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Gene: Slc30a5 (solute carrier family 30 member 5) Rattus norvegicus

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Symbol:

Slc30a5

Name:

solute carrier family 30 member 5

RGD ID:

1306931

Description:

Predicted to enable zinc efflux transmembrane transporter activity and zinc:proton antiporter activity. Predicted to be involved in intracellular zinc ion homeostasis; response to zinc ion; and zinc ion transmembrane transport. Predicted to act upstream of with a positive effect on GPI anchor biosynthetic process. Predicted to act upstream of or within cobalt ion transport and zinc ion transport. Predicted to be located in several cellular components, including Golgi apparatus; apical plasma membrane; and cytoplasmic vesicle membrane. Predicted to be active in Golgi apparatus and cytoplasmic vesicle. Orthologous to human SLC30A5 (solute carrier family 30 member 5); INTERACTS WITH 2,6-dinitrotoluene; aldehydo-D-glucose; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC294698; proton-coupled zinc antiporter SLC30A5; solute carrier family 30 (zinc transporter), member 5; zinc transporter 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC30A5 (solute carrier family 30 member 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc30a5 (solute carrier family 30 (zinc transporter), member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc30a5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC30A5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC30A5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc30a5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC30A5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC30A5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc30a5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc30a5 (solute carrier family 30 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DUSP29 (dual specificity phosphatase 29)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLC30A5 (solute carrier family 30 member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc30a5 (solute carrier family 30 (zinc transporter), member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc30a5 (solute carrier family 30 member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MSC2	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y105E8A.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc30a5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	33,679,800 - 33,710,025 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	33,679,800 - 33,712,596 (-)	Ensembl				GRCr8
mRatBN7.2	2	31,945,745 - 31,975,969 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	31,945,729 - 31,975,934 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	39,079,619 - 39,109,821 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	37,121,962 - 37,152,434 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	31,979,126 - 32,009,278 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	30,815,683 - 30,845,796 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	30,815,703 - 30,846,149 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	49,974,659 - 50,004,756 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	31,607,557 - 31,637,655 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	27,956,817 - 27,986,885 (-)	NCBI		Celera
RGSC_v3.1	2	31,527,921 - 31,558,095 (-)	NCBI
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bradycardia (ISO)

hypertrophic cardiomyopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

actinomycin D (ISO)

aldehydo-D-glucose (EXP)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

captan (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

D-glucose (EXP)

Dibutyl phosphate (ISO)

diclofenac (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

fulvestrant (ISO)

glafenine (EXP)

glucose (EXP)

heptachlor (EXP)

hydrogen peroxide (ISO)

lead diacetate (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dichloride (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

nefazodone (EXP)

nimesulide (EXP)

nitrates (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sulindac (EXP)

tetrachloromethane (ISO)

thimerosal (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

zinc atom (ISO)

zinc dichloride (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cobalt ion transport (ISO)

GPI anchor biosynthetic process (ISO)

intracellular zinc ion homeostasis (IBA,IEA,ISO)

monoatomic cation transmembrane transport (IEA)

monoatomic cation transport (IEA)

monoatomic ion transport (IEA)

response to zinc ion (ISO)

transmembrane transport (IEA)

zinc ion import across plasma membrane (ISO)

zinc ion import into Golgi lumen (IBA,IEA,ISO)

zinc ion import into organelle (IEA,ISO)

zinc ion transmembrane transport (IEA)

zinc ion transport (IEA,ISO)

Cellular Component

apical plasma membrane (ISO)

cytoplasm (IEA,ISO)

cytoplasmic vesicle (IBA,IEA)

endoplasmic reticulum membrane (ISO)

ER to Golgi transport vesicle membrane (IEA,ISO)

Golgi apparatus (IBA,IEA,ISO)

Golgi cis cisterna membrane (IEA,ISO)

Golgi cisterna membrane (IEA)

Golgi membrane (IEA,ISO)

lateral plasma membrane (IEA,ISO)

membrane (IEA,ISO)

plasma membrane (ISO)

secretory granule (IEA,ISO)

secretory granule membrane (IEA,ISO)

trans-Golgi network membrane (ISO)

transport vesicle membrane (IEA)

Molecular Function

antiporter activity (IEA)

cadmium ion transmembrane transporter activity (ISO)

metal ion binding (IEA)

monoatomic cation transmembrane transporter activity (IEA)

protein binding (ISO)

zinc efflux transmembrane transporter activity (ISO)

zinc ion transmembrane transporter activity (IBA,IEA,ISO)

zinc:proton antiporter activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Osteopenia and male-specific sudden cardiac death in mice lacking a zinc transporter gene, Znt5.	Inoue K, etal., Hum Mol Genet. 2002 Jul 15;11(15):1775-84.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10330022	PMID:11904301	PMID:11937503	PMID:12477932	PMID:17349999	PMID:25196974

Genomics

Comparative Map Data

Slc30a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	33,679,800 - 33,710,025 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	33,679,800 - 33,712,596 (-)	Ensembl				GRCr8
mRatBN7.2	2	31,945,745 - 31,975,969 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	31,945,729 - 31,975,934 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	39,079,619 - 39,109,821 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	37,121,962 - 37,152,434 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	31,979,126 - 32,009,278 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	30,815,683 - 30,845,796 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	30,815,703 - 30,846,149 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	49,974,659 - 50,004,756 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	31,607,557 - 31,637,655 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	27,956,817 - 27,986,885 (-)	NCBI		Celera
RGSC_v3.1	2	31,527,921 - 31,558,095 (-)	NCBI
Cytogenetic Map	2	q12	NCBI

SLC30A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	69,094,014 - 69,131,069 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	69,093,991 - 69,131,069 (+)	Ensembl			hg38	GRCh38
GRCh37	5	68,389,841 - 68,426,896 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	68,425,574 - 68,461,636 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	68,425,573 - 68,436,321	NCBI
Celera	5	65,389,051 - 65,425,100 (+)	NCBI		Celera
Cytogenetic Map	5	q13.1-q13.2	NCBI
HuRef	5	65,345,354 - 65,382,350 (+)	NCBI		HuRef
CHM1_1	5	68,389,460 - 68,426,612 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	69,916,495 - 69,953,585 (+)	NCBI		T2T-CHM13v2.0

Slc30a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	100,939,153 - 100,969,988 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	100,939,156 - 100,969,935 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	100,802,645 - 100,833,480 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	100,802,648 - 100,833,427 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	101,572,603 - 101,603,382 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	101,902,905 - 101,933,684 (-)	NCBI		MGSCv36	mm8
Celera	13	104,411,487 - 104,442,263 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	53.23	NCBI

Slc30a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955446	156,541 - 196,275 (-)	Ensembl
ChiLan1.0	NW_004955446	158,843 - 196,275 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC30A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	44,792,872 - 44,832,846 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	42,917,254 - 42,986,476 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	44,873,631 - 44,909,875 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	46,440,860 - 46,477,050 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	46,440,860 - 46,477,050 (-)	Ensembl			panPan2	panpan1.1

SLC30A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	54,205,510 - 54,242,451 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	54,205,483 - 54,241,895 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	51,172,683 - 51,210,706 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	54,716,157 - 54,754,620 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	54,716,228 - 54,754,538 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	51,775,907 - 51,813,957 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	52,550,485 - 52,588,884 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	53,438,066 - 53,476,413 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc30a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	191,482,103 - 191,517,787 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936480	417,205 - 454,277 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936480	418,621 - 454,303 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC30A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	47,284,760 - 47,322,347 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	47,284,974 - 47,320,892 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	51,183,110 - 51,219,031 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC30A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	65,190,394 - 65,227,480 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	65,190,499 - 65,229,027 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666049	13,918,524 - 13,955,897 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc30a5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624815	134,723 - 172,230 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624815	134,290 - 172,177 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc30a5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	158,187,475 - 158,217,303 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc30a5
202 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	342
Count of miRNA genes:	197
Interacting mature miRNAs:	230
Transcripts:	ENSRNOT00000025506
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	42977529	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
9590080	Insglur4	Insulin/glucose ratio QTL 4	28.7	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	2	6152767	51152767	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
731166	Mamtr2	Mammary tumor resistance QTL 2		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	54623581	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	44538110	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	5736325	50736325	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

RH127696

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	31,946,101 - 31,946,282 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	30,816,040 - 30,816,220	NCBI	Rnor6.0
Rnor_5.0	2	49,975,016 - 49,975,196	UniSTS	Rnor5.0
RGSC_v3.4	2	31,607,914 - 31,608,094	UniSTS	RGSC3.4
Celera	2	27,957,174 - 27,957,354	UniSTS
RH 3.4 Map	2	77.1	UniSTS
Cytogenetic Map	2	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025506 ⟹ ENSRNOP00000025506

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	33,679,800 - 33,709,898 (-)	Ensembl
mRatBN7.2 Ensembl	2	31,945,729 - 31,975,934 (-)	Ensembl
Rnor_6.0 Ensembl	2	30,815,703 - 30,846,149 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114867 ⟹ ENSRNOP00000077818

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	33,679,800 - 33,705,308 (-)	Ensembl
mRatBN7.2 Ensembl	2	31,945,729 - 31,971,254 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118048 ⟹ ENSRNOP00000095859

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	33,679,800 - 33,709,898 (-)	Ensembl
mRatBN7.2 Ensembl	2	31,945,729 - 31,975,934 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135003 ⟹ ENSRNOP00000111568

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	33,679,800 - 33,712,596 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000157896 ⟹ ENSRNOP00000105189

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	33,679,800 - 33,712,596 (-)	Ensembl

RefSeq Acc Id:

NM_001106404 ⟹ NP_001099874

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	33,679,800 - 33,709,898 (-)	NCBI
mRatBN7.2	2	31,945,745 - 31,975,844 (-)	NCBI
Rnor_6.0	2	30,815,683 - 30,845,796 (-)	NCBI
Rnor_5.0	2	49,974,659 - 50,004,756 (-)	NCBI
RGSC_v3.4	2	31,607,557 - 31,637,655 (-)	RGD
Celera	2	27,956,817 - 27,986,885 (-)	RGD

Sequence:

show sequence

TACCTGCCGAGCCCGGGCTAGCGGTGGGGACTGCTGAGCCTGAGAGGACGCGACTGAAATGGGG
GAGTGACGCGCCTGCGCCCGCGCTTCCGCAGCGGCAGCAAGACATGAGGAGAGCCCGCGGCGTG
GGCAGCGGCTCCTGAGCCGGCATGGAGGAGAAGTACGGCGGGGACCCGCGGCCCGGGCCCGGCG
GCGGCCTCGGGCCGGTGGACGTGCCCAGCGCCCGATTAACAAAATACATTGTATTACTGTGTTT
AACCAAATGTTTGAAGGCTGTGGGACTTTTTGAATCGTATGATCTCCTAAAAGCTGTTCACATT
GTTCAATTTATTTTTATATTAAAGCTCGGGACTGCGTTTTTTATGGTTTTGTTTCAAAAACCGT
TTTCTTCTGGGAAAACCGTTACAAAGCATCAGTGGATCAAAATATTTAAACATGCAGTTGCTGG
ATGTATCATATCACTTTTATGGTTTTTTGGCCTTACTCTCTGTGGACCACTAAGGACTTTGCTG
CTGTTTGAACACAGTGACATTGTCGTCATCTCTCTGCTCAGTGTTTTATTCACTAGCTCTGGAG
GAGGACCAGCAAAGACAAGAGGAGCTGCTTTTTTCATTATTGCTGTGATCTGTTTATTGCTTTT
CGACAATGATGATCTCATGGCTAAGATGGCCGAACACCCGGAAGGCCATCATGACAGTGCTCTC
ACTCACATGCTTTATACAGCTATCGCCTTCCTGGGTGTGGCAGATCACAAGGGTGGCGTACTCT
TGCTGGTGCTGGCTTTATGTTGTAAAGTTGGTTTTCACACGGCCTCCAGAAAGCTCTCTATAGA
TGTTGGTGGAGCTAAGCGCCTTCAGGCCTTATCCCAGCTTGTTTCTGTGTTTCTCCTATGCCCA
TGGGTGATTGTTCTTTCTGTGACAACTGAGAGTAAGATCGAGTCTTGGTTCCCACTCATCATGC
CTTTCACCACAGTCATCTTCTTTGTCATGATCCTGGATTTCTACATGGATTCCGTTTGTTCTGT
CAAAATGGAAGCTTCCAAATGTGCCCGCTATGGATCCTTCCCCATCTTTATTAGTGCTCTGCTC
TTTGGAAACTTCTGGACACATCCAATAACAGACCAACTGCGGGCTATGAACAGAGCAGCACACC
AGGAGAGCACAGAGCATGTCCTGTCTGGAGGAGTGGTAGTGAGTGCTGTGTTCTTCATTCTGTC
GGCCAACATCCTCTCATCTCCCTCTAAGAGAGGACAGAAAGGTACCCTTATTGGATATTCTCCA
GAAGGAACACCGCTCTATCACTTCATGGGTGATGCTTTTCAGCACAGCTCTCAGTCGGTCCCTA
GGTTTATTAAGGACTCACTGAAACAGATTCTTGAGGAGAGTGACTCTAGGCAGATCTTTTACTT
CTTGTGCTTGAATCTGCTCTTCACCTTTGTGGAGTTGTTCTATGGAGTGCTCACCAACAGTCTG
GGCCTGATCTCAGACGGATTCCACATGCTCTTTGACTGCTCCGCCTTGGTCATGGGACTGTTTG
CTGCCCTGGTGAGCAGATGGAAAGCCACCCGGATTTTCTCCTACGGGTATGGCCGAATAGAAAT
TCTCTCTGGATTTATTAATGGACTTTTCCTGATAGTGATAGCTTTTTTTGTGTTTCTGGAGTCA
GTGGCTAGACTGATTGATCCTCCGGAACTTGACACAAACATGCTGACACCAGTGTCCATTGGAG
GGCTGATAGTAAACCTTATTGGAGTCTGTGCCTTTAGTCACGCCCACAGTCATGGCCATGGGCC
TTCTCAAGGACACTGCCACTCGGATCACGGCCATTCCCACCATGCTCATGGACACAGCGACCAT
GGTCACAGCCACGGATTCACAGGTGGAGGCATGAATGCGAACATGAGGGGTGTATTTCTCCATG
TTTTGGCAGATACACTGGGCAGCATTGGCGTGATTGTGTCCACAGTTCTTATAGAGCAGTTCGG
ATGGTTTATTGCTGATCCCCTGTGTTCTCTTTTTATTGCCGTGTTAATATTTCTCAGTGTTATC
CCACTGATTAAAGACGCCTGTCAAGTTTTACTTCTGAGACTACCACCTGACTATGAAAAAGAAC
TACATATTGCTTTAGAAAAGGTACAGAAACTCGAAGGATTAATATCCTACCGAGACCCTCATTT
TTGGCGCCATTCTGCCAGTATTGTAGCAGGGACAATTCACATTCAGGTGACATCTGATGTGCTG
GAACAGAGAGTTGTGCAGCAGGTTACAGGAATACTTAAAGATGCGGGAGTAAACAACCTAACAA
TACAGGTGGAAAAGGAGGCGTACTTCCAGCACATGTCTGGCCTAAGCACTGGCTTCCACGATGT
CCTGGCTATGACTCAGCAGATGGAATCCATGAAGTACTGCAAAGACGGCACTTACATCATGTGA
GATGAGCCCCAGCGGCGTGAACAGTGGAGGTGGATAATGTCAGTTCAGAGTGAAAGTTGCACAC
AACTGTACAGAAACCTTGAAAGCTCCCTATTGTTGGATTAGGCAGTCTTTTTTAAAAGAAAATT
GAGGTGCGGAATGAAGCATTCATTGTATAAGAGAGCTATCTGCTACTCTGTTTGAATTATGTAC
TTGAAAGGAATCTTACGTTGGAATGAACATGATGTAACCTTCAGAGACGGACACATGATGATGG
ATTCTGGAGAAGACCACGTTTCTTCTGTGCATTTACTTTCTGTCAGAAAGCATCTCTACTGTAA
ATATGTATTTACATGTTTATTACAAAGACCCAGATGAAGTTTTTAGTCGATTTTTGCATATCTG
AAGGACAAAATGGGAATAAAATTCTATATTTATGAATTTTCTGTATATAAAACTGATTTCTAAT
TCTAACTTAAGTCCATTAAGTGAGAGCTGTCTTTCTGCTTGGACTGTAAACTATCCAGGAGAAA
TTTCAACCCCTGATCTGAGAGAACAATGAGAATAGAGAACTGTGATATAGTTCTTGGTGTATAC
GAGATTTAACCACTCCAGTAAATAAATTTTTTATTTTTGGT

hide sequence

RefSeq Acc Id:

XM_039101926 ⟹ XP_038957854

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	33,685,786 - 33,710,025 (-)	NCBI
mRatBN7.2	2	31,951,732 - 31,975,969 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099874	(Get FASTA)	NCBI Sequence Viewer
	XP_038957854	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM10223	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025506
	ENSRNOP00000025506.3
	ENSRNOP00000077818.1
	ENSRNOP00000095859.1
	ENSRNOP00000105189.1
	ENSRNOP00000111568.1

RefSeq Acc Id:

NP_001099874 ⟸ NM_001106404

- UniProtKB:

D3ZY54 (UniProtKB/TrEMBL), A6I5B5 (UniProtKB/TrEMBL), A0A8I5YCI7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEEKYGGDPRPGPGGGLGPVDVPSARLTKYIVLLCLTKCLKAVGLFESYDLLKAVHIVQFIFIL
KLGTAFFMVLFQKPFSSGKTVTKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDI
VVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTA
IAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSIDVGGAKRLQALSQLVSVFLLCPWVIVLSV
TTESKIESWFPLIMPFTTVIFFVMILDFYMDSVCSVKMEASKCARYGSFPIFISALLFGNFWTH
PITDQLRAMNRAAHQESTEHVLSGGVVVSAVFFILSANILSSPSKRGQKGTLIGYSPEGTPLYH
FMGDAFQHSSQSVPRFIKDSLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGF
HMLFDCSALVMGLFAALVSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFLESVARLIDP
PELDTNMLTPVSIGGLIVNLIGVCAFSHAHSHGHGPSQGHCHSDHGHSHHAHGHSDHGHSHGFT
GGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAVLIFLSVIPLIKDAC
QVLLLRLPPDYEKELHIALEKVQKLEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRVVQQ
VTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTQQMESMKYCKDGTYIM

hide sequence

Ensembl Acc Id:

ENSRNOP00000025506 ⟸ ENSRNOT00000025506

RefSeq Acc Id:	XP_038957854 ⟸ XM_039101926
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000077818 ⟸ ENSRNOT00000114867

Ensembl Acc Id:

ENSRNOP00000095859 ⟸ ENSRNOT00000118048

Ensembl Acc Id:

ENSRNOP00000111568 ⟸ ENSRNOT00000135003

Ensembl Acc Id:

ENSRNOP00000105189 ⟸ ENSRNOT00000157896

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZY54-F1-model_v2	AlphaFold	D3ZY54	1-760	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691114

Promoter ID:

EPDNEW_R1638

Type:

multiple initiation site

Name:

Slc30a5_1

Description:

solute carrier family 30 member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	30,845,887 - 30,845,947	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306931	AgrOrtholog
BioCyc Gene	G2FUF-54646	BioCyc
Ensembl Genes	ENSRNOG00000018746	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025506	ENTREZGENE
	ENSRNOT00000025506.7	UniProtKB/TrEMBL
	ENSRNOT00000114867.2	UniProtKB/TrEMBL
	ENSRNOT00000118048.2	UniProtKB/TrEMBL
	ENSRNOT00000135003.1	UniProtKB/TrEMBL
	ENSRNOT00000157896.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1510.10	UniProtKB/TrEMBL
InterPro	Cation_efflux	UniProtKB/TrEMBL
	Cation_efflux_TMD	UniProtKB/TrEMBL
	Msc2-like	UniProtKB/TrEMBL
KEGG Report	rno:294698	UniProtKB/TrEMBL
NCBI Gene	294698	ENTREZGENE
PANTHER	PTHR45755	UniProtKB/TrEMBL
	ZINC TRANSPORTER 5	UniProtKB/TrEMBL
Pfam	Cation_efflux	UniProtKB/TrEMBL
PhenoGen	Slc30a5	PhenoGen
RatGTEx	ENSRNOG00000018746	RatGTEx
Superfamily-SCOP	SSF161111	UniProtKB/TrEMBL
UniProt	A0A8I5YCI7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ANY9_RAT	UniProtKB/TrEMBL
	A0ABK0LSY5_RAT	UniProtKB/TrEMBL
	A0ABK0M2W8_RAT	UniProtKB/TrEMBL
	A6I5B5	ENTREZGENE, UniProtKB/TrEMBL
	D3ZY54	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc30a5	solute carrier family 30 member 5	Slc30a5	solute carrier family 30 (zinc transporter), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Slc30a5	solute carrier family 30 (zinc transporter), member 5	Slc30a5_predicted	solute carrier family 30 (zinc transporter), member 5 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Slc30a5_predicted	solute carrier family 30 (zinc transporter), member 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar