Oxct2b (3-oxoacid CoA transferase 2B) - Rat Genome Database

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Gene: Oxct2b (3-oxoacid CoA transferase 2B) Rattus norvegicus
Analyze
Symbol: Oxct2b
Name: 3-oxoacid CoA transferase 2B
RGD ID: 1306953
Description: Predicted to enable succinyl-CoA:3-oxo-acid CoA-transferase activity. Predicted to be involved in ketone body metabolic process. Predicted to be located in motile cilium. Predicted to be active in mitochondrion. Orthologous to human OXCT2 (3-oxoacid CoA-transferase 2); PARTICIPATES IN ketone bodies metabolic pathway; INTERACTS WITH bisphenol A; dimethylarsinic acid; 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-oxoacid CoA transferase 2A; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; LOC100365119; LOC366463; Oxct2a; rCG31267-like; SCOT-t1; succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; succinyl-CoA:3-ketoacid-coenzyme A transferase 2A, mitochondrial; testis-specific succinyl CoA:3-oxoacid CoA-transferase 1; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,681,746 - 140,683,500 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5140,671,211 - 140,696,448 (+)EnsemblGRCr8
mRatBN7.25135,396,632 - 135,398,386 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5138,103,358 - 138,105,112 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,873,329 - 139,875,083 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,880,456 - 139,882,210 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,813,957 - 140,815,711 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05144,806,548 - 144,808,302 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45142,432,259 - 142,434,013 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5133,935,353 - 133,937,107 (+)NCBICelera
RGSC_v3.15142,437,484 - 142,439,238 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA,ISO)
motile cilium  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Isolation and characterization of a haploid germ cell-specific novel complementary deoxyribonucleic acid; testis-specific homologue of succinyl CoA:3-Oxo acid CoA transferase. Koga M, etal., Biol Reprod. 2000 Dec;63(6):1601-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11756565   PMID:12477932   PMID:18614015   PMID:20025965  


Genomics

Comparative Map Data
Oxct2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85140,681,746 - 140,683,500 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5140,671,211 - 140,696,448 (+)EnsemblGRCr8
mRatBN7.25135,396,632 - 135,398,386 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx5138,103,358 - 138,105,112 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05139,873,329 - 139,875,083 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05139,880,456 - 139,882,210 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05140,813,957 - 140,815,711 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05144,806,548 - 144,808,302 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45142,432,259 - 142,434,013 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5133,935,353 - 133,937,107 (+)NCBICelera
RGSC_v3.15142,437,484 - 142,439,238 (+)NCBI
Cytogenetic Map5q36NCBI
OXCT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38139,769,523 - 39,771,348 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl139,769,523 - 39,771,348 (-)Ensemblhg38GRCh38
GRCh37140,235,195 - 40,237,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36140,007,784 - 40,009,607 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34139,904,289 - 39,906,113NCBI
Celera138,262,370 - 38,264,174 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef138,353,912 - 38,355,735 (-)NCBIHuRef
CHM1_1140,350,670 - 40,352,493 (-)NCBICHM1_1
T2T-CHM13v2.0139,638,968 - 39,640,793 (-)NCBIT2T-CHM13v2.0
Oxct2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394123,010,041 - 123,011,793 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4123,010,059 - 123,011,793 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384123,116,248 - 123,118,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4123,116,266 - 123,118,000 (+)Ensemblmm10GRCm38
MGSCv374122,793,491 - 122,795,243 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364122,618,562 - 122,620,303 (+)NCBIMGSCv36mm8
Celera4121,447,028 - 121,448,914 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map457.38NCBI
Oxct2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545217,267,971 - 17,270,072 (-)NCBIChiLan1.0ChiLan1.0
OXCT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21187,048,875 - 187,056,744 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11186,186,515 - 186,194,382 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,060,137 - 39,062,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1140,386,245 - 40,388,229 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC102162296
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1695,350,075 - 95,351,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2688,436,052 - 88,437,898 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OXCT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12093,376,142 - 93,378,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603323,718,521 - 23,721,168 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oxct2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476422,250,482 - 22,252,045 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476422,250,206 - 22,252,144 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Oxct2b
3 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
7411722Strs6Sensitivity to stroke QTL 63.9cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)5140258140143398122Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
1 8 14 15 36 27 4 12 8 19 9 9

Sequence


RefSeq Acc Id: NM_001012221   ⟹   NP_001012221
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85140,681,746 - 140,683,500 (+)NCBI
mRatBN7.25135,396,632 - 135,398,386 (+)NCBI
Rnor_6.05140,813,957 - 140,815,711 (+)NCBI
Rnor_5.05144,806,548 - 144,808,302 (-)NCBI
RGSC_v3.45142,432,259 - 142,434,013 (+)RGD
Celera5133,935,353 - 133,937,107 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001012221 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83681 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000108186
GenBank Protein Q5XIJ9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012221   ⟸   NM_001012221
- Peptide Label: precursor
- UniProtKB: Q5XIJ9 (UniProtKB/Swiss-Prot),   A6IS18 (UniProtKB/TrEMBL)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIJ9-F1-model_v2 AlphaFold Q5XIJ9 1-520 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306953 AgrOrtholog
BioCyc Gene G2FUF-40021 BioCyc
Ensembl Genes ENSRNOG00000077785 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000150838 ENTREZGENE
Gene3D-CATH Glutaconate Coenzyme A-transferase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7135892 IMAGE-MGC_LOAD
InterPro 3-oxoacid_CoA-transf_A UniProtKB/Swiss-Prot
  3-oxoacid_CoA-transf_B UniProtKB/Swiss-Prot
  3-oxoacid_CoA-transferase UniProtKB/Swiss-Prot
  CoA_trans_fam_I UniProtKB/Swiss-Prot
  CoA_transf_AS UniProtKB/Swiss-Prot
  CoA_transf_BS UniProtKB/Swiss-Prot
  NagB/RpiA_transferase-like UniProtKB/Swiss-Prot
KEGG Report rno:366463 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94532 IMAGE-MGC_LOAD
NCBI Gene 366463 ENTREZGENE
PANTHER PTHR13707 UniProtKB/Swiss-Prot
  SUCCINYL-COA:3-KETOACID COENZYME A TRANSFERASE 2, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam CoA_trans UniProtKB/Swiss-Prot
PhenoGen Oxct2b PhenoGen
PIRSF SCOT-t UniProtKB/Swiss-Prot
PROSITE COA_TRANSF_1 UniProtKB/Swiss-Prot
  COA_TRANSF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000077785 RatGTEx
SMART CoA_trans UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100950 UniProtKB/Swiss-Prot
UniProt A0ABK0LB51_RAT UniProtKB/TrEMBL
  A0ABK0LL73_RAT UniProtKB/TrEMBL
  A6IS18 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIJ9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Oxct2b  3-oxoacid CoA transferase 2B  LOC100365119  rCG31267-like  Data merged from RGD:2319655 737654 PROVISIONAL
2011-04-29 Oxct2b  3-oxoacid CoA transferase 2B  Oxct2a  3-oxoacid CoA transferase 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100365119  rCG31267-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Oxct2a  3-oxoacid CoA transferase 2A  Oxct2a_predicted  3-oxoacid CoA transferase 2A (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Oxct2a_predicted  3-oxoacid CoA transferase 2A (predicted)      Symbol and Name status set to approved 70820 APPROVED