Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Npas3 | Rat | (S)-nicotine | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of NPAS3 mRNA | CTD | PMID:23825647 | Npas3 | Rat | 1,2-dichloroethane | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of NPAS3 mRNA | CTD | PMID:28960355 | Npas3 | Rat | 1-naphthylamine | affects response to substance | ISO | NPAS3 (Homo sapiens) | 6480464 | NPAS3 gene SNP affects the susceptibility to 1-Naphthylamine | CTD | PMID:25622337 | Npas3 | Rat | 17beta-estradiol | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPAS3 mRNA | CTD | PMID:19619570 | Npas3 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of NPAS3 mRNA | CTD | PMID:26496021 | Npas3 | Rat | 17beta-estradiol | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of NPAS3 mRNA | CTD | PMID:19167446|PMID:19619570 | Npas3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPAS3 mRNA | CTD | PMID:19619570 | Npas3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NPAS3 mRNA | CTD | PMID:37172768 | Npas3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Npas3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NPAS3 mRNA | CTD | PMID:21570461 | Npas3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NPAS3 mRNA | CTD | PMID:19619570 | Npas3 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of NPAS3 mRNA | CTD | PMID:39298647 | Npas3 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of NPAS3 mRNA | CTD | PMID:28959563 | Npas3 | Rat | aflatoxin B1 | decreases methylation | ISO | NPAS3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of NPAS3 gene | CTD | PMID:27153756 | Npas3 | Rat | aflatoxin B1 | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of NPAS3 mRNA | CTD | PMID:32234424 | Npas3 | Rat | aldehydo-D-glucose | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Glucose results in decreased expression of NPAS3 mRNA | CTD | PMID:31525975 | Npas3 | Rat | arsenite(3-) | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to NPAS3 mRNA] | CTD | PMID:32406909 | Npas3 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of NPAS3 gene | CTD | PMID:35440735 | Npas3 | Rat | benzo[a]pyrene | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of NPAS3 mRNA | CTD | PMID:20713471 | Npas3 | Rat | benzo[a]pyrene | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of NPAS3 mRNA | CTD | PMID:32234424 | Npas3 | Rat | benzo[a]pyrene | decreases methylation | ISO | Npas3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of NPAS3 intron | CTD | PMID:27901495 | Npas3 | Rat | benzo[a]pyrene | affects methylation | ISO | NPAS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of NPAS3 intron | CTD | PMID:30157460 | Npas3 | Rat | benzo[a]pyrene | increases methylation | ISO | NPAS3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of NPAS3 3' UTR; Benzo(a)pyrene results in increased methylation of more ... | CTD | PMID:27901495 | Npas3 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of NPAS3 mRNA | CTD | PMID:31163220 | Npas3 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of NPAS3 mRNA | CTD | PMID:26496021 | Npas3 | Rat | bisphenol A | increases expression | ISO | Npas3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of NPAS3 mRNA | CTD | PMID:32156529 | Npas3 | Rat | bisphenol A | decreases methylation | ISO | NPAS3 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of NPAS3 gene | CTD | PMID:31601247 | Npas3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of NPAS3 mRNA | CTD | PMID:34947998 | Npas3 | Rat | Butylbenzyl phthalate | increases methylation | ISO | Npas3 (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of NPAS3 intron | CTD | PMID:28392331 | Npas3 | Rat | cadmium dichloride | increases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of NPAS3 mRNA | CTD | PMID:38382870 | Npas3 | Rat | casticin | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | casticin results in decreased expression of NPAS3 mRNA | CTD | PMID:28444820 | Npas3 | Rat | CGP 52608 | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to NPAS3 gene] | CTD | PMID:28238834 | Npas3 | Rat | chlordecone | increases expression | ISO | Npas3 (Mus musculus) | 6480464 | Chlordecone results in increased expression of NPAS3 mRNA | CTD | PMID:33711761 | Npas3 | Rat | choline | multiple interactions | ISO | Npas3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... | CTD | PMID:20938992 | Npas3 | Rat | coumestrol | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPAS3 mRNA; [Coumestrol co-treated with resveratrol] more ... | CTD | PMID:19167446 | Npas3 | Rat | coumestrol | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of NPAS3 mRNA | CTD | PMID:19167446 | Npas3 | Rat | D-glucose | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Glucose results in decreased expression of NPAS3 mRNA | CTD | PMID:31525975 | Npas3 | Rat | dorsomorphin | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Npas3 | Rat | Enterolactone | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPAS3 mRNA | CTD | PMID:19167446 | Npas3 | Rat | folic acid | multiple interactions | ISO | Npas3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... | CTD | PMID:20938992 | Npas3 | Rat | folic acid | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of NPAS3 mRNA | CTD | PMID:25629700 | Npas3 | Rat | formaldehyde | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of NPAS3 mRNA | CTD | PMID:27905399 | Npas3 | Rat | FR900359 | increases phosphorylation | ISO | NPAS3 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of NPAS3 protein | CTD | PMID:37730182 | Npas3 | Rat | fulvestrant | increases methylation | ISO | NPAS3 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of NPAS3 gene | CTD | PMID:31601247 | Npas3 | Rat | genistein | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Genistein results in decreased expression of NPAS3 mRNA | CTD | PMID:26865667 | Npas3 | Rat | glucose | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Glucose results in decreased expression of NPAS3 mRNA | CTD | PMID:31525975 | Npas3 | Rat | hydralazine | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of NPAS3 mRNA | CTD | PMID:17183730 | Npas3 | Rat | L-methionine | multiple interactions | ISO | Npas3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... | CTD | PMID:20938992 | Npas3 | Rat | Lasiocarpine | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | lasiocarpine results in decreased expression of NPAS3 mRNA | CTD | PMID:32234424 | Npas3 | Rat | methylmercury chloride | increases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of NPAS3 mRNA | CTD | PMID:23179753 | Npas3 | Rat | nicotine | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of NPAS3 mRNA | CTD | PMID:23825647 | Npas3 | Rat | O-methyleugenol | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of NPAS3 mRNA | CTD | PMID:32234424 | Npas3 | Rat | okadaic acid | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of NPAS3 mRNA | CTD | PMID:38832940 | Npas3 | Rat | phenylmercury acetate | increases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of NPAS3 mRNA | CTD | PMID:26272509 | Npas3 | Rat | phenylmercury acetate | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Npas3 | Rat | resveratrol | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [Coumestrol co-treated with Resveratrol] results in decreased expression of NPAS3 mRNA; [Plant Extracts co-treated with more ... | CTD | PMID:19167446|PMID:23557933 | Npas3 | Rat | rofecoxib | increases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | rofecoxib results in increased expression of NPAS3 mRNA | CTD | PMID:17070997 | Npas3 | Rat | SB 431542 | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Npas3 | Rat | silver atom | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Silver results in decreased expression of NPAS3 mRNA | CTD | PMID:26551752 | Npas3 | Rat | silver atom | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Silver results in decreased expression of NPAS3 mRNA | CTD | PMID:27131904 | Npas3 | Rat | silver(0) | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Silver results in decreased expression of NPAS3 mRNA | CTD | PMID:26551752 | Npas3 | Rat | silver(0) | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | Silver results in decreased expression of NPAS3 mRNA | CTD | PMID:27131904 | Npas3 | Rat | sodium arsenite | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of NPAS3 mRNA | CTD | PMID:36209798 | Npas3 | Rat | thimerosal | increases expression | ISO | Npas3 (Mus musculus) | 6480464 | Thimerosal results in increased expression of NPAS3 mRNA | CTD | PMID:24675092 | Npas3 | Rat | titanium dioxide | decreases expression | ISO | Npas3 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of NPAS3 mRNA | CTD | PMID:23557971 | Npas3 | Rat | titanium dioxide | decreases methylation | ISO | Npas3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of NPAS3 gene | CTD | PMID:35295148 | Npas3 | Rat | titanium dioxide | increases methylation | ISO | Npas3 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of NPAS3 gene | CTD | PMID:35295148 | Npas3 | Rat | titanium dioxide | increases expression | ISO | Npas3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of NPAS3 mRNA | CTD | PMID:29264374 | Npas3 | Rat | valproic acid | multiple interactions | ISO | NPAS3 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of NPAS3 mRNA; [NOG protein co-treated more ... | CTD | PMID:17183730|PMID:27188386 | Npas3 | Rat | valproic acid | increases methylation | ISO | NPAS3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of NPAS3 gene | CTD | PMID:29154799 | Npas3 | Rat | valproic acid | decreases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of NPAS3 mRNA | CTD | PMID:23179753 | Npas3 | Rat | valproic acid | increases expression | ISO | NPAS3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of NPAS3 mRNA | CTD | PMID:24383497|PMID:26272509|PMID:28001369 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















