Ntsr1 (neurotensin receptor 1) - Rat Genome Database

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Gene: Ntsr1 (neurotensin receptor 1) Rattus norvegicus
Analyze
Symbol: Ntsr1
Name: neurotensin receptor 1
RGD ID: 1306076
Description: Enables identical protein binding activity. Involved in several processes, including positive regulation of organic acid transport; regulation of inositol phosphate biosynthetic process; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including dendrite; perikaryon; and symmetric synapse. Human ortholog(s) of this gene implicated in alcohol dependence; opiate dependence; and schizophrenia. Orthologous to human NTSR1 (neurotensin receptor 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: high-affinity levocabastine-insensitive neurotensin receptor; LOC366274; neurotensin receptor; neurotensin receptor type 1; NT-R-1; NTR1; NTRH; Ntsr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,983,778 - 188,033,934 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3187,983,778 - 188,033,934 (+)EnsemblGRCr8
mRatBN7.23167,606,215 - 167,656,371 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,606,215 - 167,656,377 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3171,986,455 - 172,036,627 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,945,543 - 180,995,717 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,607,136 - 177,657,300 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,982,313 - 176,046,345 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,885,894 - 176,046,345 (+)Ensemblrn6Rnor6.0
Rnor_5.03179,681,394 - 179,747,034 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43169,567,488 - 169,633,121 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3164,925,618 - 164,973,840 (-)NCBICelera
RGSC_v3.13169,473,987 - 169,536,964 (+)NCBI
Cytogenetic Map3q43NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
DDE  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fonofos  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
isoflavones  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
neurotensin  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (ISO)
phencyclidine  (ISO)
pinostrobin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sotorasib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
associative learning  (IMP)
cAMP biosynthetic process  (IMP)
conditioned place preference  (IMP)
D-aspartate import across plasma membrane  (IDA)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
G protein-coupled receptor signaling pathway  (IEA)
inositol phosphate catabolic process  (IMP)
L-glutamate import across plasma membrane  (IDA)
learning  (IMP)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of release of sequestered calcium ion into cytosol  (IMP)
negative regulation of systemic arterial blood pressure  (IMP)
neuropeptide signaling pathway  (IBA,IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of arachidonate secretion  (IMP)
positive regulation of cation channel activity  (IMP)
positive regulation of gamma-aminobutyric acid secretion  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glutamate secretion  (IMP)
positive regulation of inhibitory postsynaptic potential  (IMP)
positive regulation of inositol phosphate biosynthetic process  (IMP)
positive regulation of locomotion  (IMP)
positive regulation of release of sequestered calcium ion into cytosol  (IMP)
regulation of behavioral fear response  (IMP)
regulation of inositol trisphosphate biosynthetic process  (IDA)
regulation of membrane depolarization  (IMP)
regulation of respiratory gaseous exchange  (IMP)
response to food  (IEP)
response to lipid  (IDA)
response to stress  (IEP)
signal transduction  (IEA)
temperature homeostasis  (IMP)
vocalization behavior  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Widespread expression in adult rat forebrain of mRNA encoding high-affinity neurotensin receptor. Alexander MJ and Leeman SE, J Comp Neurol. 1998 Dec 28;402(4):475-500.
2. Neurotensin receptor involvement in the rise of extracellular glutamate levels and apoptotic nerve cell death in primary cortical cultures after oxygen and glucose deprivation. Antonelli T, etal., Cereb Cortex. 2008 Aug;18(8):1748-57. Epub 2007 Dec 5.
3. Constitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix seven. Barroso S, etal., Br J Pharmacol. 2002 Feb;135(4):997-1002.
4. Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. Boudin H, etal., J Comp Neurol. 1996 Sep 9;373(1):76-89.
5. Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra. Boudin H, etal., J Neurosci. 1998 Oct 15;18(20):8473-84.
6. Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive. Buhler AV, etal., Pain. 2005 Mar;114(1-2):285-94. Epub 2005 Jan 26.
7. Neurotensin depolarizes globus pallidus neurons in rats via neurotensin type-1 receptor. Chen L, etal., Neuroscience. 2004;125(4):853-9.
8. Effects of neurotensin on discharge rates of rat suprachiasmatic nucleus neurons in vitro. Coogan AN, etal., Neuroscience. 2001;103(3):663-72.
9. Developmental expression of the neurotensin gene in the rat liver. Evers BM, etal., Ann Surg. 1993 Aug;218(2):183-8.
10. Distribution of the neurotensin receptor NTS1 in the rat CNS studied using an amino-terminal directed antibody. Fassio A, etal., Neuropharmacology. 2000 Jun 8;39(8):1430-42.
11. Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference. Felszeghy K, etal., Neuropsychopharmacology. 2007 Dec;32(12):2601-10. doi: 10.1038/sj.npp.1301382. Epub 2007 Mar 14.
12. Striatal NTS1 , dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release--a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat. Ferraro L, etal., Eur J Neurosci. 2012 Jan;35(2):207-20. doi: 10.1111/j.1460-9568.2011.07949.x. Epub 2011 Dec 30.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. Guillemette A, etal., Eur J Pain. 2012 Apr;16(4):473-84. doi: 10.1016/j.ejpain.2011.07.008.
16. Direct analysis of a GPCR-agonist interaction by surface plasmon resonance. Harding PJ, etal., Eur Biophys J. 2006 Oct;35(8):709-12. Epub 2006 May 18.
17. Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid. Inagaki S, etal., J Mol Biol. 2012 Mar 16;417(1-2):95-111. doi: 10.1016/j.jmb.2012.01.023. Epub 2012 Jan 27.
18. Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Johnson MD, etal., Hypertension. 2009 Sep;54(3):639-45. Epub 2009 Jul 20.
19. Characterization of neurotensin receptors. Kitabgi P and Pelaprat D, Curr Protoc Pharmacol. 2004 May;Chapter 1:Unit 1.29. doi: 10.1002/0471141755.ph0129s24.
20. The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala. Laszlo K, etal., Behav Brain Res. 2012 Jan 15;226(2):597-600. doi: 10.1016/j.bbr.2011.08.041. Epub 2011 Sep 21.
21. An Association Study of Neurotensin Receptor Gene's Polymorphism with Schizophrenia Lee YS, Kim HB, Han JH, Chai YG, Lee JS, Lee HS, Joo YH, Kim HS, Choi IG, Yang BH, J Korean Neuropsychiatr Assoc 1999 Nov;38(6):1494-1501.
22. Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. Levran O, etal., CNS Neurosci Ther. 2015 Nov;21(11):898-904. doi: 10.1111/cns.12450. Epub 2015 Sep 19.
23. Association between neurotensin receptor 1 gene polymorphisms and alcohol dependence in a male Han Chinese population. Ma H, etal., J Mol Neurosci. 2013 Oct;51(2):408-15. doi: 10.1007/s12031-013-0041-5. Epub 2013 Jun 8.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey. Mitchell VA, etal., J Physiol. 2009 Jun 1;587(Pt 11):2511-20. doi: 10.1113/jphysiol.2008.167429. Epub 2009 Apr 9.
26. Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins. Najimi M, etal., FEBS Lett. 2002 Feb 13;512(1-3):329-33.
27. Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. Najimi M, etal., FEBS Lett. 2002 Jul 17;523(1-3):224-8.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Neurotensin modulates synaptic transmission in the nucleus of the solitary tract of the rat. Ogawa WN, etal., Neuroscience. 2005;130(2):309-15.
30. High-affinity neurotensin receptor is involved in phosphoinositide hydrolysis stimulation by carbachol in neonatal rat brain. Pereyra-Alfonso S, etal., Brain Res Dev Brain Res. 2005 Feb 8;154(2):247-54. Epub 2005 Jan 11.
31. NTS2 modulates the intracellular distribution and trafficking of NTS1 via heterodimerization. Perron A, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):582-90. Epub 2006 Dec 18.
32. Neurotensin activates GABAergic interneurons in the prefrontal cortex. Petrie KA, etal., J Neurosci. 2005 Feb 16;25(7):1629-36.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats. Prus AJ, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:78-84. doi: 10.1016/j.pnpbp.2013.11.011. Epub 2013 Nov 23.
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model. Roussy G, etal., J Neurochem. 2008 May;105(4):1100-14. doi: 10.1111/j.1471-4159.2007.05205.x. Epub 2007 Dec 25.
39. Pharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cells. Sarret P, etal., J Biol Chem 2002 Sep 27;277(39):36233-43.
40. Binge-like intake of HFD attenuates alcohol intake in rats. Sirohi S, etal., Physiol Behav. 2017 Sep 1;178:187-195. doi: 10.1016/j.physbeh.2016.10.006. Epub 2016 Oct 17.
41. Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus. Skrzydelski D, etal., Mol Pharmacol. 2003 Aug;64(2):421-9. doi: 10.1124/mol.64.2.421.
42. Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdala. Toda H, etal., PLoS One. 2014 May 15;9(5):e97421. doi: 10.1371/journal.pone.0097421. eCollection 2014.
43. Neurotensin regulates intracellular calcium in ventral tegmental area astrocytes: evidence for the involvement of multiple receptors. Trudeau LE Neuroscience. 2000;97(2):293-302.
44. Immunohistochemical evidence for the implication of PC1 in the processing of proneurotensin in rat brain. Villeneuve P, etal., Neuroreport. 2000 Nov 9;11(16):3443-7.
45. Heterogeneity of melanized neurons expressing neurotensin receptor messenger RNA in the substantia nigra and the nucleus paranigralis of control and Parkinson's disease brain. Yamada M, etal., Neuroscience. 1995 Jan;64(2):405-17.
46. Regulation of daily rhythm of body temperature by neurotensin receptor in rats. Yamada M, etal., Res Commun Mol Pathol Pharmacol. 1995 Mar;87(3):323-32.
Additional References at PubMed
PMID:1694443   PMID:8381365   PMID:8839352   PMID:15353215   PMID:16953387   PMID:17620610   PMID:17664042   PMID:18835308   PMID:20403392   PMID:21725197   PMID:23051748   PMID:24978951  
PMID:25157640   PMID:25807267   PMID:26783230   PMID:26926422   PMID:27523794   PMID:27586561   PMID:28089664   PMID:29596791   PMID:32561375   PMID:34508168   PMID:38395391  


Genomics

Comparative Map Data
Ntsr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,983,778 - 188,033,934 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3187,983,778 - 188,033,934 (+)EnsemblGRCr8
mRatBN7.23167,606,215 - 167,656,371 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,606,215 - 167,656,377 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3171,986,455 - 172,036,627 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,945,543 - 180,995,717 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,607,136 - 177,657,300 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,982,313 - 176,046,345 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,885,894 - 176,046,345 (+)Ensemblrn6Rnor6.0
Rnor_5.03179,681,394 - 179,747,034 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43169,567,488 - 169,633,121 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3164,925,618 - 164,973,840 (-)NCBICelera
RGSC_v3.13169,473,987 - 169,536,964 (+)NCBI
Cytogenetic Map3q43NCBI
NTSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382062,708,836 - 62,762,771 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2062,708,836 - 62,762,771 (+)Ensemblhg38GRCh38
GRCh372061,340,188 - 61,394,123 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362060,810,634 - 60,864,568 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342060,810,633 - 60,864,567NCBI
Celera2058,015,902 - 58,069,780 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,057,195 - 58,112,133 (+)NCBIHuRef
CHM1_12061,240,216 - 61,294,517 (+)NCBICHM1_1
T2T-CHM13v2.02064,507,559 - 64,561,762 (+)NCBIT2T-CHM13v2.0
Ntsr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,141,769 - 180,186,772 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,141,769 - 180,186,773 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382180,499,976 - 180,544,979 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,499,976 - 180,544,980 (+)Ensemblmm10GRCm38
MGSCv372180,234,681 - 180,279,684 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362180,429,384 - 180,474,387 (+)NCBIMGSCv36mm8
Celera2184,584,976 - 184,630,855 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.04NCBI
Ntsr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555281,348,555 - 1,394,868 (-)Ensembl
ChiLan1.0NW_0049555281,348,616 - 1,394,798 (-)NCBIChiLan1.0ChiLan1.0
NTSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,500,208 - 68,551,762 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12068,493,332 - 68,544,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02059,100,110 - 59,151,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12060,392,736 - 60,446,056 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2060,392,736 - 60,446,056 (+)EnsemblpanPan2panpan1.1
NTSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,576,690 - 46,615,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2446,576,501 - 46,615,206 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2445,761,069 - 45,799,295 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02447,445,631 - 47,483,515 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2447,445,292 - 47,483,519 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12446,546,845 - 46,585,056 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02446,670,214 - 46,708,469 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,425,128 - 47,463,367 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ntsr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640194,786,843 - 194,821,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,241,020 - 10,272,816 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,240,990 - 10,272,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,989,402 - 62,033,548 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11761,989,601 - 62,038,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NTSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121,466,965 - 1,521,681 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21,469,378 - 1,521,323 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605049,354,595 - 49,410,303 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntsr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474128,505,037 - 28,544,122 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474128,504,814 - 28,543,592 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ntsr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15157,593,242 - 157,640,229 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:571
Count of miRNA genes:235
Interacting mature miRNAs:296
Transcripts:ENSRNOT00000039780
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 10 52 125 64 61 37 30 37 6 181 103 1 112 25 88 24 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000039780   ⟹   ENSRNOP00000035997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3187,983,778 - 188,033,934 (+)Ensembl
mRatBN7.2 Ensembl3167,606,215 - 167,656,377 (+)Ensembl
Rnor_6.0 Ensembl3175,885,894 - 176,046,345 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082073   ⟹   ENSRNOP00000072865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3175,982,777 - 176,044,152 (+)Ensembl
RefSeq Acc Id: NM_001108967   ⟹   NP_001102437
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,983,778 - 188,033,934 (+)NCBI
mRatBN7.23167,606,215 - 167,656,371 (+)NCBI
Rnor_6.03175,982,313 - 176,046,345 (+)NCBI
Rnor_5.03179,681,394 - 179,747,034 (+)NCBI
RGSC_v3.43169,567,488 - 169,633,121 (+)RGD
Celera3164,925,618 - 164,973,840 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102437 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88805 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035997
  ENSRNOP00000035997.2
GenBank Protein P20789 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102437   ⟸   NM_001108967
- UniProtKB: P20789 (UniProtKB/Swiss-Prot),   A6KM97 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072865   ⟸   ENSRNOT00000082073
Ensembl Acc Id: ENSRNOP00000035997   ⟸   ENSRNOT00000039780
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20789-F1-model_v2 AlphaFold P20789 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306076 AgrOrtholog
BioCyc Gene G2FUF-46329 BioCyc
Ensembl Genes ENSRNOG00000028708 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039780 ENTREZGENE
  ENSRNOT00000039780.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  NT1_rcpt UniProtKB/Swiss-Prot
  NT_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:366274 UniProtKB/Swiss-Prot
NCBI Gene 366274 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  NEUROTENSIN RECEPTOR TYPE 1 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ntsr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NEUROTENSINR UniProtKB/Swiss-Prot
  NEUROTENSN1R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028708 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6KM97 ENTREZGENE, UniProtKB/TrEMBL
  NTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ntsr1  neurotensin receptor 1   Ntsr1_predicted  neurotensin receptor 1 (predicted)  'predicted' is removed 2292626 APPROVED
2007-04-24 Ntsr1_predicted  neurotensin receptor 1 (predicted)  Ntsr1  neurotensin receptor 1  Data merged from RGD:619865 737654 APPROVED
2006-03-21 Ntsr1_predicted  neurotensin receptor 1 (predicted)  Ntsr_predicted  neurotensin receptor (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 Ntsr1  neurotensin receptor 1  Ntsr  neurotensin receptor  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ntsr_predicted  neurotensin receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Ntsr  neurotensin receptor      Symbol and Name status set to provisional 70820 PROVISIONAL