Dock6 (dedicator of cytokinesis 6) - Rat Genome Database

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Gene: Dock6 (dedicator of cytokinesis 6) Rattus norvegicus
Analyze
Symbol: Dock6
Name: dedicator of cytokinesis 6
RGD ID: 1306517
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aristolochic acid A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dedicator of cytokinesis protein 6; LOC367039
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,618,523 - 28,670,741 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,618,523 - 28,670,648 (-)EnsemblGRCr8
mRatBN7.2820,342,430 - 20,394,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,377,909 - 24,430,028 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,673,454 - 22,725,573 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,572,031 - 20,624,157 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,822,412 - 22,874,670 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,822,412 - 22,874,645 (-)Ensemblrn6Rnor6.0
Rnor_5.0822,876,566 - 22,928,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,896,180 - 20,966,159 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,732,745 - 21,785,834 (-)NCBICelera
RGSC_v3.1820,894,958 - 20,962,815 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Chi HC, etal., Oncogene. 2020 Sep;39(37):5933-5949. doi: 10.1038/s41388-020-01390-0. Epub 2020 Aug 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis. Li X, etal., J Exp Clin Cancer Res. 2018 Mar 27;37(1):71. doi: 10.1186/s13046-018-0729-z.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies. Sukalo M, etal., Hum Mutat. 2015 Jun;36(6):593-8. doi: 10.1002/humu.22795. Epub 2015 Apr 21.
9. Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis. Zhang ZY, etal., Arch Oral Biol. 2022 Jan;133:105297. doi: 10.1016/j.archoralbio.2021.105297. Epub 2021 Oct 28.

Genomics

Comparative Map Data
Dock6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,618,523 - 28,670,741 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,618,523 - 28,670,648 (-)EnsemblGRCr8
mRatBN7.2820,342,430 - 20,394,660 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,377,909 - 24,430,028 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,673,454 - 22,725,573 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,572,031 - 20,624,157 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,822,412 - 22,874,670 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,822,412 - 22,874,645 (-)Ensemblrn6Rnor6.0
Rnor_5.0822,876,566 - 22,928,950 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,896,180 - 20,966,159 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,732,745 - 21,785,834 (-)NCBICelera
RGSC_v3.1820,894,958 - 20,962,815 (-)NCBI
Cytogenetic Map8q13NCBI
DOCK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,199,295 - 11,262,524 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,199,295 - 11,262,524 (-)Ensemblhg38GRCh38
GRCh371911,309,971 - 11,373,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,170,971 - 11,234,157 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341911,170,972 - 11,234,128NCBI
Celera1911,204,784 - 11,268,011 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,886,047 - 10,940,482 (-)NCBIHuRef
CHM1_11911,311,180 - 11,374,238 (-)NCBICHM1_1
T2T-CHM13v2.01911,326,296 - 11,389,499 (-)NCBIT2T-CHM13v2.0
Dock6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,711,476 - 21,764,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,711,156 - 21,763,931 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,800,180 - 21,852,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,799,860 - 21,852,635 (-)Ensemblmm10GRCm38
MGSCv37921,604,624 - 21,657,079 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,594,033 - 21,603,018 (-)NCBIMGSCv36mm8
Celera919,069,771 - 19,122,226 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.89NCBI
Dock6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,174,966 - 2,216,423 (-)Ensembl
ChiLan1.0NW_0049554952,174,802 - 2,216,424 (-)NCBIChiLan1.0ChiLan1.0
DOCK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,114,565 - 16,178,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,113,252 - 15,176,888 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,747,850 - 10,811,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,458,860 - 11,521,029 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,459,062 - 11,513,220 (-)EnsemblpanPan2panpan1.1
DOCK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,029,354 - 50,066,829 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,029,369 - 50,066,829 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2049,898,472 - 49,940,350 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02050,545,683 - 50,587,769 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,545,643 - 50,587,757 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,756,044 - 49,797,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,182,747 - 50,224,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,425,668 - 50,467,527 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dock6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,967,152 - 209,013,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,341,331 - 1,379,728 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,341,144 - 1,394,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,925,854 - 69,972,316 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1269,925,853 - 69,972,326 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DOCK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,133,688 - 10,191,995 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660749,693,698 - 9,753,875 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,063,281 - 3,110,541 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,063,094 - 3,110,603 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dock6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1818,066,408 - 18,118,195 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dock6
345 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:126
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000064551
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
D8Rat52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,391,196 - 20,391,407 (+)MAPPERmRatBN7.2
Rnor_6.0822,871,284 - 22,871,494NCBIRnor6.0
Rnor_5.0822,925,583 - 22,925,793UniSTSRnor5.0
RGSC_v3.4820,962,778 - 20,963,147RGDRGSC3.4
RGSC_v3.4820,962,806 - 20,963,016UniSTSRGSC3.4
Celera821,782,481 - 21,782,691UniSTS
RGSC_v3.1820,962,806 - 20,963,016RGD
RH 3.4 Map8207.89RGD
RH 3.4 Map8207.89UniSTS
SHRSP x BN Map814.26UniSTS
SHRSP x BN Map814.26RGD
FHH x ACI Map810.7699RGD
Cytogenetic Map8q13UniSTS
BI274505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,378,226 - 20,378,386 (+)MAPPERmRatBN7.2
Rnor_6.0822,858,304 - 22,858,463NCBIRnor6.0
Rnor_5.0822,912,744 - 22,912,903UniSTSRnor5.0
RGSC_v3.4820,949,826 - 20,949,985UniSTSRGSC3.4
Celera821,769,503 - 21,769,662UniSTS
RH 3.4 Map1962.71UniSTS
Cytogenetic Map8q13UniSTS
BI282731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,376,710 - 20,377,030 (+)MAPPERmRatBN7.2
Rnor_6.0822,856,788 - 22,857,107NCBIRnor6.0
Rnor_5.0822,911,228 - 22,911,547UniSTSRnor5.0
RGSC_v3.4820,948,310 - 20,948,629UniSTSRGSC3.4
Celera821,767,987 - 21,768,306UniSTS
Cytogenetic Map8q13UniSTS
AI009950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,379,223 - 20,379,454 (+)MAPPERmRatBN7.2
Rnor_6.0822,859,301 - 22,859,531NCBIRnor6.0
Rnor_5.0822,913,601 - 22,913,831UniSTSRnor5.0
RGSC_v3.4820,950,823 - 20,951,053UniSTSRGSC3.4
Celera821,770,500 - 21,770,730UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 69 59 6 333 169 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064551   ⟹   ENSRNOP00000063161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,618,523 - 28,670,648 (-)Ensembl
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)Ensembl
Rnor_6.0 Ensembl822,822,412 - 22,874,637 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090424   ⟹   ENSRNOP00000075398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,618,523 - 28,670,648 (-)Ensembl
mRatBN7.2 Ensembl820,342,089 - 20,394,552 (-)Ensembl
Rnor_6.0 Ensembl822,822,729 - 22,874,645 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106365   ⟹   ENSRNOP00000079526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,618,523 - 28,670,648 (-)Ensembl
mRatBN7.2 Ensembl820,342,089 - 20,389,096 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118947   ⟹   ENSRNOP00000096113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,618,523 - 28,665,210 (-)Ensembl
mRatBN7.2 Ensembl820,342,089 - 20,389,096 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162151   ⟹   ENSRNOP00000111360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,618,523 - 28,670,648 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169227   ⟹   ENSRNOP00000108604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,618,523 - 28,670,648 (-)Ensembl
RefSeq Acc Id: NM_001394344   ⟹   NP_001381273
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,648 (-)NCBI
mRatBN7.2820,342,430 - 20,394,557 (-)NCBI
RefSeq Acc Id: NM_001413911   ⟹   NP_001400840
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,648 (-)NCBI
mRatBN7.2820,342,430 - 20,394,557 (-)NCBI
RefSeq Acc Id: XM_039081850   ⟹   XP_038937778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,726 (-)NCBI
mRatBN7.2820,342,430 - 20,394,635 (-)NCBI
RefSeq Acc Id: XM_039081851   ⟹   XP_038937779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,726 (-)NCBI
mRatBN7.2820,342,430 - 20,394,635 (-)NCBI
RefSeq Acc Id: XM_039081852   ⟹   XP_038937780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,670,726 (-)NCBI
mRatBN7.2820,342,430 - 20,394,635 (-)NCBI
RefSeq Acc Id: XM_039081854   ⟹   XP_038937782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,623,124 - 28,670,729 (-)NCBI
mRatBN7.2820,347,263 - 20,394,654 (-)NCBI
RefSeq Acc Id: XM_039081855   ⟹   XP_038937783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,632,872 - 28,670,741 (-)NCBI
mRatBN7.2820,356,779 - 20,394,660 (-)NCBI
RefSeq Acc Id: XM_063265869   ⟹   XP_063121939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,619,855 - 28,670,726 (-)NCBI
RefSeq Acc Id: XM_063265870   ⟹   XP_063121940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,618,523 - 28,664,514 (-)NCBI
Ensembl Acc Id: ENSRNOP00000075398   ⟸   ENSRNOT00000090424
Ensembl Acc Id: ENSRNOP00000063161   ⟸   ENSRNOT00000064551
RefSeq Acc Id: XP_038937780   ⟸   XM_039081852
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937779   ⟸   XM_039081851
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937778   ⟸   XM_039081850
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937782   ⟸   XM_039081854
- Peptide Label: isoform X6
- UniProtKB: A6JNU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937783   ⟸   XM_039081855
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000079526   ⟸   ENSRNOT00000106365
Ensembl Acc Id: ENSRNOP00000096113   ⟸   ENSRNOT00000118947
RefSeq Acc Id: NP_001400840   ⟸   NM_001413911
- Peptide Label: isoform 2
- UniProtKB: A0A0G2KAH4 (UniProtKB/TrEMBL),   A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381273   ⟸   NM_001394344
- Peptide Label: isoform 1
- UniProtKB: D3ZY19 (UniProtKB/TrEMBL),   A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121940   ⟸   XM_063265870
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121939   ⟸   XM_063265869
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ANH8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108604   ⟸   ENSRNOT00000169227
Ensembl Acc Id: ENSRNOP00000111360   ⟸   ENSRNOT00000162151
Protein Domains
C2 DOCK-type   DOCKER

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAH4-F1-model_v2 AlphaFold A0A0G2KAH4 1-2113 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695791
Promoter ID:EPDNEW_R6315
Type:multiple initiation site
Name:Dock6_1
Description:dedicator of cytokinesis 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,874,640 - 22,874,700EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306517 AgrOrtholog
BioCyc Gene G2FUF-31408 BioCyc
Ensembl Genes ENSRNOG00000010652 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064551 ENTREZGENE
  ENSRNOT00000064551.4 UniProtKB/TrEMBL
  ENSRNOT00000090424 ENTREZGENE
  ENSRNOT00000090424.3 UniProtKB/TrEMBL
  ENSRNOT00000106365 ENTREZGENE
  ENSRNOT00000106365.2 UniProtKB/TrEMBL
  ENSRNOT00000118947.2 UniProtKB/TrEMBL
  ENSRNOT00000162151 ENTREZGENE
  ENSRNOT00000162151.1 UniProtKB/TrEMBL
  ENSRNOT00000169227.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_Dock-C UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DHR-2 UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
  DUF3398 UniProtKB/TrEMBL
NCBI Gene 367039 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS PROTEIN 6 UniProtKB/TrEMBL
  PTHR23317 UniProtKB/TrEMBL
Pfam DHR-2 UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DUF3398 UniProtKB/TrEMBL
PhenoGen Dock6 PhenoGen
PROSITE DHR_1 UniProtKB/TrEMBL
  DHR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010652 RatGTEx
UniProt A0A0G2KAH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNP4_RAT UniProtKB/TrEMBL
  A0A8I6ANH8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LTS3_RAT UniProtKB/TrEMBL
  A0ABK0LZT3_RAT UniProtKB/TrEMBL
  A6JNU8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZY19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dock6  dedicator of cytokinesis 6   Dock6_predicted  dedicator of cytokinesis 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dock6_predicted  dedicator of cytokinesis 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED