat okadaic acid increases expression ISO SKA3 (Homo sapiens) 6480464 Okadaic Acid results in increased expression of SKA3 mRNA CTD PMID:38832940 Ska3 Rat oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat ozone multiple interactions ISO Ska3 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... CTD PMID:34911549 Ska3 Rat paracetamol increases expression ISO SKA3 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SKA3 mRNA CTD PMID:22230336 Ska3 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SKA3 mRNA CTD PMID:33387578 Ska3 Rat paracetamol decreases expression ISO SKA3 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of SKA3 mRNA CTD PMID:29067470 Ska3 Rat PCB138 multiple interactions ISO Ska3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Ska3 Rat perfluorooctanoic acid decreases expression ISO SKA3 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of SKA3 mRNA CTD PMID:36326898 Ska3 Rat phenethyl isothiocyanate decreases expression ISO SKA3 (Homo sapiens) 6480464 phenethyl isothiocyanate results in decreased expression of SKA3 mRNA CTD PMID:26678675 Ska3 Rat resveratrol multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of SKA3 mRNA CTD PMID:19167446 Ska3 Rat silicon dioxide decreases expression ISO SKA3 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of SKA3 mRNA CTD PMID:23806026 Ska3 Rat silicon dioxide increases expression ISO Ska3 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of SKA3 mRNA CTD PMID:29341224 Ska3 Rat sodium arsenite increases expression ISO SKA3 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SKA3 mRNA CTD PMID:25493608|PMID:29301061|PMID:39719251 Ska3 Rat sodium arsenite increases expression ISO Ska3 (Mus musculus) 6480464 sodium arsenite results in increased expression of SKA3 mRNA CTD PMID:37682722 Ska3 Rat sodium arsenite decreases expression ISO SKA3 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of SKA3 mRNA CTD PMID:38568856 Ska3 Rat sunitinib decreases expression ISO SKA3 (Homo sapiens) 6480464 Sunitinib results in decreased expression of SKA3 mRNA CTD PMID:31533062 Ska3 Rat temozolomide increases expression ISO SKA3 (Homo sapiens) 6480464 Temozolomide results in increased expression of SKA3 mRNA CTD PMID:31758290 Ska3 Rat tert-butyl hydroperoxide affects expression ISO SKA3 (Homo sapiens) 6480464 tert-Butylhydroperoxide affects the expression of SKA3 mRNA CTD PMID:23410634 Ska3 Rat testosterone decreases expression ISO SKA3 (Homo sapiens) 6480464 Testosterone results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat testosterone multiple interactions ISO SKA3 (Homo sapiens) 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of SKA3 mRNA CTD PMID:21592394 Ska3 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SKA3 mRNA CTD PMID:34492290 Ska3 Rat thiram decreases expression ISO SKA3 (Homo sapiens) 6480464 Thiram results in decreased expression of SKA3 mRNA CTD PMID:38568856 Ska3 Rat topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SKA3 mRNA CTD PMID:25729387 Ska3 Rat trovafloxacin decreases expression ISO Ska3 (Mus musculus) 6480464 trovafloxacin results in decreased expression of SKA3 mRNA CTD PMID:35537566 Ska3 Rat valproic acid decreases expression ISO SKA3 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of SKA3 mRNA CTD PMID:23179753|PMID:27188386