Spo11 (SPO11 initiator of meiotic double strand breaks) - Rat Genome Database

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Gene: Spo11 (SPO11 initiator of meiotic double strand breaks) Rattus norvegicus
Analyze
Symbol: Spo11
Name: SPO11 initiator of meiotic double strand breaks
RGD ID: 1306454
Description: Predicted to enable DNA binding activity. Predicted to be involved in meiotic DNA double-strand break formation; meiotic DNA double-strand break processing; and reciprocal meiotic recombination. Predicted to act upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear chromosome. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks); INTERACTS WITH 17beta-estradiol; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC366261; meiotic recombination protein SPO11; SPO11 meiotic protein covalently bound to DSB; SPO11 meiotic protein covalently bound to DSB homolog; SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); SPO11, initiator of meiotic double stranded breaks; sporulation protein, meiosis-specific, SPO11 homolog; sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,173,615 - 182,189,273 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3182,175,861 - 182,189,276 (+)EnsemblGRCr8
mRatBN7.23161,755,299 - 161,770,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,757,519 - 161,770,925 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3165,571,645 - 165,582,906 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,070,591 - 174,081,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,812,404 - 171,823,665 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,991,573 - 171,008,226 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,994,038 - 171,013,185 (+)Ensemblrn6Rnor6.0
Rnor_5.03177,058,150 - 177,081,041 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43163,842,817 - 163,854,067 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3160,953,190 - 160,964,440 (+)NCBICelera
RGSC_v3.13163,746,748 - 163,759,641 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15640358   PMID:16307920   PMID:17010969   PMID:17696610   PMID:18694567   PMID:20336070   PMID:20551173   PMID:22530760   PMID:24589552   PMID:27760146  


Genomics

Comparative Map Data
Spo11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,173,615 - 182,189,273 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3182,175,861 - 182,189,276 (+)EnsemblGRCr8
mRatBN7.23161,755,299 - 161,770,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,757,519 - 161,770,925 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3165,571,645 - 165,582,906 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,070,591 - 174,081,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,812,404 - 171,823,665 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,991,573 - 171,008,226 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,994,038 - 171,013,185 (+)Ensemblrn6Rnor6.0
Rnor_5.03177,058,150 - 177,081,041 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43163,842,817 - 163,854,067 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3160,953,190 - 160,964,440 (+)NCBICelera
RGSC_v3.13163,746,748 - 163,759,641 (+)NCBI
Cytogenetic Map3q42NCBI
SPO11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382057,329,803 - 57,343,993 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2057,329,803 - 57,343,994 (+)Ensemblhg38GRCh38
GRCh372055,904,859 - 55,919,049 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,338,238 - 55,352,456 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342055,338,237 - 55,352,455NCBI
Celera2052,645,068 - 52,659,286 (+)NCBICelera
Cytogenetic Map20q13.31NCBI
HuRef2052,686,790 - 52,701,008 (+)NCBIHuRef
CHM1_12055,805,942 - 55,820,160 (+)NCBICHM1_1
T2T-CHM13v2.02059,107,550 - 59,121,740 (+)NCBIT2T-CHM13v2.0
Spo11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,819,172 - 172,835,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,819,493 - 172,835,369 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382172,977,379 - 172,993,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,977,700 - 172,993,576 (+)Ensemblmm10GRCm38
MGSCv372172,805,343 - 172,819,077 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362172,622,784 - 172,636,504 (+)NCBIMGSCv36mm8
MGSCv362174,209,775 - 174,223,792 (+)NCBIMGSCv36mm8
Celera2178,918,642 - 178,957,539 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.64NCBI
Spo11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554452,088,144 - 2,103,385 (-)Ensembl
ChiLan1.0NW_0049554452,088,144 - 2,103,385 (-)NCBIChiLan1.0ChiLan1.0
SPO11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22163,080,959 - 63,095,174 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12063,074,078 - 63,088,293 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02053,669,128 - 53,684,328 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12054,948,664 - 54,962,908 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2054,948,661 - 54,963,384 (+)EnsemblpanPan2panpan1.1
SPO11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12442,345,595 - 42,360,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2442,345,547 - 42,384,481 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2441,593,229 - 41,608,456 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02443,211,094 - 43,226,379 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2443,211,048 - 43,250,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12442,296,075 - 42,311,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02442,435,814 - 42,451,039 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02443,093,993 - 43,109,232 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640183,108,577 - 183,122,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936530183,271 - 197,335 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936530183,271 - 197,549 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPO11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,730,675 - 57,745,875 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11757,730,676 - 57,745,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,894,962 - 64,910,090 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPO11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.126,778,442 - 6,792,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl26,778,985 - 6,792,643 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605054,840,590 - 54,854,921 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spo11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474123,784,298 - 23,800,168 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474123,784,362 - 23,800,127 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Spo11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15144,995,771 - 145,009,714 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:37
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000008959
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat

Markers in Region
AI232279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,770,760 - 161,770,878 (+)MAPPERmRatBN7.2
Rnor_6.03171,007,279 - 171,007,396NCBIRnor6.0
Rnor_5.03177,073,744 - 177,073,861UniSTSRnor5.0
RGSC_v3.43163,853,903 - 163,854,020UniSTSRGSC3.4
Celera3160,964,276 - 160,964,393UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS
AW532251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,763,931 - 161,764,085 (+)MAPPERmRatBN7.2
Rnor_6.03171,000,450 - 171,000,603NCBIRnor6.0
Rnor_5.03177,066,915 - 177,067,068UniSTSRnor5.0
RGSC_v3.43163,847,074 - 163,847,227UniSTSRGSC3.4
Celera3160,957,447 - 160,957,600UniSTS
RH 3.4 Map31498.4UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 50 127 53 56 25 92 25 6 299 170 9 103 81 90 31 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000008959   ⟹   ENSRNOP00000008959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3182,175,861 - 182,189,276 (+)Ensembl
mRatBN7.2 Ensembl3161,757,519 - 161,770,925 (+)Ensembl
Rnor_6.0 Ensembl3170,996,193 - 171,007,443 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081823   ⟹   ENSRNOP00000075147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3170,994,038 - 171,013,185 (+)Ensembl
RefSeq Acc Id: NM_001415816   ⟹   NP_001402745
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,856 - 182,189,270 (+)NCBI
mRatBN7.23161,757,513 - 161,770,927 (+)NCBI
RefSeq Acc Id: XM_039105609   ⟹   XP_038961537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,189,273 (+)NCBI
mRatBN7.23161,757,493 - 161,770,930 (+)NCBI
RefSeq Acc Id: XM_039105610   ⟹   XP_038961538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,173,615 - 182,189,273 (+)NCBI
mRatBN7.23161,755,299 - 161,770,930 (+)NCBI
RefSeq Acc Id: XR_005501951
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,187,820 (+)NCBI
mRatBN7.23161,757,493 - 161,769,482 (+)NCBI
RefSeq Acc Id: XR_005501952
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,187,835 (+)NCBI
mRatBN7.23161,757,493 - 161,769,492 (+)NCBI
RefSeq Acc Id: XR_005501953
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,185,736 (+)NCBI
mRatBN7.23161,757,493 - 161,767,393 (+)NCBI
Ensembl Acc Id: ENSRNOP00000008959   ⟸   ENSRNOT00000008959
Ensembl Acc Id: ENSRNOP00000075147   ⟸   ENSRNOT00000081823
RefSeq Acc Id: XP_038961538   ⟸   XM_039105610
- Peptide Label: isoform X2
- UniProtKB: A6KKY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961537   ⟸   XM_039105609
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001402745   ⟸   NM_001415816
- UniProtKB: D3Z8A8 (UniProtKB/TrEMBL)
Protein Domains
Meiosis-specific protein Spo11   Spo11/DNA topoisomerase VI subunit A N-terminal   Topoisomerase 6 subunit A/Spo11 TOPRIM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9V7-F1-model_v2 AlphaFold A0A0G2K9V7 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692717
Promoter ID:EPDNEW_R3234
Type:single initiation site
Name:Spo11_1
Description:SPO11, initiator of meiotic double stranded breaks
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03170,994,056 - 170,994,116EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306454 AgrOrtholog
BioCyc Gene G2FUF-46524 BioCyc
Ensembl Genes ENSRNOG00000006732 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008959 ENTREZGENE
  ENSRNOT00000008959.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  3.40.1360.10 UniProtKB/TrEMBL
InterPro Meiosis_Spo11 UniProtKB/TrEMBL
  Meiotic_Spo11 UniProtKB/TrEMBL
  Spo11/TopoVI_A UniProtKB/TrEMBL
  Spo11/TopoVI_A_N UniProtKB/TrEMBL
  Spo11/TopoVI_A_sf UniProtKB/TrEMBL
  TOPRIM_Topo6A/Spo11 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 366261 ENTREZGENE
PANTHER MEIOTIC RECOMBINATION PROTEIN SPO11 UniProtKB/TrEMBL
  Spo11/TopoVI_A UniProtKB/TrEMBL
Pfam SPO11_like UniProtKB/TrEMBL
  TOP6A-Spo11_Toprim UniProtKB/TrEMBL
  TP6A_N UniProtKB/TrEMBL
PhenoGen Spo11 PhenoGen
PRINTS SPO11HOMOLOG UniProtKB/TrEMBL
  TOP6AFAMILY UniProtKB/TrEMBL
PROSITE TOPO_IIB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006732 RatGTEx
Superfamily-SCOP Spo11/TopoVI_A UniProtKB/TrEMBL
UniProt A6KKY2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8A8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-25 Spo11  SPO11 initiator of meiotic double strand breaks  Spo11  SPO11, initiator of meiotic double stranded breaks  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Spo11  SPO11, initiator of meiotic double stranded breaks  Spo11  SPO11 meiotic protein covalently bound to DSB  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-14 Spo11  SPO11 meiotic protein covalently bound to DSB  Spo11  SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Spo11  SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)  Spo11  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Spo11  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)   Spo11_predicted  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Spo11_predicted  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED