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Gene: Slamf8 (SLAM family member 8) Rattus norvegicus

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Symbol:

Slamf8

Name:

SLAM family member 8

RGD ID:

1306263

Description:

Predicted to enable identical protein binding activity and signaling receptor activity. Predicted to be involved in B-1 B cell lineage commitment; immune response; and regulation of B cell differentiation. Predicted to act upstream of or within several processes, including leukocyte chemotaxis involved in inflammatory response; negative regulation of leukocyte migration; and negative regulation of respiratory burst involved in inflammatory response. Predicted to be located in membrane. Orthologous to human SLAMF8 (SLAM family member 8); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC289237; SLAM family member 8 precursor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLAMF8 (SLAM family member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slamf8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slamf8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLAMF8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLAMF8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slamf8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLAMF8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLAMF8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slamf8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slamf8 (SLAM family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IL19 (interleukin 19)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SLAMF8 (SLAM family member 8)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slamf8 (SLAM family member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-286b5.6	Alliance	DIOPT (InParanoid\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	slamf8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slamf8	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	87,580,081 - 87,589,941 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	87,580,182 - 87,589,560 (-)	Ensembl				GRCr8
mRatBN7.2	13	85,047,729 - 85,057,571 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	85,047,727 - 85,057,211 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	87,551,280 - 87,560,366 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	88,951,551 - 88,960,639 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	86,136,289 - 86,145,381 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	90,967,862 - 90,978,752 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	90,967,739 - 90,977,734 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	95,487,053 - 95,497,327 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	88,586,512 - 88,596,072 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	84,657,034 - 84,666,075 (-)	NCBI		Celera
RGSC_v3.1	13	88,764,354 - 88,785,176 (-)	NCBI
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

inflammatory bowel disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

acetamide (EXP)

acrylamide (EXP)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

D-glucose (ISO)

diquat (ISO)

diuron (ISO)

ferric oxide (ISO)

fructose (ISO)

gentamycin (EXP)

glucose (ISO)

glyphosate (ISO)

Moniliformin (ISO)

naled (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium dichromate (ISO)

testosterone (EXP)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B-1 B cell lineage commitment (ISO)

cellular response to xenobiotic stimulus (ISO)

defense response to bacterium (ISO)

immune response (IBA)

leukocyte chemotaxis involved in inflammatory response (ISO)

negative regulation of dendritic cell chemotaxis (ISO)

negative regulation of macrophage chemotaxis (ISO)

negative regulation of monocyte chemotaxis (ISO)

negative regulation of neutrophil migration (ISO)

negative regulation of respiratory burst involved in inflammatory response (ISO)

phagosome acidification (ISO)

regulation of B cell differentiation (ISO)

regulation of kinase activity (ISO)

Cellular Component

membrane (IEA)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

signaling receptor activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11313408	PMID:22593622	PMID:25799045	PMID:38158136

Genomics

Comparative Map Data

Slamf8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	87,580,081 - 87,589,941 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	87,580,182 - 87,589,560 (-)	Ensembl				GRCr8
mRatBN7.2	13	85,047,729 - 85,057,571 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	85,047,727 - 85,057,211 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	87,551,280 - 87,560,366 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	88,951,551 - 88,960,639 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	86,136,289 - 86,145,381 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	90,967,862 - 90,978,752 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	90,967,739 - 90,977,734 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	95,487,053 - 95,497,327 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	88,586,512 - 88,596,072 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	84,657,034 - 84,666,075 (-)	NCBI		Celera
RGSC_v3.1	13	88,764,354 - 88,785,176 (-)	NCBI
Cytogenetic Map	13	q24	NCBI

SLAMF8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	159,826,873 - 159,837,492 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	159,826,693 - 159,837,492 (+)	Ensembl			hg38	GRCh38
GRCh37	1	159,796,663 - 159,807,282 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	158,063,103 - 158,073,906 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	156,609,673 - 156,620,354	NCBI
Celera	1	132,864,904 - 132,875,709 (+)	NCBI		Celera
Cytogenetic Map	1	q23.2	NCBI
HuRef	1	131,152,909 - 131,163,714 (+)	NCBI		HuRef
CHM1_1	1	161,191,825 - 161,202,629 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	158,963,866 - 158,974,492 (+)	NCBI		T2T-CHM13v2.0

Slamf8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	172,408,944 - 172,418,482 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	172,409,325 - 172,418,135 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	172,581,377 - 172,590,873 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	172,581,758 - 172,590,568 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	174,511,508 - 174,520,699 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	174,418,433 - 174,427,163 (-)	NCBI		MGSCv36	mm8
Celera	1	175,435,779 - 175,444,985 (-)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.99	NCBI

Slamf8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	11,623,197 - 11,632,573 (+)	Ensembl
ChiLan1.0	NW_004955468	11,623,092 - 11,632,566 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLAMF8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	90,017,255 - 90,027,775 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	89,757,279 - 89,767,800 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	135,178,241 - 135,189,005 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	139,098,929 - 139,109,725 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

SLAMF8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	22,299,455 - 22,307,090 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	22,300,128 - 22,307,096 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	22,376,851 - 22,384,998 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	22,422,349 - 22,430,469 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	22,422,105 - 22,430,377 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0	38	22,721,713 - 22,729,848 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	23,132,591 - 23,140,763 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slamf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	5,968,095 - 5,978,925 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936740	776,455 - 786,357 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936740	776,557 - 786,182 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLAMF8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	90,661,985 - 90,672,572 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	90,661,984 - 90,673,044 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	98,822,988 - 98,834,116 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLAMF8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	4,114,403 - 4,127,122 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	4,116,630 - 4,124,988 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	3,218,491 - 3,230,109 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slamf8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	1,418,228 - 1,429,561 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	1,418,727 - 1,428,836 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slamf8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	51,698,697 - 51,708,112 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slamf8
20 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	109
Count of miRNA genes:	81
Interacting mature miRNAs:	97
Transcripts:	ENSRNOT00000011869
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	61	155	89	88	57	79	57	6	326	173	11	131	72	90	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011869 ⟹ ENSRNOP00000011869

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	87,580,182 - 87,589,104 (-)	Ensembl
mRatBN7.2 Ensembl	13	85,047,727 - 85,057,211 (-)	Ensembl
Rnor_6.0 Ensembl	13	90,967,739 - 90,977,734 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000133531 ⟹ ENSRNOP00000111960

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	87,580,493 - 87,589,560 (-)	Ensembl

RefSeq Acc Id:

NM_001105973 ⟹ NP_001099443

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	87,580,493 - 87,589,560 (-)	NCBI
mRatBN7.2	13	85,048,141 - 85,057,211 (-)	NCBI
Rnor_6.0	13	90,968,274 - 90,977,343 (-)	NCBI
Rnor_5.0	13	95,487,053 - 95,497,327 (-)	NCBI
RGSC_v3.4	13	88,586,512 - 88,596,072 (-)	RGD
Celera	13	84,657,034 - 84,666,075 (-)	RGD

Sequence:

show sequence

GACCACAGCTCCTTCCGAGCACTCCTTTGGCCTAGGATGGATATCCTGGTTTGTTGAGGGAGTC
TTCCAAAGGAGGACATCGGCCATGTGGTCCCTCTGGAGTCTTCTTCTCTTCCAAGGCCTCCTTC
CCATTGTGGTTATCAGTGTCCAAGTGCTAAGCAAGGTAGGGGACTCCGGGCTGCTGGTGGCTGA
GTGTCCTCCGGGCTTCCAAGTGCGTGAGGCTATCTGGCGATCTCTCTGGCCATCAGAGGAGCTC
CTGGCCACCTTTTTCCGGGGTTCCTTGGAGACTCTGTACCACTCTCGTTTCCTGGGCCGAGTCC
AGCTCTATGACAACCTCAGCCTGGAGCTTGGGCCCCTGAGAACTGGAGACAGTGGCAATTTCTC
TGTGCTGATGGTGGATACAGGAGGTCAAACCTGGACCCAGACCCTGCATCTCAAGGTGTACGAT
GCAGTACCCAAGCCTGAGGTTCAAGTGTTCACGGCTGCAACAGAGGAGGCTCAACCTCTCAATA
CCTGTCAGGTCTTCTTGTCCTGCTGGGCCCCCAACATCAGCGACATAACCTACAGCTGGCGACG
GGAGGGGACAATGGACTTTAATGGGGAACTGCGCAGCCTTTTCTCAAATGGACAGGTGTTAAGT
GTTTCACTGGGACTGGGGGACAAGGATGTGGCCTTTACCTGCATTGCCTCCAACCCTGTCAGCT
GGGATATGACCACAGTCACCCCCTGGGAGAGCTGCCATCATGAGGCAGCCTCCTCTGGGAAGGC
CTCCTACAAGGACGTGCTCCTGGTTGTAATGCCAATTACACTGTTCCTGATTCTGGCTGGTCTC
TTTGGGGCATGGCACCATGGCCTGTGCTCAGGGAAGAGGAAGGATGCCTGCACTGACAGAGCGC
TTCCAGAGACAGAGAGTGCCGTCGCATAGAGGATGTCATGAAAGACAGCATACACTGGTGCTTG
GACCATGATGAGATGCCTGCCCAGCCACATGATGCTCCACGTCTGGACACCTCCAGGATCCTCC
TAACTTCCACAAGTCTGTCTGCCTCTGCTGGACAGCCAAGAAAACCACCATCCTGGAACATGGC
CCTAGCCTAAACTTCCTCCCTCCTCCATTCAGTCTGCACGTGCTGGACGCTCTCTGGGCAAGGT
GGACTAATAGGACGCGTCCTTAAAAACACCGAACTTTCTCTAGGATCTACAGAGACATTGATTA
TCCAAGGCATCCATTCTTCTACCACTGTACATAAGGTCCATCTTACCCAACTGCCACCAAGAGA
TTGCCTCCAGGTCCTGGGCTCAAAGAGAGATCAGAAGTTTGAATGAACATAAGATGGAGCTCAT
CTCTGCCAACTGCACCCCCACCCCCAGAGTCTGAGGTCCTTATGTTCAAGATGTTGTCATAAGA
AAAGTCATAGAACAGGGAAAGATGGAGGGCAGGGCTTTCTCTTTCTGGCCTGAAGGACTTTAAG
GTCATCTGAGTTCAAGGACCCTCAAAGGTAAGTTGAGGTTACAGATGACGAGGGATAGCTATTG
CGCCATGTTGGGATGGAAGCCATTTTTCTAGTAGCACCACATTAATAGACATCATAATTGCCAT

hide sequence

RefSeq Acc Id:

XM_006250284 ⟹ XP_006250346

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	87,580,081 - 87,589,941 (-)	NCBI
mRatBN7.2	13	85,047,729 - 85,057,571 (-)	NCBI
Rnor_6.0	13	90,967,862 - 90,978,752 (-)	NCBI
Rnor_5.0	13	95,487,053 - 95,497,327 (-)	NCBI

Sequence:

show sequence

GCCCACCAGAACCTATGGGGTCCTTTCTCTCTTACTATCTAAATCATGCTTAACAATCCACAGG
TAGATCCAACAGATCTCGAGCATCGCTAATTGCCTGGTGCAATGAATGCTGAATGCCCCCCACA
CAGAGAGAGAGAGACATGCCCATGTGCCAGCAACCTTCACTCCCTGGCATGTCTGTTTTCACAG
GCAGGGATTTTCTCCCTAACCCTTCCTGCTCGTCAGCTCCCATCCTATATGTCTAATTCCTGAT
GCAGTGTTACCATGGTACCCATTTGACTGACAAGCTAGATACTGTATAGGACAACACACAATGA
TCCACACTCGGGACCTTTAGAAATCTTCCTCAAGGGCAGCATCTTAAAAATGACTTCCCTGCTC
CCAATACGGATACACTGCGGTAGAACATTCCAGAAGCCGTTCATTCTCTCTCTAGTACTGAGGG
AAAGAGGGAGAAAAAAGAAGCTAATATGTAAAAGCAGAGAATAAGAGTGAGGAGGGGACAACTC
ATGCTCTCTGCACCTCTGTGACCCCTGTGACCCCAGCAAGCTGCCTAACATCACCCTGGCTTTT
AATTCTTCCACCACTAATACTTCCAACAGGGTGACAAGAAGATGAGCTCTGAGAAAGGTCCAGC
CTTACATAAAAGCAAAAGGGCTATCCATGTCTGGTAGTCCTTCATTCACTTAATGGCTATCTCT
TAAACAGTAAGCATGTCCAGCACAGAAACAAATACAATTCGCTCTTAAACAGCTAGAGAAACCT
TGAAATTATGACCAGCAACACAAGGGAAGAGTAAATGCACGTGGTTACAAAGGGTTTCTCGCTC
TCGTTGTAGCCAGCAAGCCTTGAAGGACAGCCTGGGTGCAAAGCTGGGTCAGGTACGTCTGCTA
GGGAAGCCAACCCAGTGCGTGCAAATGTCAATGGATGGTTCTGAAAAGAGGTAGTCTGGCTGGG
ATGGCCGGAGAGGACAGCGGATGTGGGCAGCCAGTCTGGAGAAGCTGAAAACCCTCACGGGTTA
CGCTCAGTATTGAGTCTTTATCCAGAGGGCGACAGGAGAGTTTCGAAGGTTTTTCAGCAGAGGG
GAAGTGACCCGATCAGAATTGCAGCTCAGAGGGCTTCTCTGTGGCAATGATGGTGTTTAGACAC
ATCCACGGGCAGGGTTGGATGCAGAGACCCGGTGACCATGTGTAAGAAGCGCATGGGCTGTGTG
GGTGTGATTGTCACCACGCTCTGGCCAGCCATGGACACAGAAAGGAGGCTGATTTACAAGAATC
TGCTGCTGAAAGCCCAGCTAGGCCTAGCTGGGCCTGCAGCCAACTTCCACTTTACCCGGATGCT
TTCGCTTTCAAGACATCGTGTTTTGAGTAAAGATTCCTCCTTCTGAACACGGGACTTTCCGGCA
GGACCACAGCTCCTTCCGAGCACTCCTTTGGCCTAGGATGGATATCCTGGTTTGTTGAGGGAGT
CTTCCAAAGGAGGACATCGGCCATGTGGTCCCTCTGGAGTCTTCTTCTCTTCCAAGGCCTCCTT
CCCATTGTGGTTATCAGTGTCCAAGTGCTAAGCAAGGTAGGGGACTCCGGGCTGCTGGTGGCTG
AGTGTCCTCCGGGCTTCCAAGTGCGTGAGGCTATCTGGCGATCTCTCTGGCCATCAGAGGAGCT
CCTGGCCACCTTTTTCCGGGGTTCCTTGGAGACTCTGTACCACTCTCGTTTCCTGGGCCGAGTC
CAGCTCTATGACAACCTCAGCCTGGAGCTTGGGCCCCTGAGAACTGGAGACAGTGGCAATTTCT
CTGTGCTGATGGTGGATACAGGAGGTCAAACCTGGACCCAGACCCTGCATCTCAAGGTGTACGA
TGCAGTACCCAAGCCTGAGGTTCAAGTGTTCACGGCTGCAACAGAGGAGGCTCAACCTCTCAAT
ACCTGTCAGGTCTTCTTGTCCTGCTGGGCCCCCAACATCAGCGACATAACCTACAGCTGGCGAC
GGGAGGGGACAATGGACTTTAATGGGGAACTGCGCAGCCTTTTCTCAAATGGACAGGTGTTAAG
TGTTTCACTGGGACTGGGGGACAAGGATGTGGCCTTTACCTGCATTGCCTCCAACCCTGTCAGC
TGGGATATGACCACAGTCACCCCCTGGGAGAGCTGCCATCATGAGGCAGCCTCCTCTGGGAAGG
CCTCCTACAAGGACGTGCTCCTGGTTGTAATGCCAATTACACTGTTCCTGATTCTGGCTGGTCT
CTTTGGGGCATGGCACCATGGCCTGTGCTCAGCAGGGAAGAGGAAGGATGCCTGCACTGACAGA
GCGCTTCCAGAGACAGAGAGTGCCGTCGCATAGAGGATGTCATGAAAGACAGCATACACTGGTG
CTTGGACCATGATGAGATGCCTGCCCAGCCACATGATGCTCCACGTCTGGACACCTCCAGGATC
CTCCTAACTTCCACAAGTCTGTCTGCCTCTGCTGGACAGCCAAGAAAACCACCATCCTGGAACA
TGGCCCTAGCCTAAACTTCCTCCCTCCTCCATTCAGTCTGCACGTGCTGGACGCTCTCTGGGCA
AGGTGGACTAATAGGACGCGTCCTTAAAAACACCGAACTTTCTCTAGGATCTACAGAGACATTG
ATTATCCAAGGCATCCATTCTTCTACCACTGTACATAAGGTCCATCTTACCCAACTGCCACCAA
GAGATTGCCTCCAGGTCCTGGGCTCAAAGAGAGATCAGAAGTTTGAATGAACATAAGATGGAGC
TCATCTCTGCCAACTGCACCCCCACCCCCAGAGTCTGAGGTCCTTATGTTCAAGATGTTGTCAT
AAGAAAAGTCATAGAACAGGGAAAGATGGAGGGCAGGGCTTTCTCTTTCTGGCCTGAAGGACTT
TAAGGTCATCTGAGTTCAAGGACCCTCAAAGGTAAGTTGAGGTTACAGATGACGAGGGATAGCT
ATTGCGCCATGTTGGGATGGAAGCCATTTTTCTAGTAGCACCACATTAATAGACATCATAATTG
CCATTAATTCTGGTGTCTCCTGCATATCCGGGGTGGTGTTTCAAACTCTTTCCATATATTCTAC
ATGGTTGCCAGAAAAAAAGAAAGAAAAGCAAAGAAAAAAATACAGAGAGTTTGACCCAGCCAGC
AGGAAATTCTTCCACAATGTCAAGAGAAACAGCTAAGTTCAGGATAAGTCTGTCTTCCTAAAAC
TGGGAGAATGAAGAGCCATAAAAAGCTATGCAAGGGGGGCTGGAGAGATGGCTCAGCGGTTAAG
AGCATTGACCATTCTTCCGGAGGTCCTGAGTTCAATTCCCAGCAACCACATGGTGGCTCACAAC
CATCTGTAATGGGATCCAATGTTCTCTTCTGGTGTGTGTGAAGAGATCTATAGTGTACTCATAT
ACATAAAATAAATAAATCTTTTTTAAAAGCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099443	(Get FASTA)	NCBI Sequence Viewer
	NP_001420958	(Get FASTA)	NCBI Sequence Viewer
	XP_006250346	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94723	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011869
	ENSRNOP00000011869.7
	ENSRNOP00000111960
	ENSRNOP00000111960.1

RefSeq Acc Id:

NP_001099443 ⟸ NM_001105973

- UniProtKB:

A6JG67 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWSLWSLLLFQGLLPIVVISVQVLSKVGDSGLLVAECPPGFQVREAIWRSLWPSEELLATFFRG
SLETLYHSRFLGRVQLYDNLSLELGPLRTGDSGNFSVLMVDTGGQTWTQTLHLKVYDAVPKPEV
QVFTAATEEAQPLNTCQVFLSCWAPNISDITYSWRREGTMDFNGELRSLFSNGQVLSVSLGLGD
KDVAFTCIASNPVSWDMTTVTPWESCHHEAASSGKASYKDVLLVVMPITLFLILAGLFGAWHHG
LCSGKRKDACTDRALPETESAVA

hide sequence

RefSeq Acc Id:

XP_006250346 ⟸ XM_006250284

- Peptide Label:

isoform X1

- Sequence:

show sequence

MWSLWSLLLFQGLLPIVVISVQVLSKVGDSGLLVAECPPGFQVREAIWRSLWPSEELLATFFRG
SLETLYHSRFLGRVQLYDNLSLELGPLRTGDSGNFSVLMVDTGGQTWTQTLHLKVYDAVPKPEV
QVFTAATEEAQPLNTCQVFLSCWAPNISDITYSWRREGTMDFNGELRSLFSNGQVLSVSLGLGD
KDVAFTCIASNPVSWDMTTVTPWESCHHEAASSGKASYKDVLLVVMPITLFLILAGLFGAWHHG
LCSAGKRKDACTDRALPETESAVA

hide sequence

Ensembl Acc Id:

ENSRNOP00000011869 ⟸ ENSRNOT00000011869

Ensembl Acc Id:

ENSRNOP00000111960 ⟸ ENSRNOT00000133531

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZS24-F1-model_v2	AlphaFold	D3ZS24	1-279	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306263	AgrOrtholog
BioCyc Gene	G2FUF-17299	BioCyc
Ensembl Genes	ENSRNOG00000008736	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011869	ENTREZGENE
	ENSRNOT00000011869.8	UniProtKB/TrEMBL
	ENSRNOT00000133531	ENTREZGENE
	ENSRNOT00000133531.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	CD2/SLAM_rcpt	UniProtKB/TrEMBL
	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
KEGG Report	rno:289237	UniProtKB/TrEMBL
NCBI Gene	289237	ENTREZGENE
PANTHER	SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE	UniProtKB/TrEMBL
	SLAM FAMILY MEMBER 8	UniProtKB/TrEMBL
PhenoGen	Slamf8	PhenoGen
PROSITE	IG_LIKE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008736	RatGTEx
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0ABK0M1I8_RAT	UniProtKB/TrEMBL
	A6JG67	ENTREZGENE, UniProtKB/TrEMBL
	D3ZS24	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Slamf8	SLAM family member 8	Slamf8_predicted	SLAM family member 8 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Slamf8_predicted	SLAM family member 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD