Tmem30c (transmembrane protein 30C) - Rat Genome Database

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Gene: Tmem30c (transmembrane protein 30C) Rattus norvegicus
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Symbol: Tmem30c
Name: transmembrane protein 30C
RGD ID: 1306090
Description: Predicted to enable aminophospholipid flippase activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Orthologous to human TMEM30CP (transmembrane protein 30C, pseudogene); INTERACTS WITH bisphenol A; glyphosate; trichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell cycle control protein 50C; LOC288175; RGD1306090; similar to hypothetical protein FLJ10856
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,708,788 - 56,727,633 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1156,710,635 - 56,727,631 (+)EnsemblGRCr8
mRatBN7.21143,239,661 - 43,258,506 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,241,508 - 43,258,427 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1151,995,893 - 52,014,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,657,494 - 44,676,304 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,786,093 - 43,804,896 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1158,613,593 - 58,632,359 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1156,839,966 - 56,858,732 (+)NCBILyon_Normotensive
Lyon_Hypertensive1157,748,187 - 57,766,952 (+)NCBILyon_Hypertensive
F344_StmMcwi1156,536,788 - 56,555,584 (+)NCBIF344_StmMcwi
Rnor_6.01145,337,502 - 45,356,495 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,339,366 - 45,356,473 (+)Ensemblrn6Rnor6.0
Rnor_5.01148,533,059 - 48,552,064 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41144,075,646 - 44,094,851 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1143,033,923 - 43,052,609 (+)NCBICelera
RGSC_v3.11144,135,106 - 44,152,275 (+)NCBI
Cytogenetic Map11q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmem30c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,708,788 - 56,727,633 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1156,710,635 - 56,727,631 (+)EnsemblGRCr8
mRatBN7.21143,239,661 - 43,258,506 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,241,508 - 43,258,427 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1151,995,893 - 52,014,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01144,657,494 - 44,676,304 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,786,093 - 43,804,896 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1158,613,593 - 58,632,359 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1156,839,966 - 56,858,732 (+)NCBILyon_Normotensive
Lyon_Hypertensive1157,748,187 - 57,766,952 (+)NCBILyon_Hypertensive
F344_StmMcwi1156,536,788 - 56,555,584 (+)NCBIF344_StmMcwi
Rnor_6.01145,337,502 - 45,356,495 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,339,366 - 45,356,473 (+)Ensemblrn6Rnor6.0
Rnor_5.01148,533,059 - 48,552,064 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41144,075,646 - 44,094,851 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1143,033,923 - 43,052,609 (+)NCBICelera
RGSC_v3.11144,135,106 - 44,152,275 (+)NCBI
Cytogenetic Map11q12NCBI
TMEM30CP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383100,185,824 - 100,194,186 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3100,183,982 - 100,194,191 (+)Ensemblhg38GRCh38
GRCh38.p14 Ensembl3100,185,687 - 100,211,766 (+)Ensemblhg38GRCh38
GRCh37399,904,668 - 99,913,030 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363101,387,221 - 101,395,784 (+)NCBIBuild 36Build 36hg18NCBI36
Celera398,295,272 - 98,303,634 (+)NCBICelera
Cytogenetic Map3q12.1NCBI
HuRef397,272,830 - 97,281,194 (+)NCBIHuRef
CHM1_1399,867,723 - 99,876,085 (+)NCBICHM1_1
T2T-CHM13v2.03102,891,160 - 102,899,523 (+)NCBIT2T-CHM13v2.0
Tmem30c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391657,086,502 - 57,122,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1657,086,502 - 57,113,228 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381657,266,139 - 57,301,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1657,266,139 - 57,292,865 (-)Ensemblmm10GRCm38
MGSCv371657,266,252 - 57,292,964 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361657,187,497 - 57,214,223 (-)NCBIMGSCv36mm8
Celera1657,592,517 - 57,619,145 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1634.22NCBI
TMEM30C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1336,819,549 - 6,844,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha336,975,121 - 6,999,809 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0336,958,100 - 6,982,786 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl336,958,346 - 6,982,784 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1336,846,239 - 6,870,794 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0336,894,040 - 6,918,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0337,223,993 - 7,248,554 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TMEM30C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113158,767,127 - 158,789,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213168,330,321 - 168,380,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Tmem30c
73 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:95
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000002241
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
11528648Bss118Bone structure and strength QTL 1186.6582e-07femur strength trait (VT:0010010)femur ultimate displacement (CMO:0002719)115410798756845449Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 10 36 121 67 66 36 76 36 5 253 138 5 100 60 64 30 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000002241   ⟹   ENSRNOP00000002241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1156,710,635 - 56,727,631 (+)Ensembl
mRatBN7.2 Ensembl1143,241,508 - 43,258,427 (+)Ensembl
Rnor_6.0 Ensembl1145,339,366 - 45,356,473 (+)Ensembl
RefSeq Acc Id: NM_001105889   ⟹   NP_001099359
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,708,788 - 56,727,554 (+)NCBI
mRatBN7.21143,239,661 - 43,258,427 (+)NCBI
Dahl_SR_JrHsd1158,613,593 - 58,632,359 (+)NCBI
Lyon_Normotensive1156,839,966 - 56,858,732 (+)NCBI
Lyon_Hypertensive1157,748,187 - 57,766,952 (+)NCBI
F344_StmMcwi1156,536,788 - 56,555,584 (+)NCBI
Rnor_6.01145,337,518 - 45,356,425 (+)NCBI
Rnor_5.01148,533,059 - 48,552,064 (+)NCBI
RGSC_v3.41144,075,646 - 44,094,851 (+)RGD
Celera1143,033,923 - 43,052,609 (+)RGD
Sequence:
RefSeq Acc Id: XM_008768632   ⟹   XP_008766854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,708,801 - 56,727,633 (+)NCBI
mRatBN7.21143,239,772 - 43,258,506 (+)NCBI
Rnor_6.01145,337,679 - 45,356,495 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099359 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766854 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11030 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002241
  ENSRNOP00000002241.4
RefSeq Acc Id: NP_001099359   ⟸   NM_001105889
- UniProtKB: D4AAH8 (UniProtKB/TrEMBL),   A6IQM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766854   ⟸   XM_008768632
- Peptide Label: isoform X1
- UniProtKB: D4AAH8 (UniProtKB/TrEMBL),   A6IQM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002241   ⟸   ENSRNOT00000002241

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAH8-F1-model_v2 AlphaFold D4AAH8 1-342 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306090 AgrOrtholog
BioCyc Gene G2FUF-21544 BioCyc
Ensembl Genes ENSRNOG00000001644 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002241 ENTREZGENE
  ENSRNOT00000002241.8 UniProtKB/TrEMBL
InterPro DUF284_TM_euk UniProtKB/TrEMBL
KEGG Report rno:288175 UniProtKB/TrEMBL
NCBI Gene 288175 ENTREZGENE
PANTHER DUF284_TM_euk UniProtKB/TrEMBL
  PTHR10926:SF1 UniProtKB/TrEMBL
Pfam CDC50 UniProtKB/TrEMBL
PhenoGen Tmem30c PhenoGen
PIRSF DUF284_TM_euk UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001644 RatGTEx
UniProt A6IQM7 ENTREZGENE, UniProtKB/TrEMBL
  D4AAH8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Tmem30c  transmembrane protein 30C  RGD1306090_predicted  similar to hypothetical protein FLJ10856 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306090_predicted  similar to hypothetical protein FLJ10856 (predicted)  LOC288175_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC288175_predicted  similar to hypothetical protein FLJ10856 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL