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Gene: Creg1 (cellular repressor of E1A-stimulated genes 1) Rattus norvegicus

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Symbol:

Creg1

Name:

cellular repressor of E1A-stimulated genes 1

RGD ID:

1306804

Description:

Predicted to act upstream of or within several processes, including endocytosis; lysosomal lumen acidification; and regulation of DNA-templated transcription. Predicted to be located in endosome and lysosome. Predicted to be part of transcription regulator complex. Predicted to be active in extracellular space. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cellular repressor of E1A-stimulated genes; Creg; LOC289185

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	80,552,779 - 80,565,272 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	80,549,933 - 80,565,272 (+)	Ensembl				GRCr8
mRatBN7.2	13	78,019,814 - 78,032,310 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	78,019,843 - 78,032,308 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	80,637,560 - 80,650,213 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	81,941,543 - 81,954,198 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	79,188,447 - 79,201,041 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	83,972,186 - 83,984,675 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	83,972,212 - 83,984,675 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	88,852,216 - 88,864,665 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	81,491,304 - 81,503,755 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	77,730,987 - 77,743,427 (+)	NCBI		Celera
RGSC_v3.1	13	81,472,666 - 81,517,849 (+)	NCBI
Cytogenetic Map	13	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

diastolic heart failure (ISO)

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

acetamide (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

antimycin A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

butan-1-ol (ISO)

Butylbenzyl phthalate (ISO)

cadmium acetate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

cisplatin (EXP)

clofibrate (ISO)

clofibric acid (EXP)

cobalt dichloride (EXP)

coumarin (EXP)

cyclosporin A (ISO)

cyproconazole (ISO)

dexamethasone (EXP)

dibenzo[a,l]pyrene (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

dichloroacetic acid (ISO)

dicrotophos (ISO)

diethyl phthalate (ISO)

diisobutyl phthalate (ISO)

diisononyl phthalate (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenpyroximate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

gentamycin (EXP)

glutathione (EXP)

inulin (ISO)

ketamine (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dibromide (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

nitrofen (EXP)

paclitaxel (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenacetin (EXP)

phenobarbital (EXP,ISO)

phenylhydrazine (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

tamibarotene (ISO)

temozolomide (ISO)

testosterone (EXP)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thifluzamide (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP,ISO)

triphenyl phosphate (EXP,ISO)

valdecoxib (EXP)

valproic acid (ISO)

vincaleukoblastine (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (ISO)

endocytosis (ISO)

lysosomal lumen acidification (ISO)

lysosome organization (ISO)

regulation of DNA-templated transcription (ISO)

Cellular Component

cytoplasm (IEA)

endosome (ISO)

extracellular space (IBA,ISO)

lysosome (ISO)

transcription regulator complex (ISO)

Molecular Function

insulin-like growth factor receptor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9710587	PMID:12477932	PMID:15257182	PMID:19997978	PMID:21354106	PMID:23376485	PMID:23533145	PMID:25645918	PMID:28062494	PMID:29864918	PMID:32320986	PMID:33215442

Genomics

Comparative Map Data

Creg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	80,552,779 - 80,565,272 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	80,549,933 - 80,565,272 (+)	Ensembl				GRCr8
mRatBN7.2	13	78,019,814 - 78,032,310 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	78,019,843 - 78,032,308 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	80,637,560 - 80,650,213 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	81,941,543 - 81,954,198 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	79,188,447 - 79,201,041 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	83,972,186 - 83,984,675 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	83,972,212 - 83,984,675 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	88,852,216 - 88,864,665 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	81,491,304 - 81,503,755 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	77,730,987 - 77,743,427 (+)	NCBI		Celera
RGSC_v3.1	13	81,472,666 - 81,517,849 (+)	NCBI
Cytogenetic Map	13	q23	NCBI

CREG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	167,541,013 - 167,553,762 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	167,529,117 - 167,553,822 (-)	Ensembl			hg38	GRCh38
GRCh37	1	167,510,250 - 167,522,999 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	165,776,874 - 165,789,680 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	164,241,910 - 164,254,714	NCBI
Celera	1	140,619,537 - 140,632,329 (-)	NCBI		Celera
Cytogenetic Map	1	q24.2	NCBI
HuRef	1	138,756,302 - 138,769,107 (-)	NCBI		HuRef
CHM1_1	1	168,932,579 - 168,945,397 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	166,892,470 - 166,905,217 (-)	NCBI		T2T-CHM13v2.0

Creg1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	165,591,327 - 165,602,878 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	165,591,315 - 165,602,877 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	165,763,758 - 165,775,309 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	165,763,746 - 165,775,308 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	167,693,911 - 167,705,435 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	167,600,455 - 167,611,979 (+)	NCBI		MGSCv36	mm8
Celera	1	168,208,623 - 168,220,088 (+)	NCBI		Celera
Cytogenetic Map	1	H2.3	NCBI
cM Map	1	73.11	NCBI

Creg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	9,439,987 - 9,455,268 (+)	Ensembl
ChiLan1.0	NW_004955462	9,440,019 - 9,451,875 (+)	NCBI	ChiLan1.0	ChiLan1.0

CREG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	82,209,543 - 82,222,394 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	81,878,133 - 81,890,948 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	142,974,260 - 142,987,071 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	146,758,325 - 146,770,978 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	146,758,325 - 146,770,978 (-)	Ensembl			panPan2	panpan1.1

CREG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	30,873,556 - 30,884,257 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	30,873,556 - 30,883,370 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	30,410,119 - 30,420,868 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	30,692,302 - 30,703,079 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	30,692,274 - 30,703,079 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	30,531,652 - 30,542,279 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	30,563,220 - 30,573,966 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	30,801,915 - 30,812,664 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Creg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	100,676,273 - 100,684,477 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936481	18,523,022 - 18,531,227 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CREG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	83,458,242 - 83,469,930 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	83,458,358 - 83,469,931 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	91,134,162 - 91,145,709 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CREG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	61,472,601 - 61,485,568 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	61,472,617 - 61,488,999 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	63,196,455 - 63,209,971 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Creg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	5,589,791 - 5,605,893 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624826	5,593,190 - 5,605,946 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Creg1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	44,868,093 - 44,879,271 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Creg1
32 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	133
Count of miRNA genes:	108
Interacting mature miRNAs:	116
Transcripts:	ENSRNOT00000004394
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

RH141046

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	78,031,673 - 78,031,875 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	83,984,039 - 83,984,240	NCBI	Rnor6.0
Rnor_5.0	13	88,864,029 - 88,864,230	UniSTS	Rnor5.0
RGSC_v3.4	13	81,503,119 - 81,503,320	UniSTS	RGSC3.4
Celera	13	77,742,791 - 77,742,992	UniSTS
Cytogenetic Map	13	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004394 ⟹ ENSRNOP00000004394

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	80,549,933 - 80,565,272 (+)	Ensembl
mRatBN7.2 Ensembl	13	78,019,843 - 78,032,308 (+)	Ensembl
Rnor_6.0 Ensembl	13	83,972,212 - 83,984,675 (+)	Ensembl

RefSeq Acc Id:

NM_001105966 ⟹ NP_001099436

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	80,552,821 - 80,565,272 (+)	NCBI
mRatBN7.2	13	78,019,857 - 78,032,310 (+)	NCBI
Rnor_6.0	13	83,972,226 - 83,984,675 (+)	NCBI
Rnor_5.0	13	88,852,216 - 88,864,665 (+)	NCBI
RGSC_v3.4	13	81,491,304 - 81,503,755 (+)	RGD
Celera	13	77,730,987 - 77,743,427 (+)	RGD

Sequence:

show sequence

GCAGGTGCTCTGCAGTCAGCGCCATGGCTGCCCGCGCTCCTGAGCTCGCGCGCTCCCTGCTTGC
TGCCCTTCTGGCTCCCGCGCTAGTGGCACTACTGGTGTCGCCGGCCTGGGGACGCGGAGGCCGG
GACCACGGGGACTGGGACGTGGACAGGCGACTGCCTCCACTGCCACCCCGCGATGACGGGCCGC
GCGTGGCCCGCTTCGTGACTCACGTCTCGGACTGGGGCTCGCTGGCCACTATCTCCACGAGAGA
GGAGGTGCGCGGCAGGCCCTTCGCGGACATCATCTCAATTAGTGACGGTCCTCCGGGAGAAGGC
TCAGGCGAGCCCTACATGTACCTGAGTCCGCTGCAACAAGCAGTGAGCGACCTGCAGGGAAATC
CAGAGGCTACGCTGACTATGTCTTTAGCACAGACTGCCTACTGTAGGAACCATGGATTTGATCC
CCAGAGTCCCCTCTGTGTTCATATAATGATGTCCGGGACTGTGATCAAAGTAAATGAGACAGAA
GAGGGCTACGCACGGGACTCGCTATTCATCAGACACCCTGAGATGAAACACTGGCCTCCTAGCC
ATAAGTGGTTCTTTGCTAAGTTAAAAATAAGCAATATCTGGGTTTTGGACTACTTTGGTGGACC
GAAAGTAGTGACACCTGAAGAATATTTTAACGTCACACTGCAGTGAAGCAAATACGGTGAACTG
GATCACACCAGCGACAGGTCTTCCAAGGCTCATGCACACAGAGGGCTCGACCCTGCCTGGCTGC
TAGCCCACTCTGCCACCTCTTGTTTCGATTTCCTTTGCTTGTCTTTGCAGAGTGTTGTCCATTA
GAAGACGTGCTTGCTGGATTTAAAAAAAAAAAAAAAAGTCTTGAAGCCATTTTCAGAGAAAAAT
GCCCTTCTTTATGATCAAGGAAGCCATGCTCGGTGCTTTTTCCTCAGTGGTGCCCTCAGTAGGG
TGACATATACCAGCTGTAGACCGCCCATTGGCACTGGAGGTCCAGAGGTGCAGATGCTCTGTGC
CTGATGGCCACTGTGCCTGAAGGTGCTGTGCTCACCCAGCTGCCTCAGGAGCCAGTGCAGAGGG
GCCGTATGAATCCTCCAGTCCAGGACAGCAGTGACCACGGATGCAGCGTCCCATTCACGTCAAC
CTGTATAGCTGATCAGCACAAGGCAAAGCTGGGTCTTCTGTAAAACTCCATAAACGTCTTACAT
TCTAAAGTCATCGTTACCCAGAACAAAATAAATCAGAAAGATTTTCCTGCATCCATTCTCCATC
TAAGTAGACTGTACACTCACTCCTCATCCTTCGGAATGTGCACGCCTGAGCTGGGGCGCAGCTT
TCTTGGCACAGAGCTTGCCAAGCATGAATGGGACCATAACGTCGAAACAACCAGCCAGCCACAG
ACGACATCTTTATGTGCATGAAAAAGCAACCTCAGAAGAAAAAGGATTTCGCATATGTTGGGCT
CTTTTTCGTAAGACTTAACCCTGTGCCAGCCGCAATCCAAGCCCTCCTCCGGCATTCTGTATCT
TGAAGCTCCTGGTGCTGCCGCCTGCGTCCTCTGTGGGATGTACCACGGTACTGTGGCATAAAAA
CAAACTACAACAACAACAAAACATGTCTCTGCACCAGAGGATGGCTCAGCTTGTAAGATGACTG
CTCTAGCAGAGGACCCAAGTTCAGTACCCGCAAGGGGTCAGACAGGCACATATGCCCAGAACTC
CAGCTCCAGGAGATCAAATACCTCTAGCCTCCAAGGTCACCTGCACTGGAATACACACACCCAC
ACATAGACACACAGCGACACAATTTCAAACAGTACATCTTTTATTCCAAAGAGGTACTACTTAG
TTTAATTACCTGTTTCATGCTCTTGGATGACATAAGATTTCTTTTAACAGAGTGTGGGGGAATC
AAGACACTGACTTAAACAGCCAAAAAAAAAAAAAAAAAAGTTAACTATGAACCATCATGTTGGA
GAAAGAGATGGTAATCATAACAGAAATCCAGCAAACGACGTCTCAGTCAAAACCCACTAAACAG
TAAGGATCTTGTTATTGAAATCAGTAATTAAAAGCATTATTAT

hide sequence

RefSeq Acc Id:

XM_008769625 ⟹ XP_008767847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	80,552,779 - 80,559,674 (+)	NCBI
mRatBN7.2	13	78,019,814 - 78,026,711 (+)	NCBI
Rnor_6.0	13	83,972,186 - 83,979,076 (+)	NCBI

Sequence:

show sequence

CTAGCGTGCAATAGTTACGGCGGCAGAGTTTGGTCGCAAAGCAGGTGCTCTGCAGTCAGCGCCA
TGGCTGCCCGCGCTCCTGAGCTCGCGCGCTCCCTGCTTGCTGCCCTTCTGGCTCCCGCGCTAGT
GGCACTACTGGTGTCGCCGGCCTGGGGACGCGGAGGCCGGGACCACGGGGACTGGGACGTGGAC
AGGCGACTGCCTCCACTGCCACCCCGCGATGACGGGCCGCGCGTGGCCCGCTTCGTGACTCACG
TCTCGGACTGGGGCTCGCTGGCCACTATCTCCACGAGAGAGGAGGTGCGCGGCAGGCCCTTCGC
GGACATCATCTCAATTAGTGACGGTCCTCCGGGAGAAGGCTCAGGCGAGCCCTACATGTACCTG
AGTCCGCTGCAACAAGCAGTGAGCGACCTGCAGGGAAATCCAGAGGCTACGCTGACTATGTCTT
TAGCACAGACTGCCTACTGTAGGAACCATGGATTTGATCCCCAGAGTCCCCTCTGTGTTCATAT
AATGATGTCCGGGACTGTGATCAAAGTAAATGAGACAGAAGAGGGCTACGCACGGGACTCGCTA
TTCATCAGACACCCTGAGATGAAACACTGGCCTCCTAGCCATAAGTGGTTCTTTGCTAAGTTAA
AAATAAGCAATATCTGGGTTTTGGACTACTTTGGTGGACCGAAAGTAGTGACACCTGAAGAATA
TTTTAACGTCACACTGCAGTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099436	(Get FASTA)	NCBI Sequence Viewer
	XP_008767847	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66446	(Get FASTA)	NCBI Sequence Viewer
	EDM09314	(Get FASTA)	NCBI Sequence Viewer
	EDM09315	(Get FASTA)	NCBI Sequence Viewer
	EDM09316	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004394.5

RefSeq Acc Id:	NP_001099436 ⟸ NM_001105966
- Peptide Label:	precursor
- UniProtKB:	B2GUX7 (UniProtKB/TrEMBL), F7FH64 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAARAPELARSLLAALLAPALVALLVSPAWGRGGRDHGDWDVDRRLPPLPPRDDGPRVARFVTH VSDWGSLATISTREEVRGRPFADIISISDGPPGEGSGEPYMYLSPLQQAVSDLQGNPEATLTMS LAQTAYCRNHGFDPQSPLCVHIMMSGTVIKVNETEEGYARDSLFIRHPEMKHWPPSHKWFFAKL KISNIWVLDYFGGPKVVTPEEYFNVTLQ hide sequence

RefSeq Acc Id:	XP_008767847 ⟸ XM_008769625
- Peptide Label:	isoform X1
- UniProtKB:	B2GUX7 (UniProtKB/TrEMBL), F7FH64 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAARAPELARSLLAALLAPALVALLVSPAWGRGGRDHGDWDVDRRLPPLPPRDDGPRVARFVTH VSDWGSLATISTREEVRGRPFADIISISDGPPGEGSGEPYMYLSPLQQAVSDLQGNPEATLTMS LAQTAYCRNHGFDPQSPLCVHIMMSGTVIKVNETEEGYARDSLFIRHPEMKHWPPSHKWFFAKL KISNIWVLDYFGGPKVVTPEEYFNVTLQ hide sequence

Ensembl Acc Id:

ENSRNOP00000004394 ⟸ ENSRNOT00000004394

Protein Domains

CREG-like beta-barrel

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUX7-F1-model_v2	AlphaFold	B2GUX7	1-220	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698963

Promoter ID:

EPDNEW_R9488

Type:

multiple initiation site

Name:

Creg1_1

Description:

cellular repressor of E1A-stimulated genes 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	83,972,228 - 83,972,288	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306804	AgrOrtholog
BioCyc Gene	G2FUF-17557	BioCyc
Ensembl Genes	ENSRNOG00000003291	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004394.8	UniProtKB/TrEMBL
Gene3D-CATH	Electron Transport, Fmn-binding Protein, Chain A	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8364240	IMAGE-MGC_LOAD
InterPro	CREG	UniProtKB/TrEMBL
	CREG_beta-barrel	UniProtKB/TrEMBL
	Split_barrel_FMN-bd	UniProtKB/TrEMBL
KEGG Report	rno:289185	UniProtKB/TrEMBL
MGC_CLONE	MGC:187595	IMAGE-MGC_LOAD
NCBI Gene	289185	ENTREZGENE
PANTHER	CREG1 PROTEIN	UniProtKB/TrEMBL
	PROTEIN CREG1	UniProtKB/TrEMBL
Pfam	Pyrid_oxidase_2	UniProtKB/TrEMBL
PhenoGen	Creg1	PhenoGen
PIRSF	CREG	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003291	RatGTEx
Superfamily-SCOP	FMN-binding split barrel	UniProtKB/TrEMBL
UniProt	B2GUX7	ENTREZGENE, UniProtKB/TrEMBL
	F7FH64	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-03	Creg1	cellular repressor of E1A-stimulated genes 1	Creg_predicted	cellular repressor of E1A-stimulated genes (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Creg_predicted	cellular repressor of E1A-stimulated genes (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD