Rtel1 (regulator of telomere elongation helicase 1) - Rat Genome Database

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Pathways
Gene: Rtel1 (regulator of telomere elongation helicase 1) Rattus norvegicus
Analyze
Symbol: Rtel1
Name: regulator of telomere elongation helicase 1
RGD ID: 1306721
Description: Predicted to enable ATP binding activity; DNA helicase activity; and DNA polymerase binding activity. Predicted to be involved in DNA metabolic process and regulation of DNA metabolic process. Predicted to be located in chromosome, telomeric region. Predicted to be active in nucleus. Biomarker of silicosis. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive dyskeratosis congenita 5; female breast cancer; gastric adenocarcinoma; high grade glioma (multiple); and lung disease (multiple). Orthologous to human RTEL1 (regulator of telomere elongation helicase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: helicase-like protein NHL; LOC362288; RGD1306721; similar to helicase-like protein NHL isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp286
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,778,329 - 188,842,877 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3188,807,951 - 188,843,709 (+)EnsemblGRCr8
mRatBN7.23168,427,247 - 168,465,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3172,810,949 - 172,845,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,770,049 - 181,804,855 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,431,399 - 178,466,278 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,818,012 - 176,856,531 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,818,437 - 176,856,531 (+)Ensemblrn6Rnor6.0
Rnor_5.03180,528,554 - 180,566,701 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43170,461,613 - 170,496,959 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3164,121,122 - 164,155,994 (-)NCBICelera
RGSC_v3.13170,367,632 - 170,402,995 (+)NCBI
Cytogenetic Map3q43NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome, telomeric region  (IEA,ISO)
nuclear membrane  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility. Adel Fahmideh M, etal., Carcinogenesis. 2015 Aug;36(8):876-82. doi: 10.1093/carcin/bgv074. Epub 2015 May 25.
2. Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma. Araújo TM, etal., Mol Cytogenet. 2016 Jun 29;9:52. doi: 10.1186/s13039-016-0260-x. eCollection 2016.
3. Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome. Deng Z, etal., Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3408-16. doi: 10.1073/pnas.1300600110. Epub 2013 Aug 19.
4. Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population. Ding Y, etal., Int J Chron Obstruct Pulmon Dis. 2017 Mar 17;12:931-936. doi: 10.2147/COPD.S131246. eCollection 2017.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, etal., Int J Cancer. 2019 Apr 15;144(8):1962-1974. doi: 10.1002/ijc.31921. Epub 2018 Nov 13.
7. Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk. Gu CY, etal., J Cancer. 2019 Oct 15;10(24):6170-6174. doi: 10.7150/jca.35917. eCollection 2019.
8. The effect on melanoma risk of genes previously associated with telomere length. Iles MM, etal., J Natl Cancer Inst. 2014 Sep 17;106(10). pii: dju267. doi: 10.1093/jnci/dju267. Print 2014 Oct.
9. Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk. Lu S, etal., Mol Genet Genomic Med. 2019 Mar;7(3):e550. doi: 10.1002/mgg3.550. Epub 2019 Jan 8.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population. Namgoong S, etal., PLoS One. 2018 Nov 21;13(11):e0207660. doi: 10.1371/journal.pone.0207660. eCollection 2018.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats. Shoeb M, etal., Sci Rep. 2017 Dec 11;7(1):17284. doi: 10.1038/s41598-017-17645-y.
16. RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population. Yan S, etal., Oncotarget. 2016 Oct 25;7(43):70475-70480. doi: 10.18632/oncotarget.12297.
Additional References at PubMed
PMID:12477932   PMID:15210109   PMID:18957201   PMID:22579284   PMID:23453664   PMID:23585563   PMID:24115439   PMID:25620558  


Genomics

Comparative Map Data
Rtel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,778,329 - 188,842,877 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3188,807,951 - 188,843,709 (+)EnsemblGRCr8
mRatBN7.23168,427,247 - 168,465,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3172,810,949 - 172,845,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,770,049 - 181,804,855 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,431,399 - 178,466,278 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,818,012 - 176,856,531 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,818,437 - 176,856,531 (+)Ensemblrn6Rnor6.0
Rnor_5.03180,528,554 - 180,566,701 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43170,461,613 - 170,496,959 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3164,121,122 - 164,155,994 (-)NCBICelera
RGSC_v3.13170,367,632 - 170,402,995 (+)NCBI
Cytogenetic Map3q43NCBI
RTEL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,657,810 - 63,696,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,657,810 - 63,696,253 (+)Ensemblhg38GRCh38
GRCh372062,289,163 - 62,327,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,760,091 - 61,798,045 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342061,760,090 - 61,800,495NCBI
Celera2058,970,388 - 59,011,862 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,019,189 - 59,060,580 (+)NCBIHuRef
CHM1_12062,190,825 - 62,229,469 (+)NCBICHM1_1
T2T-CHM13v2.02065,471,931 - 65,516,559 (+)NCBIT2T-CHM13v2.0
Rtel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,961,504 - 180,998,409 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,961,532 - 180,998,409 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382181,319,711 - 181,356,616 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,319,739 - 181,356,616 (+)Ensemblmm10GRCm38
MGSCv372181,054,429 - 181,091,321 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362181,249,192 - 181,286,023 (+)NCBIMGSCv36mm8
Celera2185,402,416 - 185,438,885 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.63NCBI
Rtel1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528532,385 - 572,398 (-)Ensembl
ChiLan1.0NW_004955528531,680 - 578,003 (-)NCBIChiLan1.0ChiLan1.0
RTEL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,455,949 - 69,502,261 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,448,455 - 69,494,640 (+)NCBINHGRI_mPanPan1
PanPan1.12061,580,222 - 61,619,172 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4115,408,600 - 115,412,293 (+)EnsemblpanPan2panpan1.1
PanPan1.1 Ensembl2061,581,331 - 61,618,718 (+)EnsemblpanPan2panpan1.1
RTEL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,219,977 - 47,248,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02448,358,971 - 48,387,747 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,356,908 - 48,387,748 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12447,203,889 - 47,232,649 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,328,761 - 47,357,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02448,066,842 - 48,095,619 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rtel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,467,576 - 195,500,840 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,922,322 - 10,954,402 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,920,979 - 10,954,483 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTEL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,611,909 - 62,634,690 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11762,611,844 - 62,636,628 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RTEL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12531,905 - 567,430 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2531,085 - 566,840 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605048,086,325 - 48,123,114 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rtel1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,304,427 - 29,343,842 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474129,303,844 - 29,344,123 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rtel1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15158,416,839 - 158,450,652 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:104
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000055030
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001434399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000055030   ⟹   ENSRNOP00000051909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3188,807,962 - 188,843,709 (+)Ensembl
mRatBN7.2 Ensembl3168,430,452 - 168,465,348 (+)Ensembl
Rnor_6.0 Ensembl3176,821,652 - 176,856,531 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087279   ⟹   ENSRNOP00000069471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,430,449 - 168,465,348 (+)Ensembl
Rnor_6.0 Ensembl3176,818,437 - 176,856,530 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098539   ⟹   ENSRNOP00000094899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3188,807,998 - 188,842,877 (+)Ensembl
mRatBN7.2 Ensembl3168,430,452 - 168,465,348 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098630   ⟹   ENSRNOP00000087672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100640   ⟹   ENSRNOP00000088333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3188,807,951 - 188,842,873 (+)Ensembl
mRatBN7.2 Ensembl3168,419,579 - 168,465,348 (+)Ensembl
RefSeq Acc Id: NM_001191857   ⟹   NP_001178786
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,998 - 188,842,877 (+)NCBI
mRatBN7.23168,430,452 - 168,465,348 (+)NCBI
Rnor_6.03176,821,652 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Celera3164,121,122 - 164,155,994 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235772   ⟹   XP_006235834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,842,877 (+)NCBI
mRatBN7.23168,430,386 - 168,465,349 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235773   ⟹   XP_006235835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,801,985 - 188,842,877 (+)NCBI
mRatBN7.23168,427,247 - 168,465,349 (+)NCBI
Rnor_6.03176,818,012 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235774   ⟹   XP_006235836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,842,877 (+)NCBI
mRatBN7.23168,430,386 - 168,465,348 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235775   ⟹   XP_006235837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,842,877 (+)NCBI
mRatBN7.23168,430,386 - 168,465,349 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235776   ⟹   XP_006235838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,842,877 (+)NCBI
mRatBN7.23168,430,386 - 168,465,349 (+)NCBI
Rnor_6.03176,821,599 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235778   ⟹   XP_006235840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,819,568 - 188,842,877 (+)NCBI
mRatBN7.23168,442,020 - 168,465,349 (+)NCBI
Rnor_6.03176,833,240 - 176,856,531 (+)NCBI
Rnor_5.03180,528,554 - 180,566,701 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105561   ⟹   XP_038961489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,808,172 - 188,842,877 (+)NCBI
mRatBN7.23168,430,617 - 168,465,349 (+)NCBI
RefSeq Acc Id: XM_039105563   ⟹   XP_038961491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,841,431 (+)NCBI
mRatBN7.23168,430,386 - 168,464,064 (+)NCBI
RefSeq Acc Id: XM_039105568   ⟹   XP_038961496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,834,144 - 188,842,877 (+)NCBI
mRatBN7.23168,456,625 - 168,465,349 (+)NCBI
RefSeq Acc Id: XM_063284242   ⟹   XP_063140312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,778,329 - 188,842,877 (+)NCBI
RefSeq Acc Id: XM_063284243   ⟹   XP_063140313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,842,877 (+)NCBI
RefSeq Acc Id: XM_063284244   ⟹   XP_063140314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,811,258 - 188,842,877 (+)NCBI
RefSeq Acc Id: XM_063284245   ⟹   XP_063140315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,813,627 - 188,842,877 (+)NCBI
RefSeq Acc Id: XM_063284247   ⟹   XP_063140317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,833,315 - 188,842,877 (+)NCBI
RefSeq Acc Id: XR_010064670
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,836,021 (+)NCBI
RefSeq Acc Id: XR_010064671
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,807,932 - 188,836,021 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178786 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421322 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421323 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421324 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421325 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421326 (Get FASTA)   NCBI Sequence Viewer  
  NP_001421328 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235834 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235835 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235836 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235837 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235838 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235840 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961489 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961491 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961496 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140312 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140313 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140314 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140315 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86436 (Get FASTA)   NCBI Sequence Viewer  
  AAI61910 (Get FASTA)   NCBI Sequence Viewer  
  EDL88727 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051909
  ENSRNOP00000051909.3
  ENSRNOP00000088333
  ENSRNOP00000094899
GenBank Protein Q5RJZ1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178786   ⟸   NM_001191857
- UniProtKB: Q5RJZ1 (UniProtKB/Swiss-Prot),   A0A8I6AMG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235835   ⟸   XM_006235773
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235834   ⟸   XM_006235772
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006235836   ⟸   XM_006235774
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JVG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235837   ⟸   XM_006235775
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006235838   ⟸   XM_006235776
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JVG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235840   ⟸   XM_006235778
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AMG5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051909   ⟸   ENSRNOT00000055030
Ensembl Acc Id: ENSRNOP00000069471   ⟸   ENSRNOT00000087279
RefSeq Acc Id: XP_038961491   ⟸   XM_039105563
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038961489   ⟸   XM_039105561
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961496   ⟸   XM_039105568
- Peptide Label: isoform X10
Ensembl Acc Id: ENSRNOP00000087672   ⟸   ENSRNOT00000098630
Ensembl Acc Id: ENSRNOP00000094899   ⟸   ENSRNOT00000098539
Ensembl Acc Id: ENSRNOP00000088333   ⟸   ENSRNOT00000100640
RefSeq Acc Id: XP_063140312   ⟸   XM_063284242
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140313   ⟸   XM_063284243
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140314   ⟸   XM_063284244
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AMG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140315   ⟸   XM_063284245
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AMG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140317   ⟸   XM_063284247
- Peptide Label: isoform X11
Protein Domains
Helicase ATP-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJZ1-F1-model_v2 AlphaFold Q5RJZ1 1-1274 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692752
Promoter ID:EPDNEW_R3277
Type:initiation region
Name:Rtel1_1
Description:regulator of telomere elongation helicase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03176,821,632 - 176,821,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306721 AgrOrtholog
BioCyc Gene G2FUF-46291 BioCyc
Ensembl Genes ENSRNOG00000027513 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000055030 ENTREZGENE
  ENSRNOT00000055030.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098539 ENTREZGENE
  ENSRNOT00000100640 ENTREZGENE
Gene3D-CATH 1.20.1160.20 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7302407 IMAGE-MGC_LOAD
  IMAGE:8368052 IMAGE-MGC_LOAD
InterPro ATP-dep_Helicase_C UniProtKB/Swiss-Prot
  DEAD_2 UniProtKB/Swiss-Prot
  DinG/Rad3-like UniProtKB/Swiss-Prot
  Helic_SF1/SF2_ATP-bd_DinG/Rad3 UniProtKB/Swiss-Prot
  Helicase-like_DEXD_c2 UniProtKB/Swiss-Prot
  HHD_RTEL1 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Rad3/Chl1-like UniProtKB/Swiss-Prot
  RTEL1 UniProtKB/Swiss-Prot
KEGG Report rno:362288 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105962 IMAGE-MGC_LOAD
  MGC:187633 IMAGE-MGC_LOAD
NCBI Gene 362288 ENTREZGENE
PANTHER PTHR11472 UniProtKB/Swiss-Prot
  REGULATOR OF TELOMERE ELONGATION HELICASE 1 UniProtKB/Swiss-Prot
Pfam ARCH_RTEL1 UniProtKB/Swiss-Prot
  DEAD_2 UniProtKB/Swiss-Prot
  Helicase_C_2 UniProtKB/Swiss-Prot
  HHD_RTEL1 UniProtKB/Swiss-Prot
PhenoGen Rtel1 PhenoGen
PROSITE HELICASE_ATP_BIND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027513 RatGTEx
SMART DEXDc2 UniProtKB/Swiss-Prot
  HELICc2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2JVG0 ENTREZGENE
  A0A8I6A605 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8F3 ENTREZGENE
  A0A8I6AMG5 ENTREZGENE, UniProtKB/TrEMBL
  B1WBW1_RAT UniProtKB/TrEMBL
  Q5RJZ1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-10-20 Rtel1  regulator of telomere elongation helicase 1  RGD1306721  similar to helicase-like protein NHL isoform 2  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306721  similar to helicase-like protein NHL isoform 2  RGD1306721_predicted  similar to helicase-like protein NHL isoform 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306721_predicted  similar to helicase-like protein NHL isoform 2 (predicted)  LOC362288_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362288_predicted  similar to helicase-like protein NHL isoform 2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL