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Gene: Mettl18 (methyltransferase 18, RPL3 N3(tau)-histidine) Rattus norvegicus

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Symbol:

Mettl18

Name:

methyltransferase 18, RPL3 N3(tau)-histidine

RGD ID:

1306783

Description:

Predicted to enable heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Predicted to be involved in peptidyl-lysine monomethylation; regulation of gene expression; and regulation of ribosome biogenesis. Predicted to be located in cytosol and nucleolus. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

histidine protein methyltransferase 1 homolog; hypothetical protein LOC304928; LOC304928; methyltransferase 18, RPL3 N3-histidine; methyltransferase like 18; methyltransferase-like protein 18; MGC112676; RGD1306783; similar to 2810422O20Rik protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mettl18 (methyltransferase like 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mettl18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mettl18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mettl18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Mettl18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mettl18 (methyltransferase like 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-15f17.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG17219	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HPM1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	K01A11.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	K01A11.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mettl18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	78,879,053 - 78,881,226 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	78,838,447 - 78,912,730 (+)	Ensembl				GRCr8
mRatBN7.2	13	76,345,888 - 76,348,798 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	76,345,957 - 76,348,836 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	78,963,999 - 78,966,126 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	80,268,371 - 80,270,484 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	77,522,959 - 77,525,072 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	82,298,534 - 82,300,763 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	82,298,534 - 82,300,657 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	87,171,522 - 87,173,807 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	79,755,050 - 79,757,177 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	76,079,646 - 76,081,773 (+)	NCBI		Celera
RGSC_v3.1	13	79,769,237 - 79,771,365 (+)	NCBI
Cytogenetic Map	13	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

acrolein (ISO)

acrylamide (EXP)

alpha-pinene (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

chlordecone (ISO)

copper(II) sulfate (ISO)

Dibutyl phosphate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

iron dichloride (ISO)

methyl methanesulfonate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

potassium chloride (ISO)

potassium chromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

tetraphene (ISO)

thimerosal (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

methylation (IEA)

peptidyl-lysine monomethylation (ISO,ISS)

regulation of ribosome biogenesis (ISO,ISS)

regulation of rRNA processing (ISO,ISS)

regulation of translation (IBA,ISO,ISS)

regulation of translational elongation (ISO,ISS)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO,ISS)

nucleolus (IEA,ISO,ISS)

nucleus (IBA,IEA,ISO,ISS)

protein-containing complex (ISO)

Molecular Function

heat shock protein binding (ISO)

methyltransferase activity (IEA)

protein binding (ISO)

protein methyltransferase activity (IEA)

protein-L-histidine N-tele-methyltransferase activity (IBA,IEA,ISO,ISS)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:23349634

Genomics

Comparative Map Data

Mettl18
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	78,879,053 - 78,881,226 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	78,838,447 - 78,912,730 (+)	Ensembl				GRCr8
mRatBN7.2	13	76,345,888 - 76,348,798 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	76,345,957 - 76,348,836 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	78,963,999 - 78,966,126 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	80,268,371 - 80,270,484 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	77,522,959 - 77,525,072 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	82,298,534 - 82,300,763 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	82,298,534 - 82,300,657 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	87,171,522 - 87,173,807 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	79,755,050 - 79,757,177 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	76,079,646 - 76,081,773 (+)	NCBI		Celera
RGSC_v3.1	13	79,769,237 - 79,771,365 (+)	NCBI
Cytogenetic Map	13	q23	NCBI

METTL18
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	169,792,529 - 169,794,907 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	169,792,529 - 169,794,991 (-)	Ensembl			hg38	GRCh38
GRCh37	1	169,761,670 - 169,764,048 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	168,028,294 - 168,030,655 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	142,871,462 - 142,873,823 (-)	NCBI		Celera
Cytogenetic Map	1	q24.2	NCBI
HuRef	1	140,984,033 - 140,986,424 (-)	NCBI		HuRef
CHM1_1	1	171,183,818 - 171,186,209 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	169,148,308 - 169,150,686 (-)	NCBI		T2T-CHM13v2.0

Mettl18
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	163,822,458 - 163,824,812 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	163,822,458 - 163,824,812 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	163,994,889 - 163,997,243 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	163,994,889 - 163,997,243 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	165,925,076 - 165,927,374 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	165,831,620 - 165,833,918 (+)	NCBI		MGSCv36	mm8
Celera	1	166,435,378 - 166,437,676 (+)	NCBI		Celera
Cytogenetic Map	1	H2.2	NCBI
cM Map	1	71.3	NCBI

Mettl18
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	7,519,857 - 7,520,978 (+)	Ensembl
ChiLan1.0	NW_004955462	7,519,591 - 7,521,021 (+)	NCBI	ChiLan1.0	ChiLan1.0

METTL18
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	79,973,999 - 79,976,688 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	79,642,571 - 79,645,136 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	145,275,161 - 145,277,751 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	148,996,549 - 148,999,001 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	148,996,597 - 148,997,715 (-)	Ensembl			panPan2	panpan1.1

METTL18
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	28,835,753 - 28,838,512 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	28,837,350 - 28,838,447 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	28,367,309 - 28,370,111 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	28,637,567 - 28,640,369 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	28,637,567 - 28,640,363 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	28,486,262 - 28,489,067 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	28,521,479 - 28,524,281 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	28,758,271 - 28,761,074 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Mettl18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	99,016,421 - 99,018,870 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936481	16,864,478 - 16,865,575 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936481	16,863,048 - 16,865,619 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METTL18
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	81,216,430 - 81,220,449 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	81,216,107 - 81,218,595 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	88,842,894 - 88,845,177 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METTL18
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	59,257,843 - 59,261,129 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	59,259,130 - 59,260,248 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	60,913,750 - 60,916,244 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mettl18
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	7,701,093 - 7,702,214 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624826	7,701,043 - 7,704,251 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Mettl18
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	43,221,887 - 43,224,022 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Mettl18
29 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	176
Count of miRNA genes:	148
Interacting mature miRNAs:	160
Transcripts:	ENSRNOT00000003636
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

RH143204

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	76,347,920 - 76,348,020 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	82,300,521 - 82,300,620	NCBI	Rnor6.0
Rnor_5.0	13	87,173,565 - 87,173,664	UniSTS	Rnor5.0
RGSC_v3.4	13	79,757,037 - 79,757,136	UniSTS	RGSC3.4
Celera	13	76,081,633 - 76,081,732	UniSTS
RH 3.4 Map	13	483.4	UniSTS
Cytogenetic Map	13	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025668	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC124874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003636 ⟹ ENSRNOP00000003480

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	78,838,447 - 78,881,873 (+)	Ensembl
mRatBN7.2 Ensembl	13	76,345,957 - 76,348,836 (+)	Ensembl
Rnor_6.0 Ensembl	13	82,298,534 - 82,300,657 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136825 ⟹ ENSRNOP00000104450

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	78,879,076 - 78,912,730 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000157956 ⟹ ENSRNOP00000110677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	78,878,893 - 78,883,933 (+)	Ensembl

RefSeq Acc Id:

NM_001025668 ⟹ NP_001020839

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	78,879,099 - 78,881,226 (+)	NCBI
mRatBN7.2	13	76,345,934 - 76,348,061 (+)	NCBI
Rnor_6.0	13	82,298,534 - 82,300,661 (+)	NCBI
Rnor_5.0	13	87,171,522 - 87,173,807 (+)	NCBI
RGSC_v3.4	13	79,755,050 - 79,757,177 (+)	RGD
Celera	13	76,079,646 - 76,081,773 (+)	RGD

Sequence:

show sequence

AGGCAAGCTTCGCCAGGAGTTCCTTATGCGGCTGGCTTCTTTCACCCTGACGTCTGACTTTTAC
CGTGCAGAGACCAGAAGTCCTCAGGTTTGATATCCTCAGTCCCGGGGGACTTTGAGACTACTCG
TAATCTCAAGAGTGACTTGGGCTGTAGCCAGGATTGACTATTCCACTGTGAGGGCTAAATTGAA
AAAGGAACAAAGGCATCTGAAACGTCTTTGGAACCCCCTCTGAATATATCTGGTGGTGTATAAG
CAGCTAACAGACATTGGGCCCAGCAGAACTAATTGACTGTGTGGTCTCTTATGCTATTAAATTC
TTTTTGGAAGTTGAAGCATCATCCTTTGATTAAAAACTGTGTGCAGGGATGGCCTTTCAATTCA
ATTTCAGTATAGAAGAAGATCTGGAAAATAAATTAACTTCCCTCGATGATGGAACTTGTGTGTT
AAAAAGTCAGAAAGGAAAGGAGGACAAAAACCAGTCTACAGAACTGCCGGGCTTGCCTCAGGAT
CGCTTGTGGAAATGCTCCTCGCTGGGAAGTGCAGCTTCCTCTGAAGACACTGATAGCCCACCCA
GTACCGCTGACAGGTCAGGTGTCCCAGAAGCATGTGAAAAACAGCCCTCCCTGAAACCTGCTAA
AGAACACGTGATACCTAAAGATTGTGATCAGGTCTTAGAAAATAAGGTTTTGGAAATGCTGCCA
GGTTCCCAGCATGTTAGCACAGCAGTAGTGAAAACCATCTCTTTGAAAGAGAAATTCCCTGGAG
AAAACATAGTTTCACAAAGCTTTTCTTCTCATTCTGATCTGATTCCAGGTGTCTATGAAGGAGG
CTTAAAAATCTGGGAATGTACCTTTGATCTCATGACTTATTTCACAAAGGCCAAAGTGAAATTT
GCTGGACAGAAAGTGTTGGATCTTGGCTGTGGGTCTGGGTTGCTTGGGATAACTGCATCCAAAG
GAGGGGCTAGAGAAGTTCATTTTCAAGATTATAACGGTTTGGTAATTGATGAAGTGACCTTACC
TAATGTAGTTGCTAATGTCCCTTTGCAAGGTGACAGCAATGGCATAAATGAGCCAGCTGGGAAA
AGACAAAGGAAGTCAGAAGTAGCCCAAGAAACATGTAAGTGTCGGTTGTTCTCTGGGGAGTGGG
CTGAGTTTTGTAAGCTTGTATTAAGTGAAAAACTGTTTGTGAAATATGACCTCATTCTCACTTC
AGAAACCATTTATAATCCAGATTATTACAGCACATTGCATGAGACACTCCTCAGACTATTGAGT
AGGAACGGCCGGGTGCTTTTGGCCAGCAAAGCACATTACTTTGGTGTTGGTGGTGGTGTTCATC
TCTTCCAGAAGTTTGTAGAAGAAAAGGGTGTGTTTGAGACTCGAACACTTGAGGTAATTGATGA
AGGTCTCAAGAGGTTTCTGATGGAAATGACTTTTAAGTGCCCCAGTTAATATGCATATAACTCA
ATGGCATAATGAATTAAAAAGAATACCCCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_006250155 ⟹ XP_006250217

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	78,879,053 - 78,881,226 (+)	NCBI
mRatBN7.2	13	76,345,888 - 76,348,798 (+)	NCBI
Rnor_6.0	13	82,298,534 - 82,300,763 (+)	NCBI
Rnor_5.0	13	87,171,522 - 87,173,807 (+)	NCBI

Sequence:

show sequence

AGGCAAGCTTCGCCAGGAGTTCCTTATGCGGCTGGCTTCTTTCACCCTGACGTCTGACTTTTAC
CGTGCAGAGACCAGAAGTCCTCAGGGCTAAATTGAAAAAGGAACAAAGGCATCTGAAACGTCTT
TGGAACCCCCTCTGAATATATCTGGTGGTGTATAAGCAGCTAACAGACATTGGGCCCAGCAGAA
CTAATTGACTGTGTGGTCTCTTATGCTATTAAATTCTTTTTGGAAGTTGAAGCATCATCCTTTG
ATTAAAAACTGTGTGCAGGGATGGCCTTTCAATTCAATTTCAGTATAGAAGAAGATCTGGAAAA
TAAATTAACTTCCCTCGATGATGGAACTTGTGTGTTAAAAAGTCAGAAAGGAAAGGAGGACAAA
AACCAGTCTACAGAACTGCCGGGCTTGCCTCAGGATCGCTTGTGGAAATGCTCCTCGCTGGGAA
GTGCAGCTTCCTCTGAAGACACTGATAGCCCACCCAGTACCGCTGACAGGTCAGGTGTCCCAGA
AGCATGTGAAAAACAGCCCTCCCTGAAACCTGCTAAAGAACACGTGATACCTAAAGATTGTGAT
CAGGTCTTAGAAAATAAGGTTTTGGAAATGCTGCCAGGTTCCCAGCATGTTAGCACAGCAGTAG
TGAAAACCATCTCTTTGAAAGAGAAATTCCCTGGAGAAAACATAGTTTCACAAAGCTTTTCTTC
TCATTCTGATCTGATTCCAGGTGTCTATGAAGGAGGCTTAAAAATCTGGGAATGTACCTTTGAT
CTCATGACTTATTTCACAAAGGCCAAAGTGAAATTTGCTGGACAGAAAGTGTTGGATCTTGGCT
GTGGGTCTGGGTTGCTTGGGATAACTGCATCCAAAGGAGGGGCTAGAGAAGTTCATTTTCAAGA
TTATAACGGTTTGGTAATTGATGAAGTGACCTTACCTAATGTAGTTGCTAATGTCCCTTTGCAA
GGTGACAGCAATGGCATAAATGAGCCAGCTGGGAAAAGACAAAGGAAGTCAGAAGTAGCCCAAG
AAACATGTAAGTGTCGGTTGTTCTCTGGGGAGTGGGCTGAGTTTTGTAAGCTTGTATTAAGTGA
AAAACTGTTTGTGAAATATGACCTCATTCTCACTTCAGAAACCATTTATAATCCAGATTATTAC
AGCACATTGCATGAGACACTCCTCAGACTATTGAGTAGGAACGGCCGGGTGCTTTTGGCCAGCA
AAGCACATTACTTTGGTGTTGGTGGTGGTGTTCATCTCTTCCAGAAGTTTGTAGAAGAAAAGGG
TGTGTTTGAGACTCGAACACTTGAGGTAATTGATGAAGGTCTCAAGAGGTTTCTGATGGAAATG
ACTTTTAAGTGCCCCAGTTAATATGCATATAACTCAATGGCATAATGAATTAAAAAGAATACCC
CAGAACTTGTGACTGTTCAATTTCTATTTTACTGTTAGCTTTTTCTGAAAATATGGTGTTTGTA
TGTTTTTGCTTACTGAAATAATAAGCCAAGTATGGTAGTATCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020839	(Get FASTA)	NCBI Sequence Viewer
	XP_006250217	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98702	(Get FASTA)	NCBI Sequence Viewer
	EDM09367	(Get FASTA)	NCBI Sequence Viewer
	EDM09368	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003480.3
	ENSRNOP00000110677
GenBank Protein	Q4KM84	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020839 ⟸ NM_001025668

- UniProtKB:

Q4KM84 (UniProtKB/Swiss-Prot), A6IDD0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAFQFNFSIEEDLENKLTSLDDGTCVLKSQKGKEDKNQSTELPGLPQDRLWKCSSLGSAASSED
TDSPPSTADRSGVPEACEKQPSLKPAKEHVIPKDCDQVLENKVLEMLPGSQHVSTAVVKTISLK
EKFPGENIVSQSFSSHSDLIPGVYEGGLKIWECTFDLMTYFTKAKVKFAGQKVLDLGCGSGLLG
ITASKGGAREVHFQDYNGLVIDEVTLPNVVANVPLQGDSNGINEPAGKRQRKSEVAQETCKCRL
FSGEWAEFCKLVLSEKLFVKYDLILTSETIYNPDYYSTLHETLLRLLSRNGRVLLASKAHYFGV
GGGVHLFQKFVEEKGVFETRTLEVIDEGLKRFLMEMTFKCPS

hide sequence

RefSeq Acc Id:	XP_006250217 ⟸ XM_006250155
- Peptide Label:	isoform X1
- UniProtKB:	Q4KM84 (UniProtKB/Swiss-Prot), A6IDD0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFQFNFSIEEDLENKLTSLDDGTCVLKSQKGKEDKNQSTELPGLPQDRLWKCSSLGSAASSED TDSPPSTADRSGVPEACEKQPSLKPAKEHVIPKDCDQVLENKVLEMLPGSQHVSTAVVKTISLK EKFPGENIVSQSFSSHSDLIPGVYEGGLKIWECTFDLMTYFTKAKVKFAGQKVLDLGCGSGLLG ITASKGGAREVHFQDYNGLVIDEVTLPNVVANVPLQGDSNGINEPAGKRQRKSEVAQETCKCRL FSGEWAEFCKLVLSEKLFVKYDLILTSETIYNPDYYSTLHETLLRLLSRNGRVLLASKAHYFGV GGGVHLFQKFVEEKGVFETRTLEVIDEGLKRFLMEMTFKCPS hide sequence

Ensembl Acc Id:

ENSRNOP00000003480 ⟸ ENSRNOT00000003636

Ensembl Acc Id:

ENSRNOP00000104450 ⟸ ENSRNOT00000136825

Ensembl Acc Id:

ENSRNOP00000110677 ⟸ ENSRNOT00000157956

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KM84-F1-model_v2	AlphaFold	Q4KM84	1-362	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698952

Promoter ID:

EPDNEW_R9477

Type:

multiple initiation site

Name:

Mettl18_1

Description:

methyltransferase like 18

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	82,298,515 - 82,298,575	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306783	AgrOrtholog
BioCyc Gene	G2FUF-17616	BioCyc
Ensembl Genes	ENSRNOG00000025189	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003636.5	UniProtKB/Swiss-Prot
	ENSRNOT00000157956	ENTREZGENE
Gene3D-CATH	3.40.50.150	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7388665	IMAGE-MGC_LOAD
InterPro	Methyltransf_16	UniProtKB/Swiss-Prot
	SAM-dependent_MTases	UniProtKB/Swiss-Prot
KEGG Report	rno:304928	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112676	IMAGE-MGC_LOAD
NCBI Gene	304928	ENTREZGENE
PANTHER	HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG	UniProtKB/Swiss-Prot
	PTHR14614	UniProtKB/Swiss-Prot
Pfam	Methyltransf_16	UniProtKB/Swiss-Prot
	PrmA	UniProtKB/Swiss-Prot
PhenoGen	Mettl18	PhenoGen
RatGTEx	ENSRNOG00000025189	RatGTEx
Superfamily-SCOP	SSF53335	UniProtKB/Swiss-Prot
UniProt	A0ABK0LN77_RAT	UniProtKB/TrEMBL
	A6IDD0	ENTREZGENE, UniProtKB/TrEMBL
	MET18_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-06-09	Mettl18	methyltransferase 18, RPL3 N3(tau)-histidine	Mettl18	methyltransferase 18, RPL3 N3-histidine	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2023-05-12	Mettl18	methyltransferase 18, RPL3 N3-histidine	Mettl18	methyltransferase like 18	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-05-25	Mettl18	methyltransferase like 18	RGD1306783	similar to 2810422O20Rik protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1306783	similar to 2810422O20Rik protein	RGD1306783_predicted	similar to 2810422O20Rik protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1306783_predicted	similar to 2810422O20Rik protein (predicted)	LOC304928_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC304928_predicted	similar to 2810422O20Rik protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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