Ltbp4 (latent transforming growth factor beta binding protein 4) - Rat Genome Database

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Gene: Ltbp4 (latent transforming growth factor beta binding protein 4) Rattus norvegicus
Analyze
Symbol: Ltbp4
Name: latent transforming growth factor beta binding protein 4
RGD ID: 1307033
Description: Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in elastic fiber assembly. Predicted to act upstream of or within hormone secretion and transforming growth factor beta receptor signaling pathway. Predicted to be located in microfibril. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IC. Orthologous to human LTBP4 (latent transforming growth factor beta binding protein 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: latent-transforming growth factor beta-binding protein 4; LOC292734
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,727,769 - 91,759,822 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,727,769 - 91,760,006 (-)EnsemblGRCr8
mRatBN7.2182,600,136 - 82,634,346 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,600,136 - 82,632,178 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,002,794 - 88,034,858 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,489,706 - 96,521,689 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,758,660 - 89,790,713 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,118,046 - 84,152,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,118,046 - 84,150,084 (-)Ensemblrn6Rnor6.0
Rnor_5.0185,328,915 - 85,361,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,385,953 - 82,418,177 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,011,604 - 77,043,761 (-)NCBICelera
RGSC_v3.1182,464,068 - 82,487,843 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pyrrolidine dithiocarbamate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Sterner-Kock A, etal., Genes Dev. 2002 Sep 1;16(17):2264-73.
Additional References at PubMed
PMID:9660815   PMID:10930463   PMID:12477932   PMID:16157329   PMID:20551380   PMID:23376485   PMID:24006456   PMID:27068509   PMID:27559042  


Genomics

Comparative Map Data
Ltbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,727,769 - 91,759,822 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,727,769 - 91,760,006 (-)EnsemblGRCr8
mRatBN7.2182,600,136 - 82,634,346 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,600,136 - 82,632,178 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,002,794 - 88,034,858 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,489,706 - 96,521,689 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,758,660 - 89,790,713 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,118,046 - 84,152,095 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,118,046 - 84,150,084 (-)Ensemblrn6Rnor6.0
Rnor_5.0185,328,915 - 85,361,198 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,385,953 - 82,418,177 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,011,604 - 77,043,761 (-)NCBICelera
RGSC_v3.1182,464,068 - 82,487,843 (-)NCBI
Cytogenetic Map1q21NCBI
LTBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,593,166 - 40,629,820 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,592,883 - 40,629,821 (+)Ensemblhg38GRCh38
GRCh371941,099,072 - 41,135,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,790,912 - 45,827,565 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341945,790,911 - 45,827,562NCBI
Celera1937,898,123 - 37,934,766 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,533,157 - 37,570,214 (+)NCBIHuRef
CHM1_11941,098,957 - 41,135,597 (+)NCBICHM1_1
T2T-CHM13v2.01943,413,757 - 43,450,378 (+)NCBIT2T-CHM13v2.0
Ltbp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,004,566 - 27,039,142 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,004,561 - 27,037,117 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38727,305,140 - 27,339,720 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,305,136 - 27,337,692 (-)Ensemblmm10GRCm38
MGSCv37728,090,160 - 28,122,631 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36727,013,902 - 27,046,452 (-)NCBIMGSCv36mm8
Celera721,881,870 - 21,917,412 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.87NCBI
Ltbp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578686,211 - 712,794 (-)Ensembl
ChiLan1.0NW_004955578685,960 - 712,809 (-)NCBIChiLan1.0ChiLan1.0
LTBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,851,772 - 46,889,066 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,722,675 - 48,759,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,637,509 - 37,674,791 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,144,485 - 46,181,636 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,144,485 - 46,181,636 (+)EnsemblpanPan2panpan1.1
LTBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,124,109 - 113,152,283 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,124,109 - 113,150,442 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1112,526,364 - 112,552,684 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,722,679 - 113,749,021 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,722,688 - 113,749,021 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,282,295 - 113,308,625 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,913,954 - 112,940,503 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,908,479 - 113,934,829 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ltbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,489,689 - 14,517,783 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,919,550 - 2,945,599 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,919,444 - 2,945,847 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,831,014 - 48,861,507 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1648,831,018 - 48,861,503 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,591,804 - 44,609,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,056,287 - 35,090,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,061,225 - 35,090,542 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607313,179,976 - 13,213,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltbp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925545,438 - 573,428 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624925543,656 - 572,810 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ltbp4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12168,605,335 - 168,639,399 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ltbp4
157 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:43
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000028322
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
RH130149  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,600,303 - 82,600,497 (+)MAPPERmRatBN7.2
Rnor_6.0184,118,214 - 84,118,407NCBIRnor6.0
Rnor_5.0185,329,083 - 85,329,276UniSTSRnor5.0
RGSC_v3.4182,386,121 - 82,386,314UniSTSRGSC3.4
Celera177,011,772 - 77,011,965UniSTS
RH 3.4 Map1831.3UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 87 59 6 351 187 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028322   ⟹   ENSRNOP00000028322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,727,769 - 91,760,006 (-)Ensembl
mRatBN7.2 Ensembl182,600,136 - 82,632,178 (-)Ensembl
Rnor_6.0 Ensembl184,118,046 - 84,150,084 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081796   ⟹   ENSRNOP00000073336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,727,769 - 91,755,907 (-)Ensembl
mRatBN7.2 Ensembl182,600,136 - 82,628,134 (-)Ensembl
Rnor_6.0 Ensembl184,118,057 - 84,145,916 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113038   ⟹   ENSRNOP00000082670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,727,769 - 91,755,783 (-)Ensembl
mRatBN7.2 Ensembl182,600,136 - 82,632,178 (-)Ensembl
RefSeq Acc Id: NM_001170336   ⟹   NP_001163807
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,727,769 - 91,759,807 (-)NCBI
mRatBN7.2182,600,136 - 82,632,178 (-)NCBI
Rnor_6.0184,118,046 - 84,150,084 (-)NCBI
Rnor_5.0185,328,915 - 85,361,198 (-)NCBI
RGSC_v3.4182,385,953 - 82,418,177 (-)RGD
Celera177,011,604 - 77,043,761 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228570   ⟹   XP_006228632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,727,774 - 91,755,760 (-)NCBI
mRatBN7.2182,600,136 - 82,628,132 (-)NCBI
Rnor_6.0184,118,051 - 84,146,030 (-)NCBI
Rnor_5.0185,328,915 - 85,361,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104072   ⟹   XP_038960000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,727,774 - 91,759,822 (-)NCBI
mRatBN7.2182,600,136 - 82,632,193 (-)NCBI
RefSeq Acc Id: XM_063283287   ⟹   XP_063139357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,727,774 - 91,755,760 (-)NCBI
RefSeq Acc Id: NP_001163807   ⟸   NM_001170336
- Peptide Label: precursor
- UniProtKB: D4A917 (UniProtKB/TrEMBL),   A0A8I5ZYC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228632   ⟸   XM_006228570
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K588 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028322   ⟸   ENSRNOT00000028322
Ensembl Acc Id: ENSRNOP00000073336   ⟸   ENSRNOT00000081796
RefSeq Acc Id: XP_038960000   ⟸   XM_039104072
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYC9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082670   ⟸   ENSRNOT00000113038
RefSeq Acc Id: XP_063139357   ⟸   XM_063283287
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K588 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A917-F1-model_v2 AlphaFold D4A917 1-1631 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689866
Promoter ID:EPDNEW_R373
Type:multiple initiation site
Name:Ltbp4_1
Description:latent transforming growth factor beta binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,146,004 - 84,146,064EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307033 AgrOrtholog
BioCyc Gene G2FUF-60313 BioCyc
Ensembl Genes ENSRNOG00000020871 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028322 ENTREZGENE
  ENSRNOT00000028322.8 UniProtKB/TrEMBL
  ENSRNOT00000081796 ENTREZGENE
  ENSRNOT00000081796.3 UniProtKB/TrEMBL
  ENSRNOT00000113038 ENTREZGENE
  ENSRNOT00000113038.2 UniProtKB/TrEMBL
Gene3D-CATH 3.90.290.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124591 IMAGE-MGC_LOAD
InterPro ECM_structural_protein UniProtKB/TrEMBL
  EGF-like_reg_CS UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/TrEMBL
  TFG_b-bd UniProtKB/TrEMBL
  vWF_C/EGF_Fibrillin UniProtKB/TrEMBL
KEGG Report rno:292734 UniProtKB/TrEMBL
MGC_CLONE MGC:105869 IMAGE-MGC_LOAD
NCBI Gene 292734 ENTREZGENE
PANTHER EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  FIBRILLIN-3 UniProtKB/TrEMBL
  FIBRILLIN-RELATED UniProtKB/TrEMBL
  VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  PF00683 UniProtKB/TrEMBL
PhenoGen Ltbp4 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  PS51364 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020871 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Fibril-assoc UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0G2K588 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYC9 ENTREZGENE, UniProtKB/TrEMBL
  D4A917 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Ltbp4  latent transforming growth factor beta binding protein 4  Ltbp4_predicted  latent transforming growth factor beta binding protein 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ltbp4_predicted  latent transforming growth factor beta binding protein 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED