Prodh2 (proline dehydrogenase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prodh2 (proline dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Prodh2
Name: proline dehydrogenase 2
RGD ID: 1306761
Description: Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in L-proline catabolic process to L-glutamate. Predicted to be active in mitochondrion. Orthologous to human PRODH2 (proline dehydrogenase 2); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hydroxyproline dehydrogenase; HYPDH; LOC361538; probable proline dehydrogenase 2; probable proline oxidase 2; proline dehydrogenase (oxidase) 2; proline oxidase-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,881,000 - 94,894,609 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl194,881,061 - 94,894,609 (+)EnsemblGRCr8
mRatBN7.2185,753,558 - 85,767,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,753,644 - 85,767,162 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,170,442 - 91,183,855 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,636,602 - 99,650,023 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,928,723 - 92,942,134 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,955,125 - 88,968,501 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,955,135 - 88,968,501 (+)Ensemblrn6Rnor6.0
Rnor_5.0190,110,667 - 90,123,506 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4185,546,014 - 85,559,530 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera180,125,644 - 80,138,959 (+)NCBICelera
RGSC_v3.1185,624,134 - 85,637,586 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
clofibrate  (ISO)
clorgyline  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
epoxiconazole  (ISO)
fumonisin B1  (ISO)
GW 4064  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
inulin  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
Nivalenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trametinib  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:18614015   PMID:25697095  


Genomics

Comparative Map Data
Prodh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,881,000 - 94,894,609 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl194,881,061 - 94,894,609 (+)EnsemblGRCr8
mRatBN7.2185,753,558 - 85,767,165 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,753,644 - 85,767,162 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx191,170,442 - 91,183,855 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,636,602 - 99,650,023 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,928,723 - 92,942,134 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,955,125 - 88,968,501 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,955,135 - 88,968,501 (+)Ensemblrn6Rnor6.0
Rnor_5.0190,110,667 - 90,123,506 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4185,546,014 - 85,559,530 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera180,125,644 - 80,138,959 (+)NCBICelera
RGSC_v3.1185,624,134 - 85,637,586 (+)NCBI
Cytogenetic Map1q21NCBI
PRODH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,799,988 - 35,812,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,799,975 - 35,813,299 (-)Ensemblhg38GRCh38
GRCh371936,290,890 - 36,303,747 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,982,732 - 40,996,041 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341940,982,731 - 40,996,041NCBI
Celera1933,004,365 - 33,017,674 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,795,750 - 32,809,099 (-)NCBIHuRef
CHM1_11936,292,192 - 36,305,500 (-)NCBICHM1_1
T2T-CHM13v2.01938,345,290 - 38,358,148 (-)NCBIT2T-CHM13v2.0
Prodh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,193,011 - 30,212,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,193,047 - 30,212,827 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38730,493,586 - 30,513,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,493,622 - 30,513,402 (+)Ensemblmm10GRCm38
MGSCv37731,278,677 - 31,298,421 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36730,202,418 - 30,222,162 (+)NCBIMGSCv36mm8
Celera725,084,968 - 25,104,699 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.36NCBI
Prodh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,747,862 - 2,754,592 (+)Ensembl
ChiLan1.0NW_0049554682,747,870 - 2,754,621 (+)NCBIChiLan1.0ChiLan1.0
PRODH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,783,171 - 41,807,083 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,776,415 - 43,792,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,713,686 - 32,726,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,462,685 - 41,475,915 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,462,735 - 41,476,308 (-)EnsemblpanPan2panpan1.1
PRODH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,831,722 - 116,842,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,831,722 - 116,916,278 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1116,237,189 - 116,247,915 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01117,434,889 - 117,445,619 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,434,889 - 117,445,619 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,998,294 - 117,009,017 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,621,797 - 116,632,644 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,677,246 - 117,687,980 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prodh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,114,580 - 11,123,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570522,290 - 531,241 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936570522,275 - 531,300 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRODH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,226,332 - 45,240,442 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1645,213,712 - 45,240,437 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,673,972 - 40,688,103 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRODH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,709,269 - 30,723,735 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,709,488 - 30,723,356 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660738,501,244 - 8,515,103 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prodh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479410,098,737 - 10,104,212 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prodh2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12165,495,942 - 165,509,708 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prodh2
90 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:88
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000028392
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat

Markers in Region
RH131057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,766,931 - 85,767,111 (+)MAPPERmRatBN7.2
Rnor_6.0188,968,271 - 88,968,450NCBIRnor6.0
Rnor_5.0190,123,276 - 90,123,455UniSTSRnor5.0
RGSC_v3.4185,559,300 - 85,559,479UniSTSRGSC3.4
Celera180,138,729 - 80,138,908UniSTS
RH 3.4 Map1846.8UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 10 53 117 89 90 59 25 59 6 253 104 9 92 80 58 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000083550   ⟹   ENSRNOP00000073423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,881,061 - 94,894,609 (+)Ensembl
mRatBN7.2 Ensembl185,753,644 - 85,767,162 (+)Ensembl
Rnor_6.0 Ensembl188,955,135 - 88,968,443 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091101   ⟹   ENSRNOP00000075226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl188,955,440 - 88,968,501 (+)Ensembl
RefSeq Acc Id: NM_001038588   ⟹   NP_001033677
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,087 - 94,894,607 (+)NCBI
mRatBN7.2185,753,644 - 85,767,162 (+)NCBI
Rnor_6.0188,955,125 - 88,968,501 (+)NCBI
Rnor_5.0190,110,667 - 90,123,506 (+)NCBI
RGSC_v3.4185,546,014 - 85,559,530 (+)RGD
Celera180,125,644 - 80,138,959 (+)RGD
Sequence:
RefSeq Acc Id: XM_039081896   ⟹   XP_038937824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,937 - 94,894,609 (+)NCBI
mRatBN7.2185,754,190 - 85,767,165 (+)NCBI
RefSeq Acc Id: XM_063266424   ⟹   XP_063122494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,001 - 94,892,389 (+)NCBI
RefSeq Acc Id: XM_063266426   ⟹   XP_063122496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,000 - 94,892,385 (+)NCBI
RefSeq Acc Id: XM_063266435   ⟹   XP_063122505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,001 - 94,889,360 (+)NCBI
RefSeq Acc Id: XR_005487885
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,001 - 94,894,433 (+)NCBI
mRatBN7.2185,753,558 - 85,766,990 (+)NCBI
RefSeq Acc Id: XR_005487887
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,000 - 94,887,576 (+)NCBI
mRatBN7.2185,753,558 - 85,760,134 (+)NCBI
RefSeq Acc Id: XR_005487888
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,881,000 - 94,890,880 (+)NCBI
mRatBN7.2185,753,558 - 85,763,435 (+)NCBI
RefSeq Acc Id: NP_001033677   ⟸   NM_001038588
- UniProtKB: Q2V057 (UniProtKB/Swiss-Prot),   B0BNG1 (UniProtKB/TrEMBL),   A0A0G2K5H0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075226   ⟸   ENSRNOT00000091101
Ensembl Acc Id: ENSRNOP00000073423   ⟸   ENSRNOT00000083550
RefSeq Acc Id: XP_038937824   ⟸   XM_039081896
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122496   ⟸   XM_063266426
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122494   ⟸   XM_063266424
- Peptide Label: isoform X1
- UniProtKB: Q2V057 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063122505   ⟸   XM_063266435
- Peptide Label: isoform X4
- UniProtKB: A6J9X9 (UniProtKB/TrEMBL)
Protein Domains
Proline dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2V057-F1-model_v2 AlphaFold Q2V057 1-456 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689918
Promoter ID:EPDNEW_R441
Type:initiation region
Name:Prodh2_1
Description:proline dehydrogenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R442  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0188,955,092 - 88,955,152EPDNEW
RGD ID:13689927
Promoter ID:EPDNEW_R442
Type:single initiation site
Name:Prodh2_2
Description:proline dehydrogenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R441  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0188,955,479 - 88,955,539EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306761 AgrOrtholog
BioCyc Gene G2FUF-60107 BioCyc
BioCyc Pathway HYDROXYPRODEG-PWY [trans-4-hydroxy-L-proline degradation I] BioCyc
BioCyc Pathway Image HYDROXYPRODEG-PWY BioCyc
Ensembl Genes ENSRNOG00000057578 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000083550 ENTREZGENE
Gene3D-CATH 3.20.20.220 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7324442 IMAGE-MGC_LOAD
InterPro FAD-linked_oxidoreductase-like UniProtKB/Swiss-Prot
  Proline_DH_dom UniProtKB/Swiss-Prot
  Proline_oxidase UniProtKB/Swiss-Prot
MGC_CLONE MGC:188224 IMAGE-MGC_LOAD
NCBI Gene 361538 ENTREZGENE
PANTHER HYDROXYPROLINE DEHYDROGENASE UniProtKB/Swiss-Prot
  PTHR13914 UniProtKB/Swiss-Prot
Pfam Pro_dh UniProtKB/Swiss-Prot
PhenoGen Prodh2 PhenoGen
RatGTEx ENSRNOG00000057578 RatGTEx
Superfamily-SCOP SSF51730 UniProtKB/Swiss-Prot
UniProt A0A0G2K5H0 ENTREZGENE
  A6J9X8_RAT UniProtKB/TrEMBL
  A6J9X9 ENTREZGENE, UniProtKB/TrEMBL
  A6J9Y0_RAT UniProtKB/TrEMBL
  B0BNG1 ENTREZGENE, UniProtKB/TrEMBL
  HYPDH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Prodh2  proline dehydrogenase 2  Prodh2  proline dehydrogenase (oxidase) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Prodh2  proline dehydrogenase (oxidase) 2      Symbol and Name updated 1299863 APPROVED
2006-03-07 Prodh2  proline dehydrogenase (oxidase) 2  Prodh2_predicted  proline dehydrogenase (oxidase) 2 (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Prodh2_predicted  proline dehydrogenase (oxidase) 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED