Chac1 (ChaC glutathione-specific gamma-glutamylcyclotransferase 1) - Rat Genome Database

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Gene: Chac1 (ChaC glutathione-specific gamma-glutamylcyclotransferase 1) Rattus norvegicus
Analyze
Symbol: Chac1
Name: ChaC glutathione-specific gamma-glutamylcyclotransferase 1
RGD ID: 1307153
Description: Predicted to enable Notch binding activity and glutathione specific gamma-glutamylcyclotransferase activity. Predicted to be involved in several processes, including glutathione catabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of Notch signaling pathway. Predicted to act upstream of or within response to caloric restriction. Predicted to be located in cytosol and trans-Golgi network. Predicted to be active in cytoplasm. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: blocks Notch protein; botch; cation transport regulator homolog 1; cation transport regulator-like protein 1; ChaC, cation transport regulator homolog 1; ChaC, cation transport regulator homolog 1 (E. coli); ChaC, cation transport regulator-like 1; ChaC, cation transport regulator-like 1 (E. coli); gamma-GCG 1; glutathione-specific gamma-glutamylcyclotransferase 1; LOC362196; neuroprotective protein 7; RGD1307153; similar to RIKEN cDNA 1810008K03
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,796,131 - 126,799,352 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3126,796,024 - 126,799,361 (+)EnsemblGRCr8
mRatBN7.23106,342,302 - 106,345,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,342,302 - 106,345,526 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3110,015,555 - 110,018,821 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,611,097 - 118,614,362 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,271,480 - 116,274,744 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,160,205 - 111,163,425 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,160,205 - 111,163,425 (+)Ensemblrn6Rnor6.0
Rnor_5.03117,711,150 - 117,714,352 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43105,869,762 - 105,873,332 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3105,255,519 - 105,258,707 (+)NCBICelera
RGSC_v3.13105,766,060 - 105,769,420 (+)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-aminobenzohydrazide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol A  (EXP)
Alisol B  (EXP)
Alisol C 23-acetate  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl malate  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
entinostat  (ISO)
erastin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenpyroximate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
glucose  (EXP,ISO)
GSK-J4  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
Leonurine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sinapic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
xylitol  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO)
Golgi apparatus  (IEA)
trans-Golgi network  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19109178   PMID:21124846   PMID:22445366   PMID:31377404  


Genomics

Comparative Map Data
Chac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,796,131 - 126,799,352 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3126,796,024 - 126,799,361 (+)EnsemblGRCr8
mRatBN7.23106,342,302 - 106,345,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,342,302 - 106,345,526 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3110,015,555 - 110,018,821 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,611,097 - 118,614,362 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,271,480 - 116,274,744 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,160,205 - 111,163,425 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,160,205 - 111,163,425 (+)Ensemblrn6Rnor6.0
Rnor_5.03117,711,150 - 117,714,352 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43105,869,762 - 105,873,332 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3105,255,519 - 105,258,707 (+)NCBICelera
RGSC_v3.13105,766,060 - 105,769,420 (+)NCBI
Cytogenetic Map3q35NCBI
CHAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,953,471 - 40,956,512 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,952,962 - 40,956,512 (+)Ensemblhg38GRCh38
GRCh371541,245,669 - 41,248,710 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,032,983 - 39,036,002 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1518,013,509 - 18,016,592 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,094,116 - 18,097,199 (+)NCBIHuRef
CHM1_11541,363,562 - 41,366,645 (+)NCBICHM1_1
T2T-CHM13v2.01538,748,040 - 38,762,447 (+)NCBIT2T-CHM13v2.0
Chac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,181,723 - 119,184,807 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,181,710 - 119,184,862 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382119,351,242 - 119,354,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,351,229 - 119,354,381 (+)Ensemblmm10GRCm38
MGSCv372119,176,978 - 119,180,062 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362119,042,697 - 119,045,822 (+)NCBIMGSCv36mm8
Celera2120,503,185 - 120,506,253 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Chac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,828,482 - 7,832,391 (+)Ensembl
ChiLan1.0NW_0049554167,828,917 - 7,831,368 (+)NCBIChiLan1.0ChiLan1.0
CHAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,193,515 - 30,198,804 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,346,976 - 34,350,140 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,895,554 - 19,898,672 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,145,730 - 38,148,698 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,145,730 - 38,148,698 (+)EnsemblpanPan2panpan1.1
CHAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha308,135,431 - 8,137,791 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0308,209,426 - 8,211,786 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,209,173 - 8,211,784 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,132,762 - 8,135,122 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,239,267 - 8,241,625 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,370,410 - 8,372,770 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,496,154 - 86,498,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,344,053 - 4,346,913 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,344,234 - 4,346,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,360,514 - 130,363,308 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11130,360,510 - 130,363,332 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,522,842 - 145,525,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,038,751 - 42,041,836 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,038,528 - 42,041,760 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604898,943,403 - 98,946,939 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,201,147 - 8,203,836 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248048,201,296 - 8,203,737 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Chac1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1597,530,042 - 97,533,282 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chac1
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:78
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000019392
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH140218  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83126,798,791 - 126,799,073 (+)Marker Load Pipeline
mRatBN7.23106,344,965 - 106,345,247 (+)MAPPERmRatBN7.2
Rnor_6.03111,162,865 - 111,163,146NCBIRnor6.0
Rnor_5.03117,713,792 - 117,714,073UniSTSRnor5.0
RGSC_v3.43105,872,758 - 105,873,039UniSTSRGSC3.4
Celera3105,258,147 - 105,258,428UniSTS
RH 3.4 Map3913.1UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 90 59 6 353 190 11 142 80 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019392   ⟹   ENSRNOP00000019392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3126,796,024 - 126,799,361 (+)Ensembl
mRatBN7.2 Ensembl3106,342,302 - 106,345,526 (+)Ensembl
Rnor_6.0 Ensembl3111,160,205 - 111,163,425 (+)Ensembl
RefSeq Acc Id: NM_001173437   ⟹   NP_001166908
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,796,131 - 126,799,352 (+)NCBI
mRatBN7.23106,342,302 - 106,345,526 (+)NCBI
Rnor_6.03111,160,205 - 111,163,425 (+)NCBI
Rnor_5.03117,711,150 - 117,714,352 (+)NCBI
Celera3105,255,519 - 105,258,707 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001166908 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABX10438 (Get FASTA)   NCBI Sequence Viewer  
  B3STU3 (Get FASTA)   NCBI Sequence Viewer  
  EDL79903 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019392
  ENSRNOP00000019392.4
RefSeq Acc Id: NP_001166908   ⟸   NM_001173437
- UniProtKB: B3STU3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019392   ⟸   ENSRNOT00000019392

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B3STU3-F1-model_v2 AlphaFold B3STU3 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692327
Promoter ID:EPDNEW_R2851
Type:multiple initiation site
Name:Chac1_1
Description:ChaC glutathione-specific gamma-glutamylcyclotransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03111,160,278 - 111,160,338EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307153 AgrOrtholog
BioCyc Gene G2FUF-48205 BioCyc
BioCyc Pathway PWY-7942 [5-oxo-L-proline metabolism] BioCyc
BioCyc Pathway Image PWY-7942 BioCyc
Ensembl Genes ENSRNOG00000014387 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019392 ENTREZGENE
  ENSRNOT00000019392.5 UniProtKB/Swiss-Prot
Gene3D-CATH Gamma-glutamyl cyclotransferase-like UniProtKB/Swiss-Prot
InterPro ChaC UniProtKB/Swiss-Prot
  GGCT-like UniProtKB/Swiss-Prot
  GGCT-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:362196 UniProtKB/Swiss-Prot
NCBI Gene 362196 ENTREZGENE
PANTHER GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR12192 UniProtKB/Swiss-Prot
Pfam ChaC UniProtKB/Swiss-Prot
PhenoGen Chac1 PhenoGen
RatGTEx ENSRNOG00000014387 RatGTEx
Superfamily-SCOP SSF110857 UniProtKB/Swiss-Prot
UniProt B3STU3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-01 Chac1  ChaC glutathione-specific gamma-glutamylcyclotransferase 1  Chac1  ChaC, cation transport regulator homolog 1 (E. coli)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Chac1  ChaC, cation transport regulator homolog 1 (E. coli)  Chac1  ChaC, cation transport regulator-like 1 (E. coli)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Chac1  ChaC, cation transport regulator-like 1 (E. coli)   Chac1_predicted  ChaC, cation transport regulator-like 1 (E. coli) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Chac1_predicted  ChaC, cation transport regulator-like 1 (E. coli) (predicted)  RGD1307153_predicted  similar to RIKEN cDNA 1810008K03 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1307153_predicted  similar to RIKEN cDNA 1810008K03 (predicted)  LOC362196_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362196_predicted  similar to RIKEN cDNA 1810008K03 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL