Fras1 (Fraser extracellular matrix complex subunit 1) - Rat Genome Database

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Gene: Fras1 (Fraser extracellular matrix complex subunit 1) Rattus norvegicus
Analyze
Symbol: Fras1
Name: Fraser extracellular matrix complex subunit 1
RGD ID: 1306516
Description: Predicted to enable metal ion binding activity. Predicted to be involved in cell-matrix adhesion and epithelial structure maintenance. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; metanephros morphogenesis; and roof of mouth development. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: extracellular matrix organizing protein FRAS1; extracellular matrix protein FRAS1; extracellular matrix protein FRAS1-like; Fraser syndrome 1; Fraser syndrome 1 homolog; Fraser syndrome 1 homolog (human); LOC103693728; LOC289486
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81413,095,370 - 13,506,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1413,095,370 - 13,504,664 (-)EnsemblGRCr8
mRatBN7.21412,791,407 - 13,200,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,793,599 - 13,200,726 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1412,762,032 - 13,168,346 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01414,061,884 - 14,468,203 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,778,367 - 13,184,674 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1412,787,489 - 13,195,899 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1412,768,446 - 13,176,855 (-)NCBILyon_Normotensive
Lyon_Hypertensive1412,767,725 - 13,176,128 (-)NCBILyon_Hypertensive
F344_StmMcwi1413,029,993 - 13,441,593 (-)NCBIF344_StmMcwi
Rnor_6.01414,438,392 - 14,853,016 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1414,439,082 - 14,689,554 (-)Ensemblrn6Rnor6.0
Rnor_5.01414,380,117 - 14,795,559 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41414,309,668 - 14,574,022 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1412,851,004 - 13,251,138 (-)NCBICelera
RGSC_v3.11414,340,005 - 14,589,252 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
1,2-dichloroethane  (ISO)
1,4-dioxane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
lipoic acid  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
Nivalenol  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
potassium dichromate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein. McGregor L, etal., Nat Genet. 2003 Jun;34(2):203-8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:15345741   PMID:15623520   PMID:15838507   PMID:16880404   PMID:17251066   PMID:17596926   PMID:18757743   PMID:23469164   PMID:23669348  


Genomics

Comparative Map Data
Fras1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81413,095,370 - 13,506,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1413,095,370 - 13,504,664 (-)EnsemblGRCr8
mRatBN7.21412,791,407 - 13,200,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,793,599 - 13,200,726 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1412,762,032 - 13,168,346 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01414,061,884 - 14,468,203 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,778,367 - 13,184,674 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1412,787,489 - 13,195,899 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1412,768,446 - 13,176,855 (-)NCBILyon_Normotensive
Lyon_Hypertensive1412,767,725 - 13,176,128 (-)NCBILyon_Hypertensive
F344_StmMcwi1413,029,993 - 13,441,593 (-)NCBIF344_StmMcwi
Rnor_6.01414,438,392 - 14,853,016 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1414,439,082 - 14,689,554 (-)Ensemblrn6Rnor6.0
Rnor_5.01414,380,117 - 14,795,559 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41414,309,668 - 14,574,022 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1412,851,004 - 13,251,138 (-)NCBICelera
RGSC_v3.11414,340,005 - 14,589,252 (-)NCBI
Cytogenetic Map14p22NCBI
FRAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38478,057,323 - 78,544,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl478,057,323 - 78,544,269 (+)Ensemblhg38GRCh38
GRCh37478,978,477 - 79,465,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36479,198,120 - 79,684,447 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34479,336,312 - 79,724,964NCBI
Celera476,280,569 - 76,761,461 (+)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef474,729,839 - 75,211,820 (+)NCBIHuRef
CHM1_1478,955,468 - 79,441,921 (+)NCBICHM1_1
T2T-CHM13v2.0481,398,139 - 81,879,833 (+)NCBIT2T-CHM13v2.0
Fras1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39596,518,622 - 96,932,592 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl596,521,814 - 96,932,587 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38596,373,777 - 96,784,733 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl596,373,955 - 96,784,728 (+)Ensemblmm10GRCm38
MGSCv37596,802,974 - 97,213,747 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36596,614,257 - 97,025,030 (+)NCBIMGSCv36mm8
Celera593,713,114 - 94,117,836 (+)NCBICelera
Cytogenetic Map5E3NCBI
cM Map547.29NCBI
Fras1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554332,547,323 - 2,957,495 (+)Ensembl
ChiLan1.0NW_0049554332,547,228 - 2,957,294 (+)NCBIChiLan1.0ChiLan1.0
FRAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2351,518,280 - 52,008,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1451,707,425 - 52,195,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0445,650,346 - 46,138,222 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1451,497,242 - 51,983,161 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl451,500,396 - 51,981,476 (-)EnsemblpanPan2panpan1.1
FRAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1322,558,442 - 2,993,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl322,558,354 - 2,991,063 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3238,900,653 - 39,334,034 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0322,585,113 - 3,019,145 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl322,585,107 - 3,017,320 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1322,573,250 - 3,006,733 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0322,521,646 - 2,954,866 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03237,216,085 - 37,650,773 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fras1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052859,368,402 - 9,787,973 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366761,870,814 - 2,135,823 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366761,870,856 - 2,138,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl873,502,717 - 73,957,375 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1873,502,368 - 73,959,454 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2877,753,520 - 78,204,495 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FRAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1726,545,048 - 26,992,346 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl726,700,869 - 26,954,352 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660374,899,779 - 5,375,874 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fras1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475712,532,466 - 12,972,918 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475712,529,475 - 12,973,751 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fras1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1117,484,806 - 7,735,111 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fras1
4116 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:107
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000002814
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
D14Rat42  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,800,200 - 12,800,448 (+)MAPPERmRatBN7.2
Rnor_6.01414,444,994 - 14,445,241NCBIRnor6.0
Rnor_5.01414,386,719 - 14,386,966UniSTSRnor5.0
RGSC_v3.41414,315,728 - 14,315,976RGDRGSC3.4
RGSC_v3.41414,315,729 - 14,315,976UniSTSRGSC3.4
Celera1412,857,606 - 12,857,845UniSTS
RGSC_v3.11414,315,710 - 14,316,035RGD
SHRSP x BN Map146.9RGD
SHRSP x BN Map146.9UniSTS
Cytogenetic Map14p22UniSTS
D14Rat98  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21413,015,311 - 13,015,539 (+)MAPPERmRatBN7.2
Rnor_6.01414,673,206 - 14,673,433NCBIRnor6.0
Rnor_5.01414,613,528 - 14,613,755UniSTSRnor5.0
RGSC_v3.41414,535,071 - 14,535,299RGDRGSC3.4
RGSC_v3.41414,535,072 - 14,535,299UniSTSRGSC3.4
Celera1413,068,404 - 13,068,631UniSTS
RGSC_v3.11414,535,071 - 14,535,299RGD
FHH x ACI Map1414.9399RGD
FHH x ACI Map1414.9399UniSTS
Cytogenetic Map14p22UniSTS
D14Rat79  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81413,381,365 - 13,381,569 (+)Marker Load Pipeline
mRatBN7.21413,077,415 - 13,077,619 (+)MAPPERmRatBN7.2
Rnor_6.01414,734,626 - 14,734,829NCBIRnor6.0
Rnor_5.01414,674,948 - 14,675,151UniSTSRnor5.0
Celera1413,129,481 - 13,129,684UniSTS
SHRSP x BN Map146.9RGD
SHRSP x BN Map146.9UniSTS
Cytogenetic Map14p22UniSTS
D14Rat103  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81413,112,711 - 13,112,938 (+)Marker Load Pipeline
mRatBN7.21412,808,749 - 12,808,976 (+)MAPPERmRatBN7.2
Rnor_6.01414,453,543 - 14,453,769NCBIRnor6.0
Rnor_5.01414,395,268 - 14,395,494UniSTSRnor5.0
RGSC_v3.41414,324,277 - 14,324,505RGDRGSC3.4
RGSC_v3.41414,324,278 - 14,324,505UniSTSRGSC3.4
Celera1412,866,147 - 12,866,373UniSTS
RGSC_v3.11414,324,277 - 14,324,505RGD
SHRSP x BN Map146.9UniSTS
SHRSP x BN Map146.9RGD
Cytogenetic Map14p22UniSTS
D14Mco13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81413,478,667 - 13,479,035 (+)Marker Load Pipeline
mRatBN7.21413,174,727 - 13,175,095 (+)MAPPERmRatBN7.2
Rnor_6.01414,826,719 - 14,827,086NCBIRnor6.0
Rnor_5.01414,769,262 - 14,769,629UniSTSRnor5.0
RGSC_v3.41414,676,254 - 14,676,622RGDRGSC3.4
RGSC_v3.41414,676,255 - 14,676,622UniSTSRGSC3.4
Celera1413,225,369 - 13,225,736UniSTS
RGSC_v3.11414,676,254 - 14,676,622RGD
Cytogenetic Map14p22UniSTS
RH144158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,881,386 - 12,881,521 (+)MAPPERmRatBN7.2
Rnor_6.01414,536,124 - 14,536,258NCBIRnor6.0
Rnor_5.01414,477,092 - 14,477,226UniSTSRnor5.0
RGSC_v3.41414,399,815 - 14,399,949UniSTSRGSC3.4
Celera1412,936,975 - 12,937,109UniSTS
Cytogenetic Map14p22UniSTS
BF405012  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01414,401,871 - 14,401,969NCBIRnor5.0
Rnor_5.01414,400,561 - 14,400,659NCBIRnor5.0
RGSC_v3.41414,331,752 - 14,331,849UniSTSRGSC3.4
Celera1412,871,993 - 12,872,090UniSTS
RH 3.4 Map14157.07UniSTS
Cytogenetic Map14p22UniSTS
AU048978  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,922,320 - 12,922,560 (+)MAPPERmRatBN7.2
Rnor_6.01414,576,926 - 14,577,165NCBIRnor6.0
Rnor_5.01414,517,829 - 14,518,068UniSTSRnor5.0
RGSC_v3.41414,441,160 - 14,441,399UniSTSRGSC3.4
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 158 89 88 57 25 57 6 286 125 11 135 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000002814   ⟹   ENSRNOP00000002814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,095,370 - 13,504,664 (-)Ensembl
mRatBN7.2 Ensembl1412,793,599 - 13,200,726 (-)Ensembl
Rnor_6.0 Ensembl1414,439,082 - 14,689,554 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100214   ⟹   ENSRNOP00000093123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,095,370 - 13,504,664 (-)Ensembl
mRatBN7.2 Ensembl1412,793,599 - 13,200,726 (-)Ensembl
RefSeq Acc Id: NM_001415086   ⟹   NP_001402015
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81413,095,370 - 13,504,664 (-)NCBI
mRatBN7.21412,791,407 - 13,200,726 (-)NCBI
Dahl_SR_JrHsd1412,787,489 - 13,195,899 (-)NCBI
Lyon_Normotensive1412,768,446 - 13,176,855 (-)NCBI
Lyon_Hypertensive1412,767,725 - 13,176,128 (-)NCBI
F344_StmMcwi1413,029,993 - 13,441,593 (-)NCBI
RefSeq Acc Id: XM_039091669   ⟹   XP_038947597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81413,095,370 - 13,506,895 (-)NCBI
mRatBN7.21412,791,407 - 13,200,862 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001402015 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947597 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99640 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002814.9
  ENSRNOP00000093123
  ENSRNOP00000093123.1
Ensembl Acc Id: ENSRNOP00000002814   ⟸   ENSRNOT00000002814
RefSeq Acc Id: XP_038947597   ⟸   XM_039091669
- Peptide Label: isoform X1
- UniProtKB: F1M3H3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093123   ⟸   ENSRNOT00000100214
RefSeq Acc Id: NP_001402015   ⟸   NM_001415086
- Peptide Label: precursor
- UniProtKB: A0A8I6AIZ0 (UniProtKB/TrEMBL),   F1M3H3 (UniProtKB/TrEMBL)
Protein Domains
VWFC

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306516 AgrOrtholog
BioCyc Gene G2FUF-16326 BioCyc
Ensembl Genes ENSRNOG00000002053 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002814.9 UniProtKB/TrEMBL
  ENSRNOT00000100214 ENTREZGENE
  ENSRNOT00000100214.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2030 UniProtKB/TrEMBL
  6.20.200.20 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
  Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2 UniProtKB/TrEMBL
InterPro CalX-like_sf UniProtKB/TrEMBL
  Calx_beta UniProtKB/TrEMBL
  CSPG_rpt UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  FRAS1_ECM UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  Growth_fac_rcpt UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
NCBI Gene 289486 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1 UniProtKB/TrEMBL
  MATRIX PROTEIN, PUTATIVE-RELATED UniProtKB/TrEMBL
Pfam Cadherin_3 UniProtKB/TrEMBL
  Calx-beta UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
PhenoGen Fras1 PhenoGen
PROSITE CSPG UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002053 RatGTEx
SMART Calx_beta UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  SM00261 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/TrEMBL
  Grow_fac_recept UniProtKB/TrEMBL
  SSF141072 UniProtKB/TrEMBL
UniProt A0A8I6AIZ0 ENTREZGENE, UniProtKB/TrEMBL
  F1M3H3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fras1  Fraser extracellular matrix complex subunit 1  LOC103693728  extracellular matrix protein FRAS1-like  Data merged from RGD:9208189 737654 PROVISIONAL
2014-08-25 LOC103693728  extracellular matrix protein FRAS1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-07-09 Fras1  Fraser extracellular matrix complex subunit 1  Fras1  Fraser syndrome 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-17 Fras1  Fraser syndrome 1  Fras1  Fraser syndrome 1 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fras1  Fraser syndrome 1 homolog (human)   Fras1_predicted  Fraser syndrome 1 homolog (human) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Fras1_predicted  Fraser syndrome 1 homolog (human) (predicted)    Fraser syndrome 1 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Fras1_predicted  Fraser syndrome 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED